Abstract: Provided are a peptidyl nitrile compound and a use thereof; specifically provided are a compound represented by formula (I) and/or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the compound and/or the pharmaceutically acceptable salt thereof, a method for preparing the compound, and a use of the compound in treating diseases caused by cathepsin C and a downstream serine protease thereof.

Abstract: This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.

Abstract: A keyboard and an electronic device are provided. The keyboard includes a button switch, a keyboard frame, and a mechanical part. The keyboard frame includes a transverse frame and a longitudinal frame. The transverse frame extends in a row direction and is continuously disposed. The longitudinal frame extends in a column direction and is connected between two adjacent transverse frames. A plurality of longitudinal frames are arranged in a staggered manner in the column direction. The mechanical part includes a transverse support rib and a longitudinal support rib. On a side that is of the keyboard frame and that is connected to the mechanical part, the longitudinal frame protrudes relative to the transverse frame, the longitudinal frame abuts and is attached to the transverse support rib, and an adhesive-accommodating gap for accommodating adhesive is formed between the transverse frame and the transverse support rib.

Abstract: The present disclosure relates to a composite lithium battery separator and a preparation process therefor. The composite lithium battery separator includes a base film or a ceramic film, and a coating layer covering one side or both sides of the base film or the ceramic film. The coating layer is formed by coating a slurry. The slurry includes 5%-45% by weight of a coating polymer and 55%-95% by weight of an organic solvent, and the coating polymer includes 10-100 parts by weight of a fluorine or acrylic resin polymer, 0.5-10 parts of a polymer adhesive, and 0-90 parts of inorganic nanoparticles.

Abstract: Disclosed are a glass-packaged ceramic feedthrough filter and a preparation method thereof, which includes a guide needle and a metal shell sleeved in the middle of the guide needle; the bottom of the metal shell is encapsulated by a glass body; a gasket sleeved on the guide needle is arranged above the glass body; a disc-shaped multilayer ceramic capacitor is sleeved on the guide needle above the gasket; a first gap is formed between the bottom of the disc-shaped multilayer ceramic capacitor and the top of the glass body; a second gap is formed between the capacitor and the inner wall of the metal shell; and the first gap is communicated with the second gap. The size of the first gap is increased through the gasket, a second gap is reserved between the capacitor and the metal shell, so that the first gap is communicated with the second gap.

Abstract: Disclosed are a stress-resistant, creep-resistant, high-temperature resistant and high-insulation sheath material for a maglev train cable, and a manufacturing method and use thereof. A multiple chemical crosslinking structure is constructed by blending a functional polyvinylsilicone grease with ultra-high molecular weight polyethylene (UHMWPE) and a ceramicized silicone rubber as a cable material matrix and using electron beam irradiation. In addition, organic/inorganic fillers in the matrix can form physical crosslinking points in the material. A physical-chemical dual crosslinking structure is constructed in the matrix, which can limit the motion and relaxation of molecular chains and improve the interaction between the insulation layer and sheath layer and refractory layers such as fillers and mica tapes to avoid the relative displacement during the laying and operation and improve the high-temperature resistance, creep resistance and stress relaxation resistance of a UHMWPE cable sheath material.

Abstract: Provided herein are methods for identifying sequences of viruses. Also provided are compositions for carrying out the same. Compositions provided herein may comprise, consist essentially of, or consist of a plurality of primers. Furthermore, the disclosure provides kits comprising the compositions. Kits provided herein may also comprise oligonucleotides, probes, and solid supports.

Abstract: Disclosed are a stress-resistant, creep-resistant, high-temperature resistant and high-insulation sheath material for a maglev train cable, and a manufacturing method and use thereof. A multiple chemical crosslinking structure is constructed by blending a functional polyvinylsilicone grease with ultra-high molecular weight polyethylene (UHMWPE) and a ceramicized silicone rubber as a cable material matrix and using electron beam irradiation. In addition, organic/inorganic fillers in the matrix can form physical crosslinking points in the material. A physical-chemical dual crosslinking structure is constructed in the matrix, which can limit the motion and relaxation of molecular chains and improve the interaction between the insulation layer and sheath layer and refractory layers such as fillers and mica tapes to avoid the relative displacement during the laying and operation and improve the high-temperature resistance, creep resistance and stress relaxation resistance of a UHMWPE cable sheath material.

