Abstract: The invention relates to a drilling tool (36), in particular for working concrete, rock, masonry and suchlike materials, having a single- or multi-edge tool head with at least one cutting body (1) which comprises a central region (12) which is designed in a roof shape, has rake faces and flanks and is defined laterally by two outer regions (13, 14) set back in the effective direction of the drill. In this case, the ground surfaces of the central region (12) form a pyramidal point (15) while avoiding the formation of a chisel edge.

Abstract: The invention proposes a drilling tool, in particular rock-drilling tool for rotary and/or percussive operation, in which, for the purpose of improving the drilling properties, the drilling-dust discharge groove is subdivided into at least two discharge-groove sections, each section having its own drilling-dust-carrying surface.

Abstract: A rock drill which has a cutting tip of roof-shaped design at its front end is proposed. In order to achieve a reduction in the loading of the carbide cutting tip or an increased drilling capacity in particular in concrete, the flanks are subdivided into flank sections in order to achieve a slimmer embodiment of the drill head.

Abstract: The present invention relates to proteins or polypeptides, referred to herein as isolated and/or recombinant mammalian (e.g., human) IP-10/Mig receptor proteins designated CXC Chemokine Receptor 3 (CXCR3) and variants thereof, including those characterized by selective binding of one or more chemokines (e.g., IP-10 and/or Mig), and/or the ability to induce a cellular response (e.g., chemotaxis, exocytosis). Antibodies reactive with CXCR3 receptors can be produced using the proteins or variants thereof or host cells comprising same as immunogen. Another aspect of the invention relates to isolated and/or recombinant nucleic acids encoding a mammalian (e.g., human) CXCR3 protein and variants thereof, including antisense nucleic acid, recombinant nucleic acid constructs, such as plasmids or retroviral vectors, comprising a nucleic acid which encodes a protein of the present invention or variant thereof, and to host cells comprising a nucleic acid or construct, useful in the production of recombinant proteins.

Abstract: The present invention relates to methods of identifying ligands, and inhibitors (e.g., antagonists) or promoters (e.g., agonists) of receptor function, including methods in which host cells comprising a nucleic acid encoding a CXCR3 or variant thereof are used in an assay to identify and assess the efficacy of ligands, inhibitors or promoters. Inhibitors and promoters of receptor function can be used to modulate receptor activity, permitting selective inhibition of lymphocyte function, particularly of effector cells such as activated T lymphocytes and NK cells for therapeutic purposes.

Abstract: A drilling tool, in particular for rotary percussion drilling preferably of rock, is proposed, with a drill body preferably equipped with cutting tips toward the drilling side and with an axially arranged bore for receiving an exchangeable center drill. In order to carry out easy mounting and demounting of the center drill, the drilling tool is designed in two parts, the center drill being capable of being introduced into the drilling tool on the clamping side.

Abstract: An annular bit (1) having an attachable center drill (6) is proposed, in which annular bit (1), on the one hand, reliable holding of the center drill (6) in the annular bit (1) is ensured and, in particular, distributions of the cutting segments (3) on the annular bit (1) differing from the 90.degree. symmetry are made possible. This is achieved according to the invention in that the center-drill holder (4) has at least one push-in pin (11) and the wall of the annular bit (1) has at least one recess (14, 15, 16) for accommodating the push-in pin (11), which pin and recess are formed in such a way that the push-in pin (11) is retained in the recess (14, 15, 16) in the axial direction relative to the annular-bit axis in the locked state of the center-drill holder (4).

Abstract: A drill bit is proposed, in particular for the rotary-percussive drilling of preferably rock, concrete or the like, which includes a thin-walled cylindrical drilling body (106) open to the drilling side and a drill-bit base (20) extending essentially radially and having an axially arranged drill-bit shank (101) for fastening the drill bit. The drill-bit base (20) has an outer contour in the radial direction, which outer contour follows a curve shape which has at least one inflection point. Furthermore, a drill bit is proposed whose drill-bit base (20) has an outer contour which passes through a minimum in the radial direction, the drill-bit base being connected in the rising radially outer curve section of its outer contour to the cylindrical drilling body.

Abstract: A drilling tool for rotary percussion drilling including: a drilling body defining: a longitudinal centerline axis extending in a drilling direction; a bore extending in a direction of the centerline axis and having a bore bottom; and a recess extending in a direction transverse to the centerline axis and eccentrically with respect thereto. A centering drill is adapted to move in the drilling direction and has a centering drill end, a centering drill shank and a chucking portion having a flattened clearance on one side thereof, the centering drill shank having an end side cylinder section for limiting an axial path of the centering drill during its movement in the drilling direction, the centering drill extending in the bore of the drilling body and the bore bottom being effective as an exclusive stop for the centering drill end when the centering drill is being subjected to percussion stress.

