Abstract: The present invention relates to nucleic acid sequences encoding novel Babesia canis associated proteins and to cDNA fragments, recombinant DNA molecules and live recombinant carriers comprising these sequences. Furthermore, the invention relates to host cells comprising such nucleic acid sequences, cDNA fragments, recombinant DNA molecules and live recombinant carriers. Also, the invention relates to proteins encoded by these nucleotide sequences, to vaccines for combating Babesia canis infections comprising these proteins or genetic material encoding these proteins and methods for the preparation of vaccines. Another embodiment of the invention relates to these Babesia canis associated proteins for use in vaccines and to the use of the Babesia canis associated proteins in the manufacture of vaccines.

Abstract: The invention relates to a process for separating off maleic anhydride from a gas stream comprising maleic anhydride, in which a) the gas stream comprising maleic anhydride is brought into contact with a liquid absorbent phase comprising at least one high-boiling inert absorption medium for maleic anhydride and b) maleic anhydride is separated off from the resulting liquid absorbate phase by stripping with a hydrogen-comprising gas as stripping medium in a column, wherein the stripping medium is fed in at two points on the column which are at least one theoretical plate apart.

Abstract: The invention relates to the bis-hydrochloride of 4,4?-dithiobis-(3-aminobutane-1-sodium sulphonate) and the bis-trifluoracetate of 4,4?-dithiobis-(3-aminobutane-1-sulphonate of 2,2-dimethylpropyl). The invention also relates to a pharmaceutical composition comprising one of said compounds and to the use of one of said compounds for the production of a medicament. The invention is suitable for use in a treatment method for hypertension and indirectly- or directly-linked illnesses.

Abstract: The invention concerns the use of a PyA-(Z)x-pNF group in a substrate for detecting, identifying and/or analyzing by fluorometry peptidases or proteases capable of cleaving the or a bond between a PyA and pNF and/or compounds with inhibiting or activating activity with respect to enzymes capable of cleaving said bond.

Abstract: The present invention relates to nucleic acid sequences encoding novel Babesia canis associated proteins and to cDNA fragments, recombinant DNA molecules and live recombinant carriers comprising these sequences. Furthermore, the invention relates to host cells comprising such nucleic acid sequences, cDNA fragments, recombinant DNA molecules and live recombinant carriers. Also, the invention relates to proteins encoded by these nucleotide sequences, to vaccines for combating Babesia canis infections comprising these proteins or genetic material encoding these proteins and methods for the preparation of vaccines. Another embodiment of the invention relates to these Babesia canis associated proteins for use in vaccines and to the use of the Babesia canis associated proteins in the manufacture of vaccines.

Abstract: The invention is directed to the induction of mitochondrial membrane permeabilization via the physical and functional interaction of the HIV-1 Vpr protein with the mitochondrial inner membrane protein ANT (adenine nucleotide translocator, also called adenine nucleotide translocase or ADP/ATP carrier). Reagents and methods for inducing and/or inhibiting the binding of Vpr to ANT, mitochondrial membrane permeabilization, and apoptosis are provided.

Abstract: The invention concerns the use of a PyA-(Z)x-pNF group in a substrate for detecting, identifying and/or analysing by fluorometry peptidases or proteases capable of cleaving the or a bond between a PyA and pNF and/or compounds with inhibiting or activating activity with respect to enzymes capable of cleaving said bond.

Abstract: In a method for perforating a thin film (14), in particular a plastic film, in which the film (14) is quided over a perforating cylinder (10), with the result that perforations are formed in the film (14), a thin-walled hollow cylinder (10) which comprises at least one layer (52) of fibre-reinforced plastic is used, the fibres in which layer are oriented at least in one direction. A fibre-reinforced cylinder of this type has the required rigidity and is not expensive.

Abstract: The invention is directed to the induction of mitochondrial membrane permeabilization via the physical and functional interaction of the HIV-1 Vpr protein with the mitochondrial inner membrane protein ANT (adenine nucleotide translocator, also called adenine nucleotide translocase or ADP/ATP carrier). Reagents and methods for inducing and/or inhibiting the binding of Vpr to ANT, mitochondrial membrane permeabilization, and apoptosis are provided.

Abstract: The present invention relates to nucleic acid sequences encoding novel Babesia canis associated proteins and to cDNA fragments, recombinant DNA molecules and live recombinant carriers comprising these sequences. Furthermore, the invention relates to host cells comprising such nucleic acid sequences, cDNA fragments, recombinant DNA molecules and live recombinant carriers. Also, the invention relates to proteins encoded by these nucleotide sequences, to vaccines for combating Babesia canis infections comprising these proteins or genetic material encoding these proteins and methods for the preparation of vaccines. Another embodiment of the invention relates to these Babesia canis associated proteins for use in vaccines and to the use of the Babesia canis associated proteins in the manufacture of vaccines.

