Patents by Inventor Bjarne Due Larsen

Bjarne Due Larsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antiarrhythmic peptides
    Patent number: 7250397
    Abstract: Disclosed are novel peptides including antiarrhythmic peptides that have improved stability. Further disclosed are compositions that include such peptides and methods of using the compositions particularly as medicaments.
    Type: Grant
    Filed: February 22, 2001
    Date of Patent: July 31, 2007
    Assignee: Zealand Pharma A/S
    Inventors: Bjarne Due Larsen, David Knott
  • Diuretic peptide conjugate
    Patent number: 7244701
    Abstract: Disclosed are a variety of peptide conjugates represented by the following general formula: R1-Z-X-Z?-R2 including methods of making and using such conjugates. Also provided are antibodies that specifically bind the peptide conjugates. The present invention has a wide spectrum of important applications including use in the treatment of disorders impacted by nociceptin and related opioid-like peptides.
    Type: Grant
    Filed: June 15, 2001
    Date of Patent: July 17, 2007
    Assignee: Zealand Phama A/S
    Inventors: Bjarne Due Larsen, Daniel R. Kapusta
  • Solid-phase peptide synthesis and agent for use in such synthesis
    Patent number: 7176282
    Abstract: The present invention relates to an improved process for the production of peptides by solid-phase synthesis. The invention also relates to agents, which are useful in solid-phase peptide synthesis.
    Type: Grant
    Filed: April 18, 2000
    Date of Patent: February 13, 2007
    Assignee: Zealand Pharma A/S
    Inventors: Arne Holm, Bjarne Due Larsen
  • Compositions and methods for modulating connexin hemichannels
    Patent number: 7153822
    Abstract: Disclosed are compositions and methods for modulating hemichannel function in a cell, tissue or organ. The invention also relates to useful screens for detecting such compounds, particularly those capable of modulating connexin phosphorylation. Further provided are therapeutic methods for preventing or treating conditions impacted by undesired hemichannel function in a mammal such as heart arrhythmia.
    Type: Grant
    Filed: January 29, 2003
    Date of Patent: December 26, 2006
    Assignee: Wyeth
    Inventors: Peter Holme Jensen, Bjarne Due Larsen, Lars Bo Laurenborg Hansen, Jørgen Søberg Petersen, Soren Neve, Morten Schak Nielsen, Eddi Meier, Eva Steiness
  • Compositions and methods for modulating guanylyl cyclase signaling receptor (gc-c) activity and for treating meniere's disease
    Publication number: 20040152868
    Abstract: Disclosed are compositions and methods for modulating guanylyl cyclase signaling receptor (GC-C). Further disclosed are highly useful in vitro and in vivo screens for detecting compounds that modulate the GC-C receptor. The invention has a wide spectrum of useful applications including providing therapeutic compounds that can be employed to prevent and/or treat inner ear disorders and particularly Ménière's disease.
    Type: Application
    Filed: March 29, 2004
    Publication date: August 5, 2004
    Inventors: Bjarne Due Larsen, Soren Neve, Klaus Ovortrup, Eddi Meier, Soberg J. Peterson
  • Novel peptide agonists of GLP-1 activity
    Publication number: 20040106547
    Abstract: Novel peptide agonists of GLP-1 activity useful for lowering blood glucose levels. The novel peptides comprise variants of the GLP-1 or the exendin-4 polypeptide sequence and are pharmacologically active and stable. These peptides are useful in the treatment of diseases that benefit from regulation of excess levels of blood glucose and/or regulation of gastric emptying, such as diabetes and eating disorders.
    Type: Application
    Filed: November 8, 2002
    Publication date: June 3, 2004
    Applicant: Zealand Pharma A/S
    Inventors: Bjarne Due Larsen, Jens Damsgaard Mikkelsen, Soren Neve
  • Compositions and methods for modulating connexin hemichannels
    Publication number: 20040092429
    Abstract: Disclosed are compositions and methods for modulating hemichannel function in a cell, tissue or organ. The invention also relates to useful screens for detecting such compounds, particularly those capable of modulating connexin phosphorylation. Further provided are therapeutic methods for preventing or treating conditions impacted by undesired hemichannel function in a mammal such as heart arrhythmia.
    Type: Application
    Filed: January 29, 2003
    Publication date: May 13, 2004
    Applicant: Zealand Pharma A/S
    Inventors: Peter Holme Jensen, Bjarne Due Larsen, Lars Bo Laurenborg Hansen, Jorgen Soberg Petersen, Soren Neve, Morten Schak Nielsen, Eddi Meier, Eva Steiness
  • Novel antiarrythmic peptides
    Publication number: 20030092609
    Abstract: Disclosed are novel peptides including antiarrhythmic peptides that have improved stability. Further disclosed are compositions that include such peptides and methods of using the compositions particularly as medicaments.
    Type: Application
    Filed: February 22, 2001
    Publication date: May 15, 2003
    Inventors: Bjarne Due Larsen, Jorgen Soberg Petersen, Eddi Meier, Anne Louise Kjolbye, Niklas Rye Jorgensen, Morten Schak Nielsen, James B. Martins, Niels-Henrik Holstein-Rathlou
  • Peptide agonists of GLP-1 activity
    Patent number: 6528486
    Abstract: The present invention relates to novel peptide conjugates which have increased stability and are useful in the treatment of excess levels of blood glucose.
    Type: Grant
    Filed: July 12, 2000
    Date of Patent: March 4, 2003
    Assignee: Zealand Pharma A/S
    Inventors: Bjarne Due Larsen, Jens Damsgaard Mikkelsen, Søren Neve
  • Novel peptide conjugates
    Publication number: 20030040472
    Abstract: Disclosed are a variety of peptide conjugates represented by the following general formula.
    Type: Application
    Filed: June 15, 2001
    Publication date: February 27, 2003
    Applicant: Zealand Pharmaceuticals A/S
    Inventors: Bjarne Due Larsen, Jorgen Soberg Petersen, Daniel R. Kapusta, Kenneth W. Harlow