Publication number: 20260193620
Abstract: The invention discloses a HcCYP81Q58 gene of Hemsleya chinensis cytochrome oxidase, a sequence of the gene is shown in SEQ NO:1. The invention constructs a genetically modified Saccharomyces cerevisiae engineering bacteria of Cuol-04-1, it is capable of producing a variety of cucurbitacin intermediates at a high level, including 11-Carbonyl-cucurbita-5,23-diene-3?, 20,25-triol, 11-Carbonyl-cucurbita-5,24-diene-3?, 20,23-triol, 11-Carbonyl-cucurbita-5,23-diene-20,25-diol-3?-one, and 11-Carbonyl-cucurbita-5,24-diene-20,23-diol-3?-one, it provides a source for the production of cucurbitacins.
Type:
Application
Filed:
January 8, 2025
Publication date:
July 9, 2026
Applicants:
Yunnan Agricultural University, Yunnan Yunke Characteristic Plant Extraction Laboratory Co., Ltd.
Inventors:
Guanghui ZHANG, Zhiyuan LI, Shengchao YANG, Bing HAO, Geng CHEN, Yanyu SHU, Xiaolin FENG, Dina MA, Simei HE, Yingchun LU
Publication number: 20250236894
Abstract: The invention provides a Hemsleya chinensis cytochrome oxidase HcCYP87D19 gene, and the sequence of the gene is shown in SEQ NO: 1. This invention constructs a transgenic Saccharomyces cerevisiae engineering bacteria co-transfected with Hemsleya cathayensis cytochrome oxidase HcCYP87D19 and HcCYP81Q58, the bacteria can produce a variety of cucurbitacin intermediates including 11-Carbonyl-cucurbita-5,23-diene-3?,16a,20,25-tetrol (6), 11-Carbonyl-cucurbita-5,23-diene-3?,16?,20,23-tetrol (6b), 11-Carbonyl-cucurbita-5,23-diene-16?,20,25-triol-3-one (6a), 11-Carbonyl-cucurbita-5,24-diene-16?,20,23-triol-3-one (6c), it provides a source for cucurbitacin production.
Type:
Application
Filed:
January 8, 2025
Publication date:
July 24, 2025
Applicants:
Yunnan Agricultural University, Yunnan Yunke Characteristic Plant Extraction Laboratory Co., Ltd.
Inventors:
Guanghui ZHANG, Chunli HUANG, Shengchao YANG, Bing HAO, Geng CHEN, Yanyu SHU, Zhiyuan LI, Xiaolin FENG, Simei HE, Yingchun LU