Patents by Inventor Bing Guan

Bing Guan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic compounds useful as RAF kinase inhibitors
    Patent number: 7968536
    Abstract: The present invention provides compounds useful as inhibitors of protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
    Type: Grant
    Filed: June 30, 2008
    Date of Patent: June 28, 2011
    Assignees: Millennium Pharmaceuticals, Inc., Sunesis Pharmaceuticals, Inc.
    Inventors: Jennifer Cossrow, Bing Guan, Alexey Ishchenko, John Howard Jones, Gnanasambandam Kumaravel, Alexey Lugovskoy, Hairuo Peng, Noel Powell, Brian C. Raimundo, Hiroko Tanaka, Jeffrey Vessels, Thomas Wynn, Zhili Xin
  • FUSION PROTEINS OF RECOMBINANT SARS CORONAVIRUS STRUCTURAL PROTEINS, THEIR PRODUCTION AND USES
    Publication number: 20100150923
    Abstract: Fusion proteins of recombinant SARS coronavirus structural proteins, their production and uses are provided. An optimized SARS coronavirus S protein gene which can be highly expressed in the mammalian cell strains and SARS coronavirus S protein variants comprising deletion, modification or mutation amino acids 318-510 corresponding to SARS coronavirus S protein are also provided.
    Type: Application
    Filed: June 13, 2006
    Publication date: June 17, 2010
    Applicant: Chinese Academy of Medical Sciences, Institute of Basic Medical Sciences
    Inventors: Chengyu Jiang, Feng Guo, Shuan Rao, Bing Guan, Yi Huan, Peng Yang
  • DETECTOR FOR DUAL BAND ULTRAVIOLET DETECTION
    Publication number: 20100012849
    Abstract: The invention concerns a single detector with two designable wavelengths and bandwidths for ultraviolet detection based on n?/n+-GaN and AlGaN structures grown over sapphire substrates. The detector has several layers grown over a sapphire substrates, including a buffer layer comprising AlN; a first band-edge comprising AlXGa1-XN; a second band-edge comprising AlYGa1-YN; a third band-edge comprising AlZGa1-ZN. The detector also has ohmic contacts formed on the AlXGa1-XN band-edge. A bias voltage is applied to the detector through the ohmic contacts so as to select a range of wavelengths in the UV region of interest.
    Type: Application
    Filed: July 21, 2008
    Publication date: January 21, 2010
    Applicant: United States of America as represented by the Administrator of the National Aeronautics and Spac
    Inventors: Laddawan R. Miko, David Franz, Carl M. Stahle, Bing Guan
  • Aryl sulfonamides useful as inhibitors of chemokine receptor activity
    Publication number: 20090275556
    Abstract: The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein R1, X, Z, R2, X1, Ar, n, R3 and R4 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR8 and accordingly are useful for the treatment of a variety of inflammatory and allergic disorders.
    Type: Application
    Filed: August 27, 2008
    Publication date: November 5, 2009
    Inventors: Mingshi Dai, Bing Guan, Roert A. Bennett, Douglas F. Burdi, Shomir Ghosh, Gang Li, Charles Minor, Tracy J. Jenkins
  • Aryl sulfonamides useful as inhibitors of chemokine receptor activity
    Patent number: 7491827
    Abstract: The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein R1, X, Z, R2, X1, Ar, n, R3 and R4 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR8 and accordingly are useful for the treatment of a variety of inflammatory and allergic disorders.
    Type: Grant
    Filed: July 14, 2004
    Date of Patent: February 17, 2009
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Mingshi Dai, Bing Guan, Robert A. Bennett, Douglas F. Burdi, Shomir Ghosh, Gang Li, Charles Minor, Tracy J. Jenkins
  • COMPOUNDS USEFUL AS RAF KINASE INHIBITORS
    Publication number: 20090036419
    Abstract: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
    Type: Application
    Filed: June 30, 2008
    Publication date: February 5, 2009
    Applicant: Sunesis Pharmaceuticals, Inc.