Abstract: The invention concerns compounds derived from (&agr;-aminophosphino) peptides, of general formula (I), in which R1 and R2 each represents a hydrogen atom or taken together form an imine with the adjacent nitrogen atom; R3 represents an alkyl group, an alkenyl group, a phenyl group, a benzyl group, all these groups capable of being substituted or not, a hydrogen atom, a cycloalkyl group, a cycloalkylmethyl group or finally, a methyl group substituted by a heterocyclic, aromatic or saturated group; R4 represents a phenyl group, a benzyl group, these groups capable of being substituted or not, a hydrogen atom, an alkyl group, analkenyl group or a cycloalkyl group; R5 represents an alkyl group, an alkenyl group, a phenyl group, a benzyl group, all these groups capable of being substituted or not, a hydrogen atom, a cycloalkyl, cycloalkylmethyl group or finally a methyl group substituted by a heterocyclic, aromatic or saturated group; R6, R7 and R8 can in particular represent a hydrogen atom, an alkyl group, a phe

Abstract: The invention is directed to the induction of mitochondrial membrane permeabilization via the physical and functional interaction of the HIV-1 Vpr protein with the mitochondrial inner membrane protein ANT (adenine nucleotide translocator, also called adenine nucleotide translocase or ADP/ATP carrier). Reagents and methods for inducing and/or inhibiting the binding of Vpr to ANT, mitochondrial membrane permeabilization, and apoptosis are provided.

Abstract: The invention relates primarily to a pharmaceutical composition which can be used for lowering arterial blood pressure and is characterized in that it contains as active ingredient at least one selective aminopeptidase A inhibitor. Said inhibitor can notably be (S) 3-amino-4-mercaptobutyl sulfonic acid or one of its salts.

Abstract: Products of formula (I), wherein n is 0 or 1, R.sub.1 is particularly phenyl or biphenyl optionally substituted particularly by benzyloxy, dioxol or halogen, R.sub.2 is particularly hydrogen or methyl substituted particularly by indolyl, phenylthio or phenyl, which may in turn be substituted, and A is carboxy, tetrazolyl or substituted alkyl as well as all salts and isomers thereof, are disclosed.

Abstract: A method and device for the detection of vapors of cocaine and associated compounds are disclosed. The method involves sampling a volume of air suspected of containing cocaine vapors, passing this air through a filtration system that removes any particulate matter and binds vapors of cocaine and associated compounds, if present, for further analysis. A preferred associated compound-vapor is that of ecgonidine methyl ester (EDME), and a marker for the presence of cocaine. The device is comprised of a sampling, filtration and vacuum port components and can be easily attached to a container, and suction source, for the sampling of air.

Abstract: N-?Mercaptoacyl(amino acid or peptide)! compounds and S-lipophilic aliphatic carbonyl derivatives thereof, and pharmaceutical compositions comprising such compounds, as well as the use of these compounds as antihypertensives by the inhibition of neutral endopeptidase and/or peptidyldipeptidase A are disclosed. Methods for preparing such compounds and derivatives are disclosed also.

Abstract: An accelerometric sensor for measuring pinking in an internal combustion engine. The sensor includes a base in the form of a sleeve with a flange extending therefrom and supporting at least one stacked piezoelectric ring, connecting disks and a seismic weight. The underside of the base is used as a contact surface between the sensor and the part to be measured. The underside has a central recess such that the average load distribution diameter over the contract surface is no smaller than the average of the shoulder. This shape may be achieved with a recess which is coaxial with the sleeve and which has a diameter greater than the external diameter thereof. The shape may alternatively be achieved by forming the underside in a concave shape.

Abstract: Compound of formula (I): ##STR1## wherein R, R.sub.1, R.sub.2, R', X and n are as defined in the description, and NEP and ACE inhibitory medicaments containing the same.

Abstract: N-[Mercaptoacyl(amino acid or peptide)] compounds and S-lipophilic aliphatic carbonyl derivatives thereof, and pharmaceutical compositions comprising such compounds, as well as the use of these compounds as antihypertensives by the inhibition of neutral endopeptidase and/or peptidyldipeptidase A are disclosed. Methods for preparing the such compounds and derivatives are disclosed also.

Abstract: A device for assisting extraction of a material contained in a cartridge for preparation of a beverage has a wall which forms a hollowed enclosure which has an interior surface which defines a frustoconically shaped cavity for containing the cartridge. A rim intersects and extends laterally from the interior surface of the wall to form a peripheral rim base surface which intersects the wall for supporting a cartridge contained by the interior wall surface. A plurality of fins integral with the rim extend from the rim laterally, with respect to the interior wall surface, to converge and connect at an area which is centrally disposed, with respect to the interior wall surface and rim, and displaced at a distance away from a plane defined by the intersection of the interior wall and rim base surfaces so that the area of convergence is displaced away from a cartridge contained and supported by the wall and rim base surfaces.