Patents by Inventor Bernd Kuhn

Bernd Kuhn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indolyl derivatives as liver-X-receptor (LXR) modulators
    Patent number: 7173048
    Abstract: The invention relates to compounds of formula (I): and pharmaceutically acceptable salts and pharmaceutically acceptable esters thereof, wherein R1, R2, R3, R4, R5, R6, A, m, n and p are defined as in claim 1. These compounds can be used as pharmaceutical compositions for the treatment of, for example, diabetes.
    Type: Grant
    Filed: April 27, 2005
    Date of Patent: February 6, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Henrietta Dehmlow, Bernd Kuhn, Narendra Panday, Hasane Ratni, Tanja Schulz-Gasch, Matthew Blake Wright
  • New pyridazines as 11B-HSD1 inhibitors
    Publication number: 20070010519
    Abstract: Compounds of formula as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R4 have the significance given in claim 1 can be used in the form of pharmaceutical compositions.
    Type: Application
    Filed: July 5, 2006
    Publication date: January 11, 2007
    Inventors: Kurt Amrein, Daniel Hunziker, Bernd Kuhn, Alexander Mayweg, Werner Neidhart
  • Pyrido [2,1-a] isoquinoline derivatives
    Patent number: 7122555
    Abstract: The present invention provides compounds of formula (I) wherein R1, R2, R3 and R4 are as indicated in the description, or a pharmaceutically acceptable salt thereof. The compounds are useful for the treatment of diseases which are associated with DPP-IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
    Type: Grant
    Filed: June 17, 2004
    Date of Patent: October 17, 2006
    Assignee: Hoffmann-la Roche Inc.
    Inventors: Markus Boehringer, Bernd Kuhn, Patrizio Mattei, Robert Narquizian
  • Phenyl derivatives, their manufacture and use as pharmaceutical agents
    Patent number: 7115611
    Abstract: This invention relates to compounds of the formula wherein one of R5, R6 and R7 is and X1, X2, Y1 to Y4, R1 to R13 and m and n are defined in the description, and to all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR? and/or PPAR? agonists.
    Type: Grant
    Filed: October 29, 2004
    Date of Patent: October 3, 2006
    Assignee: Hoffmann-la Roche Inc.
    Inventors: Jean Ackermann, Johannes Aebi, Alfred Binggeli, Uwe Grether, Georges Hirth, Bernd Kuhn, Hans-Peter Maerki, Markus Meyer, Peter Mohr, Matthew Blake Wright
  • Indolyl derivatives
    Patent number: 7098228
    Abstract: The present invention provides compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R4, A and n have the significance given in the specification. The compounds or their salts may be administered to a patient for treating non-insulin dependent diabetes mellitus.
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: August 29, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alfred Binggeli, Uwe Grether, Hans Hilpert, Georges Hirth, Bernd Kuhn, Hans-Peter Maerki, Markus Meyer, Peter Mohr
  • Amide bridged piphenyl or biazaphenyl derivatives
    Publication number: 20060183754
    Abstract: This invention is concerned with compounds of the formula wherein one of R5, R6 and R7 is and R1 to R13, X1, X2, m and n are defined in the description, and all pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR? and/or PPAR? agonists.
    Type: Application
    Filed: February 10, 2006
    Publication date: August 17, 2006
    Inventors: Jean Ackermann, Johannes Aebi, Alfred Binggeli, Uwe Grether, Bernd Kuhn, Hans-Peter Maerki, Markus Meyer
  • 4-Aminopiperidine derivatives
    Publication number: 20060135561
    Abstract: The present invention relates to compounds of the formula (I) wherein R1 and R2 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP-IV, such as diabetes, non-insulin dependent diabetes mellitus and/or impaired glucose tolerance, obesity, and/or metabolic syndrome or ?-cell protection.
    Type: Application
    Filed: December 14, 2005
    Publication date: June 22, 2006
    Inventors: Markus Boehringer, Daniel Hunziker, Bernd Kuhn, Bernd Loeffler, Thomas Luebbers, Fabienne Ricklin
  • Novel hexafluoroisopropanol substituted cyclohexane derivatives
    Publication number: 20060135601
    Abstract: The invention is concerned with novel hexafluoroisopropanol substituted cyclohexane derivatives of formula (I) wherein R1 to R4, X, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to LXR alpha and LXR beta and can be used as medicaments.
    Type: Application
    Filed: December 16, 2005
    Publication date: June 22, 2006
    Inventors: Henrietta Dehmlow, Bernd Kuhn, Raffaello Masciadri, Narendra Panday, Hasane Ratni, Matthew Wright
  • Aminocycloalkanes as DPP-IV inhibitors
    Publication number: 20060135512
    Abstract: The present invention relates to compounds of formula (I) wherein R1 is as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP-IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
    Type: Application
    Filed: December 13, 2005
    Publication date: June 22, 2006
    Inventors: Markus Boehringer, Daniel Hunziker, Bernd Kuhn, Bernd Loeffler, Hans Marty, Patrizio Mattei, Robert Narquizian
  • Substituted pyrido [2,1-a] isoquinoline derivatives
    Publication number: 20060116393
    Abstract: The present invention relates to compounds of formula (I) wherein R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP-IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
    Type: Application
    Filed: November 28, 2005
    Publication date: June 1, 2006
    Inventors: Markus Boehringer, Daniel Hunziker, Bernd Kuhn, Bernd Loeffler, Fabienne Ricklin, Hans Wessel
  • Pyridines
    Publication number: 20060074237
    Abstract: Compounds of formula as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R6 have the significance given in claim 1 can be used in the form of pharmaceutical compositions.
