Patents by Inventor Birgit Bossenmaier

Birgit Bossenmaier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR DETERMINING THE ANTI-TUMOR EFFICACY OF MONOCLONAL ANTIBODIES
    Publication number: 20110165082
    Abstract: The present invention relates to a method for determining the anti-tumor efficacy of monoclonal antibodies in pre-clinical rodent testings and the use of said method for the reduction of side testings.
    Type: Application
    Filed: September 21, 2009
    Publication date: July 7, 2011
    Inventors: Birgit Bossenmaier, Valeria Lifke, Werner Scheuer
  • Methods for Identifying Tumors That are Responsive to Treatement With Anti-ErbB2 Antibodies
    Publication number: 20110117096
    Abstract: Tumors are identified as responsive to treatment with anti-HER2 antibodies by detecting the presence of a HER2/HER3 and/or HER2/HER1 protein complex or for HER2 phosphorylation in a sample of tumor cells. Patients suffering from a tumor comprising HER/2/HER1 and/or HER2/HER3 heterodimers and/or HER2 phosphorylation are treated with anti-HER2 antibodies, such as rhuMAb 2C4.
    Type: Application
    Filed: November 29, 2010
    Publication date: May 19, 2011
    Inventors: BIRGIT BOSSENMAIER, HANS-JOACHIM MÜLLER, HANS KOLL, MARK X. SLIWKOWSKI, STEPHEN MICHAEL KELSEY
  • Antibodies Against CDCP1 for the Treatment of Cancer
    Publication number: 20110070246
    Abstract: The present invention relates to antibodies against human CDCP1 binding to the same epitope as CUB4 (Deposition No. DSM ACC2551) for the treatment of cancer.
    Type: Application
    Filed: August 26, 2010
    Publication date: March 24, 2011
    Inventors: Birgit Bossenmaier, Georg Fertig, Hans-Willi Krell, Reiner Lammers, Alexander Lifke, Gerhard Niederfellner
  • Humanized Anti-CDCP1 Antibodies
    Publication number: 20110052582
    Abstract: The present invention relates to humanized antibodies against human CDCP1 (anti-CDCP1 antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
    Type: Application
    Filed: August 26, 2010
    Publication date: March 3, 2011
    Inventors: Johannes Auer, Birgit Bossenmaier, Guy Georges, Alexander Lifke, Ekkehard Moessner, Gerhard Niederfellner
  • Bispecific Anti ErbB1 / Anti c Met Antibodies
    Publication number: 20100254989
    Abstract: The present invention relates to bispecific antibodies against human ErbB-1 and against human c-Met, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
    Type: Application
    Filed: April 2, 2010
    Publication date: October 7, 2010
    Inventors: Birgit Bossenmaier, Ulrich Brinkmann, Christian Klein, Gerhard Niederfellner, Wolfgang Schaefer, Juergen Michael Schanzer, Claudio Sustmann, Pablo Umana
  • Bispecific Anti ErbB3 / Anti cMet Antibodies
    Publication number: 20100256339
    Abstract: The present invention relates to bispecific antibodies against human ErbB-3 and against human c-Met, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
    Type: Application
    Filed: April 1, 2010
    Publication date: October 7, 2010
    Inventors: Birgit Bossenmaier, Ulrich Brinkmann, Wilma Dormeyer, Eike Hoffmann, Christian Klein, Gerhard Niederfellner, Juergen Michael Schanzer, Jan Olaf Stracke, Claudio Sustmann, Pablo Umana
  • Bispecific Anti ErbB2 / Anti cMet Antibodies
    Publication number: 20100254988
    Abstract: The present invention relates to bispecific antibodies against human ErbB-2 and against human c-Met, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
    Type: Application
    Filed: April 2, 2010
    Publication date: October 7, 2010
    Inventors: Birgit Bossenmaier, Ulrich Brinkmann, Christian Klein, Gerhard Niederfellner, Wolfgang Schaefer, Juergen Michael Schanzer, Claudio Sustmann, Pablo Umana
  • Ether derivatives
    Patent number: 7432291
    Abstract: The present invention provides the compounds of formula (I) their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: March 17, 2005
    Date of Patent: October 7, 2008
    Assignee: Hoffman-La Roche Inc.
