Patents by Inventor Bernd Kuhn

Bernd Kuhn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • UREA DERIVATIVES AND THEIR USE AS FATTY-ACID BINDING PROTEIN (FABP) INHIBITORS
    Publication number: 20160002152
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, W, A and B are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: September 17, 2015
    Publication date: January 7, 2016
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: BERND BUETTELMANN, SIMONA M. CECCARELLI, AURELIA CONTE, HOLGER KUEHNE, BERND KUHN, WERNER NEIDHART, ULRIKE OBST SANDER, HANS RICHTER
  • NEW DIHYDROQUINOLINE-2-ONE DERIVATIVES
    Publication number: 20160002207
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R9, R10, R11 and A are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: September 10, 2015
    Publication date: January 7, 2016
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Johannes Aebi, Kurt Amrein, Benoit Hornsperger, Bernd Kuhn, Hans P. Maerki, Alexander V. Mayweg, Xuefei Tan
  • DIHYDROQUINOLINE-2-ONE DERIVATIVES
    Publication number: 20150376180
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R9, R10 and R11 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: September 10, 2015
    Publication date: December 31, 2015
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Johannes Aebi, Kurt Amrein, Benoit Hornsperger, Bernd Kuhn, Hans P. Maerki, Alexander V. Mayweg, Xuefei Tan
  • NEW BICYCLICPYRIDINE DERIVATIVES
    Publication number: 20150368256
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, A1, A2, A3, m, n and p are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: February 20, 2015
    Publication date: December 24, 2015
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Bernd Buettelmann, Aurelia Conte, Holger Kuehne, Bernd Kuhn, Werner Neidhart, Ulrike Obst Sander, Hans Richter
  • Aryl-quinoline derivatives
    Patent number: 9199938
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6 and n are as described herein, compositions including the compounds and methods of using the compounds. The present compounds are useful as fatty-acid binding protein (FABP) 4 and/or 5 inhibitors and may be used for the treatment or prophylaxis of lipodystrophy, type 2 diabetes, dyslipidemia, atherosclerosis, liver diseases involving inflammation, steatosis and/or fibrosis, such as non-alcoholic fatty liver disease, in particular non-alcoholic steatohepatitis, metabolic syndrome, obesity, chronic inflammatory and autoimmune inflammatory diseases.
    Type: Grant
    Filed: November 1, 2012
    Date of Patent: December 1, 2015
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Simona M. Ceccarelli, Aurelia Conte, Holger Kuehne, Bernd Kuhn, Werner Neidhart, Ulrike Obst Sander, Markus Rudolph
  • Substituted pyridazines as PDE10A inhibitors
    Patent number: 9187455
    Abstract: The present invention is concerned with novel pyridazinone derivatives of formula (I) wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used as pharmaceuticals.
    Type: Grant
    Filed: February 16, 2010
    Date of Patent: November 17, 2015
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Daniela Alberati, Matthias Koerner, Bernd Kuhn, Jens-Uwe Peters, Rosa Maria Rodriguez Sarmiento, Mark Rogers-Evans, Markus Rudolph
  • Phenyl-tetrahydroisoquinoline derivatives
    Patent number: 9187429
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A and n are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: April 17, 2013
    Date of Patent: November 17, 2015
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Johannes Aebi, Kurt Amrein, Benoit Hornsperger, Bernd Kuhn, Yongfu Liu, Hans P. Maerki, Rainer E. Martin, Alexander V. Mayweg, Peter Mohr, Xuefei Tan
  • NOVEL PYRIDINE DERIVATIVES
    Publication number: 20150307472
    Abstract: The invention relates to a compound of formula (I) wherein A1, A2 and R1 to R6 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: February 20, 2015
    Publication date: October 29, 2015
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Lilli Anselm, David Banner, Wolfgang Haap, Bernd Kuhn, Thomas Luebbers, Jens-Uwe Peters, Beat Spinnler
  • 4-AMINO-IMIDAZOQUINOLINE COMPOUNDS
    Publication number: 20150299194
    Abstract: This invention relates to novel 4-amino-imidazoquinoline compounds of the formula wherein R1 to R4 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are TLR agonists and may therefore be useful as medicaments for the treatment of diseases such as cancer or infectious diseases.
    Type: Application
    Filed: April 22, 2015
    Publication date: October 22, 2015
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Sabine Hoves, Bernd Kuhn, Fabienne Ricklin, Stephan Roever
  • Protective Packaging for a Container
    Publication number: 20150298888
    Abstract: The present invention relates to a protective packaging for a container accommodating a light-sensitive substance, the packaging comprising: an opaque cover to completely enclose the container for transportation and/or storage in a sealed storage configuration, wherein the cover is transferable from said storage configuration into an application configuration by means of an opening structure which is adapted to provide access to at least one port structure of the container from outside the cover.
    Type: Application
    Filed: November 5, 2013
    Publication date: October 22, 2015
    Inventors: Bernd Kuhn, Ernst-Josef Todt
  • Bicyclic dihydroisoquinoline-1-one derivatives
    Patent number: 9133158
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, A1, A2, A3, A4, A5 and n are as described herein, compositions including the compounds and methods of using the compounds. The compounds are useful, for example, as aldosterone synthase (CYP11B2 or CYP11B1) inhibitors for the treatment or prophylaxis of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrome.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: September 15, 2015
    Assignee: HOFFMAN-LA ROCHE INC.
