Patents by Inventor Bernhard Luy

Bernhard Luy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200141647
    Abstract: The present invention provides, inter alia, for a liquid feeding device for the generation of droplets, in particular for the use in a process line for the production of freeze-dried particles, with a droplet ejection section for ejecting liquid droplets in an ejection direction, the droplet ejection section comprising at least one inlet port for receiving a liquid to be ejected, a liquid chamber for retaining the liquid, and a nozzle for ejecting the liquid from the liquid chamber to form droplets, wherein the liquid chamber is restricted by a membrane on one side thereof, the membrane being vibratable by an excitation unit, wherein the longitudinal axis of the liquid chamber is tilted relative to the longitudinal axis of the nozzle, and/or the liquid feeding device further comprises a deflection section for separating the droplets from each other by means of at least one gas jet, wherein the deflection section gas jet intersects perpendicular with an ejection path of the liquid ejected from the liquid chamb
    Type: Application
    Filed: January 8, 2020
    Publication date: May 7, 2020
    Applicant: Sanofi Pasteur SA
    Inventors: Thomas GEBHARD, Roland KAISER, Bernhard LUY, Matthias PLITZKO, Manfred STRUSCHKA, Christian ZERILLO
  • Publication number: 20200116428
    Abstract: A heating device (124) for heating particles to be freeze-dried in a rotary drum (102) of a freeze-dryer (100) is provided, the device comprising at least one radiation emitter (202) for applying radiation heat to the particles, and a tube-shaped separator (204) for separating the particles from the at least one emitter (202), The separator (202) being integrally closed at one end and separating an emitter volume (206) encompassing the at least one emitter (202) from a drum process volume (126) inside the drum (102), wherein the heating device (124) protrudes into the drum process volume (126) such that said integrally closed end of the separator (204) is arranged inside the drum (102) as a free end.
    Type: Application
    Filed: October 16, 2019
    Publication date: April 16, 2020
    Applicant: Sanofi Pasteur SA
    Inventors: Thomas GEBHARD, Roland KAISER, Matthias PLITZKO, Manfred STRUSCHKA, Bernhard LUY
  • Publication number: 20200109896
    Abstract: A process line for the production of freeze-dried particles under closed conditions is provided, the process line comprising a freeze-dryer for the bulkware production of freeze-dried particles under closed conditions, the freeze-dryer comprising a rotary drum for receiving the frozen particles, and a stationary vacuum chamber housing the rotary drum, wherein for the production of the particles under closed conditions the vacuum chamber is adapted for closed operation during processing of the particles; the drum is in open communication with the vacuum chamber; and at least one transfer section is provided for a product transfer between a separate device of the process line and the freeze-dryer, the freeze-dryer and the transfer section being separately adapted for closed operation, wherein the transfer section comprises a temperature-controllable inner wall surface.
    Type: Application
    Filed: November 27, 2019
    Publication date: April 9, 2020
    Applicant: Sanofi Pasteur SA
    Inventors: Matthias Plitzko, Manfred Struschka, Thomas Gebhard, Bernhard Luy
  • Patent number: 10533800
    Abstract: The present invention provides, inter alia, for a liquid feeding device for the generation of droplets, in particular for the use in a process line for the production of freeze-dried particles, with a droplet ejection section for ejecting liquid droplets in an ejection direction, the droplet ejection section comprising at least one inlet port for receiving a liquid to be ejected, a liquid chamber for retaining the liquid, and a nozzle for ejecting the liquid from the liquid chamber to form droplets, wherein the liquid chamber is restricted by a membrane on one side thereof, the membrane being vibratable by an excitation unit, wherein the longitudinal axis of the liquid chamber is tilted relative to the longitudinal axis of the nozzle, and/or the liquid feeding device further comprises a deflection section for separating the droplets from each other by means of at least one gas jet, wherein the deflection section gas jet intersects perpendicular with an ejection path of the liquid ejected from the liquid chamb
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: January 14, 2020
    Assignee: Sanofi Pasteur SA
    Inventors: Thomas Gebhard, Roland Kaiser, Bernhard Luy, Matthias Plitzko, Manfred Struschka, Christian Zerillo
  • Patent number: 10527350
