Patents by Inventor Bernd Misselwitz

Bernd Misselwitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8263040
    Abstract: The invention relates to the subjects characterized in the patent claims, namely metal chelates having a perfluorinated PEG radical, processes for their preparation, and their use, processes for their preparation and their use in NMR and X-ray diagnosis, radiodiagnosis and radiotherapy, and in MRT lymphography.
    Type: Grant
    Filed: October 17, 2007
    Date of Patent: September 11, 2012
    Assignee: Bayer Schering Pharma AG
    Inventors: Johannes Platzek, Heiko Schirmer, Hanns-Joachim Weinmann, Bernd Misselwitz, Ludwig Zorn
  • Publication number: 20090297454
    Abstract: The invention relates to the subjects that are characterized in the claims, namely perfluoroalkyl-containing metal complexes with nitrogen-containing radicals of general formula I, process for their production and their use in NMR and x-ray diagnosis, radiodiagnosis, and radiotherapy, as well as in MRT lymphography and in blood-pool imaging.
    Type: Application
    Filed: May 20, 2009
    Publication date: December 3, 2009
    Inventors: Heiko SCHIRMER, Hanns-Joachim Weinmann, Johannes Platzek, Ludwig Zorn, Bernd Misselwitz, Joerg Meding, Heribert Schmitt-Willich, Thomas Brumby
  • Patent number: 7618957
    Abstract: The invention relates to the subjects that are characterized in the claims, namely perfluoroalkyl-containing metal complexes with nitrogen-containing radicals of general formula I, process for their production and their use in NMR and x-ray diagnosis, radiodiagnosis, and radiotherapy, as well as in MRT lymphography and in blood-pool imaging.
    Type: Grant
    Filed: July 17, 2006
    Date of Patent: November 17, 2009
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Heiko Schirmer, Hanns-Joachim Weinmann, Johannes Platzek, Ludwig Zorn, Bernd Misselwitz, Joerg Meding, Heribert Schmitt-Willich, Thomas Brumby
  • Publication number: 20080213187
    Abstract: The invention relates to novel cascade polymer complexes, to compositions comprising these compounds, to the use of the complexes in NMR diagnosis, and to processes for preparing these compounds and compositions.
    Type: Application
    Filed: January 17, 2008
    Publication date: September 4, 2008
    Inventors: Heribert SCHMITT-WILLICH, Heiko Schirmer, Bernd Misselwitz, Hanns-Joachim Weinmann, Peter Caravan
  • Publication number: 20080159954
    Abstract: The invention relates to the subjects characterized in the patent claims, namely metal chelates having a perfluorinated PEG radical, processes for their preparation, and their use, processes for their preparation and their use in NMR and X-ray diagnosis, radiodiagnosis and radiotherapy, and in MRT lymphography.
    Type: Application
    Filed: October 17, 2007
    Publication date: July 3, 2008
    Inventors: Johannes Platzek, Heiko Schirmer, Hanns-Joachim Weinmann, Bernd Misselwitz, Ludwig Zorn
  • Patent number: 7344704
    Abstract: The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration <10?3 mol/l, a hydrodynamic micelle diameter (2 Rh)>1 nm and a proton relaxivity in plasma (R1)>10 l/mmol·s as contrast media in MR imaging for visualization of intravascular thrombi.
    Type: Grant
    Filed: July 10, 2003
    Date of Patent: March 18, 2008
    Assignee: Schering AG
    Inventors: Bernd Misselwitz, Johannes Platzek, Yoko Kawata, Hanns-Joachim Weinmann, Takashi Yokawa, Ulrich Niedballa
  • Publication number: 20080044358
    Abstract: Methods and contrast agents for imaging the lymph system are provided. The methods allow the diagnosis and staging of diseases of the lymph system, such as cancer and infections.
    Type: Application
    Filed: August 16, 2007
    Publication date: February 21, 2008
    Inventors: Vincent Jacques, Peter Caravan, Bernd Misselwitz, Hanns-Joachim Weinmann
  • Publication number: 20070269384
    Abstract: The invention relates to the use of metal complexes that contain at least one perfluorinated alkyl radical and at least one chelating agent radical and at least one metal ion equivalent of the atomic numbers 21-29, 31-33, 37-39, 42-44, 49 or 57-83, as well as salts thereof for the production of a diagnostic agent for visualizing amyloid-containing plaques.
    Type: Application
    Filed: May 8, 2007
    Publication date: November 22, 2007
    Inventors: Bernd Misselwitz, Hanns-Joachim Weinmann, Joerg Meding
  • Publication number: 20070189969
    Abstract: The invention relates to the subjects that are characterized in the claims, namely perfluoroalkyl-containing metal complexes with nitrogen-containing radicals of general formula I, process for their production and their use in NMR and x-ray diagnosis, radiodiagnosis, and radiotherapy, as well as in MRT lymphography and in blood-pool imaging.
    Type: Application
    Filed: July 17, 2006
    Publication date: August 16, 2007
    Inventors: Heiko Schirmer, Hanns-Joachim Weinmann, Johannes Platzek, Ludwig Zorn, Bernd Misselwitz, Joerg Meding, Heribert Schmitt-Willich, Thomas Brumby
  • Patent number: 7226578
    Abstract: The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.
    Type: Grant
    Filed: October 5, 2004
    Date of Patent: June 5, 2007
    Assignee: Shering aG
    Inventors: Johannes Platzek, Ulrich Niedballa, Bernd Radüchel, Wolfgang Schlecker, Hanns-Joachim Weinmann, Thomas Frenzel, Bernd Misselwitz, Wolfgang Ebert
  • Publication number: 20070020183
    Abstract: The invention relates to the subjects that are characterized in the claims, namely perfluoroalkyl-containing metal complexes with an N-alkyl group of general formula 1, process for their production and their use in NMR and x-ray diagnosis, radiodiagnosis, and radiotherapy, as well as in MRT lymphography.
