Abstract: Cytotoxic ?? T cells form an essential component in immunity to infections and tumors, and are also implicated in host defense against these challenges. The present disclosure demonstrates the ability of activated ?? T cells to cross-present exogenous antigens to CD8+ ?? T cells, a process previously thought to be mediated best by dendritic cells. In particular, the present disclosure provides a method for cross-presentation of antigen derived from tumor cell or microbial organisms such as viruses, bacteria, yeasts, parasites, and the like, or from cells infected with such organisms, to a CD8+ ?? T cell. Still further, the present disclosure provides a method for treatment of a tumor or a chronic or recurrent infectious disease, comprising delivering an antigen-presenting autologous ?? T cell population above into a patient requiring such treatment. Still yet further, a method is described for preparing a peptide-specific effector T cell.

Abstract: The invention relates to a method for the preparation of efficient antigen-presenting human ?? T cells, to the ?? T cells prepared by such a method, and to their use in immunotherapy, vaccination, vaccine development and diagnostics. Similar to dendritic cells (DCs) in potency and efficacy, these human ?? T cells process antigens and present antigenic peptides to ?? T cells and induce antigen-specific responses (proliferation and differentiation) in naïve ?? T cells. ?? T cells are easily purified from peripheral blood, acquire “maturation” status (expression of essential adhesion, co-stimulatory and major histocompatibility complex molecules) within 1 day of in vitro culture under stimulation and induce strong primary and secondary T helper cell and cytotoxic T cell responses. The ?? T cells may be used in a method of treatment of tumors or chronic or recurrent infectious diseases, in identification of novel tumor or pathogen-derived antigens, and in the diagnosis of the immune competence of a patient.

Abstract: A method for generating a pseudo holographic image (11) from a first original image (10) comprising a plurality of first pixels (3) and a second original image (10?) comprising a plurality of second pixels (3?), whereby first image analysis pixels (1) are selected from the plurality of first pixels (3) in a predetermined order, the method of the invention comprising the following steps for each selected image analysis pixel: creating of a first variable, adaptive environment area (2) in the first original image (10) around a first analysis pixel (1), searching for a second environment area in the second original image (10?), said second environment area (2?) correlating with the first environment area (2), determining a second image analysis pixel (1?) in the second environment area (2?), said second image analysis pixel (1?) correlating with the first image analysis pixel (1).

Abstract: A device for fixing an adapter unit (1) comprising an optical film (16) and/or an optical plate to a monitor (4) consisting of a display (7) and a frame (4), said device (11) comprising a first means by which the adapter unit is spaced apart from the display (7) by a defined distance by means of a defined first force (3, 3?) which is substantially directed from the adapter unit (1) towards the monitor (7).

Abstract: The invention relates to a drilling tool, especially for percussion drilling, which comprises a cutting element (3) that is configured as a plate (3) or head and that has at least one cutting edge (11) defined by a cutting face (6) and a free face (10). The cutting edge (11) is associated with a first free face section (10a) which is limited in a cutting plane at a right angle to the cutting edge (11) and parallel to the longitudinal axis (L) of the drilling tool (1) by a convex bulge (13) or a convex polygon outline. The vertical height of a rib (14) defined by the first free face section (10a) and an associated first cutting face section (6a) ranges from 0.1 mm to 1.0 mm.

Abstract: The present invention relates to proteins or polypeptides, referred to herein as isolated and/Or recombinant mammalian (e.g., human) IP-10/Mig receptor proteins designated CXC Chemokine Receptor 3 (CXCR3) and variants thereof, including those characterized by selective binding of one or more chemokines (e.g., IP-10 and/or Mig), and/or the ability to induce a cellular response (e.g., chemotaxis, exocytosis). Antibodies reactive with CXCR3 receptors can be produced using the proteins or variants thereof or host cells comprising same as immunogen.