    Abstract: A process line for the production of freeze-dried particles under closed conditions is provided, the process line comprising a freeze-dryer (100) for the bulkware production of freeze-dried particles under closed conditions, the freeze-dryer (100) comprising a rotary drum (104, 302) for receiving the frozen particles, and a stationary vacuum chamber (102) housing the rotary drum (104, 302), wherein for the production of the particles under closed conditions the vacuum chamber (102) is adapted for closed operation during processing of the particles. The drum (104, 302) is in open communication with the vacuum chamber (102) and at least one transfer section (106, 108) is provided for a product transfer between a separate device of the process line and the freeze-dryer (100), the freeze-dryer (100) and the transfer section (106, 108) being separately adapted for closed operation, wherein the transfer section (106, 108) comprises a temperature-controllable inner wall surface.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: January 7, 2020
    Assignee: Sanofi Pasteur SA
    Inventors: Matthias Plitzko, Manfred Struschka, Thomas Gebhard, Bernhard Luy
  • Patent number: 10451345
    Abstract: A heating device (124) for heating particles to be freeze-dried in a rotary drum (102) of a freeze-dryer (100) is provided, the device comprising at least one radiation emitter (202) for applying radiation heat to the particles, and a tube-shaped separator (204) for separating the particles from the at least one emitter (202). The separator (202) being integrally closed at one end and separating an emitter volume (206) encompassing the at least one emitter (202) from a drum process volume (126) inside the drum (102), wherein the heating device (124) protrudes into the drum process volume (126) such that said integrally closed end of the separator (204) is arranged inside the drum (102) as a free end.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: October 22, 2019
    Assignee: Sanofi Pasteur SA
    Inventors: Thomas Gebhard, Roland Kaiser, Matthias Plitzko, Manfred Struschka, Bernhard Luy
  • Patent number: 10407489
    Abstract: A method for the production of freeze-dried pellets comprising factor VIII comprises the steps of: a) freezing droplets of a solution comprising factor VIII to form pellets; b) freeze-drying the pellets; wherein in step a) the droplets are formed by means of droplet formation of the solution comprising factor VIII into a cooling tower which has a temperature-controllable inner wall surface and an interior temperature below the freezing temperature of the solution and wherein in step b) the pellets are freeze-dried in a rotating receptacle which is housed inside a vacuum chamber.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: September 10, 2019
    Assignee: Bayer Pharma Aktiengesellschaft
    Inventors: Carsten Olbrich, Matthias Plitzko, Bernhard Luy, Stefan Christian Schneid
  • Publication number: 20180327478
    Abstract: A method for the production of freeze-dried pellets comprising factor VIII comprises the steps of: a) freezing droplets of a solution comprising factor VIII to form pellets; b) freeze-drying the pellets; wherein in step a) the droplets are formed by means of droplet formation of the solution comprising factor VIII into a cooling tower which has a temperature-controllable inner wall surface and an interior temperature below the freezing temperature of the solution and wherein in step b) the pellets are freeze-dried in a rotating receptacle which is housed inside a vacuum chamber.
    Type: Application
    Filed: November 4, 2016
    Publication date: November 15, 2018
    Applicant: Bayer Pharma Aktiengesellschaft
    Inventors: Carsten OLBRICH, Matthias PLITZKO, Bernhard LUY, Stefan Christian SCHNEID
  • Patent number: 10006706
    Abstract: A process line (300) for the production of freeze-dried particles under closed conditions is provided, the process line comprising at least the following separate devices: a spray chamber (302) for droplet generation and freeze congealing of the liquid droplets to form particles, and a bulk freeze-dryer (304) for freeze drying the particles, wherein a transfer section (308) is provided for a product transfer from the spray chamber (302) to the freeze-dryer (304), for the production of the particles under end-to-end closed conditions each of the devices (302, 304) and of the transfer section (308) is separately adapted for closed operation, and the spray chamber (302) is adapted for separation of the liquid droplets from any cooling circuit.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: June 26, 2018
    Assignee: Sanofi Pasteur SA
    Inventors: Bernhard Luy, Matthias Plitzko, Manfred Struschka
  • Patent number: 9920989
    Abstract: A process line (300) for the production of freeze-dried particles under closed conditions comprising at least a spray chamber (302) for droplet generation and freeze congealing of the liquid droplets to form particles and a bulk freeze-dryer (304) for freeze drying the particles, the freeze-dryer (304) comprising a rotary drum for receiving the particles. Further, a transfer section (308) is provided for a product transfer from the spray chamber (302) to the freeze-dryer (304). For the production of the particles under end-to-end closed conditions each of the devices (302, 304) and of the transfer section (308) is separately adapted for operation preserving sterility of the product to be freeze-dried and/or containment.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: March 20, 2018
