Abstract: The present invention relates to a degradable vascular stent capable of avoiding late restenosis, comprising a base region formed by a polylactic acid based polymer; at least one storage region in which an active agent is stored; and an outer layer of a drug sustained release coating covered on the base region and/or the storage region. Before the mass of the polylactic acid based polymer is decreased by 10-20%, the active agent is retained in structural units of the polylactic acid based polymer. After the mass of the polylactic acid based polymer is decreased by 10-20%, the active agent is released from the storage region. The base region provides a supporting capacity for ensuring patency of blood vessels; the drug sustained release coating is used for drug release in an early stage; and the active agent only works in late degradation of the stent to avoid late restenosis.

Abstract: The present invention relates to a novel insulin derivative, a pharmaceutical formulation thereof, a pharmaceutical composition thereof with a long-acting GLP-1 compound and medical use of the insulin derivative, the pharmaceutical formulation and the pharmaceutical composition. The novel acylated insulin has surprisingly and significantly increased drug effect, longer duration of action, longer in vivo half-life, good bioavailability and more satisfactory physical stability and chemical stability compared with insulin degludec or other insulin derivatives.

Abstract: The present disclosure provides use of an effective part extract of Monochasma savatieri in preparation of a drug for treating an inflammatory disease or a tumor. In the present disclosure, an effective part of Monochasma savatieri is separated and purified by various separation and purification methods (including solvent extraction, macroporous resin column chromatography, MCI column separation, and Sephadex LH-20 gel column separation) separately, to obtain the effective part extract of Monochasma savatieri. The effective part extract of Monochasma savatieri is capable of significantly inhibiting secretion of TNF-?, and significantly inhibiting proliferation of breast cancer cells and lung cancer cells, thereby effectively treating the inflammatory disease or the tumor. The present disclosure provides a favorable theoretical basis for finding a drug that can effectively treat the inflammatory disease or the tumor from the Monochasma savatieri, which is of great significance to development of novel drugs.

Abstract: A two-dimensional metal-organic framework (2D MOF) includes a first transition metal M1 and a second transition metal M2. The first transition metal and the second transition metal are different and are coupled by a linker group L to yield a two-dimensional metal-organic framework alloy having a formula M1xM21-xL, where 0<x<1. Each transition metal is dispersed uniformly throughout the 2D MOF. The 2D MOF is synthesized by combining a first transition metal precursor, a second transition metal precursor, and a linker; agitating the solution; and heating the solution to yield a crystalline two-dimensional metal-organic framework alloy.

Abstract: The disclosure relates to a method for mechanochemical preparation of an iron red pigment, which comprise steps: mixing a clay mineral, a soluble iron source and an alkali source in a mill for grinding to obtain a precursor, wherein the ratio of ball to material is controlled at 20-50, the grinding speed is 300-1200 rpm, and the grinding time is 30-360 min; and calcining the precursor at 500-900° C. for 30-120 min to obtain a high-performance iron oxide red/clay mineral hybrid pigment. The iron oxide red/clay mineral hybrid pigment has a bright and beautiful color, high-temperature and acid resistance, and can satisfy requirements for high-performance iron oxide red pigments in fields of paints, inks, ceramics, anti-corrosive coatings, etc. Furthermore the method is a simple process without waste that is environmentally friendly and suitable for industrialized production, thus it is expected to replace existing processes of iron oxide red pigments.

Abstract: A two-dimensional metal-organic framework (2D MOF) includes a first transition metal M1 and a second transition metal M2. The first transition metal and the second transition metal are different and are coupled by a linker group L to yield a two-dimensional metal-organic framework alloy having a formula M1xM21-xL, where 0<x<1. Each transition metal is dispersed uniformly throughout the 2D MOF. The 2D MOF is synthesized by combining a first transition metal precursor, a second transition metal precursor, and a linker; agitating the solution; and heating the solution to yield a crystalline two-dimensional metal-organic framework alloy.