    Inventors: Birgit Bossenmaier, Walter-Gunar Friebe, Thomas Friess, Ulrike Reiff, Edgar Voss
  • Phenylpyridine derivatives
    Patent number: 7429605
    Abstract: The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing such compounds and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: August 1, 2006
    Date of Patent: September 30, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Birgit Bossenmaier, Thomas Friess, Rolf Juchem, Lothar Kling, Irene Kolm, Hans-Willi Krell, Thomas von Hirschheydt, Edgar Voss
  • Oxidized thioether derivatives
    Patent number: 7405231
    Abstract: The present invention provides the compounds of formula I their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: March 4, 2005
    Date of Patent: July 29, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Birgit Bossenmaier, Walter-Gunar Friebe, Thomas Friess, Lothar Kling, Matthias Rueth, Edgar Voss
  • Arylazole derivatives, their manufacture and use as pharmaceutical agents
    Patent number: 7259262
    Abstract: There are presented compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms thereof, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: October 15, 2004
    Date of Patent: August 21, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Birgit Bossenmaier, Walter-Gunar Friebe, Ulrike Reiff, Matthias Rueth, Edgar Voss
  • Oxazoles, their manufacture and use as pharmaceutical agents
    Patent number: 7247649
    Abstract: The present invention relates to novel oxazoles of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: August 3, 2004
    Date of Patent: July 24, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Birgit Bossenmaier, Walter-Gunar Friebe, Ulrike Reiff, Matthias Rueth, Edgar Voss
  • Pentafluorosulfanyl compounds
    Patent number: 7235574
    Abstract: The present invention provides the compounds of formula I-A their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: March 4, 2005
    Date of Patent: June 26, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Birgit Bossenmaier, Walter-Gunar Friebe, Guy Georges, Matthias Rueth, Edgar Voss
  • Oxazole derivatives
    Patent number: 7205325
    Abstract: The present invention 1 includes compounds of formula (I), and their pharmaceutically acceptable salts. These compounds are useful in the control or prevention of cancer.
    Type: Grant
    Filed: March 25, 2004
    Date of Patent: April 17, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Birgit Bossenmaier, Walter-Gunar Friebe, Thomas Friess, Bernhard Goller, Matthias Rueth, Edgar Voss
  • Aniline derivatives, their manufacture and use as pharmaceutical agents
    Patent number: 7205326
    Abstract: Compounds of formula (I) are useful in the therapy and/or prevention of illnesses with known over-expression of receptor tyrosine kinases of the HER-family like HER-2 and EGFR (HER-1). Accordingly, these compounds are useful for the treatment of diseases such as cancer in humans or animals.
    Type: Grant
    Filed: April 28, 2004
    Date of Patent: April 17, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Birgit Bossenmaier, Walter-Gunar Friebe, Ulrike Reiff, Matthias Rueth, Edgar Voss
  • Diazine derivatives
    Patent number: 7179812
    Abstract: The present invention provides compounds of formula (I): their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: March 31, 2005
    Date of Patent: February 20, 2007
    Assignee: Hoffmann-la Roche Inc.
    Inventors: Birgit Bossenmaier, Walter-Gunar Friebe, Wolfgang Jenni, Matthias Rueth, Edgar Voss
  • Phenylpyridine derivatives
    Publication number: 20070032530
    Abstract: The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing such compounds and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: August 1, 2006
    Publication date: February 8, 2007
    Inventors: Birgit Bossenmaier, Thomas Friess, Rolf Juchem, Lothar Kling, Irene Kolm, Hans-Willi Krell, Thomas von Hirschheydt, Edgar Voss
  • Benzylether derivatives
    Patent number: 7163953
    Abstract: Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: May 18, 2005
    Date of Patent: January 16, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Birgit Bossenmaier, Walter-Gunar Friebe, Thomas Friess, Christian Geletneky, Guy Georges, Irene Kolm, Edgar Voss
  • Amide derivatives
    Publication number: 20060116407
    Abstract: The present invention relates to the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: November 15, 2005
    Publication date: June 1, 2006
    Inventors: Birgit Bossenmaier, Walter-Gunar Friebe, Eike Hoffmann, Thomas von Hirschheydt, Edgar Voss
  • Thioether derivatives
    Patent number: 7005526
    Abstract: Objects of the present invention are the compounds of formula (I) formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: May 18, 2005
    Date of Patent: February 28, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Birgit Bossenmaier, Walter-Gunar Friebe, Thomas Friess, Lothar Kling, Ulrike Reiff, Edgar Voss