Patents by Inventor Bernd Misselwitz

Bernd Misselwitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20040131546
    Abstract: The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration <10−3 mol/l, a hydrodynamic micelle diameter (2 Rh)>1 nm and a proton relaxivity in plasma (R)>10 l/mmol s as contrast media in MR imaging for visualization of intravascular thrombi.
    Type: Application
    Filed: July 10, 2003
    Publication date: July 8, 2004
    Applicant: Schering AG
    Inventors: Bernd Misselwitz, Johannes Platzek, Yoko Kawata, Hanns-Joachim Weinmann, Takashi Yokawa, Ulrich Niedballa
  • Patent number: 6676928
    Abstract: Perfluoroalkyl-containing complexes with polar radicals of general formula I (K)1-G-(Z-Rf)m(R)p  (I) in which R means the polar radical, Rf means a perfluorinated carbon chain, K is a metal complex, and Z represents a linker group, are suitable for intravenous lymphography, for tumor diagnosis and for infarction and necrosis imaging.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: January 13, 2004
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Peter Mareski, Ulrich Niedballa, Bernd Raduechel, Hanns-Joachim Weinmann, Bernd Misselwitz
  • Publication number: 20030232012
    Abstract: The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy.
    Type: Application
    Filed: July 18, 2002
    Publication date: December 18, 2003
    Applicant: Schering AG
    Inventors: Johannes Platzek, Ulrich Niedballa, Bernd Raduchel, Wolfgang Schlecker, Hanns-Joachim Weinmann, Thomas Frenzel, Bernd Misselwitz, Wolfgang Ebert
  • Patent number: 6641797
    Abstract: Perfluoroalkyl-containing complexes with sugar radicals of general formula I in which R represents a monosaccharide or oligosaccharide radical that is bonded via the 1-OH position or 1-SH position, Rf means a perfluorinated carbon chain, K is a metal complex, and Y and Z represent linker groups, are suitable for intravenous lymphography, for tumor diagnosis and for infarction and necrosis imaging.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: November 4, 2003
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Peter Mareski, Ulrich Niedballa, Bernd Raduechel, Hanns-Joachim Weinmann, Bernd Misselwitz
  • Publication number: 20030072713
    Abstract: The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration <10−3 mol/l, a hydrodynamic micelle diameter (2 Rh)>1 nm and a proton relaxivity in plasma (R1)>10 l/mmol·s) as contrast media in MR imaging for visualization of plaque, lymph nodes, infarcted and necrotic tissue and for independent visualization of necrotic tissue and tumor tissue.
    Type: Application
    Filed: August 10, 2001
    Publication date: April 17, 2003
    Inventors: Johannes Platzek, Peter Mareski, Ulrich Niedballa, Bernd Raduechel, Hanns-Joachim Weinmann, Bernd Misselwitz
  • Patent number: 6468502
    Abstract: The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.
    Type: Grant
    Filed: November 8, 1999
    Date of Patent: October 22, 2002
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Ulrich Niedballa, Bernd Radüchel, Wolfgang Schlecker, Hanns-Joachim Weinmann, Thomas Frenzel, Bernd Misselwitz, Wolfgang Ebert
  • Patent number: 6461587
    Abstract: The invention relates to macrocyclic perfluoroalkylamides, their production and their use in diagnosis.
    Type: Grant
    Filed: March 22, 2000
    Date of Patent: October 8, 2002
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Ulrich Niedballa, Detlev Suelzle, Wolfgang Schlecker, Bernd Raduechel, Hanns-Joachim Weinmann, Thomas Frenzel, Bernd Misselwitz, Wolfgang Ebert
  • Publication number: 20020076380
    Abstract: Perfluoroalkyl-containing complexes with polar radicals of general formula I
    Type: Application
    Filed: August 10, 2001
    Publication date: June 20, 2002
    Applicant: Schering AG
    Inventors: Johannes Platek, Peter Mareski, Ulrich Niedballa, Bernd Raduechel, Hanns-Joachim Weinmann, Bernd Misselwitz
  • Publication number: 20020076379
    Abstract: Perfluoroalkyl-containing complexes with sugar radicals of general formula I 1
    Type: Application
    Filed: August 10, 2001
    Publication date: June 20, 2002
    Applicant: Schering AG
    Inventors: Johannes Platzek, Peter Mareski, Ulrich Niedballa, Bernd Raduechel, Hanns-Joachim Weinmann, Bernd Misselwitz
  • Patent number: 6057419
    Abstract: Cascade polymer complexes that contain a) complexing ligands of general formula (I), in which A stands for a nitrogen-containing cascade nucleus of base multiplicity a, X and Y, independently of one another, stand for a direct bond or a cascade reproduction unit of reproduction multiplicity x or y, z and W, independently of one another, stand for a cascade reproduction unit of reproduction multiplicity z or w, K stands for the radical of a complexing agent, a stands for numbers 2 to 12, x, y, z and w, independently of one another, stand for numbers 1 to 4, provided that at least two reproduction units are different, and that 16.ltoreq.a.multidot.x.multidot.y.multidot.z.multidot.w.ltoreq.