Abstract: Disclosed is a method for preparing an attapulgite-based pH-responsive antibacterial material, including: directly spraying a natural aldehyde-based antibacterial agent onto an attapulgite powder under stirring, and constantly stirring the attapulgite powder for 20-30 min; grinding the attapulgite powder in a ball mill for 30-60 min to obtain a ground attapulgite powder; placing the ground attapulgite powder in a stirred tank, and spraying a chitosan-citric acid aqueous solution onto the ground attapulgite powder; after spraying, constantly stirring the ground attapulgite powder for 30-120 min; and finally drying the ground attapulgite powder to obtain a dried attapulgite powder, sieving the dried attapulgite powder to obtain a sieved attapulgite powder, and packaging the sieved attapulgite powder to obtain the antibacterial material.

Abstract: A method for preparing a natural antibacterial agent by utilizing attapulgite pore channels to immobilize plant essential oil. Natural antibacterial agent plant essential oil is sprayed on the surface of attapulgite powder while stirring, after mechanically grinding the materials, a liquid glycerol monolaurate and quaternary ammonium salt aqueous solution are sequentially sprayed, after uniformly stirring and mixing the materials, a mixture is extruded by using an extruder, and drying, crushing and packaging are performed.

Abstract: Embodiments of the present disclosure relate generally devices for detecting analytes in a subject. More particularly, the present disclosure provides a biosensor array for detecting analytes in a subject. Embodiments of the present disclosure include a biosensor array comprising a plurality of sensor cells for detecting an analyte in a subject. In accordance with these embodiments, the plurality of sensor cells comprises at least one electrode, at least one antibody immobilized on a surface of the at least one electrode, and a biodegradable coating in contact with the at least one antibody.

Abstract: Disclosed is an acylated insulin, a pharmaceutical formulation thereof, a pharmaceutical composition thereof with a long-acting GLP-1 compound, and a medical use of the acylated insulin, the pharmaceutical formulation and the pharmaceutical composition. Compared with insulin degludec or other insulin derivatives, the acylated insulin has an unexpected, significantly increased drug effect, a longer duration of action, a longer in vivo half-life, an excellent bioavailability, as well as better physical and chemical stabilities.

Abstract: Disclosed is a method for preparing an attapulgite-based pH-responsive antibacterial material, including: directly spraying a natural aldehyde-based antibacterial agent onto an attapulgite powder under stirring, and constantly stirring the attapulgite powder for 20-30 min; grinding the attapulgite powder in a ball mill for 30-60 min to obtain a ground attapulgite powder; placing the ground attapulgite powder in a stirred tank, and spraying a chitosan-citric acid aqueous solution onto the ground attapulgite powder; after spraying, constantly stirring the ground attapulgite powder for 30-120 min; and finally drying the ground attapulgite powder to obtain a dried attapulgite powder, sieving the dried attapulgite powder to obtain a sieved attapulgite powder, and packaging the sieved attapulgite powder to obtain the antibacterial material.

Abstract: Embodiments of the present disclosure relate generally devices for detecting analytes in a subject. More particularly, the present disclosure provides a biosensor array for detecting analytes in a subject. Embodiments of the present disclosure include a biosensor array comprising a plurality of sensor cells for detecting an analyte in a subject. In accordance with these embodiments, the plurality of sensor cells comprises at least one electrode, at least one antibody immobilized on a surface of the at least one electrode, and a biodegradable coating in contact with the at least one antibody.

Abstract: Embodiments of the present disclosure relate generally devices for detecting analytes in a subject. More particularly, the present disclosure provides a biosensor array for detecting analytes in a subject. Embodiments of the present disclosure include a biosensor array comprising a plurality of sensor cells for detecting an analyte in a subject. In accordance with these embodiments, the plurality of sensor cells comprise at least one electrode, at least one antibody immobilized on a surface of the at least one electrode, and a biodegradable coating in contact with the at least one antibody.

Abstract: The present disclosure relates to a method for preparation of a high temperature-resistant bismuth yellow pigment. The method comprises: mixing an oxide which served as a matrix and dopan with a bismuth source, a vanadium source, or a molybdenum source, and then placing the mixture into a mill for grinding to obtain a precursor; further calcining and crushing the precursor to obtain the high temperature-resistant bismuth yellow pigment powder. The bismuth yellow pigment has a bright color, a b* value greater than 90, a stable performance, and a high heat-resistance above 800° C. The method is environmentally friendly without waste, and reaction conditions are simple. Doping of BiVO4 crystal lattices by incorporation of oxides can be achieved, so that the particle size and distribution of the bismuth yellow pigment can be effectively controlled while the color performance of the bismuth yellow pigment is greatly improved.

