Abstract: In a method to determine a complete parameter of a pulse sequence composed of multiple pulse sequence modules for operating a magnetic resonance examination apparatus parameter information of the pulse sequence modules is stored in a memory in leaves and nodes of a tree structure, and the parameter information stored in the tree structure is evaluated to determine the complete parameter of the pulse sequence.

Abstract: The invention relates to a pharmaceutical composition comprising methyl (2R.3R)-2-{3-[amino(imino)methyl]benzyl}-3-{[4-(1-oxidopyridin-4-yl)benzoyl]amino} butanoate or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable acidic reacting compound or to an aqueous solution or dispersion of the composition as well as a process for the preparation of the same, methods of using such compositions to treat subjects suffering from conditions which can be ameliorated by the administration of an inhibitor of Factor Xa.

Abstract: In a method and a magnetic resonance (MR) system, a marked area is determined that demarcates a predetermined volume segment of the subject relative to the regions adjacent thereto. Nuclei in the predetermined volume segment are excited, or nuclei in a region adjacent thereto are saturated with an RF excitation pulse at the same time a magnetic field gradient is activated. The center frequency of a frequency range of the RF excitation pulse and the direction of the magnetic field gradient are adjusted dependent on resonant frequencies of substances present within the predetermined volume segment in order, starting from the predetermined volume segment to shift an actual excitation volume segment excited by the RF excitation pulse toward the marked area, or to shift a saturation volume saturated by the RF excitation pulse away from the marked area. MR data are then acquired from the predetermined volume segment.

Abstract: In a method and apparatus for automatic magnetic resonance imaging of a patient, an MR overall image is composed from several MR partial images. An MR overview image is received by a process that determines several scanning ranges based on the MR overview image. The MR scanning ranges are characterized by a length along a first direction. For all MR scanning ranges: the length along the first direction is set equal to the length of the longest MR scanning range in the first direction.

Abstract: In a method and apparatus for magnetic resonance (MR) imaging, a magnetization of nuclear spins in a subject is prepared in multiple preparation modules of an acquisition sequence. MR signals are acquired with at least one imaging module of the sequence. Spoiler gradient fields are generated in the multiple preparation modules in order to affect a transverse magnetization of the spins. The spoiler gradient fields that are applied in at least two different preparation modules are spatially varied along different directions. Spoiler gradient moments of the spoiler gradient fields are selected so that, for at least one of three orthogonal spatial directions, a weighted sum of the spoiler gradient moments that are applied along this spatial direction satisfies a threshold condition.

Abstract: A sterile packaging system for use in the manufacture and sale of combination medical product preferably one that is attachable to an injection system to co-deliver at least two medicaments is disclosed where a tray grid comprises sterile receptacles that are removably connected, sealable and configured for use in an automated drug filling and assembly line.

Abstract: In a method for determining time windows in a scan sequence, in which values of setting parameters of a scan can be changed during a current scan without adversely affecting the scan data obtained with the scan, comprising the following a scan sequence is loaded into a control computer, that then determines the time windows in the scan sequence in which values of setting parameters can be changed during a current scan, on the basis of an analysis of useful coherences in the scan sequence. The determined time windows are stored or processed so as to be available to operate an imaging apparatus to execute the scan sequence.

Abstract: In a method for operating a medical imaging examination apparatus having multiple subsystems, current ambient conditions in a scan volume of the apparatus are determined and stored in a global ambient condition parameter set. A control computer starts a scan sequence according to a selected scan protocol, and sequence control data that define different functional sub-sequences for the respective subsystems are provided to the control computer. Different effective volumes are assigned to each functional sub-sequence, and respective current sub-regions in the effective volume associated with the respective sub-sequence are determined, in which a volume optimization is to take place. Control signals for the scan sequence are calculated using the sequence control data, the global ambient condition parameter set, and the determined current sub-regions of the affected volumes, in order to optimize the functional sub-sequences at least with regard to the current sub-region of the assigned effective volume.

Abstract: In a method for operating a medical imaging apparatus having subsystems, a control protocol assigned to a scan sequence to be performed is provided to a control computer that determines sequence control data for the control protocol, which define different functional subsequences of the scan sequence. Different effective volumes are assigned to each functional subsequence, and current ambient conditions of the apparatus are determined for the sequence control data and associated effective volumes, for a series of states of physiological processes that occur during the scan sequence. Control signals for the scan sequence are determined from the sequence control data, the effective volumes and the current ambient conditions per observed state, that optimize the functional subsequences of the scan sequence locally.

