Patents by Inventor Biao He

Biao He has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for treating cancer using anti-Wnt2 monoclonal antibodies and siRNA
    Patent number: 7959923
    Abstract: This invention relates to methods of inhibiting the growth of cells, in particular cancer cells, that overexpress Wnt2. The methods comprise contacting the cell with an agent that binds to Wnt2 mRNA or Wnt2 protein, interferes with Wnt2 signaling or inhibits binding of the Wnt2 protein to another protein, such as a Frizzled receptor.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: June 14, 2011
    Assignee: The Regents of the University of California
    Inventors: Liang You, Biao He, Zhidong Xu, David M. Jablons
  • SOCS-3 PROMOTER METHYLATION IN CANCER
    Publication number: 20100292162
    Abstract: This invention provides compositions and methods for the diagnosis and treatment of cancers that exhibit decreased SOCS-3 expression.
    Type: Application
    Filed: February 5, 2010
    Publication date: November 18, 2010
    Applicant: Regents of the University of California
    Inventors: Biao HE, Liang YOU, Zhidong XU, David M. JABLONS
  • EMX2 IN CANCER DIAGNOSIS AND PROGNOSIS
    Publication number: 20100233703
    Abstract: The present invention provides methods for determining a prognosis of disease free or overall survival in a patient suffering from cancer. The methods generally involve determining a normalized expression level of an EMX2 gene product, which correlates with prognosis and likelihood of survival.
    Type: Application
    Filed: February 5, 2010
    Publication date: September 16, 2010
    Applicant: The Regents of the University of California
    Inventors: Biao He, David M. Jablons
  • Targeting GLI proteins in human cancer by small molecules
    Patent number: 7714014
    Abstract: This invention provides compositions, methods and kits for the diagnosis and treatment of cancers expressing a GLI polypeptide, and in particular a GLI1, GLI2 or GLI3 polypeptide. The invention provides small molecule compounds mimicking the transcriptional activation domain of a GLI polypeptide. The small molecule inhibitors of the invention specifically block the activator function of a GLI polypeptide, but not the repressor function of GLI3.
    Type: Grant
    Filed: December 7, 2006
    Date of Patent: May 11, 2010
    Assignee: The Regents of the University of California
    Inventors: Biao He, Naoaki Fujii, Liang You, Zhidong Xu, David M. Jablons
  • METHODS FOR TREATING CANCER BY INHIBITING WNT SIGNALING
    Publication number: 20090304695
    Abstract: This invention relates to methods of inhibiting the growth of cancer cells that overexpress a Wnt protein. The methods comprise contacting the cell with an agent that inhibits binding of the Wnt protein to a Frizzled receptor.
    Type: Application
    Filed: January 30, 2009
    Publication date: December 10, 2009
    Applicant: REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Biao He, Liang You, Zhidong Xu, David M. Jablons
  • Methods for treating and diagnosing cancer with WNT inhibitory Factor-1 (WIF-1)
    Patent number: 7618936
    Abstract: This invention provides compositions, methods and kits for the diagnosis and treatment of cancers wherein Wnt Inhibitory Factor-1 (WIF-1) is underexpressed.
    Type: Grant
    Filed: May 23, 2005
    Date of Patent: November 17, 2009
    Assignee: The Regents of the University of California
    Inventors: Liang You, Biao He, Zhidong Xu, David M. Jablons
  • Small molecule inhibition of a PDZ-domain interaction
    Patent number: 7601750
    Abstract: Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and interactions between the PDZ domain in the Dishevelled (Dvl) protein and other proteins such as the Frizzled (Fz) protein, have the general formula The invention also includes combinatorial libraries, arrays and methods for screening and studying proteins using such compounds. Compounds of the invention have produced apoptosis in certain cell lines that overexpress the Dishevelled protein (Dvl); inhibiting Wnt signaling.
