Patents by Inventor Bernd Kuhn

Bernd Kuhn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Two-chamber injection device having gas-permeable membrane
    Patent number: 8376987
    Abstract: The invention relates to a two-chamber syringe device comprising a cylinder element (2), a closure element (6), two plungers (3) and (4) and optionally an intermediate plunger (3a), wherein one or more fluid-tight, gas-permeable membranes (8) and optionally valve membranes (15) are arranged in the wall of the cylinder element (2) or in the closure element (6), allowing gas in the chambers to escape from the cylinder element (2) when the plungers (3), (3a) and (4) are displaced in the distal direction.
    Type: Grant
    Filed: June 15, 2010
    Date of Patent: February 19, 2013
    Assignee: Sanofi-Aventis Deustchland GmbH
    Inventor: Bernd Kuhn
  • NEW ARYL-BENZOCYCLOALKYL AMIDE DERIVATIVES
    Publication number: 20130018055
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A1, A2 and n are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: January 17, 2012
    Publication date: January 17, 2013
    Inventors: Johannes Aebi, Alfred Binggeli, Cornelia Hertel, Anish Ashok Konkar, Holger Kuehne, Bernd Kuhn, Hans P. Maerki, Haiyan Wang
  • Benzimidazole derivatives
    Patent number: 8309581
    Abstract: The present invention relates to compounds of formula (I), as well as pharmaceutically acceptable salts thereof can be used in the form of pharmaceutical compositions, wherein A, B, R1, R2, R3, R4, R5, n, m and p have the significance defined herein.
    Type: Grant
    Filed: September 20, 2010
    Date of Patent: November 13, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Gregory Martin Benson, Konrad Bleicher, Song Feng, Uwe Grether, Bernd Kuhn, Rainer E. Martin, Jean-Marc Plancher, Hans Richter, Markus Rudolph, Sven Taylor
  • Piperazine amide derivatives
    Patent number: 8288541
    Abstract: The invention is concerned with novel piperazine amide derivatives of formula (I) wherein R1 to R11, W, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds bind to LXR alpha and LXR beta and can be used as medicaments.
    Type: Grant
    Filed: August 6, 2008
    Date of Patent: October 16, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Henrietta Dehmlow, Bernd Kuhn, Ulrike Obst Sander, Stephan Roever, Tanja Schulz-Gasch, Matthew Wright, Rene Wyler
  • ASSEMBLY KIT FOR PREPARING OF A PRE-FILLED SYRINGE
    Publication number: 20120259288
    Abstract: The present invention relates to an assembly kit for preparing of a pre-filled syringe and in particular to a method of preparing of such pre-filled syringe assemblies by means of an assembly kit, wherein the assembly kit comprises: a gripping means to be attached to a proximal end section of a cartridge which comprises an axially displaceable bung for sealing of an interior volume of the cartridge being pre-filled with an injectable medicinal product, a needle mount to be attached to a distal end section of the cartridge and providing a mount for a needle assembly to be coupled to the interior volume of the cartridge in a fluid-transferring way, a plunger rod connectable with the bung of the cartridge for applying distally directed thrust to the bung, wherein the cartridge is at least partially embedded in a protecting sleeve.
    Type: Application
    Filed: August 26, 2010
    Publication date: October 11, 2012
    Applicant: Sanofi-Aventis Deutschland GmbH
    Inventors: Daniel Wagner, Bernd Kühn, Jörn Möckel
  • OTAMIXABAN FORMULATIONS WITH IMPROVED STABILITY
    Publication number: 20120252852
    Abstract: The invention relates to a pharmaceutical composition comprising methyl (2R,3R)-2-{3-[amino(imino)methyl]benzyl}-3-{[4-(1-oxidopyridin-4-yl)benzoyl]amino}butanoate or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable acidic reacting compound or to an aqueous solution or dispersion of the composition as well as a process for the preparation of the same, methods of using such compositions to treat subjects suffering from conditions which can be ameliorated by the administration of an inhibitor of Factor Xa.