    Type: Grant
    Filed: June 4, 1998
    Date of Patent: May 2, 2000
    Assignee: Schering Aktiengesellschaft
    Inventors: Heribert Schmitt-Willich, Johannes Platzek, Bernd Raduchel, Hanns-Joachim Weinmann, Wolfgang Ebert, Bernd Misselwitz, Andreas Muhler, Thomas Frenzel
  • Patent number: 6019959
    Abstract: Oligomeric compounds that contain perfluoroalkyl of general formula IA--R.sup.F (I)in whichA is a molecule portion that contains 2-6 metal complexes that are connected directly or via a linker to a nitrogen atom of an annular skeleton chain, andR.sup.F is a perfluorinated, straight-chain or branched carbon chain with formula --C.sub.n F.sub.2n E, in which E represents a terminal fluorine, chlorine, bromine, iodine, or hydrogen atom and n stands for numbers 4-30,are valuable compounds for diagnosis, especially as in-vivo contrast media.
    Type: Grant
    Filed: June 29, 1998
    Date of Patent: February 1, 2000
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Ulrich Niedballa, Bernd Raduchel, Wolfgang Schlecker, Hanns-Joachim Weinmann, Thomas Frenzel, Bernd Misselwitz, Wolfgang Ebert
  • Patent number: 5874061
    Abstract: Cascade polymer complexes that containa) complexing ligands of general formula IA--{X--?Y--(Z--(W--K.sub.w).sub.z).sub.y!.sub.x }.sub.a, (I)in whichA stands for a nitrogen-containing cascade nucleus of base multiplicity a,X and Y, independently of one another, stand for a direct bond or a cascade reproduction unit of reproduction multiplicity x or y,Z and W, independently of one another, stand for a cascade reproduction unit of reproduction multiplicity z or w,K stands for the radical of a complexing agent, a stands for numbers 2 to 12, x, y, z and w, independently of one another, stand for numbers 1 to 4,provided that at least two reproduction units are different, that 16.ltoreq.a.multidot.x.multidot.y.multidot.z.multidot.w.ltoreq.
    Type: Grant
    Filed: December 20, 1996
    Date of Patent: February 23, 1999
    Assignee: Schering Aktiengesellschaft
    Inventors: Heribert Schmitt-Willich, Johannes Platzek, Bernd Raduchel, Hanns-Joachim Weinmann, Wolfgang Ebert, Bernd Misselwitz, Andreas Muhler, Thomas Frenzel
  • Patent number: 5730956
    Abstract: The invention relates to diethylenetriaminepentaacetic acid monoamide derivatives, their complexes and complex salts, containing gadolinium, dysprosium, iron or manganese, pharmaceutical agents containing these compounds, their use as contrast media and process for their production.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 24, 1998
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Ulrich Niedballa, Peter Mareski, Bernd Raduchel, Hanns-Joachim Weinmann, Andreas Muhler, Bernd Misselwitz
  • Patent number: 5676923
    Abstract: Diethylenetriaminepentaacetic acid monoamide derivatives, their complexes and complex salts, containing an element of atomic numbers 21-29, 31, 32, 39, 42-44, 49 or 57-83, pharmaceutical agents containing these compounds, their use as contrast media and process for their production.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 14, 1997
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Ulrich Niedballa, Peter Mareski, Bernd Raduchel, Hanns-Joachim Weinmann, Andreas Muhler, Bernd Misselwitz