Abstract: This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

Abstract: This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

Abstract: Described herein are compounds of Formula (I), Formula (I-A), and Formula (I-B), solvates thereof, tautomers thereof, and pharmaceutically acceptable salts of the foregoing, Further described herein are methods of inhibiting NLRP3 using said compounds, and methods of and compositions useful in treating NLRP3-dependent disorders.

Abstract: An information processing apparatus includes a reception unit that receives a progress condition of a group printing job constituted by plural printing jobs, and a presentation unit that presents the progress condition of the group printing job in accordance with an item for presenting the progress condition.

Abstract: A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are defined herein, are useful as inhibitors of one or more Janus kinases. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient are disclosed.

Abstract: Provided are a kit for detecting chronic rhinosinusitis with nasal polyps subtype, and the use of a CST1 gene as a biomarker and a method for detecting chronic rhinosinusitis with nasal polyps subtype. The CST1 gene, as a biomarker, can detect chronic rhinosinusitis with nasal polyps subtype or predict the sensitivity of a patient with chronic rhinosinusitis with nasal polyps to glucocorticoid. The detection method includes PCR using specific primers of the CST1 gene, such as real-time fluorescence quantitative PCR, so as to detect the expression amount of the CST1 gene.

Abstract: Mo doped AlCrSiN/Mo self-lubricating films and a preparation method thereof are provided. The AlCrSiN/Mo self-lubricating films are prepared by doping Mo element into the AlCrSiN films, and the Mo content in the resulted films is in the range of 0.3-6.3 at. %. The films are prepared on the substrates by high power impulse magnetron sputtering (HiPIMS) and pulsed DC magnetron sputtering hybrid coating technology. The prepared AlCrSiN/Mo self-lubricating films possess high hardness, good toughness, excellent antifriction characteristics and good chemical stability.

Abstract: The disclosure provides a catalyst system and a method for ethylene oligomerization using this. The catalyst system contains: ligand a, containing carbene groups of imidazole ring type; transition metal compound b, that is one of IVB˜VIII group metal compounds; activator c, that is a compound containing III A group metals; the ligand a contains at least one group as shown in general formula I: in which, bridging group A contains a main chain including alkyl, alkenyl, aryl groups or the combination of them and the first heteratom; E is a linear or cyclic group containing the second heteroatom; R is a hydrocarbyl group. The catalyst system is especially used for trimerization and tetramerization of ethylene. The catalyst system has high selectivity for 1-hexene and 1-octene, low selectivity for 1-butene and 1-C10+, and the total percent content of C6˜C8 linear ??-olefin in the product is more than 90% by mass.

Abstract: The present disclosure describes methods, systems, and devices adjusting multimedia playing progress. In one implementation, a method includes playing, by a terminal, a multimedia file; receiving, by the terminal, a user input indicating a fast-forward operation that is for a playing progress of the multimedia file and that is input by a user; obtaining, by the terminal, a fast-forward record of the multimedia file; and automatically adjusting, by the terminal, the playing progress of the multimedia file according to the fast-forward record.

Abstract: The present disclosure describes methods, systems, and devices adjusting multimedia playing progress. In one implementation, a method includes playing, by a terminal, a multimedia file; receiving, by the terminal, a user input indicating a fast-forward operation that is for a playing progress of the multimedia file and that is input by a user; obtaining, by the terminal, a fast-forward record of the multimedia file; and automatically adjusting, by the terminal, the playing progress of the multimedia file according to the fast-forward record.

Abstract: The present invention belongs to the field of environmental materials, and discloses a simulation method for analyzing a diffusion property of a water-soluble monomer in a hydrogel membrane. The method specifically includes the following steps: 1) selecting a hydrogel membrane material and a water-soluble monomer to be simulated; 2) constructing an initial model; 3) optimizing a molecular dynamics model of the hydrogel membrane system; 4) performing a molecular dynamics simulation of the optimized model; 5) drawing a mean square displacement-time (MSD-t) curve; and 6) calculating a diffusion coefficient of a water-soluble monomer molecule in the hydrogel membrane system. The present invention analyzes the diffusion performance of the water-soluble monomer molecule in the hydrogel membrane system on a molecular level.

