Abstract: Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme glycolate oxidase (GO). Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

Abstract: A modified T cell comprising a functional exogenous receptor is provided. The functional exogenous receptor comprises: (a) an extracellular ligand binding domain, (b) a transmembrane domain, and (c) an intracellular signaling domain (ISD) comprising a chimeric signaling domain (CMSD), wherein the CMSD comprises a plurality of Immune-receptor Tyrosine-based Activation Motifs (ITAMs) optionally connected by one or more linkers. Further provided are vectors, methods of producing, pharmaceutical compositions, kits, and methods of treatment thereof.

Abstract: Aspects of the subject disclosure may include, for example, a method in which a data-budget aware video streaming rate adaptation system receives information including a total data budget and a target quality level for a video streaming session presenting a video program; the video program has a plurality of tracks each encoding video content and including video content segments for successive presentation. The method also includes determining a target track for each of the video content segments; providing to a video streaming system the target track for a next successive video content segment; calculating a remaining data budget based on the total data budget and current data usage; and dynamically adjusting, in accordance with the remaining data budget, the target track for each remaining video content segment. Other embodiments are disclosed.

Abstract: Aspects of the subject disclosure may include, for example, obtaining data budget for a communication session, identifying video content associated with the communication session, and determining a group of segments associated with the video content. Further embodiments can include determining a segment size for each of the group of segments, identifying a base track for each segment of the group of segments based on the segment size for each segment of the group of segments and the data budget, and identifying a target track for each segment of the group of segments based on the base track for each segment of the group of segments, the segment size for each segment of the group of segments, and the data budget. Additional embodiments can include providing a request for the target track for each segment to a video content server over a communication network. Other embodiments are disclosed.

Abstract: A secondary cell adding method, a terminal, and a chip are disclosed, which relate to the field of communication technologies. The method is performed by a terminal and includes: camping on a first primary cell supporting NSA; receiving, a secondary cell measurement message from a network device, where the secondary cell measurement message includes a frequency of a first secondary cell and a first signal energy threshold, and a frequency of a second secondary cell and a second signal energy threshold; performing secondary cell measurement based on the frequency of the first secondary cell, where a priority of the frequency of the first secondary cell is higher than a priority of the frequency of the second secondary cell; and performing an operation of adding the first secondary cell if signal energy detected at the frequency of the first secondary cell is greater than the first signal energy threshold.

Abstract: Aspects of the subject disclosure may include, for example, embodiments that comprise obtaining a data budget associated with a communication session for streaming video content over a communication network from a video content server, determining a first portion of the data budget that is associated with a first segment of the video content, and obtaining quality information associated with the video content from the video content server over the communication network. Further embodiments can include identifying a first group of tracks for the first segment, and determining a first target quality for the first segment based on the first portion of the data budget and the quality information. Other embodiments are disclosed.

Abstract: The present disclosure describes a power supply switch that includes a voltage generator, a switch circuit, and a confirmation circuit. The voltage generator is configured to compare a first power supply voltage to a second power supply voltage and to output the first power supply voltage or the second power supply voltage as a bulk voltage (Vbulk). The switch circuit includes one or more transistors and is configured to (i) bias bulk terminals of the one or more transistors with the Vbulk and (ii) output either the first power supply voltage or the second power supply voltage as a voltage output signal. The confirmation circuit is configured to output a confirmation signal that indicates whether the voltage output signal transitioned from the first power supply voltage to the second power supply voltage.

Abstract: A disposable flushing and suction drainage tube and a-using method thereof comprises a flushing tube, a suction tube, and a mounting base. The flushing tube and the suction tube are respectively mounted at one end of the mounting base, and an air connector and a water connector are mounted at the other end; the mounting base comprises a tube body base and a control base, the flushing tube and the suction tube are mounted at one end of the tube body base, and the other end is detachably connected to the control base. The disposable flushing and suction drainage tube controls suction for the suction tube by a negative pressure adjusting opening on the mounting base; opening, closing, and water flow of the flushing tube is controlled by a water control switch on the mounting base, and switching between flushing and drainage and the flow of drainage can be controlled.

Abstract: A refrigeration system, comprising an evaporator, a condenser, a throttling device, a compressor, an economizer and an ejector, these devices together form a closed-loop refrigerant circulation loop, the ejector being connected to the economizer, and the ejector being provided on an exhaust side of the compressor. The structure enables the refrigeration system to realize the dual-stage boost, does not affect the stability of the compressor due to the instability of the airflow of the ejector, and does not affect the oil property of the compressor, thereby ensuring the operation safety of the compressor.

Abstract: A polyester copolymer, having a number average molecular weight of equal to or more than 4000 gram/mole and having a glass transition temperature of less than 140° C., containing: (a) in the range from equal to or more than 45 mole % to equal to or less than 50 mole % of one or more bicyclic diol monomer units derived from the group consisting of isosorbide, isoidide, isomannide, 2,3:4,5-di-O-methylenegalactitol and 2,4:3,5-di-O-methylene-D-mannitol; (b) in the range from equal to or more than 25 mole % to equal to or less than 49.9 mole %, of an oxalate monomer unit; (c) in the range from equal to or more than 0.1 mole % to equal to or less than 25 mole % of one or more linear C3-C12 dicarboxylate monomer units; and (d) optionally equal to or more than 0 mole % to equal to or less than 5 mole % of one or more additional monomer units, the percentages based on the total amount of moles of monomer units within the polyester copolymer.

