Abstract: The invention relates to compounds of the general formula (I): 1

Abstract: Novel proteins obtainable by mutagenesis of surface-exposed amino acids of domains of natural bacterial receptors, said proteins being obtained without substantial loss of basic structure and stability of said natural bacterial receptors; proteins which have been selected from a protein library embodying a repertoire of said novel proteins; and methods for the manufacture of artificial bacterial receptor structures.

Abstract: Compounds of the general formula (I): wherein the variables are as defined in the specification are useful for the prophylaxis or treatment of serotonin-related, especially 5-HT2 receptor-related, diseases in human beings or animals, particularly diseases related to the 5-HT2c receptor, especially diseases such as eating disorders, memory disorders, schizophrenia, mood disorders, anxiety disorders, pain, sexual dysfunctionions, and urinary disorders.

Abstract: Substantially pure dimers of Apolipoprotein Al-Milano (Al-M/APO Al-M) isolated and characterized from plasma are provided. Pharmaceutical compositions comprising the Apo Al-M/Apo Al-M are also provided. Apolipoprotein Al-M dimer can be produced in a recombinant Escherichia coli system or collected from plasma from Apolipoprotein Al-Milano carriers. Atherosclerosis and cardiovascular diseases can be treated with the dimer. Medicaments containing the dimer can also be used for preventing thrombosis in different clinical circumstances, both at the arterial and at the venous level. The dimer can also act as a prodrug for the monomer.

Abstract: Novel proteins obtainable by mutagenesis of surface-exposed amino acids of domains of natural bacterial receptors, said proteins being obtained without substantial loss of basic structure and stability of said natural bacterial receptors; proteins which have been selected from a protein library embodying a repertoire of said novel proteins; and methods for the manufacture of artificial bacterial receptor structures.

Abstract: A method is provided for displaying prices of articles on display units adjacent to the location of the articles at a point of sale. The method is useful in operating a number of detached display units, which reproduce information, which is changeable by a wireless communication from a central computer or a portable terminal. A problem related to information systems of this type consists in easily and conveniently providing for assigning an identification code corresponding to a particular article to a display unit. According to the method described herein, this is achieved by a control unit, integrated within the display unit, and being able to be set by an external switch or signal, the control unit in such set state being arranged to receive and to store an identification code transmitted from the portable terminal.

Abstract: Processes for refolding of insulin-like growth factor (IGF) comprise contacting IGF in a reduced or misfolded form with insulin-like growth factor binding protein (IGF-BP), and recovering native IGF.

Abstract: A sensor system comprises a plurality of sensor stations of the same type for surveillance of an area intended to include an object to be protected, the sensor stations being distributed essentially along the periphery of a circle, in the central part of which an object to be protected is intended to be contained. Each sensor station includes a detector unit which is arranged to scan an arc in an azimuth sector of the circle allocated to it up towards the background of the sky in each of two detection fields formed along the arc having different elevation angles with respect to the detector unit. The time of the passage of a target between the two detection fields is measured, and the target position is calculated relative to the sensor station on the basis of the measured time, the speed of the target, the angle between the detection fields and the angle to the target.

Abstract: A process for preparing antibodies specific for an amino acid sequence which comprises immunizing a mammal with a fused protein comprising said amino acid sequence fused to an immunogenic IgG binding protein is disclosed.

Abstract: A process for expressing proteins in Gram(-) bacteria and providing for extracellular secretion thereof, comprising the steps: a) introducing into a Gram(-) bacterium a recombinant DNA construction comprising a promoter, a signal sequence enabling translocation and processing, and a structural gene encoding the desired protein to be expressed; b) cultivating the bacterium under conditions resulting in filamentous growth; and c) recovering the extracellularly secreted protein; a recombinant DNA construction comprising:a promoter, a signal sequence and a structural gene including a cleavage region,wherein the structural gene is of the formula:(E).sub.n (B).sub.m -Y,where n is an integer .gtoreq.

Abstract: A recombinant DNA fragment (Z) coding for an immunoglobulin G binding domain related to staphylococcal protein A. The methionine codon of the recombinant DNA fragment has been replaced with a codon of an amino acid residue other than methionine to enable expression of a methionine-free protein. The present invention is also directed to recombinant DNA sequence containing such recombinant DNAS fragment (Z) as well as a recombinant DNA molecule, plasmid vector and bacterial cell containing such recombinant DNAS fragment. Also disclosed is a process for cleaving a fused protein expressed in a biological system using said recombinant DNA fragment.