Abstract: The invention generally relates to an improved processes for the preparation of a cyclic dinucleotide which is useful as a STING agonist of the following formula (I), involving the use of compounds A and B.

Abstract: The invention discloses a method for correcting the pointing errors of a biaxial rotation system based on the spherical cap function, comprising: error collection: selecting stars or radio sources distributed evenly in a star catalogue for tracking and observation to obtain the theoretical position and measurement position of the stars, and subtracting the measurement positions and the theoretical positions to obtain the error distribution; error model fitting: selecting a suitable orthogonal spherical cap function for the obtained error distribution and performing fitting to calculate an error fitting coefficient, the orthogonal spherical cap function model comprising a hemispheric harmonic function HSH, a Zernike spherical cap function ZSF, and a longitudinal spherical cap function LSF; and error control and compensation: putting the error model and the related fitting coefficient into a pointing control system for compensation.

Abstract: Provided herein is a technology for an Autonomous Vehicle Cloud System (AVCS). This AVCS provides sensing, data fusion, prediction, decision-making, and/or control instructions for specific vehicles at a microscopic level based on data from one or more of other vehicles, roadside unit (RSU), cloud-based platform, and traffic control center/traffic control unit (TCC/TCU). Specifically, the AVs can be effectively and efficiently operated and controlled by the AVCS. The AVCS provides individual vehicles with detailed time-sensitive control instructions for fulfilling driving tasks, including car following, lane changing, route guidance, and other related information. The AVCS is configured to predict individual vehicle behavior and provide planning and decision-making at a microscopic level. In addition, the AVCS is configured to provide one or more of virtual traffic light management, travel demand assignment, traffic state estimation, and platoon control.

Abstract: Provided are a peptidyl nitrile compound and a use thereof; specifically provided are a compound represented by formula (I) and/or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the compound and/or the pharmaceutically acceptable salt thereof, a method for preparing the compound, and a use of the compound in treating diseases caused by cathepsin C and a downstream serine protease thereof.

Abstract: An integrated circuit (IC) solder ball mounting apparatus comprises a ball storage unit for storing solder balls, a ball buffer unit configured to receive the solder balls from the ball storage unit in response to one or more pressure-actuated actions, and a gate valve configured to allow the solder balls to transfer to a ball mounting brush configured to place the solder balls onto area array contact structures formed on a wafer containing the integrated circuit.

Abstract: The invention discloses a display module comprising a black optical layer and a transparent protective layer. The black optical layer covers the light-emitting units and ensures proper alignment and sealing. Light-emitting units penetrate the optical layers to maintain uninterrupted light output. The packaging structure reduces moisture intrusion and protects against environmental damage. A transparent protective layer overlays the black optical layer, enhancing durability and structural integrity. Additionally, the module incorporates an anti-glare film press-fitted onto the packaging layer, minimizing external light interference and optimizing light distribution across viewing angles. These design features enable a thinner display with consistent optical performance.

Abstract: A tiled apparatus is provided by the present disclosure. at least two of the tiled apparatus include display panels, backlight modules and lens parts. the display panel includes a display part and a tiled part. The tiled part is composed of transparent materials. An orthographic projection of the backlight module on the display panel covers the display part and at least a part of the tiled part. The lens part is disposed on a side of the display panel away from the backlight module and covers adjacent two tiled parts and a seam. The lens part partially overlaps with display parts of adjacent two display panels.

Abstract: Disclosed is a fully immersed energy storage device, which includes a casing and a water pump. An insulation box is mounted inside the casing, and the insulation box is assembled with an assembly plate thereon. A mounting platform is mounted on the assembly plate and assembled with an annular rack. A rotating groove is provided between the mounting platform and the annular rack. Balls are placed in the rotating groove. The mounting platform is assembled with an assembly block, on which a rotating shaft is mounted. One end of the rotating shaft connects to a gear. The other end of the rotating shaft connects to a first assembly rod, to which a second assembly rod is connected. The second assembly rod connects to a fixed block, which is connected to an energy storage box. A motor base is mounted on the casing. A motor is mounted on the motor base.

Abstract: Embodiments of the present application provide a spliced display panel and a spliced display device. In the spliced display panel provided by the embodiments of the present application, a second display module is disposed on a non-display surface of a first display module and corresponding to a spliced region.

Abstract: The present application relates to a silicone oil-based immersion coolant for an electronic component. The silicone oil-based immersion coolant for an electronic component includes a base oil and an additive. The base oil includes a low-viscosity silicone oil. The additive includes a silicone oil diluent and a thermally conductive inorganic filler. The viscosity of the low-viscosity silicone oil is less than or equal to 1000 cSt. The thermally conductive inorganic filler is an insulating filler. Based on the mass of the immersion coolant, a mass percentage content of the base oil is in a range from 70% to 85%, a mass percentage content of the silicone oil diluent is in a range from 10% to 20%, and a mass percentage content of the thermally conductive inorganic filler is in a range from 5% to 10%.

