Abstract: The disclosure relates to a field of electrical technology, and particularly discloses an electrical apparatus, a door opening and closing device and a control method of a clutch thereof. The door opening and closing device includes: a drive mechanism, a door ejection mechanism, a door rotation mechanism and an angle acquisition unit. a drive mechanism including a driver, a first transmission assembly, a second transmission assembly connected to the driver and simultaneously separably connected to the first transmission assembly, and a clutch-ejection-push assembly pushing the second transmission assembly to separate from or connect to the first transmission assembly; and a linkage gear connected to the first transmission assembly and simultaneously connected to the door ejection mechanism 00) and the door rotation mechanism. The angle acquisition unit is configured to acquire a rotation angle of the linkage gear.

Abstract: The present disclosure relates to choline salts, and crystalline forms thereof, of a compound which is N—((S)-1-(3-(4-chloro-3-(methylsulfonamido)-1-(2,2,2-trifluoroethyl)-1H-indazol-7-yl)-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-((3bS,4aR)-5,5-difluoro-3- (trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamide, which is useful in the treatment and prevention of a Retroviridae viral infection including an infection caused by the HIV virus.

Abstract: The disclosure discloses a refrigerator, including: a main body formed with an accommodation space that has an opening; a door body rotatably disposed on the main body via a rotating shaft to enclose or open the opening, the door opening and closing device including a front connecting rod; and a sliding assembly which includes a connecting member and a sliding member. The connecting member is fixed to one of the front connecting rod and the door body, the sliding member is disposed on another of the front connecting rod and the door body, and the sliding member is slidably connected to the connecting member, and thus the front connecting rod can move along an axial direction of the rotating shaft relative to the door body.

Abstract: The door opening and closing device is used to open a door body disposed on a main body. The door opening and closing device includes: a base, a driving mechanism, a linkage gear and a door rotation mechanism. The linkage gear is rotatably disposed on the base and is in transmission connection with the driving mechanism. The door rotation mechanism is disposed between the linkage gear and the base. An end of the door rotation mechanism is connected to the linkage gear, and another end of the door rotation mechanism is connected to the door body. In a condition that the driving mechanism drives the linkage gear to rotate, the door rotation mechanism drives the door body to rotate relative to the main body to open or close the door body.

Abstract: The present disclosure relates to pharmaceutically acceptable salts, cocrystals, and crystalline forms thereof, of a compound which is N—((S)-1-(3-(4-chloro-3-(methylsulfonamido)-1-(2,2,2-trifluoroethyl)-1H-indazol-7-yl)-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2- ((3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-TH-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamide, which is useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.

Abstract: Disclosed are solid forms of a Cot (cancer Osaka thyroid) inhibitor and corresponding methods of preparation thereof, wherein the Cot inhibitor has the following formula:

Abstract: The disclosure relates to a field of electrical technology, and particularly discloses an electrical apparatus, a door opening and closing device and a control method of a clutch thereof. The door opening and closing device includes: a drive mechanism, a door ejection mechanism, a door rotation mechanism and an angle acquisition unit. a drive mechanism including a driver, a first transmission assembly, a second transmission assembly connected to the driver and simultaneously separably connected to the first transmission assembly, and a clutch-ejection-push assembly pushing the second transmission assembly to separate from or connect to the first transmission assembly; and a linkage gear connected to the first transmission assembly and simultaneously connected to the door ejection mechanism 00) and the door rotation mechanism. The angle acquisition unit is configured to acquire a rotation angle of the linkage gear.

Abstract: The disclosure discloses a door opening and closing device and an electrical apparatus, and belongs to the field of electrical apparatus. The door opening and closing device includes: a door ejection mechanism and a door rotation mechanism which are driven by a same drive mechanism. The drive mechanism includes: a driver, a first transmission assembly, a second transmission assembly connected to the driver and simultaneously separably connected to the first transmission assembly, and a clutch-ejection-push assembly, including an ejection-push sleeve which is sleeved on the second transmission assembly and a push rod for pushing the ejection-push sleeve, and the ejection-push sleeve is ejected and pushed by the push rod to push the second transmission assembly to separate from or connect to the first transmission assembly; and a linkage gear connected to the first transmission assembly and simultaneously connected to the door ejection mechanism and the door rotation mechanism.

Abstract: The disclosure discloses a door opening and closing device and an electrical apparatus, and belongs to a field of electrical apparatus. The door opening and closing device includes a door ejection mechanism and a door rotation mechanism driven by a same drive mechanism; the door rotation mechanism includes a drive member and a door rotation member; a first end of the door rotation member is rotatably disposed on a door body; a second end of the door rotation member is rotatably connected to a first end of the drive member; a second end of the drive member is rotatably disposed on a base; the drive mechanism includes a linkage gear; the linkage gear can drive the drive member to rotate to drive the door rotation member to rotate the door body, and drive the door ejection mechanism to eject and push the door body.

Abstract: The present invention relates to novel crystalline forms of salts and/or co-crystals of tenofovir alafenamide, the pharmaceutical formulations, and the therapeutic uses thereof in treating viral infections.

Abstract: The present invention is related to processes for preparing antiviral prodrugs, co-crystals, solvents, salts or combinations thereof, and related synthetic intermediate compounds.

Abstract: The present disclosure relates to crystalline and solvate forms of a nucleoside reverse transcriptase translocation inhibitor (NRTTI), and pharmaceutical compositions thereof, which are useful in the treatment and prevention of a Retroviridae viral infection including an infection caused by the HIV virus.

Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.

Abstract: The present invention relates to novel crystalline forms of salts and/or co-crystals of tenofovir alafenamide, the pharmaceutical formulations, and the therapeutic uses thereof in treating viral infections.

Abstract: The present disclosure relates to solid forms of compounds and pharmaceutical compositions thereof, which are useful in the treatment and prevention of a Retroviridae viral infection including an infection caused by the HIV virus

Abstract: The present disclosure generally describes methods of preparing 1?-cyano nucleosides, such as a compound of Formula (I). For example, the compound of Formula (I) can be prepared from a compound of Formula (II-a) in a flow reactor.

Abstract: Described herein are crystalline forms of 5-(((2R,3S)-1-((7-chloro-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl)-2-methylazetidin-3-yl)oxy)-N-cyclopropylpicolinamide (Compound 1), or a pharmaceutically acceptable salt or solvate thereof.

Abstract: The present disclosure relates to pharmaceutically acceptable salts, cocrystals, and crystalline forms thereof, of a compound which is N—((S)-1-(3-(4-chloro-3-(methylsulfonamido)-1-(2,2,2-trifluoroethyl)-1H-indazol-7-yl)-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2- ((3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-TH-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamide, which is useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.

Abstract: The present disclosure relates to choline salts, and crystalline forms thereof, of a compound which is N—((S)-1-(3-(4-chloro-3-(methylsulfonamido)-1-(2,2,2-trifluoroethyl)-1H-indazol-7-yl)-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-((3bS,4aR)-5,5-difluoro-3- (trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamide, which is useful in the treatment and prevention of a Retroviridae viral infection including an infection caused by the HIV virus.

Abstract: The present invention relates to stable novel salt forms of N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide that are suitable for the preparation of pharmaceutical formulations thereof, and their therapeutic use.