Abstract: Provided are compounds of Formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R7, R8, R9, A1, A2, Q1, Q2, Q3, A, Z, m and n are as defined herein; pharmaceutical compositions comprising said compounds or pharmaceutically acceptable salts thereof, and pharmaceutically acceptable excipients; and methods of treating a disorder responsive to inhibition of Bruton's tyrosine kinase using said compounds, or pharmaceutically acceptable salts thereof, or said pharmaceutical compositions.

Abstract: An IV device assembly may include a lumen forming a fluidic channel within the IV device assembly. The lumen may be fluidically coupled to a vascular access device (VAD) coupler via a funnel coupler, and an IV device assembly coupler at a proximal end of the lumen. The IV device assembly may also include one or more of the following: a collapsible sleeve formed coaxially around a first portion of the lumen and mechanically coupled to the funnel coupler, a patency instrument formed along a second portion of the lumen within the collapsible sleeve and into the VAD coupler, a translation handle that translates the patency instrument out of a distal end of the VAD coupler, and a fixed grip formed around the lumen to maintain a position of the IV device assembly relative to the translation handle.

Abstract: The present disclosure discloses a composite crossarm and a power transmission tower. The composite crossarm includes a post insulator and three suspension insulators. The post insulator and the suspension insulators each has an end configured to be connected to a tower body of the power transmission tower, and another end connected together to form an end of the composite crossarm that is configured to attach a transmission line. The three suspension insulators are arranged at intervals around the post insulator. Axes of two suspension insulators and an axis of the post insulator are in the same plane. The two suspension insulators whose axes are in the same plane as the axis of the post insulator are defined as first suspension insulators, the remaining suspension insulator is defined as a second suspension insulator. The two first suspension insulators form an angle ranged from 45° to 90°.

Abstract: A composition is disclosed that includes a first compound capable of functioning as a host in an emissive layer of an OLED at room temperature; and a second compound that includes a ligand LA of Formula III where ring A is a 5-membered or 6-membered carbocyclic or heterocyclic ring; where R represents two adjacent substituents that are joined together to form a ring that is fused to ring B, and R has a structure of Formula IV or Formula V disclosed herein.

Abstract: A rapid preparation method of transition metal borides includes steps of: using a tungsten rod as the cathode, and a block mixture of boron powder and metal oxide as the anode, the block mixture and the tungsten rod are placed in an plasma device; the plasma device is evacuated, and then filled with a buffer gas and an electric arc is started to obtain a transition metal boride. The present disclosure adopts the direct current arc plasma method with the advantages of simple operation, low cost, environmental friendliness and controllable reaction atmosphere to prepare the transition metal boride, the preparation process is simple, the preparation process is fast, and the environment will not be affected.

Abstract: The present invention provides a 3D printing method for a complex curved hollow structure. The 3D printing method comprises the following steps: firstly, manufacturing a bottom die attached with the complex curved hollow structure, and molding the complex curved hollow structure on a molding surface C of the bottom die by taking the bottom die as a support, wherein the molding of the bottom die and the molding of the complex curved hollow structure are completed in the same world coordinate system, and the bottom die does not need to be taken down from an objective table and then transplanted into a printing system of a to-be-molded part. The 3D printing method has the advantage that a high-precision complex curved hollow structure can be manufactured.

Abstract: A compound comprising a ligand LA, having a structure of Formula I, is provided. In Formula I, A1 to A8 are each independently CR or N; at least two adjacent ones of A1 to A8 are CR and the Rs are joined together to form a six-membered ring fused to ring A or ring C; X is O, S, or Se; each R and RB is independently hydrogen or a substituent; any adjacent substituents are optionally joined or fused into a ring; the ligand LA is coordinated to a metal M; the metal M is bonded to ring A through a M-C bond; the metal M can be coordinated to other ligands; and the ligand LA is optionally linked with other ligands. Formulations, OLEDs, and consumer products containing such compounds are also disclosed.

Abstract: A rapid preparation method of transition metal borides includes steps of: using a tungsten rod as the cathode, and a block mixture of boron powder and metal oxide as the anode, the block mixture and the tungsten rod are placed in an plasma device; the plasma device is evacuated, and then filled with a buffer gas and an electric arc is started to obtain a transition metal boride. The present disclosure adopts the direct current arc plasma method with the advantages of simple operation, low cost, environmental friendliness and controllable reaction atmosphere to prepare the transition metal boride, the preparation process is simple, the preparation process is fast, and the environment will not be affected.

Abstract: A display device, and a display panel and a manufacturing method therefor, relating to the technical field of display. The display panel includes a substrate, a driver layer, a barrier structure, and a light-emitting layer covering the driver layer and the barrier structure and being discontinuously at least at a barrier groove of the barrier structure. The barrier structure includes a support layer, a barrier layer and a second protective layer. The barrier layer is in a different area of a same film layer than a wiring layer of the driver layer, and a side wall of the barrier layer is provided with the barrier groove surrounding the driver layer. The second protective layer is on a surface of the barrier layer away from the substrate and in a different area of a same protective film than a first protective layer of the driver layer.

