Patents by Inventor Bo Lu

Bo Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9276610
    Abstract: The architecture is able to switch to Non-blocking check-node-update (CNU) scheduling architecture which has better performance than blocking CNU scheduling architecture. The architecture uses an Offset Min-Sum with Beta=1 with a clock domain operating at 440 MHz. The constraint macro-matrix is a spare matrix where each “1’ corresponds to a sub-array of a cyclically shifted identity matrix which is a shifted version of an identity matrix. Four core processors are used in the layered architecture where the constraint matrix uses a sub-array of 42 (check nodes)×42 (variable nodes) in the macro-array of 168×672 bits. Pipeline processing is used where the delay for each layer only requires 4 clock cycles.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: March 1, 2016
    Assignee: Tensorcom, Inc.
    Inventors: Bo Xia, Ricky Lap Kei Cheung, Bo Lu
  • Patent number: 9248013
    Abstract: Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 ?m to 5 ?m thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be rough compared with the smooth front sides. The membranes can be used in vitro to grow monolayers of cells in a laboratory or in vivo as surgically implantable growth layers, such as to replace the Bruch's membrane in the eye. The application further provides an implantable cage-like apparatus for culturing cells comprising the parylene membrane.
    Type: Grant
    Filed: January 11, 2013
    Date of Patent: February 2, 2016
    Assignees: California Institute of Technology, University of Southern California
    Inventors: Yu-Chong Tai, Bo Lu, Mark Humayun
  • Publication number: 20160023239
    Abstract: In a method for forming nanopores, two opposing surfaces of a membrane are exposed to an electrically conducting liquid environment. A nanopore nucleation voltage pulse, having a first nucleation pulse amplitude and duration, is applied between the two membrane surfaces, through the liquid environment. After applying the nanopore nucleation voltage pulse, the electrical conductance of the membrane is measured and compared to a first prespecified electrical conductance. Then at least one additional nanopore nucleation voltage pulse is applied between the two membrane surfaces, through the liquid environment, if the measured electrical conductance is no greater than the first prespecified electrical conductance.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Applicant: President and Fellows of Harvard College
    Inventors: Jene A. Golovchenko, Bo Lu, Aaron T. Kuan
  • Publication number: 20150374443
    Abstract: A cranial alignment device for use in intracranial stereotactic radiotherapy includes a nosepiece that is custom shaped to mate with the dorsum and alae of the patient's nose.
    Type: Application
    Filed: June 26, 2014
    Publication date: December 31, 2015
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Kathryn Elizabeth Mittauer, Guanghua Yan, Richard Helmig, Chihray Liu, Bo Lu
  • Patent number: 9182387
    Abstract: The present invention provides a method for diagnosing cancer, predicting a disease outcome or response to therapy in a patient sample. The method involves isolating a circulating tumor cell (CTC), for example, a viable CTC, from a sample using a parylene microfilter device comprising a membrane filter having or consisting of a parylene substrate, which has an array of holes with a predetermined shape and size; and detecting and quantifying telomerase activity in blood circulating tumor cells. The invention further provides methods of using cells live-captured in various applications.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: November 10, 2015
    Assignee: California Institute of Technology
    Inventors: Amir Goldkorn, Yu-Chong Tai, Tong Xu, Bo Lu
  • Publication number: 20150293890
    Abstract: This disclosure discloses a method, device and system for webpage transcoding. The method comprises: obtaining a Hypertext Markup Language (HTML) document from a target website based on a client request; parsing the HTML document, and when it is detected that the HTML document contains picture information, notifying a picture processor and downloading individual sub-resources except for the picture information from the target website; transcoding the downloaded individual sub-resources, and sending them to the client after the completion of transcoding, wherein reserving a typesetting space for the picture information when transcoding; obtaining the picture information in the HTML document fed back by the picture processor, and transcoding the picture information and then sending it to the client.
    Type: Application
    Filed: August 16, 2013
    Publication date: October 15, 2015
    Inventors: Yuanjiang Zhou, Bo Lu
  • Publication number: 20150242365
    Abstract: A plurality of three bit units (called triplets) are permuted by a shuffler to shuffle the positions of the triplets into different patterns which are used to specific the read/write operation of a memory. For example, the least significant triplet in a conventional counter can be placed in the most significant position of a permuted three triplet pattern. The count of this permuted counter triplet generates addresses that jump 64 positions each clock cycle. These permutations can then be used to generate read and write control information to read from/write to memory banks conducive for efficient Radix-8 Butterfly operation. In addition, one or more triplets can also determine if a barrel shifter or right circular shift is required to shift data from one data lane to a second data lane. The triplets allow efficient FFT operation in a pipelined structure.