    Assignee: Sanofi Pasteur SA
    Inventors: Bernhard Luy, Matthias Plitzko, Manfred Struschka
  • Publication number: 20170219283
    Abstract: The present invention provides, inter alia, for a liquid feeding device for the generation of droplets, in particular for the use in a process line for the production of freeze-dried particles, with a droplet ejection section for ejecting liquid droplets in an ejection direction, the droplet ejection section comprising at least one inlet port for receiving a liquid to be ejected, a liquid chamber for retaining the liquid, and a nozzle for ejecting the liquid from the liquid chamber to form droplets, wherein the liquid chamber is restricted by a membrane on one side thereof, the membrane being vibratable by an excitation unit, wherein the longitudinal axis of the liquid chamber is tilted relative to the longitudinal axis of the nozzle, and/or the liquid feeding device further comprises a deflection section for separating the droplets from each other by means of at least one gas jet, wherein the deflection section gas jet intersects perpendicular with an ejection path of the liquid ejected from the liquid chamb
    Type: Application
    Filed: July 20, 2015
    Publication date: August 3, 2017
    Inventors: Thomas GEBHARD, Roland KAISER, Bernhard LUY, Matthias PLITZKO, Manfred STRUSCHKA, Christian ZERILLO
  • Patent number: 9347707
    Abstract: A rotary drum (302) for use within a vacuum chamber (212) in a vacuum freeze-dryer (204) for the bulkware production of freeze-dried particles is provided. The drum (302) is in open communication with the vacuum chamber (212) and comprises a main section (304) terminated by a front plate (306) and a rear plate (308), the rear plate (308) is adapted for connection with a rotary supporting shaft (312) for rotary support of the drum (302), and the rear plate (308) is permeable for sublimation vapor from freeze-drying the particles.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: May 24, 2016
    Assignee: Sanofi Pasteur SA
    Inventors: Manfred Struschka, Matthias Plitzko, Thomas Gebhard, Bernhard Luy
  • Publication number: 20150007445
    Abstract: A heating device (124) for heating particles to be freeze-dried in a rotary drum (102) of a freeze-dryer (100) is provided, the device comprising at least one radiation emitter (202) for applying radiation heat to the particles, and a tube-shaped separator (204) for separating the particles from the at least one emitter (202). The separator (202) being integrally closed at one end and separating an emitter volume (206) encompassing the at least one emitter (202) from a drum process volume (126) inside the drum (102), wherein the heating device (124) protrudes into the drum process volume (126) such that said integrally closed end of the separator (204) is arranged inside the drum (102) as a free end.
    Type: Application
    Filed: October 4, 2012
    Publication date: January 8, 2015
    Inventors: Thomas Gebhard, Roland Kasier, Matthias Plitzko, Manfred Struschka, Bernhard Luy
  • Publication number: 20140373383
    Abstract: A rotary drum (302) for use within a vacuum chamber (212) in a vacuum freeze-dryer (204) for the bulkware production of freeze-dried particles is provided. The drum (302) is in open communication with the vacuum chamber (212) and comprises a main section (304) terminated by a front plate (306) and a rear plate (308), the rear plate (308) is adapted for connection with a rotary supporting shaft (312) for rotary support of the drum (302), and the rear plate (308) is permeable for sublimation vapor from freeze-drying the particles.
    Type: Application
    Filed: October 4, 2012
    Publication date: December 25, 2014
    Applicant: SANOFI PASTEUR SA
    Inventors: Manfred Struschka, Matthias Plitzko, Thomas Gebhard, Bernhard Luy
  • Publication number: 20140245629
    Abstract: A process line (300) for the production of freeze-dried particles under closed conditions comprising at least a spray chamber (302) for droplet generation and freeze congealing of the liquid droplets to form particles and a bulk freeze-dryer (304) for freeze drying the particles, the freeze-dryer (304) comprising a rotary drum for receiving the particles. Further, a transfer section (308) is provided for a product transfer from the spray chamber (302) to the freeze-dryer (304). For the production of the particles under end-to-end closed conditions each of the devices (302, 304) and of the transfer section (308) is separately adapted for operation preserving sterility of the product to be freeze-dried and/or containment.