    Inventors: Johannes Aebi, Kurt Amrein, Wenming Chen, Benoit Hornsperger, Bernd Kuhn, Yongfu Liu, Hans P. Maerki, Alexander V. Mayweg, Peter Mohr, Xuefei Tan, Zhanguo Wang, Mingwei Zhou
  • PEN-TYPE DRUG INJECTION DEVICE AND ELECTRONIC ADD-ON MONITORING MODULE FOR|MONITORING AND LOGGING DOSE SETTING AND ADMINISTRATION
    Publication number: 20150202375
    Abstract: A supplemental device for attachment to an injection device, the supplemental device is presented having a processor arrangement; and a quantity determiner for determining a quantity of medicament that has been delivered, wherein the quantity determiner has a sensor arranged to detect movement of a drive screw of the injection device during medicament delivery.
    Type: Application
    Filed: August 7, 2013
    Publication date: July 23, 2015
    Inventors: Michael Schabbach, Bernd Kuhn
  • New non-annulated thiophenylamides
    Publication number: 20150183778
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, A, E and n are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: March 11, 2015
    Publication date: July 2, 2015
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Bernd Buettelmann, Simona M. Ceccarelli, Holger Kuehne, Bernd Kuhn, Werner Neidhart, Ulrike Obst Sander, Hans Richter
  • NEW BICYCLIC THIOPHENYLAMIDE COMPOUNDS
    Publication number: 20150175594
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, A, E and n are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: December 18, 2014
    Publication date: June 25, 2015
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Bernd Buettelmann, Simona M. Ceccarelli, Holger Kuehne, Bernd Kuhn, Werner Neidhart, Ulrike Obst Sander, Hans Richter
  • TRIAZOLO COMPOUNDS AS PDE10 INHIBITORS
    Publication number: 20150148332
    Abstract: The present invention provides compounds of formula (Ia) and (Ib) wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used as medicaments.
    Type: Application
    Filed: November 25, 2014
    Publication date: May 28, 2015
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Alexander Flohr, Katrin Groebke Zbinden, Bernd Kuhn, Christian Lerner, Markus Rudolph, Herve Schaffhauser
  • NEW BIARYL AMIDE DERIVATIVES
    Publication number: 20150065516
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and A are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: October 29, 2014
    Publication date: March 5, 2015
    Inventors: Johannes Aebi, Alfred Binggeli, Cornelia Hertel, Anish Ashok Konkar, Holger Kuehne, Bernd Kuhn, Hans P. Maerki, Halyan Wang
  • RESERVOIR OR MEDICATED MODULE FOR A DRUG DELIVERY SYSTEM AND METHOD OF AND ASSEMBLY FOR FILLING THE SAME
    Publication number: 20150013827
    Abstract: A reservoir for a drug delivery system is provided, wherein the reservoir comprises a cavity, the cavity being filled with a dose of a fluid drug such that the dose of the drug occupies 95% or more of the cavity, wherein the dose volume is less than 5 ml. Furthermore, a method for filling a reservoir for a drug delivery system is provided.
    Type: Application
    Filed: December 14, 2012
    Publication date: January 15, 2015
    Inventor: Bernd Kühn
  • Biaryl amide derivatives
    Patent number: 8912221
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and A are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: December 16, 2014
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Johannes Aebi, Alfred Binggeli, Cornelia Hertel, Anish Ashok Konkar, Holger Kuehne, Bernd Kuhn, Hans P. Maerki, Haiyan Wang
  • Azetidine derivatives
    Patent number: 8822505
    Abstract: The invention relates to a compound of formula (I) wherein A1, A2 and R1 to R8 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Grant
    Filed: February 6, 2013
    Date of Patent: September 2, 2014
    Assignee: Genentech, Inc.
    Inventors: Lilli Anselm, David Banner, Wolfgang Haap, Bernd Kuhn, Thomas Luebbers, Jens-Uwe Peters, Beat Spinnler
  • HEAT-RESISTANT IRON-CHROMIUM-ALUMINUM ALLOY WITH LOW CHROMIUM VAPORIZATION RATE AND ELEVATED THERMAL STABILITY
    Publication number: 20140219855
    Abstract: An iron-chromium-aluminum alloy with improved heat resistance, low chromium vaporization rate and good processability, comprising (in % by mass), 2.0 to 4.5% Al, 12 to 25% Cr, 1.0 to 4% W, 0.25 to 2.0% Nb, 0.05 to 1.2% Si, 0.001 to 0.70% Mn, 0.001 to 0.030% C, 0.0001 to 0.05% Mg, 0.0001 to 0.03% Ca, 0.001 to 0.030% P, max. 0.03% N, max. 0.01% S, remainder iron and the usual melting-related impurities.
    Type: Application
    Filed: June 6, 2012
    Publication date: August 7, 2014
    Applicant: OUTOKUMPU VDM GMBH
    Inventors: Heike Hattendorf, Bernd Kuhn, Thomas Eckardt, Tilmann Beck, Willem Joe Quadakkers, Werner Theisen, Nilofar Nabiran