Abstract: The present invention provides processes for preparation of substituted pyrazole compounds of formula II, that can be used as intermediates for preparation of substituted piperidine urea compounds useful for the treatment of dilated cardiomyopathy (DCM). R2 is independently selected from F, C1-C4 alkyl, C1-C4 haloalkyl, R3 is independently selected from H, F, C1-C4 alkyl, C1-C4 haloalkyl, R4 is C1-C4 alkyl, R6 is H or a protecting group and R7 is selected from H, CI or trialkylsilyl.

Abstract: Methods, systems, and computer program products for selection of a witness during virtualization system recovery after a disaster event. A recovery plan is configured to identify a witness that is then used to elect a leader to implement the recovery. Various system, and/or network, and/or component failures and/or various loss of function of components of the virtualization system can trigger initiation of the recovery plan. Based on the particular recovery plan that is invoked upon a determination of a network outage, or component failure or loss of function of a component of the virtualization system, a particular witness corresponding to a subset of entities of the particular recovery plan is selected. The witness is used to elect the leader, and the leader initiates actions of the recovery plan. The implementation of the recovery plan includes consideration of the health of components that would potentially be involved in the recovery actions.

Abstract: Methods, systems and computer program products for data protection across computing infrastructure comprising a plurality of geographically distant computing clusters. The geographically distant computing clusters form a distributed system comprising clusters that are assigned into availability zones. Disaster recovery policies are maintained in each of the availability zones. A first cluster detects a modification of a disaster recovery policy. The modification of the disaster recovery policy that occurred at the first cluster is to be communicated over a wide area network. Synchronization of the disaster recovery policy is accomplished by carrying out a peer-to-peer communication protocol over the wide area network.

Abstract: Embodiments of methods and apparatuses for forming the metal oxide nanostructure on surfaces are disclosed. In certain embodiments, the nanostructures can be formed on a substrate made of a nickel titanium alloy, resulting in a nanostructure that can include both titanium oxide and nickel oxide. The nanostructure can be formed on the surface(s) of an implantable medical device, such as a stent.

Abstract: Methods and system for directing traffic flows to a fast data path or a slow data path are disclosed. Parsers can produce packet header vectors (PHVs) for use in match-action units. The PHVs are also used to generate feature vectors for the traffic flows. A flow training engine produces a classification model. Feature vectors input to the classification model result in output predictions predicting if a traffic flow will be long lived or short lived. The classification models are used by network appliances to install traffic flows into fast data paths or the slow data paths based on the predictions.

Abstract: The invention provides for a method of producing a modified alumina for use in a coating composition, the method being characterised by hydrothermally treating an alumina suspension under specific conditions before and/or after adding an organic modifier. The invention further provides for a modified alumina made according to the method of the invention and to uses of the modified alumina in coating applications including anti-corrosive compositions and adhesive coatings.

Abstract: The disclosed systems emulate high-frequency application-consistent snapshots by forming restore point data sets based on remote site replay of I/O commands. A method embodiment commences upon identifying a primary computing site and a secondary computing site, then identifying an application to be restored from the secondary computing site after a disaster. Prior to the disaster, a group of computing entities of the application to be restored from the secondary computing site are identified. Input/output operations that are performed over any of the computing entities at the primary site are streamed to the secondary site where they are stored. An I/O map that associates a time with an indication of a last received I/O command that had been performed over a changing set of computing entities is sent to the secondary site. An agent at the secondary site accesses the I/O map and the streamed-over I/Os to construct recovery data.

Abstract: Reinforcement learning enables a framework of information technology assets that include software elements, computational hardware assets, and/or, bundled software and computational hardware systems and products. The performance of successive sessions of an inner loop reinforcement learning is directed and monitored by an outer loop reinforcement learning wherein the outer loop reinforcement learning is designed to reduce financial costs and computational asset requirements and/or optimize learning time in successive instantiations of inner loop reinforcement learning training sessions. The framework enables consideration of the license costs of domain specific simulators, the usage cost of hardware platforms, and the progress of a particular reinforcement learning training. The framework further enables reductions of these costs to orchestrate and train a neural network under budget constraints with respect to the available hardware and software licenses available at runtime.

Abstract: Methods, systems, and computer program products for moving a container-based application from a source HCI cluster to a target HCI cluster. An HCI storage cluster data replication mechanism operates to copy data and metadata from a plurality of storage devices that constitute a storage pool of the source HCI cluster. A container-based application replication mechanism operates to copy data and metadata from an executable container that is running on a node of the source HCI cluster. Periodically (1) the state of the container-based application is saved using the container-based application replication mechanism, and (2) the state of the storage cluster data of the HCI storage cluster is saved using the HCI storage cluster data replication mechanism. The saved state of the container-based application including its application data and metadata are combined with the saved state of the storage cluster data to bring-up the container-based application at the target HCI cluster.

Abstract: Embodiments herein describe using software or firmware to manage the device capability list of a PCIe device. That is, rather than relying on pure hardware to advertise the capabilities of a PCIe device, the embodiments herein permit software or firmware executing on a processor in the PCIe device to manage read and write requests associated with discovering the capabilities of the device and configuring the device.