    Type: Grant
    Filed: October 11, 2006
    Date of Patent: October 13, 2009
    Assignee: The Regents of the University of California
    Inventors: R. Kiplin Guy, Irwin D. Kuntz, Jose Haresco, Naoaki Fujii, Kathleen P. Novak, David Stokoe, Biao He, Liang You, Zhidong Xu, David M. Jablons
  • METHOD FOR TREATING CANCER USING ANTI-WNT2 MONOCLONAL ANTIBODIES AND siRNA
    Publication number: 20090202539
    Abstract: This invention relates to methods of inhibiting the growth of cells, in particular cancer cells, that overexpress Wnt2. The methods comprise contacting the cell with an agent that binds to Wnt2 mRNA or Wnt2 protein, interferes with Wnt2 signaling or inhibits binding of the Wnt2 protein to another protein, such as a Frizzled receptor.
    Type: Application
    Filed: January 30, 2009
    Publication date: August 13, 2009
    Applicant: REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Liang You, Biao He, Zhidong Xu, David M. Jablons
  • KIT FOR DIAGNOSIS OF CANCER
    Publication number: 20090203056
    Abstract: The present invention relates to a kit for assaying the activity of the human arylsulphatase or its isozymes, including 4-MUS and 4-MU. The kit can be used for initial screening, therapeutic effect monitoring and recurrence inspecting of human cancers.
    Type: Application
    Filed: February 11, 2008
    Publication date: August 13, 2009
    Applicant: BEIJING ACCB BIOTECH LTD.
    Inventors: Junpu XU, Biao HE
  • Methods for Treating Cancer Using Agents That Inhibit Wnt16 Signaling
    Publication number: 20080267951
    Abstract: This invention relates to methods of inhibiting the growth of cells, in particular cancer cells that over express Wnt16 protein. The methods comprise contacting the cell with an agent that binds to Wnt16 mRNA or Wnt16 protein, interferes with Wnt16 signaling or inhibits binding of the Wnt16 protein to another protein, such as a Frizzled receptor.
    Type: Application
    Filed: July 11, 2005
    Publication date: October 30, 2008
    Applicant: The Regets of the University of Califoria Office of Technology Management, UCSF
    Inventors: Liang You, Biao He, Zhidong Xu, David M. Jablons
  • Small molecule inhibition of a PDZ-domain interaction
    Publication number: 20080021082
    Abstract: Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and interactions between the PDZ domain in the Dishevelled (Dvl) protein and other proteins such as the Frizzled (Fz) protein, have the general formula The invention also includes combinatorial libraries, arrays and methods for screening and studying proteins using such compounds. Compounds of the invention have produced apoptosis in certain cell lines that overexpress the Dishevelled protein (Dvl); inhibiting Wnt signaling.
    Type: Application
    Filed: October 11, 2006
    Publication date: January 24, 2008
    Applicant: The Regents of the University of California
    Inventors: R. Guy, Irwin Kuntz, Jose Haresco, Naoaki Fujii, Kathleen Novak, David Stokoe, Biao He, Liang You, Zhidong Xu, David Jablons
  • TARGETING GLI PROTEINS IN HUMAN CANCER BY SMALL MOLECULES
    Publication number: 20070149592
    Abstract: This invention provides compositions, methods and kits for the diagnosis and treatment of cancers expressing a GLI polypeptide, and in particular a GLI1, GLI2 or GLI3 polypeptide. The invention provides small molecule compounds mimicking the transcriptional activation domain of a GLI polypeptide. The small molecule inhibitors of the invention specifically block the activator function of a GLI polypeptide, but not the repressor function of GLI3.
    Type: Application
    Filed: December 7, 2006
    Publication date: June 28, 2007
    Applicant: REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Biao He, Naoaki Fujii, Liang You, Zhidong Xu, David Jablons
  • Socs-3 promoter methylation in cancer
    Publication number: 20070037157
    Abstract: This invention provides compositions and methods for the diagnosis and treatment of cancers that exhibit decreased SOCS-3 expression.