Abstract: The present disclosure describes methods, systems, and devices adjusting multimedia playing progress. In one implementation, a method includes playing, by a terminal, a multimedia file; receiving, by the terminal, a user input indicating a fast-forward operation that is for a playing progress of the multimedia file and that is input by a user; obtaining, by the terminal, a fast-forward record of the multimedia file; and automatically adjusting, by the terminal, the playing progress of the multimedia file according to the fast-forward record.

Abstract: The present disclosure describes methods, systems, and devices adjusting multimedia playing progress. In one implementation, a method includes playing, by a terminal, a multimedia file; receiving, by the terminal, a user input indicating a fast-forward operation that is for a playing progress of the multimedia file and that is input by a user; obtaining, by the terminal, a fast-forward record of the multimedia file; and automatically adjusting, by the terminal, the playing progress of the multimedia file according to the fast-forward record.

Abstract: This application discloses a head region recognition method performed at a computing device. The method includes: acquiring an input image; processing the input image using n cascaded neural network layers to obtain n sets of candidate recognition results of a head region, each of the n neural network layers outputting one respective set of candidate recognition results, the neural network layer being used for recognizing the head region according to a preset extraction box, sizes of extraction boxes used by at least two of the neural network layers being different, and n being a positive integer and n?2; and aggregating the n sets of candidate recognition results to obtain a final recognition result of the head region in the input image. Therefore, head regions with different sizes in the input image can be recognized, thereby improving recognition accuracy.

Abstract: Disclosed are devices capable of heterogeneous electrochemical catalysis. Also disclosed are methods of using the devices in various electrochemical reactions.

Abstract: An energy storage system, including: a first switch and a first inductor connected in series and connected to a positive electrode of an external DC system; a pre-stage bidirectional buck-boost conversion circuit, the circuit including a first terminal, a second terminal, and a third terminal; a pre-charge circuit, a fourth switch, and a super-capacitor sequentially connected in series, two terminals of a series structure resulting therefrom being connected to the third terminal of the pre-stage bidirectional buck-boost conversion circuit and the negative electrode of the external DC system, respectively; a post-stage bidirectional buck-boost conversion circuit, the circuit including a first terminal, a second terminal, and a third terminal; and a battery, a second switch, and a second inductor connected in series.

Abstract: A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are defined herein, are useful as inhibitors of one or more Janus kinases. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient are disclosed.

Abstract: An automation component includes a display having addressable locations in an array for display of data, and control circuitry that is configured to control the display. In a first mode, the control circuitry controls illumination of one or more individual locations of the display in the array for conveying individual data corresponding to the individual locations. In a second mode, the control circuitry controls illumination of two or more individual locations in the array to display an amalgamated alphanumeric character.

Abstract: An information processing apparatus includes a reception unit that receives a progress condition of a group printing job constituted by plural printing jobs, and a presentation unit that presents the progress condition of the group printing job in accordance with an item for presenting the progress condition.

Abstract: The disclosure provides a catalyst system and a method for ethylene oligomerization using this. The catalyst system contains: ligand a, containing carbene groups of imidazole ring type; transition metal compound b, that is one of IVB˜VIII group metal compounds; activator c, that is a compound containing III A group metals; the ligand a contains at least one group as shown in general formula I: in which, bridging group A contains a main chain including alkyl, alkenyl, aryl groups or the combination of them and the first heteratom; E is a linear or cyclic group containing the second heteroatom; R is a hydrocarbyl group. The catalyst system is especially used for trimerization and tetramerization of ethylene. The catalyst system has high selectivity for 1-hexene and 1-octene, low selectivity for 1-butene and I-C10+, and the total percent content of C6˜C8 linear ??-olefin in the product is more than 90% by mass.