    Inventors: Weirong Chen, Jennifer Cossrow, Lloyd Franklin, Bing Guan, John Howard Jones, Gnanasambandam Kumaravel, Benjamin Lane, Adam Littke, Alexey Lugovskoy, Hairuo Peng, Noel Powell, Brian C. Raimundo, Hiroko Tanaka, Jeffrey Vessels, Thomas Wynn, Zhili Xin
  • Heterocyclic Compounds Useful as RAF Kinase Inhibitors
    Publication number: 20090005359
    Abstract: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
    Type: Application
    Filed: June 30, 2008
    Publication date: January 1, 2009
    Applicant: Sunesis Pharmaceuticals, Inc
    Inventors: Jennifer Cossrow, Bing Guan, Alexey Ishchenko, John Howard Jones, Gnanasambandam Kumaravel, Alexey Lugovskoy, Hairuo Peng, Noel Powell, Brian C. Raimundo, Hiroko Tanaka, Jeffrey Vessels, Thomas Wynn, Zhili Xin
  • FC gamma RIIA-specific nucleic acid interference
    Publication number: 20080293659
    Abstract: The present invention provides methods and compositions for attenuating expression of Fc?RIIA. In general, the described methodology involves the use of RNAi constructs that are targeted to a Fc?RIIA mRNA sequence.
    Type: Application
    Filed: March 25, 2008
    Publication date: November 27, 2008
    Inventors: Diana S. Beardsley, Bing-Guan Chen
  • CCR8 inhibitors
    Patent number: 7378525
    Abstract: Disclosed are CCR8 inhibitors represented by Structural Formulas (I): The variables in Structural Formula (I) are described herein. Also disclosed are methods of treating a subject with a CCR8 mediated condition, especially asthma, by administering one of the disclosed CCR8 inhibitors to the subject.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: May 27, 2008
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Bing Guan, Charles Minor, Mingshi Dai, Shomir Ghosh, Tracy J. Jenkins, Gang Li, Douglas F. Burdi, Robert A. Bennett
  • Fc?RIIA-specific nucleic acid interference
    Patent number: 7368559
    Abstract: The present invention provides methods and compositions for attenuating expression of Fc?RIIA. In general, the described methodology involves the use of RNAi constructs that are targeted to a Fc?RIIA mRNA sequence.
    Type: Grant
    Filed: November 15, 2004
    Date of Patent: May 6, 2008
    Inventors: Diana Beardsley, Bing-Guan Chen
  • CCR8 inhibitors
    Patent number: 7329755
    Abstract: Disclosed is an inhibitor of CCR8 that is represented by Structural Formula (I): Also disclosed are pharmaceutical compositions comprising a pharmaceutically acceptable carrier or diluent and a CCR8 inhibitor represented by Structural Formula (I). Also disclosed is a method of treating inflammatory disorders in a subject by administering a CCR8 inhibitor to the subject.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: February 12, 2008
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Mingshi Dai, Tracy J. Jenkins, Bing Guan, Shomir Ghosh, Charles Minor
  • ACE-2 modulating compounds and methods of use thereof
    Patent number: 7045532
    Abstract: ACE-2 inhibitors for the treatment of body weight and related disorders are disclosed. ACE-2 inhibitors include peptides and small molecules. Examples of small molecule ACE-2 inhibitors include compounds of formula (I): Z-???(I) Wherein Z is a zinc coordinating moiety and ? is an amino-acid mimicking moiety, and pharmaceutically acceptabale salts thereof. Methods of using the inhibitors and pharmaceutical compositions containing the inhibitors to treat a body weight disorder, to decrease appetite, to increase muscle mass, to decrease body fat, to treat diabetes and to treat a state associated with altered lipid metabolism, are also described.