    Type: Application
    Filed: September 3, 2004
    Publication date: February 15, 2007
    Applicant: The Regents of the University of California
    Inventors: Biao He, Liang You, Zhidong Xu, David Jablons
  • Small molecule inhibition of a PDZ-domain interaction
    Patent number: 7141600
    Abstract: Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and interactions between the PDZ domain in the Dishevelled (Dvl) protein and other proteins such as the Frizzled (Fz) protein, have the general formula The invention also includes combinatorial libraries, arrays and methods for screening and studying proteins using such compounds. Compounds of the invention have produced apoptosis in certain cell lines that overexpress the Dishevelled protein (Dvl); inhibiting Wnt signaling.
    Type: Grant
    Filed: April 15, 2004
    Date of Patent: November 28, 2006
    Assignee: The Regents of the University of California
    Inventors: R. Kiplin Guy, Irwin D. Kuntz, Jose Haresco, Naoaki Fujii, Kathleen P. Novak, David Stokoe, Biao He, Liang You, Zhidong Xu, David M. Jablons
  • Methods for treating cancer using anti-Wnt2 monoclonal antibodies and siRNA
    Publication number: 20060040883
    Abstract: This invention relates to methods of inhibiting the growth of cells, in particular cancer cells, that overexpress Wnt2. The methods comprise contacting the cell with an agent that binds to Wnt2 mRNA or Wnt2 protein, interferes with Wnt2 signaling or inhibits binding of the Wnt2 protein to another protein, such as a Frizzled receptor.
    Type: Application
    Filed: May 16, 2005
    Publication date: February 23, 2006
    Applicant: The Regents of the University of California
    Inventors: Liang You, Biao He, Zhidong Xu, David Jablons
  • Methods for treating and diagnosing cancer with WNT inhibitory Factor-1 (WIF-1)
    Publication number: 20050288226
    Abstract: This invention provides compositions, methods and kits for the diagnosis and treatment of cancers wherein Wnt Inhibitory Factor-1 (WIF-1) is underexpressed.
    Type: Application
    Filed: May 23, 2005
    Publication date: December 29, 2005
    Applicant: REGENTS OF THE UNIVERSITY OF California; Office of Technology Transfer
    Inventors: Liang You, Biao He, Zhidong Xu, David Jablons
  • Small molecule inhibition of a PDZ-domain interaction
    Publication number: 20050043385
    Abstract: Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and interactions between the PDZ domain in the Dishevelled (Dvl) protein and other proteins such as the Frizzled (Fz) protein, have the general formula The invention also includes combinatorial libraries, arrays and methods for screening and studying proteins using such compounds. Compounds of the invention have produced apoptosis in certain cell lines that overexpress the Dishevelled protein (Dvl); inhibiting Wnt signaling.
    Type: Application
    Filed: April 15, 2004
    Publication date: February 24, 2005
    Applicant: The Regents of the University of California
    Inventors: R. Guy, Irwin Kuntz, Jose Haresco, Naoaki Fujii, Kathleen Novak, David Stokoe, Biao He, Liang You, Zhidong Xu, David Jablons
  • Methods for treating cancer by inhibiting Wnt signaling
    Publication number: 20040247593
    Abstract: This invention relates to methods of inhibiting the growth of cancer cells that overexpress a Wnt protein. The methods comprise contacting the cell with an agent that inhibits binding of the Wnt protein to a Frizzled receptor.
    Type: Application
    Filed: October 3, 2003
    Publication date: December 9, 2004
    Applicant: REGENTS OF THE UNIVERSITY OF CALIFORNIA,
    Inventors: Biao He, Liang You, Zhidong Xu, David M. Jablons
  • Methods of amplifying sense strand RNA
    Publication number: 20030104432
    Abstract: The present invention provides efficient and novel methods for synthesizing and amplifying sense-strand RNA. The methods of the invention include methods of synthesizing probes useful for probing oligo and cDNA microarrays and for the development of subtractive and normalized expression libraries.
    Type: Application
    Filed: July 26, 2002
    Publication date: June 5, 2003
    Applicant: The Regents of the University of California
    Inventors: Zhidong Xu, David Jablons, Liang You, Biao He