Abstract: The invention relates to a method for the preparation of efficient antigen-presenting human ?? T cells, to the ?? T cells prepared by such a method, and to their use in immunotherapy, vaccination, vaccine development and diagnostics. Similar to dendritic cells (DCs) in potency and efficacy, these human ?? T cells process antigens and present antigenic peptides to ?? T cells and induce antigen-specific responses (proliferation and differentiation) in naïve ?? T cells. ?? T cells are easily purified from peripheral blood, acquire “maturation” status (expression of essential adhesion, co-stimulatory and major histocompatibility complex molecules) within 1 day of in vitro culture under stimulation and induce strong primary and secondary T helper cell responses. The ?? T cells may be used in a method of treatment of tumors or chronic or recurrent infectious diseases, in identification of novel tumor or pathogen-derived antigens, and in the diagnosis of the immune competence of a patient.

Abstract: Cytotoxic ?? T cells form an essential component in immunity to infections and tumors, and are also implicated in host defense against these challenges. The present disclosure demonstrates the ability of activated ?? T cells to cross-present exogenous antigens to CD8+ ?? T cells, a process previously thought to be mediated best by dendritic cells. In particular, the present disclosure provides a method for cross-presentation of antigen derived from tumor cell or microbial organisms such as viruses, bacteria, yeasts, parasites, and the like, or from cells infected with such organisms, to a CD8+ ?? T cell. Still further, the present disclosure provides a method for treatment of a tumor or a chronic or recurrent infectious disease, comprising delivering an antigen-presenting autologous ?? T cell population above into a patient requiring such treatment. Still yet further, a method is described for preparing a peptide-specific effector T cell.

Abstract: A drilling and/or chiseling tool, in particular for machining materials such as concrete, rock, masonry, and the like, having a hard metal cutting element (1) contained in the machining end of the tool head, a radially outer, second working region (II) of the hard metal cutting element (1) being set back in relation to a central, first working region (I) of the hard metal cutting element (1) and the two working regions (I, II) transitioning into each other via a third working region (III). The third working region (III) is at least partially comprised of at least one partial circumference surface (5, 6) of at least one conical surface.

Abstract: The present invention relates to proteins or polypeptides, referred to herein as isolated and/or recombinant mammalian (e.g., human) IP-10/Mig receptor proteins designated CXC Chemokine Receptor 3 (CXCR3) and variants thereof, including those characterized by selective binding of one or more chemokines (e.g., IP-10 and/or Mig), and/or the ability to induce a cellular response (e.g., chemotaxis, exocytosis). Antibodies reactive with CXCR3 receptors can be produced using the proteins or variants thereof or host cells comprising same as immunogen.

Abstract: The invention relates to a method for the preparation of efficient antigen-presenting human ?? T cells, to the ?? T cells prepared by such a method, and to their use in immunotherapy, vaccination, vaccine development and diagnostics. Similar to dendritic cells (DCs) in potency and efficacy, these human ?? T cells process antigens and present antigenic peptides to ?? T cells and induce antigen-specific responses (proliferation and differentiation) in naïve ?? T cells. ?? T cells are easily purified from peripheral blood, acquire “maturation” status (expression of essential adhesion, co-stimulatory and major histocompatibility complex molecules) within 1 day of in vitro culture under stimulation and induce strong primary and secondary T helper cell and cytotoxic T cell responses. The ?? T cells may be used in a method of treatment of tumors or chronic or recurrent infectious diseases, in identification of novel tumor or pathogen-derived antigens, and in the diagnosis of the immune competence of a patient.

Abstract: The invention relates to a drilling tool, especially for percussion drilling, which comprises a cutting element (3) that is configured as a plate (3) or head and that has at least one cutting edge (11) defined by a cutting face (6) and a free face (10). The cutting edge (11) is associated with a first free face section (10a) which is limited in a cutting plane at a right angle to the cutting edge (11) and parallel to the longitudinal axis (L) of the drilling tool (1) by a convex bulge (13) or a convex polygon outline. The vertical height of a rib (14) defined by the first free face section (10a) and an associated first cutting face section (6a) ranges from 0.1 mm to 1.0 mm.