    Type: Grant
    Filed: October 31, 2001
    Date of Patent: May 16, 2006
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Susan L. Acton, Timothy D. Ocain, Alexandra E. Gould, Natalie A. Dales, Bing Guan, James A. Brown, Michael Patane, Vivek J. Kadambi, Michael Solomon, Alain Stricker-Krongrad
  • Syk-targeted nucleic acid interference
    Publication number: 20050267059
    Abstract: The present invention provides methods and compositions for attenuating expression of Spleen Tyrosine Kinase, Syk. In general, the described methodology involves the use of RNAi constructs that are targeted to a Syk mRNA sequence.
    Type: Application
    Filed: November 15, 2004
    Publication date: December 1, 2005
    Inventors: Diana Beardsley, Bing-Guan Chen, Alejandro Candelario
  • FcgammaRIIA-specific nucleic acid interference
    Publication number: 20050250722
    Abstract: The present invention provides methods and compositions for attenuating expression of Fc?RIIA. In general, the described methodology involves the use of RNAi constructs that are targeted to a Fc?RIIA mRNA sequence.
    Type: Application
    Filed: November 15, 2004
    Publication date: November 10, 2005
    Inventors: Diana Beardsley, Bing-Guan Chen
  • Aryl sulfonamides useful as inhibitors of chemokine receptor activity
    Publication number: 20050085518
    Abstract: The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein R1, X, Z, R2, X., Ar, n, R3 and R4 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR8 and accordingly are useful for the treatment of a variety of inflammatory and allergic disorders.
    Type: Application
    Filed: July 14, 2004
    Publication date: April 21, 2005
    Inventors: Mingshi Dai, Bing Guan, Robert Bennett, Douglas Burdi, Shomir Ghosh, Gang Li, Charles Minor, Tracy Jenkins
  • CCR8 inhibitors
    Publication number: 20040224978
    Abstract: Disclosed is an inhibitor of CCR8 that is represented by Structural Formula (I): 1
    Type: Application
    Filed: December 23, 2003
    Publication date: November 11, 2004
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Mingshi Dai, Tracy J. Jenkins, Bing Guan, Shomir Ghosh, Charles Minor
  • CCR8 Inhibitors
    Publication number: 20040209948
    Abstract: Disclosed are CCR8 inhibitors represented by Structural Formulas (I): 1
    Type: Application
    Filed: December 23, 2003
    Publication date: October 21, 2004
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Bing Guan, Charles Minor, Mingshi Dai, Shomir Ghosh, Tracy J. Jenkins, Gang Li, Douglas F. Burdi, Robert A. Bennett
  • ACE-2 modulating compounds and methods of use thereof
    Publication number: 20040082496
    Abstract: ACE-2 modulating compounds for the treatment of body weight disorders are disclosed. Methods of using the compounds and pharmaceutical compositions containing the compounds are also claimed.
    Type: Application
    Filed: October 31, 2001
    Publication date: April 29, 2004
    Inventors: Susan L. Acton, Timothy D. Ocain, Alexandra E. Gould, Natalie A. Dales, Bing Guan, James A. Brown, Michael Patane, Vivek J. Kadambi, Michael Solomon, Alain Stricker-Krongrad
  • ACE-2 inhibiting compounds and methods of use thereof
    Patent number: 6632830
    Abstract: ACE-2 inhibiting compounds are disclosed. These compounds include compounds of formula (IV): wherein the variables are as described in the specification. Pharmaceutical compositions containing the compounds are also discussed. The pharmaceutical compositions may contain an effective amount of a compound of the invention to treat ACE-2 associated disorders such as a blood pressure related disease or disorder, cell proliferation disorder, kidney disorder, kinetensin associated disorder, inflammation associated disorder, or an allergic disorder.
    Type: Grant
    Filed: April 28, 2000
    Date of Patent: October 14, 2003
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Susan L. Acton, Timothy D. Ocain, Alexandra E. Gould, Natalie A. Dales, Bing Guan, James A. Brown