Abstract: A method of protecting an in-vivo sensor includes forming a sensing surface on a surface of the in-vivo sensor, the sensing surface including a functionalized monolayer that will bind to an analyte of interest; and coating the sensing surface of the sensor with a bioabsorbable polymeric coating including a bioabsorbable polymer; wherein the bioabsorbable polymeric coating is configured to protect the in-vivo sensor until needed for implantation.

Abstract: Described herein are systems and methods for generating an embedding—a learned representation—for an image. The embedding for the image is derived to capture visual aspects, as well as textual aspects, of the image. An encoder-decoder is trained to generate the visual representation of the image. An optical character recognition (OCR) algorithm is used to identify text/words in the image. From these words, an embedding is derived by performing an average pooling operation on pre-trained embeddings that map to the identified words. Finally, the embedding representing the visual aspects of the image is combined with the embedding representing the textual aspects of the image to generate a final embedding for the image.

Abstract: Methods, systems, and computer program products for selection of a witness during virtualization system recovery after a disaster event. A recovery plan is configured to identify a witness that is then used to elect a leader to implement the recovery. Various system, and/or network, and/or component failures and/or various loss of function of components of the virtualization system can trigger initiation of the recovery plan. Based on the particular recovery plan that is invoked upon a determination of a network outage, or component failure or loss of function of a component of the virtualization system, a particular witness corresponding to a subset of entities of the particular recovery plan is selected. The witness is used to elect the leader, and the leader initiates actions of the recovery plan. The implementation of the recovery plan includes consideration of the health of components that would potentially be involved in the recovery actions.

Abstract: Embodiments herein describe using software or firmware to manage the device capability list of a PCIe device. That is, rather than relying on pure hardware to advertise the capabilities of a PCIe device, the embodiments herein permit software or firmware executing on a processor in the PCIe device to manage read and write requests associated with discovering the capabilities of the device and configuring the device.

Abstract: Embodiments of methods and apparatuses for forming the metal oxide nanostructure on surfaces are disclosed. In certain embodiments, the nanostructures can be formed on a substrate made of a nickel titanium alloy, resulting in a nanostructure that can include both titanium oxide and nickel oxide. The nanostructure can be formed on the surface(s) of an implantable medical device, such as a stent.

Abstract: Described herein are techniques for using supervised machine learning to determine whether an image that has been posted to a feed of an online service includes a quotation. In some instance, supervised machine learning techniques are used to infer or predict an intent of a content poster in posting a content item to a feed of an online service. By better understanding the nature of the content being posted, various recommendations can be made during the time when an end-user is posting content, and thereafter.

Abstract: A network appliance or smart switch can include service devices as well as a switching device such as those used in high-speed switches having limited processing ability and are stateless with respect to sessions. Service devices can provide stateful and complex processing. A first exposed port of a switching device can receive network packets and can determine which network packets the service devices are to process to produce processed network packets. A network packet can be sent to a service device in a redirected packet. A processed network packet can be received from a service device in a reinjected packet that is used to recover a port identifier of the first exposed port. The port identifier can be used to determine a network destination of the processed network packet. The processed network packet can be sent from a second exposed port of the switching device toward the network destination.

Abstract: Task scheduling in a computing device may be based in part on voltage regulator efficiency. For an additional task to be scheduled, multiple task scheduling cases may be determined that represent execution of the additional task on each of a number of processors concurrently with one or more other tasks executing among the processors. For each task scheduling case, a regulator input power level for a voltage regulator may be determined based on a performance level indication associated with the additional task, the one or more other tasks executing on the processors, and the efficiency level of each voltage regulator. For each task scheduling case, a total regulator input power level may be determined by summing the regulator input power levels for all voltage regulators. The additional task may be executed on a processor associated with a task scheduling case for which total regulator input power is lowest.

Abstract: Embodiments of nanostructures comprising metal oxide and methods for forming the nanostructure on surfaces are disclosed. In certain embodiments, the nanostructures can be formed on a substrate made of a nickel titanium alloy, resulting in a nanostructure containing both titanium oxide and nickel oxide. The nanostructure can include a lattice layer disposed on top of a nanotube layer. The distal surface of the lattice layer can have a titanium oxide to nickel oxide ratio of greater than 10:1, or about 17:1, resulting in a nanostructure that promotes human endothelial cell migration and proliferation at the interface between the lattice layer and human cells or tissue. The nanostructure may be formed on the outer surface of an implantable medical device, such a stent or an orthopedic implant (e.g. knee implant, bone screw, or bone staple).

Abstract: Various embodiments include methods and devices for system on chip infrastructure of system on chip infrastructure secure memory access and power management. Some embodiments, include determining whether a processor is performing a secure memory access transaction, and gating a clock signal from being transmitted to a secure portion of a memory in response to determining that the processor is not performing a secure memory access transaction. Some embodiments include determining whether any processor is operating in a secure mode, and transmitting a retention signal to the secure portion of the memory in response to determining that no processor is operating in a secure mode. The retention signal may be configured to set a retention state for the secure portion of the memory.