Abstract: The present invention provides human interleukin-8 (IL-8) analogs that are modified in the Glu4 Leu5 Arg6 region, and have a core structure corresponding to the IL-8 (7-51) sequence are provided. These neutrophil binding analogs display altered IL-8 activities that can be exploited for therapeutic and other purposes. Such antagonists include those in which, for example, the Leu5 and/or Arg6 residues are replaced, and in which the Glu4 and/or Leu5 residues are deleted. Also provided are biologically active human interleukin-8 (IL-8) analogs comprising a core sequence that includes IL-8 (1-51), IL-8 (3-51) or IL-8 (4-51). The invention also provides pharmaceutical compositions containing the aforementioned analogs.

Abstract: A rock drill for hammer drilling machines is proposed, which has a helical shank and a drill head which is connected thereto and on whose end face are arranged a main cutting tip inclined in the shape of a roof and also auxiliary cutting tips disposed transversely thereto. The drill head has two laterally opposite flats for the formation of drilling dust grooves. In plan view the drill head has a very largely rectangular shape in cross section, an acute angle .beta..sub.1 being enclosed between the main cutting tip and the trailing auxiliary cutting tips.

Abstract: A drilling tool and, in particular, a rock drill for the creation of breaches in concrete or masonry for the use of drill hammers is proposed, which is configured as a cross drill bit having four cutting fins. In order to optimize drilling capacity, the drilling tool is provided with a cross drilling head which merges in one piece into a conveyor spiral matched to the drill head. A purpose-specific cutting element facing serves to optimize the drilling capacity.

Abstract: A drilling tool which is suitable especially for clearing drill dust from a drillhole in rock-drilling work is provided. For this purpose, the spiral shank has brush elements (6, 17) which are arranged in the groove bottom of a conventional drilling tool or which themselves form spiral feed coils.

Abstract: A drilling tool, in particular for use in axially striking drive machines for drilling in rock, concrete or the like, which drilling tool is designed from both a vibration point of view by varying the abrupt changes in cross-section and from a drilling point of view by optimising the transport of the drilling dust. In order to arrange, from a vibration point of view, the abrupt changes in cross section, caused by the flute webs, in asymmetrically arranged axial positions, the inclination of the conveying flute constantly changes its size within a lead. Furthermore, the radial, tangential and axial force vector which acts on the drilling dust constantly changes its size, the radial force vector also changing its direction. In this way, the drilling dust is subjected to a constantly changing acceleration.

Abstract: A rock drill having a drilling head which, in an asymmetric arrangement relative to the main cutting tip, has at least one additional secondary cutting tip, the angle enclosed between the single cutting edge of the main cutting tip and the secondary cutting tip being formed as an acute angle.

Abstract: A drilling tool is proposed which is preferably suitable for making apertures in concrete work or masonry is fissured rock. To avoid damaging an interchangeable conveying helix (4), the connection between the conveying helix (4) and drilling head (3) is made as a frictional-resistance connection (FIG. 2).

Abstract: A rock drill for rotary and/or percussive stress, in particular for use in percussion or hammer drilling machines, is proposed, which by its geometrical design makes improved efficiency and simplified production possible. For this purpose, the feed spiral 5 is designed alternately with horizontal feed sections 8,8' with a 0.degree. pitch, and adjoining lead sections 9,9', the respective feed sections assuming an angle of rotation of 90.degree. on the drilling tool.

Abstract: A rock drill haivng a drill head with cruciform cutting tips is proposed which has improved chiselling properties in the case of percussive loading in hard rock or the like. For this purpose, the main cutting tip (4) is of a design know per se with secondary cutting tips (7,8) which are arranged transverse thereto and have a roof-shaped cross-section in side elevation. Additional, radially further outward bit points (16) for working the material result from the roof-shaped cross-section of the secondary cutting timps (7,8,) (cf. drawing).

Abstract: A rock drill is provided in which an optimum support of the carbide cutting tip or of a cross cutting edge is achieved by the drill head being made square or rectangular in cross-section. This results in an optimum strengthening of the cross-section against fracture in the slot root for the cutting tips. Moreover, catching of the drill in fissured rock and under extreme loads such as in reinforcement drill holes is avoided.

Abstract: A rock drill for rotary and percussive stressing exhibits equally good or improved transport characteristics of driling dust for a smaller transport groove as compared with prior rock drills. In order to achieve this, a main transport groove having longitudinal profiles is formed, with an interrupted secondary transport groove integrated in the main transport groove, the transport ribs of which exhibit a greater angle of twist than the angle of twist of the main transport groove.