Abstract: The invention generally relates to an improved processes for the preparation of a cyclic dinucleotide which is useful as a STING agonist of the following formula (I), involving the use of compounds A and B.

Abstract: The invention discloses a display module comprising a black optical layer and a transparent protective layer. The black optical layer covers the light-emitting units and ensures proper alignment and sealing. Light-emitting units penetrate the optical layers to maintain uninterrupted light output. The packaging structure reduces moisture intrusion and protects against environmental damage. A transparent protective layer overlays the black optical layer, enhancing durability and structural integrity. Additionally, the module incorporates an anti-glare film press-fitted onto the packaging layer, minimizing external light interference and optimizing light distribution across viewing angles. These design features enable a thinner display with consistent optical performance.

Abstract: The method of preparing polyethyleneimine-lipid nanoparticles (PEI-LNPs) for transfecting stem cells includes the following steps: S1, adding anhydride to a PEI solution to produce polycarboxylic acid; S2, dissolving the PEI-LNPs from S1, together with DPPC, DPPG, DPPE-PEG-COOH and cholesterol in chloroform, dissolving cGAMP in a water and then adding to such chloroform solution, and performing vacuum evaporation to remove the chloroform; S3, adding PBS for hydration, and performing ultrasonication to obtain liposomes; and S4, adding EDC/NHS to the liposome solution obtained for reaction for 15 min, then adding mRNA, and stirring the mixed solution to obtain a bionic virus nanovaccine. The prepared PEI-LNPs are used for delivering an mRNA vaccine and transfecting stem cells, wherein through a lipid PEI derivative library synthesized based on short-branched PEI with a variable length and hydrophobic tail substitution ratio, short-branched PEI can form a stable complex with the mRNA vaccine.

Abstract: Disclosed is a high anticoagulation ECMO and extracorporeal circulation consumable, which include the following preparation methods: S1, aminating the surface of ECMO blood circulation device and extracorporeal circulation consumables; S2, activating heparin groups; S3, heparinizing the ECMO blood circulation device and extracorporeal circulation consumables; S4, modification of enhancer. The application can produce a novel high anticoagulation extracorporeal circulation tube with low price and high biocompatibility, which expands the application in clinic.

Abstract: The present invention provides engineered BRD4 polypeptides comprising deletions of one or more of bromodomain 1 (BD1), bromodomain 2 (BD2), and extra terminal domain (ET). Also provided are polynucleotides encoding the engineered BRD4 polypeptides, and constructs and vectors comprising the polynucleotides. Also provided are methods for using the engineered BRD4 polypeptides to assess the effects of candidate BRD4 C-terminal specific inhibitors on Pol II pausing.

Abstract: A display module, an LED optical device and a manufacturing method therefor. The display module and the LED optical device each includes a substrate (1), a plurality of light-emitting units (2) arranged on the top surface of the substrate (1), and a packaging layer (3) arranged on the substrate (1) and covering each light-emitting unit (2), where each light-emitting unit (2) includes at least one LED chip, and the packaging layer (3) is configured to transmit light emitted by the LED chip.

Abstract: An eye-like focusing metasurface system driven by a supervised-evolving learning algorithm, comprises: a transmissive metasurface, an array probe, a focusing guidance module, and an evolving learning module, wherein, after an external electromagnetic wave signal penetrates through the transmissive metasurface, the array probe arranged behind the transmissive metasurface detects external electromagnetic wave data, by means of analysis of the focusing guidance module and the evolving learning module, a regulation and control strategy for the transmissive metasurface is outputted, and the state of the transmissive metasurface changes; then the array probe collects new data, and the focusing guidance module and the evolving learning module further analyze the intensity and the characteristics of the external electromagnetic wave data and output a next regulation and control instruction; the process is repeated until the external electromagnetic wave is focused to a specified position.

Abstract: An optical fiber capillary tube power stripper includes a capillary tube having an elongated body including an outer surface and an inner surface that surrounds an elongated optical fiber. The capillary tube (a) defines one or more spaces or gaps in the elongated body between first and second ends of the capillary tube; or (b) includes one or more lateral openings in the elongated body between first and second ends of the capillary tube; or (c) includes the outer surface defining one or more ridges and one or more valleys or grooves that surround the outer surface of the body between first and second ends of the capillary tube.

Abstract: An optical fiber cladding optical filter includes an elongated capillary tube including an inner surface positioned surrounding an elongated optical fiber proximate or adjacent an exterior surface of the optical fiber and an outer surface positioned spaced from the exterior surface of the optical fiber. A grating formed on the outer surface of the elongated capillary tube aids in suppressing evanescent laser light that exits the optical fiber transverse to a longitudinal axis of the optical fiber. The elongated optical fiber and surrounding elongated capillary tube can include one or more curves along a length thereof to aid in the removal of one or more higher order laser modes as evanescent laser light that exits the optical fiber. The one or more curves can be received in a container to prevent or avoid evanescent laser exiting the optical fiber from propagating into an ambient environment.

Abstract: The present invention relates to novel phosphorous (V) (P(V)) reagents, methods for preparing thereof, and methods for preparing organophosphorous (V) compounds by using the novel reagents.

Abstract: The present disclosure provides novel synthetic intermediates useful in the synthesis of MK2 kinase inhibitors.

Abstract: A method and system for monitoring an electrotherapy treatment applied to a subject in need of such therapy. An ultrasound transducer array is positioned adjacent a tissue of the subject to which the electrotherapy treatment is to be applied. The electrotherapy treatment is administered to the tissue as a plurality of ultra-short electric pulses which generate an electric field in the vicinity of the tissue. The ultrasound transducer array detects acoustic signals which are induced by the electric field. The detected acoustic signals are then used to construct tomographic images which represent the electric field generated by the electrotherapy treatment during real-time.

Abstract: The present invention relates to novel phosphorous (V) (P(V)) reagents methods for preparing thereof, and methods for preparing nucleoside phosphorothioate compounds by using the novel reagents.

Abstract: A method for non-enzymatic 3D culture and amplification of mesenchymal stem cells (MSCs) includes the followings steps: preparing PLGA porous microspheres; preparing a PLGA-PEG-PLGA thermosensitive coating microcarrier; culturing and amplifying MSCs; and performing non-enzymatic separation of MSCs, including reducing a culture temperature to below a critical phase transition temperature, and centrifuging a culture medium to collect stem cells. The present invention adopts the method for non-enzymatic 3D culture and amplification of MSCs, wherein the PLGA porous microspheres are used as a cell culture microcarrier scaffold and the thermosensitive hydrogel PLGA-PEG-PLGA is coated on surfaces of such microspheres, without needing additional enzymolysis process, thus efficiently amplifying the stem cells.