Patents by Inventor Bing Shi

Bing Shi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLYMORPHIC FORMS OF (S)-2-(1-(9H-PURIN-6-YLAMINO)PROPYL)-5-FLUORO-3-PHENYLQUINAZOLIN-4(3H)-ONE
    Publication number: 20150080572
    Abstract: Polymorphs of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one, compositions thereof, methods for their preparation, and methods for their use are disclosed.
    Type: Application
    Filed: September 22, 2014
    Publication date: March 19, 2015
    Applicant: GILEAD CALISTOGA LLC
    Inventors: Ernest CARRA, Michael GERBER, Bing SHI, Keiko SUJINO, Duong TRAN, Fang WANG, Jerry B. EVARTS
  • Solid forms of an antiviral compound
    Patent number: 8969588
    Abstract: Amorphous and crystalline solid forms of the anti-HCV compound (1-{3-[6-(9,9-difluoro-7-{2 -[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2.4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]-2-aza-bicyclo[2.2.1]heptane-2-carbonyl}-2-methyl -propyl)-carbamic acid methyl ester (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the amorphous and crystalline forms.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: March 3, 2015
    Assignee: Gilead Pharmasset LLC
    Inventors: Robert William Scott, Fang Wang, Bing Shi, Erik Mogalian
  • Polymorphic forms of ()-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3)-one
    Patent number: 8865730
    Abstract: Polymorphs of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one, compositions thereof, methods for their preparation, and methods for their use are disclosed.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: October 21, 2014
    Assignee: Gilead Calistoga LLC
    Inventors: Ernest Carra, Michael Gerber, Bing Shi, Keiko Sujino, Duong Tran, Fang Wang, Jerry B. Evarts
  • SOLID FORMS OF AN ANTIVIRAL COMPOUND
    Publication number: 20140309187
    Abstract: Crystalline solid forms and the amorphous form of the anti-HCV compound 5-(3,3-dimethylbutyn-1-yl)-3-[(cis-4-hydroxy-4-{[(3S)-tetrahydrofuran-3-yloxy]methyl}cyclohexyl){[(1R)-4-methylcyclohex-3-en-1-yl]carbonyl}amino]thiophene-2-carboxylic acid (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.
    Type: Application
    Filed: June 24, 2014
    Publication date: October 16, 2014
    Inventors: Ahmad Hashash, Scott Wolckenhauer, Bing Shi
  • Solid forms of an antiviral compound
    Patent number: 8841340
    Abstract: Crystalline solid forms and the amorphous form of the anti-HCV compound 5-(3,3-dimethylbutyn-1-yl)-3-[(cis-4-hydroxy-4-{[(3S)-tetrahydrofuran-3-yloxy]methyl}cyclohexyl){[(1R)-4-methylcyclohex-3-en-1-yl]carbonyl}amino]thiophene-2-carboxylic acid (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: September 23, 2014
    Assignee: Gilead Sciences, Inc.
    Inventors: Ahmad Hashash, Scott Wolckenhauer, Bing Shi
  • TENOFOVIR ALAFENAMIDE HEMIFUMARATE
    Publication number: 20140187773
    Abstract: A hemifumarate form of 9-[(R)-2-[[(S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]propyl]adenine (tenofovir alafenamide), and antiviral therapy using tenofovir alafenamide hemifumarate (e.g., anti-HIV and anti-HBV therapies).
    Type: Application
    Filed: March 5, 2014
    Publication date: July 3, 2014
    Applicant: GILEAD SCIENCES, INC.
    Inventors: Dazhan Liu, Bing Shi, Fang Wang, Richard Hung Chiu Yu
  • Tenofovir alafenamide hemifumarate
    Patent number: 8754065
    Abstract: A hemifumarate form of 9-[(R)-2-[[(S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]propyl]adenine (tenofovir alafenamide), and antiviral therapy using tenofovir alafenamide hemifumarate (e.g., anti-HIV and anti-HBV therapies).
    Type: Grant
    Filed: August 15, 2012
    Date of Patent: June 17, 2014
    Assignee: Gilead Sciences, Inc.
    Inventors: Dazhan Liu, Bing Shi, Fang Wang, Richard Hung Chiu Yu
  • Tenofovir alafenamide hemifumarate
    Patent number: 8697675
    Abstract: A hemifumarate form of 9-[(R)-2-[[(S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]propyl]adenine (tenofovir alafenamide), and antiviral therapy using tenofovir alafenamide hemifumarate (e.g., anti-HIV and anti-HBV therapies).
    Type: Grant
    Filed: August 15, 2012
    Date of Patent: April 15, 2014
    Assignee: Gilead Sciences, Inc.
