Abstract: The invention provides novel pharmaceutical compositions based on semifluorinated alkanes which are useful as carriers for a broad range of active ingredients. Preferred active ingredients include poorly water-soluble and/or hydrolytically sensitive drug substances. The compositions are designed as suspensions and have superior physical properties which make them highly useful as pharmaceutical delivery systems. The compositions may be administered topically into the eye, or injected via the subcutaneous or intramuscular route. The invention further provides kits comprising such compositions.

Abstract: The invention provides novel pharmaceutical compositions based on semifluorinated alkanes which are useful as carriers for a broad range of active ingredients. Preferred active ingredients include poorly water-soluble and/or hydrolytically sensitive drug substances. The compositions are designed as suspensions and have superior physical properties which make them highly useful as pharmaceutical delivery systems. The compositions may be administered topically into the eye, or injected via the subcutaneous or intramuscular route. The invention further provides kits comprising such compositions.

Abstract: The invention provides novel compositions comprising at least two or more semifluorinated alkanes. The compositions can be used as medicines that are topically administered to an eye or ophthalmic tissue, such as for use in the treatment of keratoconjunctivitis sicca (dry eye) and/or meibomian gland dysfunction and symptoms associated therewith. The invention further provides kits comprising such compositions.

Abstract: The invention provides novel pharmaceutical compositions based on semifluorinated alkanes which are useful as carriers for a broad range of active ingredients. Preferred active ingredients include poorly water-soluble and/or hydrolytically sensitive drug substances. The compositions are designed as suspensions and have superior physical properties which make them highly useful as pharmaceutical delivery systems. The compositions may be administered topically into the eye, or injected via the subcutaneous or intramuscular route. The invention further provides kits comprising such compositions.

Abstract: The invention provides novel compositions comprising semifluorinated alkanes and at least one compound sensitive or prone to oxidation. The compositions can be used as medicines that are topically administered to an eye or ophthalmic tissue. The invention further provides kits comprising such compositions.

Abstract: The invention provides novel compositions of bioactive polypeptides and proteins with improved stability and shelf-life. The compositions are based on liquid vehicles selected from semifluorinated alkanes. These vehicles are remarkably effective in protecting polypeptides and proteins from degradation and/or aggregation. The compositions are useful for topical administration, e.g. into an eye, or by parenteral injection, e.g. via the subcutaneous or intramuscular route.

Abstract: The invention provides novel pharmaceutical compositions based on semifluorinated alkanes which are useful as carriers for a broad range of active ingredients. Preferred active ingredients include poorly water-soluble and/or hydrolytically sensitive drug substances. The compositions are designed as suspensions and have superior physical properties which make them highly useful as pharmaceutical delivery systems. The compositions may be administered topically into the eye, or injected via the subcutaneous or intramuscular route. The invention further provides kits comprising such compositions.

Abstract: A screen device for sorting screening material into one or more fine grain fractions and one or more oversize grain fractions. The screen device includes a frame and a roller screen including screen rollers which are arranged, such that they can be rotary-driven about a roller axis each, next to each other and which are supported on the frame and which each comprise a roller body and one or more screen structures which protrude radially relative to the roller body. There is a fine grain screen gap between the roller bodies of respectively adjacent screen rollers, through which a fine grain fraction falls, while an oversize grain fraction is conveyed on the roller screen in the axial direction of the rollers when the screen rollers are rotary-driven.

Abstract: The invention provides liquid compositions in the form of physically stable emulsions comprising a semifluorinated alkane. The semifluorinated alkane is comprised in the dispersed phase, which may also include an active pharmaceutical ingredient. One of the preferred active ingredients is propofol. The compositions are optionally heat sterilisable and can be used for pharmaceutical or cosmetic product applications, and administered topically, intravenously, or via other routes.

Abstract: The invention relates to the use of semi-fluorinated alkanes, in particular mixed with ethanol, as solubilising agents, permeation promoters and/or enhancers for lipophilic and/or poorly skin-permeable pharmaceutical agents that are administered via a transdermal therapeutic system (TTS), and to corresponding TTSs containing such substances.