    Type: Application
    Filed: July 14, 2006
    Publication date: January 25, 2007
    Inventors: Heiko Schirmer, Hanns-Joachim Weinmann, Johannes Platzek, Ludwig Zorn, Bernd Misselwitz, Joerg Meding, Heribert Schmitt-Willich, Thomas Brumby
  • Publication number: 20070003484
    Abstract: The invention relates to hydroxypyridinone derivatives, their metal complexes, their preparation and their use for preparing conjugates with biomolecules. The conjugates are suitable as contrast agents in NMR diagnosis. A high relaxivity is achieved and the NMRD maximum is raised through a specific design of the ligands.
    Type: Application
    Filed: December 20, 2005
    Publication date: January 4, 2007
    Inventors: Heribert Schmitt-Willich, Heiko Schirmer, Johannes Platzek, Stephane Dumas, Vincent Jacques, Thomas Brumby, Detlev Suelzle, Bernd Misselwitz
  • Publication number: 20060292079
    Abstract: The invention relates to conjugates of hydroxypyridinone derivative metal complexes and to their preparation. The conjugates are suitable as contrast agents in NMR diagnosis. A high relaxivity is achieved and the NMRD maximum is raised through a specific design of the ligands.
    Type: Application
    Filed: December 20, 2005
    Publication date: December 28, 2006
    Inventors: Heribert Schmitt-Willich, Heiko Schirmer, Johannes Platzek, Stephane Dumas, Vincent Jacques, Thomas Brumby, Detlev Suelzle, Bernd Misselwitz
  • Publication number: 20060257322
    Abstract: The invention relates to pharmaceutical agents that contain at least one fluoroalkyl-containing metal complex that has a critical micelle-formation concentration of <10?3 mol/l and a hydrodynamic micelle diameter (2Rh) of >1 nm, and at least one natural or synthetic epothilone or epothilone derivative, optionally with the additives that are commonly used in galenicals.
    Type: Application
    Filed: February 16, 2006
    Publication date: November 16, 2006
    Inventors: Ruediger Lawaczeck, Rolf Press, Katja Schoen, Jens Hoffmann, Ulirch Klar, Bernd Misselwitz, Johannes Platzek, Heiko Schirmer
  • Publication number: 20060093554
    Abstract: This invention describes new galenical formulations that contain paramagnetic and diamagnetic perfluoroalkyl-containing compounds. The new formulations are suitable as contrast media for nuclear spin tomography.
    Type: Application
    Filed: September 12, 2005
    Publication date: May 4, 2006
    Inventors: Johannes Platzek, Ulrich Niedballa, Bernd Raduechel, Peter Mareski, Bernd Misselwitz, Thomas Frenzel, Hanns-Joachim Weinmann
  • Patent number: 6916461
    Abstract: The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: July 12, 2005
    Assignee: Schering AG
    Inventors: Johannes Platzek, Ulrich Niedballa, Bernd Radüchel, Wolfgang Schlecker, Hanns-Joachim Weinmann, Thomas Frenzel, Bernd Misselwitz, Wolfgang Ebert
  • Publication number: 20050147563
    Abstract: The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.
    Type: Application
    Filed: October 5, 2004
    Publication date: July 7, 2005
    Inventors: Johannes Platzek, Ulrich Niedballa, Bernd Raduchel, Wolfgang Schlecker, Hanns-Joachim Weinmann, Thomas Frenzel, Bernd Misselwitz, Wolfgang Ebert
  • Publication number: 20050074409
    Abstract: The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration<10?3 mol/l, a hydrodynamic micelle diameter (2 Rh)>1 nm and a proton relaxivity in plasma (R1)>10 I/mmol.s) as contrast media in MR imaging for visualization of plaque, lymph nodes, infarcted and necrotic tissue and for independent visualization of necrotic tissue and tumor tissue.
    Type: Application
    Filed: June 2, 2004
    Publication date: April 7, 2005
    Inventors: Johannes Platzek, Peter Mareski, Ulrich Niedballa, Bernd Raduechel, Hanns-Joachim Weinmann, Bernd Misselwitz
  • Patent number: 6818203
    Abstract: The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration <10−3 mol/l, a hydrodynamic micelle diameter (2 Rh)>1 nm and a proton relaxivity in plasma (R1)>10 l/mmol·s) as contrast media in MR imaging for visualization of plaque, lymph nodes, infarcted and necrotic tissue and for independent visualization of necrotic tissue and tumor tissue.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: November 16, 2004
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Peter Mareski, Ulrich Niedballa, Bernd Raduechel, Hanns-Joachim Weinmann, Bernd Misselwitz
  • Publication number: 20040189297
    Abstract: For easy detection and imaging of even microscopically small pathological structures bordering blood vessels in a human or animal body, especially of lymphatic tissue and arteriosclerotic deposits in the blood vessels, an arrangement and a process are proposed according to which a nuclear spin tomography device is used to obtain data for locally-resolved imaging of the magnetic resonance behavior of the atomic nuclei in a selected field of view in the body, the device being made and programmed such that the body can be exposed by the device to high frequency and magnetic field gradient echo pulse sequences that produce magnetization in the body so that magnetization of a medium that is flowing in at least one direction in space in the body can be attenuated by dephasing the spins of the atomic nuclei in the medium, an MR contrast medium being supplied to the body.
    Type: Application
    Filed: December 15, 2003
    Publication date: September 30, 2004
    Inventors: Michael Bock, Christian Fink, Bernd Misselwitz