Abstract: Disclosed is a highly reliable multilayer ceramic through-hole capacitor. It includes a multilayer ceramic through-hole capacitor body, which has at least one inner hole for inserting a first controlled expansion alloy tube. A guide pin is inserted into the first controlled expansion alloy tube, which undergoes annealing and surface electroplating treatment. The guide pin, first controlled expansion alloy tube, and inner hole are all fixed using lead-free solder. By welding the first controlled expansion alloy tube with the inner hole of the disk-shaped multilayer ceramic capacitor, the stress resistance capability of the capacitor is improved. This eliminates the need for lead-containing soldering materials with high ductility in the production process, allowing the capacitor to withstand multiple temperature changes without ceramic cracking. As a result, the multilayer ceramic through-hole capacitor achieves high reliability even in harsh external environments.

Abstract: A keyboard and an electronic device are provided. The keyboard includes a button switch, a keyboard frame, and a mechanical part. The keyboard frame includes a transverse frame and a longitudinal frame. The transverse frame extends in a row direction and is continuously disposed. The longitudinal frame extends in a column direction and is connected between two adjacent transverse frames. A plurality of longitudinal frames are arranged in a staggered manner in the column direction. The mechanical part includes a transverse support rib and a longitudinal support rib. On a side that is of the keyboard frame and that is connected to the mechanical part, the longitudinal frame protrudes relative to the transverse frame, the longitudinal frame abuts and is attached to the transverse support rib, and an adhesive-accommodating gap for accommodating adhesive is formed between the transverse frame and the transverse support rib.

Abstract: This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.

Abstract: The present disclosure belongs to the field of kitchen equipment, and in particular relates to a cooking device. The cooking device of the present disclosure includes a cabinet and an installation bracket. A cooking chamber is formed in the cabinet, and the installation bracket is detachably connected to the cabinet. A fan assembly is arranged on the installation bracket, and a fume exhaust duct that communicates with the fan assembly is arranged in the installation bracket or in the cabinet. According to the cooking device of the present disclosure, the cabinet and the fan assembly are arranged separately, the fan assembly is arranged on the installation bracket, and a fume exhaust duct that communicates with the fan assembly is arranged inside the installation bracket.

Abstract: The present application discloses a cooking device, which includes a cabinet; the cabinet includes an inner cavity, a first heating assembly and a second heating assembly; the inner cavity is provided with a cooking chamber, as well as a first side wall and a second side wall that are arranged opposite to each other, the first side wall is provided with a first ventilation structure, and the second side wall is provided with a second ventilation structure; the first heating assembly is arranged outside the inner cavity and arranged corresponding to the first ventilation structure, and is configured to circularly heat air in the cooking chamber; the second heating assembly is arranged outside the inner cavity and arranged corresponding to the second ventilation structure, and is configured to circularly heat the air in the cooking chamber.

Abstract: This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.

Abstract: The present disclosure relates to a composite lithium battery separator and a preparation process therefor. The composite lithium battery separator includes a base film or a ceramic film, and a coating layer covering one side or both sides of the base film or the ceramic film. The coating layer is formed by coating a slurry. The slurry includes 5%-45% by weight of a coating polymer and 55%-95% by weight of an organic solvent, and the coating polymer includes 10-100 parts by weight of a fluorine or acrylic resin polymer, 0.5-10 parts of a polymer adhesive, and 0-90 parts of inorganic nanoparticles.

Abstract: Disclosed are a method, a device and/or a system of a lights-guided piano key learning and teaching device. In one aspect, a piano teaching apparatus includes an elongated enclosure overlaid atop a portion of a set of keys of a piano and a set of lights, each light corresponding with each key of the set of keys respectively. A depth of an underside of the elongated enclosure permits the set of keys to be played in an unobstructed manner. The set of light illuminates when an application of a data processing system communicatively coupled with the piano teaching apparatus communicates a set of instructions synchronized with a musical note of a compilation displayed on the application of the data processing device. The musical note corresponds with a particular light that is directly above a particular key of the set of keys associated with the musical note.

Abstract: The disclosure relates to a chain intelligent pre-tensioning and chain length detection method and device thereof. The device includes a rack, a work platform, a pre-tensioning power device, a measuring power device, a length measuring device and a console. The console receives the information of the length measuring device to adjust and control the pre-tensioning power device. The pre-tensioning and chain length measurement adopts a combination structure of an independently operated screw loading system as well as two sets of unique straight guide rails and four pallets mounted on the guide rail. The pre-tensioning force loading adopts the servo system and works with decelerator and precision grinding screw for loading. The measuring force loading adopts stepper motor and works with precision grinding screw for loading. The pretension and measurement adopt two tensile force sensors, so that chain pre-tensioning force and the chain length measuring force can be controlled accurately.