Abstract: In a method for operating a medical imaging apparatus having multiple subsystems, a control protocol assigned to a scan sequence to be performed is provided to a control computer that determines sequence control data for the control protocol, which define different functional subsequences of the scan sequence. Different effective volumes are assigned to each functional subsequence, and current ambient conditions of the apparatus are determined for the sequence control data and associated effective volumes. Control signals for the scan sequence are determined from the sequence control data, the effective volumes and the current ambient conditions that optimize the functional subsequences of the scan sequence locally, at least with regard to a sub-region of the respective effective volumes.

Abstract: In a method for operating a medical imaging examination apparatus having multiple subsystems controlled by a control computer in a scan sequence, a control protocol for the scan is provided to the control computer, which determines sequence control data for the control protocol that define different functional subsequences of the scan, with different effective volumes assigned to each functional subsequence. Current ambient conditions of the apparatus are determined that are decisive for the determined relevant sequence control data and associated effective volumes. Control signals for the scan are determined from the sequence control data, the effective volumes and the current ambient conditions determined that optimize the functional subsequences of the scan.

Abstract: In a method for operating a medical imaging apparatus having subsystems, a control protocol assigned to a scan sequence to be performed is provided to a control computer that determines sequence control data for the control protocol, which define different functional subsequences of the scan sequence. Different effective volumes are assigned to each functional subsequence, and current ambient conditions of the apparatus are determined for the sequence control data and associated effective volumes, for a series of states of physiological processes that occur during the scan sequence. Control signals for the scan sequence are determined from the sequence control data, the effective volumes and the current ambient conditions per observed state, that optimize the functional subsequences of the scan sequence locally.

Abstract: In a magnetic resonance apparatus and an operating method therefore, a data acquisition sequence for operating the apparatus is repeatedly reviewed in a number of ascertainment passes executed in a processor, each ascertainment pass involving a calculation step, and in each calculation step a determination is made as to other respective values of data elements used in a previous calculation step have changed. If no change has occurred, a re-calculation in the current calculation step is not implemented, thereby reducing the time and computing capacity that are needed to generate a final data acquisition sequence.

Abstract: A reservoir for a drug delivery system is provided, wherein the reservoir comprises a cavity, the cavity being filled with a dose of a fluid drug such that the dose of the drug occupies 95% or more of the cavity, wherein the dose volume is less than 5 ml. Furthermore, a method for filling a reservoir for a drug delivery system is provided.

Abstract: In a method to configure at least one partial range of a pulse sequence for operating a magnetic resonance device, the pulse sequence is composed of at least two different program units, and information and/or at least one parameter is exchanged between the individual program units by a computerized mediator unit.

Abstract: In a method and apparatus for automatic magnetic resonance imaging of a patient, an MR overall image is composed from several MR partial images. An MR overview image is received by a process that determines several scanning ranges based on the MR overview image. The MR scanning ranges are characterized by a length along a first direction. For all MR scanning ranges: the length along the first direction is set equal to the length of the longest MR scanning range in the first direction.

Abstract: The invention relates to a pharmaceutical composition comprising methyl (2R.3R)-2-{3-[amino(imino)methyl]benzyl}-3-{[4-(1-oxidopyridin-4-yl)benzoyl]amino}butanoate or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable acidic reacting compound or to an aqueous solution or dispersion of the composition as well as a process for the preparation of the same, methods of using such compositions to treat subjects suffering from conditions which can be ameliorated by the administration of an inhibitor of Factor Xa.

Abstract: The invention refers to a cartridge (100), such as an injection cartridge, and to a needle system (200) therefore. Further, the invention refers to a combination of such an injection cartridge and a needle system. More specifically, the invention refers to a closure system for an injection cartridge which allows attachment of a needle system to the cartridge.

Abstract: In a method and a magnetic resonance (MR) system, a marked area is determined that demarcates a predetermined volume segment of the subject relative to the regions adjacent thereto. Nuclei in the predetermined volume segment are excited, or nuclei in a region adjacent thereto are saturated with an RF excitation pulse at the same time a magnetic field gradient is activated. The center frequency of a frequency range of the RF excitation pulse and the direction of the magnetic field gradient are adjusted dependent on resonant frequencies of substances present within the predetermined volume segment in order, starting from the predetermined volume segment to shift an actual excitation volume segment excited by the RF excitation pulse toward the marked area, or to shift a saturation volume saturated by the RF excitation pulse away from the marked area. MR data are then acquired from the predetermined volume segment.

Abstract: In a method to determine a complete parameter of a pulse sequence composed of multiple pulse sequence modules for operating a magnetic resonance examination apparatus parameter information of the pulse sequence modules is stored in a memory in leaves and nodes of a tree structure, and the parameter information stored in the tree structure is evaluated to determine the complete parameter of the pulse sequence.