Abstract: The invention provides novel compositions comprising semifluorinated alkanes and at least one compound sensitive or prone to oxidation. The compositions can be used as medicines that are topically administered to an eye or ophthalmic tissue. The invention further provides kits comprising such compositions.

Abstract: A sorting device that can be transported by road or rail has rotary driven sorting rollers, supported on a frame, that together form a roller screen for sorting a material mixture into a fine grain size which falls through the roller screen and an oversize grain that is conveyed by the sorting rollers over a side edge of the roller screen. An oversize grain conveyor and collector is arranged below the sorting rollers. A channelling means extends along the side edge and is inclined in an operating position towards the oversize grain conveyor and collector, at least in sections, between an upper region, which faces the side edge at a distance, and a lower region which is near the oversize grain conveyor and collector, in order to channel oversize grain, which is conveyed over the side edge of the roller screen, downwards to the oversize grain conveyor and collector.

Abstract: The invention provides novel compositions of antibodies based on liquid vehicles selected from semifluorinated alkanes. The use of these vehicles provides for improved stability and shelf-life of antibodies and their derivatives. The compositions are useful for topical administration or for parenteral injection.

Abstract: A screen device for sorting screening material into one or more fine grain fractions and one or more oversize grain fractions. The screen device includes a frame and a roller screen including screen rollers which are arranged, such that they can be rotary-driven about a roller axis each, next to each other and which are supported on the frame and which each comprise a roller body and one or more screen structures which protrude radially relative to the roller body. There is a fine grain screen gap between the roller bodies of respectively adjacent screen rollers, through which a fine grain fraction falls, while an oversize grain fraction is conveyed on the roller screen in the axial direction of the rollers when the screen rollers are rotary-driven.

Abstract: A sorting device that can be transported by road or rail has rotary driven sorting rollers, supported on a frame, that together form a roller screen for sorting a material mixture into a fine grain size which falls through the roller screen and an oversize grain that is conveyed by the sorting rollers over a side edge of the roller screen. An oversize grain conveyor and collector is arranged below the sorting rollers. A channelling means extends along the side edge and is inclined in an operating position towards the oversize grain conveyor and collector, at least in sections, between an upper region, which faces the side edge at a distance, and a lower region which is near the oversize grain conveyor and collector, in order to channel oversize grain, which is conveyed over the side edge of the roller screen, downwards to the oversize grain conveyor and collector.

Abstract: The invention provides novel compositions comprising semifluorinated alkanes and at least one compound sensitive or prone to oxidation. The compositions can be used as medicines that are topically administered to an eye or ophthalmic tissue. The invention further provides kits comprising such compositions.

Abstract: The invention provides novel compositions comprising at least two or more semifluorinated alkanes. The compositions can be used as medicines that are topically administered to an eye or ophthalmic tissue, such as for use in the treatment of keratoconjunctivitis sicca (dry eye) and/or meibomian gland dysfunction and symptoms associated therewith. The invention further provides kits comprising such compositions.

Abstract: The invention provides novel compositions of bioactive polypeptides and proteins with improved stability and shelf-life. The compositions are based on liquid vehicles selected from semifluorinated alkanes. These vehicles are remarkably effective in protecting polypeptides and proteins from degradation and/or aggregation. The compositions are useful for topical administration, e.g. into an eye, or by parenteral injection, e.g. via the subcutaneous or intramuscular route.

Abstract: The invention provides liquid compositions in the form of physically stable emulsions comprising a semifluorinated alkane. The semifluorinated alkane is comprised in the dispersed phase, which may also include an active pharmaceutical ingredient. One of the preferred active ingredients is propofol. The compositions are optionally heat sterilisable and can be used for pharmaceutical or cosmetic product applications, and administered topically, intravenously, or via other routes.

Abstract: The invention provides novel pharmaceutical compositions for the treatment of keratoconjunctivitis sicca comprising liquid vehicles which include one or more semifluorinated alkanes. The compositions incorporate an active ingredient selected from the group of macrolide immunosuppressants. They can be administered topically into the eye. The invention further provides kits comprising such compositions.