Abstract: A terminal device determines whether an available first resource is present, where the available first resource is associated with a hybrid automatic repeat request (HARQ) process configured with a HARQ mode A, and the HARQ mode A supports retransmission. When the available first resource is present, the terminal device sends a timing advance report to a network device by using the available first resource.

Abstract: Provided is a method for preparing copper azide and cuprous azide encapsulated by conductive metal-organic framework. The method uses a conductive copper-containing metal-organic framework material as a precursor, and completes the azidation of the precursor by means of a liquid-solid electrochemical azidation reaction. Copper azide and cuprous azide nanocrystals are highly uniformly embedded within a conductive framework, which may effectively avoid the agglomeration of copper azide and cuprous azide, and reduce static charge generated by friction, displacement, and the like. Meanwhile, the conductive framework may promote the effective transfer of charge, avoid the accumulation of static charge, and improve the electrostatic safety.

Abstract: The method of preparing polyethyleneimine-lipid nanoparticles (PEI-LNPs) for transfecting stem cells includes the following steps: S1, adding anhydride to a PEI solution to produce polycarboxylic acid; S2, dissolving the PEI-LNPs from S1, together with DPPC, DPPG, DPPE-PEG-COOH and cholesterol in chloroform, dissolving cGAMP in a water and then adding to such chloroform solution, and performing vacuum evaporation to remove the chloroform; S3, adding PBS for hydration, and performing ultrasonication to obtain liposomes; and S4, adding EDC/NHS to the liposome solution obtained for reaction for 15 min, then adding mRNA, and stirring the mixed solution to obtain a bionic virus nanovaccine. The prepared PEI-LNPs are used for delivering an mRNA vaccine and transfecting stem cells, wherein through a lipid PEI derivative library synthesized based on short-branched PEI with a variable length and hydrophobic tail substitution ratio, short-branched PEI can form a stable complex with the mRNA vaccine.

Abstract: A lighting apparatus includes an isolation transformer, an output rectification and voltage regulation circuit, an output current limiting and filtering circuit, and a signal detection and generation circuit. The homonymous terminal of the primary side opposes the homonymous terminal of the secondary side. The output rectification and voltage regulation circuit is connected to the secondary coil of the isolation transformer. The output rectification and voltage regulation circuit rectifies and stabilizes the voltage signal output by the isolation transformer. The output current limiting and filtering circuit is connected to the dimmer and the output rectification and voltage regulation circuit. The output current limiting and filtering circuit adjusts the output current and output voltage according to the operation of the dimmer, and the output current limiting and filtering circuit limits and filters the signal output by the output rectification and voltage regulation circuit.

Abstract: Disclosed is a high anticoagulation ECMO and extracorporeal circulation consumable, which include the following preparation methods: S1, aminating the surface of ECMO blood circulation device and extracorporeal circulation consumables; S2, activating heparin groups; S3, heparinizing the ECMO blood circulation device and extracorporeal circulation consumables; S4, modification of enhancer. The application can produce a novel high anticoagulation extracorporeal circulation tube with low price and high biocompatibility, which expands the application in clinic.

Abstract: The present invention provides engineered BRD4 polypeptides comprising deletions of one or more of bromodomain 1 (BD1), bromodomain 2 (BD2), and extra terminal domain (ET). Also provided are polynucleotides encoding the engineered BRD4 polypeptides, and constructs and vectors comprising the polynucleotides. Also provided are methods for using the engineered BRD4 polypeptides to assess the effects of candidate BRD4 C-terminal specific inhibitors on Pol II pausing.

Abstract: A display module, an LED optical device and a manufacturing method therefor. The display module and the LED optical device each includes a substrate (1), a plurality of light-emitting units (2) arranged on the top surface of the substrate (1), and a packaging layer (3) arranged on the substrate (1) and covering each light-emitting unit (2), where each light-emitting unit (2) includes at least one LED chip, and the packaging layer (3) is configured to transmit light emitted by the LED chip.

Abstract: An eye-like focusing metasurface system driven by a supervised-evolving learning algorithm, comprises: a transmissive metasurface, an array probe, a focusing guidance module, and an evolving learning module, wherein, after an external electromagnetic wave signal penetrates through the transmissive metasurface, the array probe arranged behind the transmissive metasurface detects external electromagnetic wave data, by means of analysis of the focusing guidance module and the evolving learning module, a regulation and control strategy for the transmissive metasurface is outputted, and the state of the transmissive metasurface changes; then the array probe collects new data, and the focusing guidance module and the evolving learning module further analyze the intensity and the characteristics of the external electromagnetic wave data and output a next regulation and control instruction; the process is repeated until the external electromagnetic wave is focused to a specified position.