    Type: Application
    Filed: March 27, 2012
    Publication date: October 4, 2012
    Applicant: SANOFI
    Inventors: Walter KAMM, Till Bussemer, Doris Andert, Bernd Kühn, Ernst-Josef Todt
  • Imidazopyridines
    Patent number: 8263584
    Abstract: The invention is concerned with novel imidazopyridine derivatives of formula (I) wherein R1, R2, R3, R4, R5 and A are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used for the treatment of various diseases, including central nervous system disorders such as Alzheimer's disease, Parkinson's disease, and schizophrenia.
    Type: Grant
    Filed: June 2, 2011
    Date of Patent: September 11, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Daniela Alberati, Ruben Alvarez Sanchez, Konrad Bleicher, Alexander Flohr, Katrin Groebke Zbinden, Matthias Koerner, Bernd Kuhn, Jens-Uwe Peters, Markus Rudolph
  • Cyclopentyl- and cycloheptylpyrazoles
    Patent number: 8252826
    Abstract: This invention relates to novel cyclopentyl- and cycloheptylpyrazole derivatives of the formula I wherein A and R1 to R4 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. The invention relates also to compositions including these compounds and methods of using the compounds.
    Type: Grant
    Filed: March 17, 2011
    Date of Patent: August 28, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Gregory Martin Benson, Konrad Bleicher, Uwe Grether, Bernd Kuhn, Hans Richter, Sven Taylor
  • Cannula Assembly for Co-Delivery of Medicaments
    Publication number: 20120197210
    Abstract: A cannula assembly (10) comprising a hub (76) and a cannula (12) mounted in the hub (76). The cannula defines an inner space (36). The cannula comprises a distal end (16) and a proximal end (18). A first medicament (40) is provided in the inner space of the cannula. In one arrangement, the hub of the cannula assembly is configured to be coupled to an injection device (26). The cannula assembly may be removably or permanently coupled to the injection device containing a second medicament (17).
    Type: Application
    Filed: June 24, 2010
    Publication date: August 2, 2012
    Applicant: Sanofi-Aventis Deutschland GmbH
    Inventors: Bernd Kuhn, Gerrit Hauck
  • 5-aryl pyridines as 11-beta inhibitors for the treatment of diabetes
    Patent number: 8211913
    Abstract: Compounds of formula (I): as well as pharmaceutically acceptable salts and esters thereof used in the form of pharmaceutical compositions.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: July 3, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Kurt Amrein, Daniel Hunziker, Bernd Kuhn, Alexander Mayweg, Werner Neidhart
  • NEW BIARYL AMIDE DERIVATIVES
    Publication number: 20120165338
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and A are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: December 19, 2011
    Publication date: June 28, 2012
    Inventors: Johannes Aebi, Alfred Binggeli, Cornelia Hertel, Anish Ashok Konkar, Holger Kuehne, Bernd Kuhn, Hans P. Maerki, Haiyan Wang
  • Pyridazinones
    Patent number: 8178538
    Abstract: The present invention is concerned with novel pyridazinones of formula (I) wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used for the treatment of CNS disorders.
    Type: Grant
    Filed: November 30, 2009
    Date of Patent: May 15, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Daniela Alberati, Luca Gobbi, Matthias Koerner, Bernd Kuhn, Jens-Uwe Peters, Rosa Maria Rodriguez-Sarmiento, Mark Rogers-Evans, Markus Rudolph
  • Pyridines as FBPase inhibitors for treatment of diabetes
    Patent number: 8163778
    Abstract: Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof wherein the residues have the significance given in claim 1 and which can be used in the form of pharmaceutical compositions.
    Type: Grant
    Filed: November 24, 2008
    Date of Patent: April 24, 2012
    Assignee: Hoffmann-LA Roche Inc.