    Inventors: Dazhan Liu, Bing Shi, Fang Wang, Richard Hung Chiu Yu
  • SOLID FORMS OF AN ANTIVIRAL COMPOUND
    Publication number: 20140051749
    Abstract: Crystalline solid forms and the amorphous form of the anti-HCV compound 5-(3,3-dimethylbutyn-1-yl)-3-[(cis-4-hydroxy-4-{[(3S)-tetrahydrofuran-3-yloxy]methyl}cyclohexyl){[(1R)-4-methylcyclohex-3-en-1-yl]carbonyl}amino]thiophene-2-carboxylic acid (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.
    Type: Application
    Filed: March 13, 2013
    Publication date: February 20, 2014
    Inventors: Ahmad Hashash, Scott Wolckenhauer, Bing Shi
  • SOLID FORMS OF AN ANTIVIRAL COMPOUND
    Publication number: 20130324496
    Abstract: Amorphous and crystalline solid forms of the anti-HCV compound (1-{3-[6-(9,9-difluoro-7-{2-[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2.4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]-2-aza-bicyclo[2.2.1]heptane-2-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the amorphous and crystalline forms.
    Type: Application
    Filed: March 13, 2013
    Publication date: December 5, 2013
    Inventors: Robert William Scott, Fang Wang, Bing Shi, Erik Mogalian
  • POLYMORPHIC FORMS OF (S)-2-(1-(9H-PURIN-6-YLAMINO)PROPYL)-5-FLUORO-3-PHENYLQUINAZOLIN-4(3H)-ONE
    Publication number: 20130252976
    Abstract: Polymorphs of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one, compositions thereof, methods for their preparation, and methods for their use are disclosed.
    Type: Application
    Filed: March 5, 2013
    Publication date: September 26, 2013
    Applicant: GILEAD CALISTOGA LLC
    Inventors: Ernest CARRA, Michael GERBER, Bing SHI, Keiko SUJINO, Duong TRAN, Fang WANG
  • TENOFOVIR ALAFENAMIDE HEMIFUMARATE
    Publication number: 20130065856
    Abstract: A hemifumarate form of 9-[(R)-2-[[(S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]propyl]adenine (tenofovir alafenamide), and antiviral therapy using tenofovir alafenamide hemifumarate (e.g., anti-HIV and anti-HBV therapies).
    Type: Application
    Filed: August 15, 2012
    Publication date: March 14, 2013
    Applicant: GILEAD SCIENCES, INC.
    Inventors: Dazhan Liu, Bing Shi, Fang Wang, Richard Hung Chiu Yu
  • Methods of preparing indazole compounds
    Patent number: 7232910
    Abstract: The present invention relates to methods for preparing indazole compounds of formula I, which are useful as modulators and/or inhibitors of protein kinases. The present invention also relates to intermediate compounds useful in the preparation of compounds of formula I.
    Type: Grant
    Filed: October 31, 2005
    Date of Patent: June 19, 2007
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Brigitte Leigh Ewanicki, Erik Jon Flahive, Annie Judith Kasparian, Mark Bryan Mitchell, Michael David Perry, Stacy Ann O'Neill-Slawecki, Neal William Sach, James Edward Saenz, Bing Shi, Nebojsa Slobodan Stankovic, Jayaram Kasturi Srirangam, Qingping Tian, Shu Yu
  • Methods of preparing indazole compounds
    Publication number: 20060094881
    Abstract: The present invention relates to methods for preparing indazole compounds of formula I, which are useful as modulators and/or inhibitors of protein kinases. The present invention also relates to intermediate compounds useful in the preparation of compounds of formula I.
    Type: Application
    Filed: October 31, 2005
    Publication date: May 4, 2006
    Inventors: Brigitte Ewanicki, Erik Flahive, Annie Kasparian, Mark Mitchell, Michael Perry, Stacy O'Neill-Slawecki, Neal Sach, James Saenz, Bing Shi, Nebojsa Stankovic, Jayaram Srirangam, Qingping Tian, Shu Yu
  • Methods for the removal of heavy metals
    Publication number: 20060091067
    Abstract: The present invention relates to novel compositions such as cysteine adsorbed on solid support media and trimercaptotriazine bound to silica gel, which are useful for the removal of heavy metals such as palladium from organic phases. The present invention also relates to methods of removing heavy metals by using these compositions.
    Type: Application
    Filed: October 31, 2005
    Publication date: May 4, 2006
    Inventors: Yunying Fan, James Saenz, Bing Shi, Jayaram Srirangam, Shu Yu