Abstract: Disclosed is a double-layer oil film lubrication analysis method and system based on a floating bushing. The method includes: determining a roller motion track and a floating bushing motion track according to a roller displacement and a floating bushing displacement; determining, when the motion tracks are closed end to end, minimum values of inner-layer and outer-layer oil film thickness of the floating bushing according to an oil film thickness at each moment; and determining that an abnormality exists in double-layer oil film lubrication when either of the minimum values of the inner-layer and outer-layer oil film thickness of the floating bushing is less than a preset oil film thickness threshold value. According to the present disclosure, more accurate abnormality analysis of double-layer oil film lubrication can be realized.

Abstract: A system for multi-factor user authentication for payment card-based transactions are described. The multifactor authentication may be based on a one-time passcode/password (OTP) as sent by an authentication server. A user device may, based on receiving the OTP, send an authentication code. The authentication code may be generated/determined based on the OTP. The authentication code may be augmented biometric identifier (ID) of a user associated with the user device. The authentication server may validate a transaction based on the authentication code.

Abstract: A method for manufacturing a display substrate is provided. The method includes: forming a first active layer arranged in the NMOS transistor region and a second active layer arranged in the PMOS transistor region on the base substrate; coating one side, facing away from the base substrate, of the first active layer and one side, facing away from the base substrate, of the second active layer with a first photoresist layer, forming a first pattern layer by patterning the first photoresist layer to expose at least two ends of the first active layer; forming N-type heavily doped regions by performing N-type heavy doping on the two ends of the first active layer with the first pattern layer as a mask; forming a second pattern layer by processing the first pattern layer to expose at least a middle region of the first active layer.

Abstract: The invention provided herein relates to methods and uses of a bispecific antibody, which specifically binds the surface antigen CD3 of immune cells and the BCMA antigen on the surface of tumor cells and which may bind to human CD3 with high affinity, induce T cell proliferation, and mediate tumor cell killing effects. The bispecific antibody may be used to mediate the T cell-specific killing of target cells in in vitro tests.

Abstract: A compound useful as a host material in an OLED is provided. The compound includes at least one chemical group selected from the group consisting of triphenylene, carbazole, indolocarbazole, dibenzothiphene, dibenzofuran, dibenzoselenophene, aza-triphenylene, azacarbazole, aza-indolocarbazole, aza-dibenzothiophene, aza-dibenzofuran, and aza-dibenzoselenophene; wherein the compound is substituted by at least one R selected from the group consisting of alkyl, cycloalkyl, spiroalkyl, partially or fully deuterated variants thereof, partially or fully fluorinated variants thereof, and combination thereof.

Abstract: Provided is a method for introducing a point mutation to a BBD29_04920 gene coding sequence in Corynebacterium or improving the expression thereof. The point mutation causes a mutation to the base at position 1560 in the BBD29_04920 gene sequence from cytosine (C) to adenine (A) such that asparagine at position 520 of a coded corresponding amino acid sequence is substituted by lysine. The method can increase fermentation yield of glutamic acid in a strain with the mutation. Also provided are the bacterium generating L-glutamic acid, a nucleic acid and protein comprising the mutation, a recombinant vector and recombinant strain comprising the nucleic acid, and use of these biomaterials in the regulation of the production of L-glutamic acid of a microorganism.

Abstract: The present invention discloses a refrigerator, comprising a compressor compartment disposed in its lower rear portion thereof, wherein the back plate of the compressor compartment has a first air port and a second air port, and the bottom plate is provided with a third air port. The refrigerator further comprises a baffle movably disposed at the first air port to open or close the first air port. The baffle may prevent the hot air discharged from the compressor compartment from blending with cold air and re-entering the compressor compartment after the refrigerator is embedded in the cupboard.

Abstract: The present disclosure discloses a substation frame comprising: a supporting assembly comprising at least two supporting posts arranged at intervals, the at least two supporting posts comprising one side supporting post at each end; a beam assembly comprising a beam provided between every two adjacent supporting posts; and a side wire attaching assembly provided on at least one side supporting post and positioned on a side of the side supporting post facing away from the beam.

Abstract: The present application relates to methods for determining antibody heavy and light chain pairing in an antibody and/or antibody fragment mixture. The methods include a step of submitting the mixture to a separation step under non-reducing condition to obtain isolated antibodies or antibody fragments, or of contacting the mixture with a protein cross-linking agent. The isolated or cross-linked antibodies and/or antibody fragments are then digested using one or more proteases to generate antibody or antibody fragment peptides, which are then analyzed for example by mass spectrometry (MS) to determining heavy chain and light chain pairing of the antibody or antibody fragment in the mixture.

Abstract: A fan, comprising blades (102), an upper hub (111), and a lower hub (112). Each blade (102) comprises a connecting part (211). The connecting part (211) is clamped between a lower surface of the upper hub (111) and an upper surface of the lower hub (112). The lower surface of the upper hub (111) is provided with an upper hub connecting area, and the upper surface of the lower hub (112) is provided with a lower hub connecting area. An upper surface and a lower surface of the connecting part (211) are separately provided with a junction surface extending from the connecting part (211). The lower surface of the upper hub (111) and the upper surface of the lower hub (112) are separately provided with a matching surface matching the junction surface.

Abstract: An automation system includes a controller, an AGV (Automated Guided Vehicle), and a carrier component. The controller generates a control signal, so as to perform a moving process. The AGV receives the control signal. The AGV moves the carrier component from a first location to a second location according to the control signal.