Abstract: This invention relates to the use of a nutritional composition comprising sialylated oligosaccharides for enhancing cognitive development and learning skills in mammals. The nutritional composition comprises 3?-Siallylactose (3?-SL) and 6?-Siallylactose (6?-SL) in a weight ratio between 10:1 and 1:10 and is specifically for use in enhancing learning skills and/or enhancing memory function in an individual by increasing the sialic acid (Neu5Ac) concentration in the brain of said individual.

Abstract: A device and a method for acquiring brain electrical signal. The device for acquiring brain electrical signal includes a plurality of electrodes and an electrode base. The electrode base is provided with a plurality of screw holes, and each of the plurality of electrodes passes through a corresponding screw hole of the plurality of screw holes.

Abstract: The fingerprint-based login method includes: waking up an operating system of a terminal device where a fingerprint sensor is disposed based on a detected non-press-type touch operation against the fingerprint sensor; controlling the fingerprint sensor to acquire fingerprint data based on a fingerprint data acquisition instruction sent by the waken-up operating system; storing the acquired fingerprint data to a designated security region in the terminal device by the waken-up operating system; and judging whether the fingerprint data stored in the designated security region matches fingerprint password data by the waken-up operating system upon detecting a press-type touch operation against the fingerprint sensor, such that a login operation is performed in the operating system if the stored fingerprint data matches the fingerprint password data, the problem that the fingerprint modules using the conventional MCUs failing to satisfy the requirements may not implement the system login function is effectively s

Abstract: Embodiments of the invention relate to concrete admixtures, provide a phosphonato block polymer, a preparation method and an application. The method includes: the phosphonato block polymer prepared by copolycondensating an ether-type segment A, a phosphonato segment B, and a third part of aldehyde C. The ether-type segment A is obtained by polycondensating a polyether monomer and a first part of aldehyde C. The phosphonato segment B is obtained by polycondensating a monomer b containing phosphonato, a monomer c, and a second part of aldehyde C in an aprotic weak polar solvent E. By preparing a block polymer using arylalkane as a main chain and using a phosphonic acid or phosphinic acid functional group as an adsorption group, the invention improves the resistance of the block polymer to sulfate and clay interference, and can achieve initial high dispersion of concrete with a low water-cement ratio and decreasing of the system viscosity.

Abstract: An atomizing device includes a housing, an end lid and a cover. The end lid is disposed at an end of the housing, and is hermitically connected with the housing. The cover is disposed to cover around the end lid. A first conducting groove is disposed to extend circumferentially at a selective one of an outer wall of the end lid and an inner wall of the cover. A second conducting groove is spatially communicated with the first conducting groove, and an included angle is formed between the first conducting groove and the second conducting groove. A sliding piece is disposed at the rest of the outer wall of the end lid and the inner wall of the cover to mate with the first conducting groove and the second conducting groove. The sliding piece is disposed to move in the first conducting groove and the second conducting groove.

Abstract: A multi-function handheld electric tool includes a motor housing receiving a motor, a settable clutch coupled with a speed reduction transmission, transmission housing coupled to the motor housing and having a first housing portion coupled to the motor housing, and a second housing portion extending from the first portion towards a chuck, and a setting collar which is rotatably fit over the second housing portion of the transmission housing and rotatable between a plurality of predetermined angular positions of which at least one corresponds to a non-torque limited first operation mode of the tool and the remaining positions correspond to different torque output levels of a torque limited second operation mode of the tool.

Abstract: A display panel and a fabrication method thereof, and a display apparatus are provided. The display panel includes: a base substrate, and a display region and a non-display region on the base substrate. The display region has a special shaped boundary, and includes: a plurality of display pixels and transition pixels; the transition pixels are provided between the display pixels and the special-shaped boundary; each of the display pixels and each of the transition pixels respectively include: a first electrode and a second electrode. An area of each of the first electrodes of the transition pixels is different from an area of each of the first electrodes of the display pixels; and/or, an area of each of the second electrodes of the transition pixels is different from an area of each of the second electrodes of the display pixel.

Abstract: The present invention discloses an opposite belt-type precise seeding device. The opposite belt-type precise seeding device comprises a seed metering tube consisting of a U-shaped shell and a cover plate, two conveying devices provided inside the seed metering tube in parallel, and a conveying plate provided at the lower end of the seed metering tube. The opposite belt-type precise seeding device belongs to the field of agricultural machinery. In a seeder, a tubular seed conveying tube is usually used for guiding movement of seeds, but the movement of the seeds in the seed conveying tube has certain randomness, so that the seed distance consistency of the seeds in a seed bed is reduced. Through control of the seeds by the conveying devices, the stable movement of the seeds is achieved and the seed distance consistency of the seeds in the seed bed is guaranteed.

Abstract: A modified T cell comprises: i) an exogenous Negative Regulatory Factor (Nef) protein; and ii) a functional exogenous receptor comprising: (a) an extracellular ligand binding domain, (b) a transmembrane domain, and (c) an intracellular signaling domain (ISD) comprising a chimeric signaling domain (CMSD), wherein the CMSD comprises one or a plurality of Immune-receptor Tyrosine-based Activation Motifs (ITAMs), wherein the plurality of CMSD ITAMs are optionally connected by one or more linkers. Provided are also Nef proteins (e.g., non-naturally occurring Nef), and modified T cells comprising such Nef proteins. Provided are methods of making and uses thereof.