    Type: Application
    Filed: September 29, 2005
    Publication date: April 6, 2006
    Inventors: Kurt Amrein, Daniel Hunziker, Bernd Kuhn, Alexander Mayweg, Werner Neidhart
  • Novel hexafluoroisopropanol substituted ether derivatives
    Publication number: 20060074115
    Abstract: The invention is concerned with novel hexafluoroisopropanol substituted ether derivatives of formula (I): wherein R1 to R3 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to LXR alpha and LXR beta and can be used as medicaments.
    Type: Application
    Filed: September 28, 2005
    Publication date: April 6, 2006
    Inventors: Henrietta Dehmlow, Bernd Kuhn, Narendra Panday, Hasane Ratni, Matthew Wright
  • Novel indazolone derivatives useful as 11b-HSD1 inhibitors
    Publication number: 20060069269
    Abstract: Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R7 have the significances given in the description and claims can be used in the form of pharmaceutical compositions.
    Type: Application
    Filed: September 26, 2005
    Publication date: March 30, 2006
    Inventors: Kurt Amrein, Jianping Cai, Robert Goodnow, Daniel Hunziker, Bernd Kuhn, Alexander Mayweg, Werner Neidhart
  • Pressure plate assembly for a friction clutch
    Patent number: 7014025
    Abstract: A housing arrangement can be connected to a flywheel for rotation in common around an axis of rotation, and a pressure element is connected to the housing arrangement for rotation in common around the axis of rotation but is able to shift in the axial direction. A release spring arrangement includes at least one spring element which acts on the pressure element and is supported against the flywheel after the housing arrangement has been attached to the flywheel. Each spring element is held in place on the pressure element by means of a fastening element.
    Type: Grant
    Filed: February 26, 2004
    Date of Patent: March 21, 2006
    Assignee: ZF Sachs AG
    Inventors: Alfred Schauer, Bernd Kuhn, Thomas Schubert, Jürgen Pfeifer
  • Indole derivatives comprising an acetylene group
    Publication number: 20060035956
    Abstract: This invention is directed to compounds of the formula (I): wherein one of R6, R7, R8 and R9 is and X, R1 to R12, m, n and o are as defined in the description, and pharmaceutically acceptable salts and/or esters thereof. The invention is also directed to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR? and/or PPAR? agonists.
    Type: Application
    Filed: August 2, 2005
    Publication date: February 16, 2006
    Inventors: Jean Ackermann, Johannes Aebi, Alfred Binggeli, Uwe Grether, Bernd Kuhn, Hans-Peter Maerki, Markus Meyer
  • Indolyl and dihydroindolyl derivatives, their manufacture and use as pharmaceutical agents
    Patent number: 6995263
    Abstract: This invention relates to compounds of the formula wherein one of R6, R7 and R8 is and X, Y1 to Y4, R1 to R14 and n are as defined in the description, and to all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR? and/or PPAR? agonists.
    Type: Grant
    Filed: October 29, 2004
    Date of Patent: February 7, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean Ackermann, Johannes Aebi, Alfred Binggeli, Uwe Grether, Georges Hirth, Bernd Kuhn, Hans-Peter Maerki, Markus Meyer, Peter Mohr, Matthew Blake Wright
  • New 5-aryl pyridines as 11-beta inhibitors for the treatment of diabetes
    Publication number: 20060025455
    Abstract: Compounds of formula (I): as well as pharmaceutically acceptable salts and esters thereof used in the form of pharmaceutical compositions.
    Type: Application
    Filed: July 26, 2005
    Publication date: February 2, 2006
    Inventors: Kurt Amrein, Daniel Hunziker, Bernd Kuhn, Alexander Mayweg, Werner Neidhart
  • Aqueous formulations of (2-hydroxymethyl-indanyl-4-oxy)-phenyl-4,4,4-trifluorobutane-1-sulfonate
    Publication number: 20060009420
    Abstract: The invention relates to aqueous formulations containing (?)-(R)-3-(2-hydroxymethyl-indanyl-4-oxy)-phenyl-4,4,4-trifluobutane-1-sulfonate. Said formulations are suitable as infusion solutions or as concentrate for producing these infusion solutions.
    Type: Application
    Filed: March 31, 2003
    Publication date: January 12, 2006
    Inventors: Bernd Kuhn, Antje Bruck, Yoshifumi Katakawa, Masami Yasui
  • Novel hexafluoroisopropanol derivatives
    Publication number: 20060004068
    Abstract: The invention is concerned with novel hexafluoroisopropanol derivatives of formula (I) wherein R1 to R6, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to LXR alpha and LXR beta and can be used as medicaments.
    Type: Application
    Filed: June 27, 2005
    Publication date: January 5, 2006
    Inventors: Henrietta Dehmlow, Bernd Kuhn, Raffaello Masciadri, Narendra Panday, Hasane Ratni, Matthew Wright
  • Phenyl derivatives comprising an acetylene group
    Publication number: 20060004091
    Abstract: This invention is concerned with compounds of the formula I: wherein one of R5, R6 and R7 is and X1, X2, R1 to R12, m, n and o are as defined in the description, and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR? and/or PPAR? agonists.
    Type: Application
    Filed: June 30, 2005
    Publication date: January 5, 2006
    Inventors: Jean Ackermann, Johannes Aebi, Alfred Binggeli, Uwe Grether, Bernd Kuhn, Hans-Peter Maerki, Markus Meyer