Abstract: The invention relates to methods of identifying ligands, and inhibitors (e.g., antagonists) or promoters (e.g., agonists) of receptor function, including methods in which host cells comprising a nucleic acid encoding a CXCR3 or variant thereof are used in an assay to identify and assess the efficacy of ligands, inhibitors or promoters. Inhibitors and promoters of receptor function can be used to modulate receptor activity, permitting selective inhibition of lymphocyte function, particularly of effector cells such as activated T lymphocytes and NK cells for therapeutic purposes.

Abstract: The invention relates to a drilling tool (36), in particular for working concrete, rock, masonry and suchlike materials, having a single- or multi-edge tool head with at least one cutting body (1) which comprises a central region (12) which is designed in a roof shape, has rake faces and flanks and is defined laterally by two outer regions (13, 14) set back in the effective direction of the drill. In this case, the ground surfaces of the central region (12) form a pyramidal point (15) while avoiding the formation of a chisel edge.

Abstract: The invention relates to a drilling tool (1), in particular for working concrete, rock, masonry and suchlike materials, having a tool head with cutting body (5) which has at least one front rake face (9, 10), at least one rear flank ([lacuna] 18) and at least one front-end cutting edge (7, 8), the cutting edge (7, 8) separating the rake face (9, 10) and the flank ([lacuna] 18). In this case, the rake face (9, 10) is formed by at least two cutting faces (11, 13; 12 [lacuna]) merging into one another at at least one second cutting edge (15, 16).

Abstract: The present invention relates to proteins or polypeptides, referred to herein as isolated and/or recombinant mammalian (e.g., human) IP-10/Mig receptor proteins designated CXC Chemokine Receptor 3 (CXCR3) and variants thereof, including those characterized by selective binding of one or more chemokines (e.g., IP-10 and/or Mig), and/or the ability to induce a cellular response (e.g., chemotaxis, exocytosis). Antibodies reactive with CXCR3 receptors can be produced using the proteins or variants thereof or host cells comprising same as immunogen.

Abstract: The invention relates to isolated and/or recombinant nucleic acids encoding a mammalian (e.g., human) CXCR3 protein and variants thereof, including antisense nucleic acid, recombinant nucleic acid constructs, such as plasmids or retroviral vectors, comprising a nucleic acid which encodes a protein of the present invention or variant thereof, and to host cells comprising a nucleic acid or construct, useful in the production of recombinant proteins. The invention also relates to a method for producing a mammalian (e.g., human) CXCR3 protein.

Abstract: The invention relates to a method for the production of a tool, in particular a drill (6) or milling cutter, having at least one conveying helix (8a, 8b), proceeding from a bar-shaped blank (1). In this case, there is provision for introducing the conveying helix (8a, 8b) in a single operation by means of a machine tool, the blank (1) having a diameter (DR) which is larger than a diameter (dF) of the conveying helix (8a, 8b).

Abstract: The invention relates to a drilling tool (1), in particular for working concrete, rock, masonry and suchlike materials, having a tool head with cutting body (5) which has at least one front rake face (9, 10), at least one rear flank ([lacuna] 18) and at least one front-end cutting edge (7, 8), the cutting edge (7, 8) separating the rake face (9, 10) and the flank ([lacuna] 18). In this case, the rake face (9, 10) is formed by at least two cutting faces (11, 13; 12 [lacuna]) merging into one another at at least one second cutting edge (15, 16).

Abstract: The present invention relates to proteins or polypeptides, referred to herein as isolated and/or recombinant mammalian (e.g., human) IP-10/Mig receptor proteins designated CXC Chemokine Receptor 3 (CXCR3) and variants thereof, including those characterized by selective binding of one or more chemokines (e.g., IP-10 and/or Mig), and/or the ability to induce a cellular response (e.g., chemotaxis, exocytosis). Antibodies reactive with CXCR3 receptors can be produced using the proteins or variants thereof or host cells comprising same as immunogen.