    Inventors: Wolfgang Haap, Paul Hebeisen, Eric Argirios Kitas, Bernd Kuhn, Peter Mohr, Hans Peter Wessel
  • 3-amino-indazole or 3-amino-4,5,6,7-tetrahydro-indazole derivatives
    Patent number: 8153663
    Abstract: This invention relates to novel indazole derivatives of formula I: wherein R1 to R7 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are FXR modulators and can be used as medicaments.
    Type: Grant
    Filed: September 21, 2009
    Date of Patent: April 10, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Gregory Martin Benson, Konrad Bleicher, Song Feng, Uwe Grether, Bernd Kuhn, Rainer E. Martin, Jean-Marc Plancher, Hans Richter, Markus Rudolph, Sven Taylor
  • Benzimidazole derivatives
    Patent number: 8143422
    Abstract: The invention is concerned with novel benzimidazole derivatives of formula (I) wherein R1 to R6 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds can be used as medicaments.
    Type: Grant
    Filed: October 13, 2009
    Date of Patent: March 27, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Gregory Martin Benson, Konrad Bleicher, Song Feng, Uwe Grether, Bernd Kuhn, Rainer E. Martin, Jean-Marc Plancher, Hans Richter, Sven Taylor
  • Imidazolone and imidazoloidinone derivatives as 11b-HSD1 inhibitors
    Patent number: 8129423
    Abstract: Compounds of formula as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R6 have the significance given in claim 1 can be used in the form of pharmaceutical compositions.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: March 6, 2012
    Assignee: Hoffman-La Roche Inc.
    Inventors: Jean Ackermann, Kurt Amrein, Daniel Hunziker, Bernd Kuhn, Alexander V. Mayweg, Werner Neidhart, Tadakatsu Takahashi
  • Imidazolidinone derivatives as 11B-HSD1 inhibitors
    Patent number: 8124636
    Abstract: Compounds of formula as well as pharmaceutically acceptable salts and esters thereof, wherein A and R1 to R4 have the significance given in claim 1 can be used in the form of pharmaceutical compositions.
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: February 28, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean Ackermann, Kurt Amrein, Bernd Kuhn, Alexander V. Mayweg, Werner Neidhart
  • Benzimidazole derivatives
    Patent number: 8088930
    Abstract: The invention is concerned with novel benzimidazole derivatives of formula (I) wherein A, n and R1 to R7 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds can be used as medicaments.
    Type: Grant
    Filed: September 4, 2009
    Date of Patent: January 3, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Gregory Martin Benson, Konrad Bleicher, Song Feng, Uwe Grether, Bernd Kuhn, Rainer E. Martin, Jean-Marc Plancher, Hans Richter, Sven Taylor
  • NITROGEN CONTAINING HETEROARYL COMPOUNDS
    Publication number: 20110306589
    Abstract: The invention is concerned with novel nitrogen-containing heteroaryl compounds of formula (I) wherein A1, A2, R1, R2, R3, R4, R5 and R6 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used as therapeutics.
    Type: Application
    Filed: June 2, 2011
    Publication date: December 15, 2011
    Inventors: Konrad Bleicher, Alexander Flohr, Katrin Groebke Zbinden, Felix Gruber, Matthias Koerner, Bernd Kuhn, Jens-Uwe Peters, Rosa Maria Rodriguez Sarmiento
  • NOVEL IMIDAZOPYRIDINES
    Publication number: 20110294779
    Abstract: The invention is concerned with novel imidazopyridine derivatives of formula (I) wherein R1, R2, R3, R4, R5 and A are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used for the treatment of various diseases, including central nervous system disorders such as Alzheimer's disease, Parkinson's disease, and schizophrenia.
    Type: Application
    Filed: June 2, 2011
    Publication date: December 1, 2011
    Inventors: DANIELA ALBERATI, RUBÉN ALVAREZ SÁNCHEZ, KONRAD BLEICHER, ALEXANDER FLOHR, KATRIN GROEBKE ZBINDEN, MATTHIAS KOERNER, BERND KUHN, JENS-UWE PETERS, MARKUS RUDOLPH