Abstract: The disclosure relates to a method for mechanochemical preparation of an iron red pigment, which comprise steps: mixing a clay mineral, a soluble iron source and an alkali source in a mill for grinding to obtain a precursor, wherein the ratio of ball to material is controlled at 20-50, the grinding speed is 300-1200 rpm, and the grinding time is 30-360 min; and calcining the precursor at 500-900° C. for 30-120 min to obtain a high-performance iron oxide red/clay mineral hybrid pigment. The iron oxide red/clay mineral hybrid pigment has a bright and beautiful color, high-temperature and acid resistance, and can satisfy requirements for high-performance iron oxide red pigments in fields of paints, inks, ceramics, anti-corrosive coatings, etc. Furthermore the method is a simple process without waste that is environmentally friendly and suitable for industrialized production, thus it is expected to replace existing processes of iron oxide red pigments.

Abstract: A two-dimensional metal-organic framework (2D MOF) includes a first transition metal M1 and a second transition metal M2. The first transition metal and the second transition metal are different and are coupled by a linker group L to yield a two-dimensional metal-organic framework alloy having a formula M1xM21-xL, where 0<x<1. Each transition metal is dispersed uniformly throughout the 2D MOF. The 2D MOF is synthesized by combining a first transition metal precursor, a second transition metal precursor, and a linker; agitating the solution; and heating the solution to yield a crystalline two-dimensional metal-organic framework alloy.

Abstract: A carbon dioxide capture and release method of forming a MOF matrix material including at least one metal-organic-framework crystal that includes at least one metal ion or metal ion cluster coordinated to polydentate organic ligands. The method includes forming a positive moisture swing CO2 host by application of at least a portion of the MOF matrix material to at least a portion of a good, and exposing the good to a feed gas. The method also includes altering the absorption and desorption of CO2 in the CO2 host through a swing absorption/desorption process of moisture content, where an equilibrium pressure of CO2 over the CO2 host is based at least in part on the moisture content. The metal-organic-framework crystal can be UIO-66 including Zr6O4(OH)4(CO2)12 clusters linked by terephthalate acid ligands, and/or Zr6O4(OH)4(CO2)12 clusters linked by amino-terephthalic acid ligands, and/or Zr6O4(OH)4(CO2)12 clusters linked by nitro-terephthalic acid ligands.

Abstract: Synthesizing a metal-organic-framework includes combining a first solution and a second solution to yield a synthetic medium. The first solution typically includes a solvent, an inhibitor, a metal capping agent, a ligand, and a metal source, and the second solution typically includes a deprotonating agent and a buffer. The metal and the ligand are reacted in the synthetic medium to yield a two-dimensional metal-organic-framework in the form of a nanosheet, and the two-dimensional metal-organic-framework is removed from the synthetic medium. The two-dimensional metal-organic framework has an aspect ratio of at least 300 or at least 1000.

Abstract: Embodiments of the present disclosure relate generally devices for detecting analytes in a subject. More particularly, the present disclosure provides a biosensor array for detecting analytes in a subject. Embodiments of the present disclosure include a biosensor array comprising a plurality of sensor cells for detecting an analyte in a subject. In accordance with these embodiments, the plurality of sensor cells comprise at least one electrode, at least one antibody immobilized on a surface of the at least one electrode, and a biodegradable coating in contact with the at least one antibody.

Abstract: Some embodiments include a method of preparing a phototuned metal-organic framework by forming a first solution by dissolving ZrOCl2.8H2O in dimethylformamide (DMF) and formic acid, mixing and dissolving 1,4-phenylenediacrylic acid in a second solution of dimethylformamide (DMF) and trimethylamine, and at least partially mixing the first and second solutions to form a mixture. The method further includes sealing the mixture in an autoclave and heating the mixture to above ambient temperature for a specified period of time to prepare ZrPDA metal-organic framework, and extracting the ZrPDA metal-organic framework and at least partially reacting to a specified degree at least some of ZrPDA metal-organic framework through [2+2] cycloaddition reactions. The specified degree can be tunable based at least in part on at least one of the intensity of UV radiation, the exposure time, and the UV wavelength.