    Type: Application
    Filed: October 4, 2012
    Publication date: September 4, 2014
    Inventors: Bernhard Luy, Mtthias Plitzko, Manfred Struschka
  • Publication number: 20140237846
    Abstract: A process line for the production of freeze-dried particles under closed conditions is provided, the process line comprising a freeze-dryer (100) for the bulkware production of freeze-dried particles under closed conditions, the freeze-dryer (100) comprising a rotary drum (104, 302) for receiving the frozen particles, and a stationary vacuum chamber (102) housing the rotary drum (104, 302), wherein for the production of the particles under closed conditions the vacuum chamber (102) is adapted for closed operation during processing of the particles.
    Type: Application
    Filed: October 4, 2012
    Publication date: August 28, 2014
    Inventors: Matthias Plitzko, Manfred Struschka, Thomas Gebhard, Bernhard Luy
  • Publication number: 20140230266
    Abstract: A process line (300) for the production of freeze-dried particles under closed conditions is provided, the process line comprising at least the following separate devices: a spray chamber (302) for droplet generation and freeze congealing of the liquid droplets to form particles, and a bulk freeze-dryer (304) for freeze drying the particles, wherein a transfer section (308) is provided for a product transfer from the spray chamber (302) to the freeze-dryer (304), for the production of the particles under end-to-end closed conditions each of the devices (302, 304) and of the transfer section (308) is separately adapted for closed operation, and the spray chamber (302) is adapted for separation of the liquid droplets from any cooling circuit.
    Type: Application
    Filed: October 4, 2012
    Publication date: August 21, 2014
    Inventors: Bernhard Luy, Matthias Plitzko, Manfred Struschka
  • Patent number: 8505834
    Abstract: The invention concerns a spray nozzle for a fluidized bed device, said nozzle comprising a central liquid outlet (15) for a liquid coating agent and an annular air outlet (17) for conveying spraying air coaxially. An enclosing body (1) having a central recess (4) is maintained in a wall of the box of the fluidized bed device. Said enclosing body (1) is connected to a spraying air source through an air duct (6) and an axially mobile nozzle head (14) is centrally mounted inside said enclosing body (1). Said nozzle head (14) is connected to a liquid coating agent source through a liquid duct (10), said liquid duct (10) having a flexible tubular section (12) and being centrally guided inside the air duct (6).
    Type: Grant
    Filed: April 21, 2006
    Date of Patent: August 13, 2013
    Assignee: Glatt GmbH
    Inventors: Bernhard Luy, Manfred Struschka, Matthias Tondar
  • Patent number: 8187663
    Abstract: A process for measuring, monitoring and/or controlling directed product movements of fluidized products in process systems (1) selected from fluidized bed and spouted bed systems during a spraying process for coating and/or granulation, which includes, with the aid of one or more microwave sensor devices (8), injecting microwave radiation without contact into one or more product streams, receiving the microwave radiation reflected by the particles of the particular product stream and, on the basis of the microwave radiation received, forming and transmitting a measurement signal for the characterization of the product stream, the corresponding use of microwave sensor devices (8) and correspondingly equipped apparatus (1).
    Type: Grant
    Filed: January 23, 2007
    Date of Patent: May 29, 2012
    Assignee: Glatt GmbH
    Inventors: Jochen A. Dressler, Manfred Struschka, Bernhard Luy
  • Publication number: 20090218419
    Abstract: The invention concerns a spray nozzle for a fluidized bed device, said nozzle comprising a central liquid outlet (15) for a liquid coating agent and an annular air outlet (17) for conveying spraying air coaxially. An enclosing body (1) having a central recess (4) is maintained in a wall of the box of the fluidized bed device. Said enclosing body (1) is connected to a spraying air source through an air duct (6) and an axially mobile nozzle head (14) is centrally mounted inside said enclosing body (1). Said nozzle head (14) is connected to a liquid coating agent source through a liquid duct (10), said liquid duct (10) having a flexible tubular section (12) and being centrally guided inside the air duct (6).
    Type: Application
    Filed: April 21, 2006
    Publication date: September 3, 2009
    Inventors: Bernhard Luy, Manfred Struschka, Matthias Tondar