    Type: Application
    Filed: February 27, 2014
    Publication date: August 27, 2015
    Applicant: Tensoroom, Inc.
    Inventors: Bo Lu, Ricky Lap Kei Cheung, Bo Xia
  • Publication number: 20150214980
    Abstract: The architecture is able to switch to Non-blocking check-node-update (CNU) scheduling architecture which has better performance than blocking CNU scheduling architecture. The architecture uses an Offset Min-Sum with Beta=1 with a clock domain operating at 440 MHz. The constraint macro-matrix is a spare matrix where each “1’ corresponds to a sub-array of a cyclically shifted identity matrix which is a shifted version of an identity matrix. Four core processors are used in the layered architecture where the constraint matrix uses a sub-array of 42 (check nodes)×42 (variable nodes) in the macro-array of 168×672 bits. Pipeline processing is used where the delay for each layer only requires 4 clock cycles.
    Type: Application
    Filed: January 27, 2014
    Publication date: July 30, 2015
    Applicant: Tensorcom, Inc.
    Inventors: Bo Xia, Ricky Lap Kei Cheung, Bo Lu
  • Publication number: 20150147810
    Abstract: Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 ?m to 5 ?m thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be rough compared with the smooth front sides. The membranes can be used in vitro to grow monolayers of cells in a laboratory or in vivo as surgically implantable growth layers, such as to replace the Bruch's membrane in the eye. The thin regions of parylene are semipermeable to allow for proteins in serum to pass through, and the thick regions give mechanical support for handling by a surgeon. The smooth front side allows for monolayer cell growth, and the rough back side helps prevents cells from attaching there.
    Type: Application
    Filed: September 26, 2014
    Publication date: May 28, 2015
    Inventors: Yu-Chong Tai, Bo Lu, Mark Humayun
  • Publication number: 20150126796
    Abstract: A patient safety system (PSS) (100) uses optical tracking in a linear accelerator treatment room to prevent gross setup errors. A patient (150) undergoes a computed tomography (CT) treatment-simulation scan while a CT ball bearing (BB) is on patient's surface. The CT BB is replaced with an infrared reflective marker (IRRM) (160) before radiotherapy treatment starts. Coordinates of the CT BB relative to an isocenter of the treatment room are used as reference for tracking. The coordinate system of an optical tracking system is converted to a coordinate system of the treatment room. The PSS evaluates setup accuracy for a radiotherapy session by comparing real-time position of the single IRRM determined by the optical tracking technology with a predicted reference position, and displays results on a graphical user interface. The PSS stops radiation when a deviation between real-time coordinates and predicted coordinates of the IRRM (160) exceeds a predefined threshold.
    Type: Application
    Filed: April 12, 2013
    Publication date: May 7, 2015
    Applicant: University of Florida Research Foundation, Inc.
    Inventors: Guanghua Yan, Bo Lu, Chihray Liu, Jonathan G. Li
  • Patent number: 9006491
    Abstract: The current invention relates to the structure, synthesis of dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine or its tetrafluoroborate, as well as its applications in the palladium catalyzed carbon-chlorine bond activation for Suzuki coupling reactions and carbon-nitrogen bond formation reactions. The dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine or its tetrafluoroborate could coordinate with the palladium catalyst to activate the inert carbon-chlorine bond highly selectively and catalyze Suzuki coupling reaction with arylboronic acid or carbon-nitrogen bond formation reaction with organic amines. The current invention uses only one step to synthesize dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine and its tetrafluoroborate is stable in the air. Compared with known synthetic routes of ligands used in activating carbon-chlorine bonds, the method of current invention is short, easy to operate.
    Type: Grant
    Filed: December 21, 2009
    Date of Patent: April 14, 2015
    Assignee: Zhejiang University
    Inventors: Shengming Ma, Bo Lü, Chunling Fu
  • Publication number: 20150085072
    Abstract: An ambiguity-free optical tracking system (100) includes a position sensor unit (104), a control box (106), a computer (110) and software. The position sensor unit includes two cameras (121 and 122) that track a plurality of individual infra-red reflecting markers (160) affixed on a patient's skin. Coordinates of the cameras in a coordinate system of the cameras are determined as part of a system calibration process by intentionally creating ambiguous markers with two true markers. Using this information, an ambiguity elimination algorithm automatically identifies and eliminates ambiguous markers. A recursive backtracking algorithm builds a one-to-one correspondence between reference markers and markers optically observed during treatment. By utilizing a concept of null markers, the backtracking algorithm deals with missing, misplaced and occluded markers.
    Type: Application
    Filed: April 12, 2013
    Publication date: March 26, 2015
    Inventors: Guanghua Yan, Bo Lu, Chihray Liu, Jonathan G. Li
  • Publication number: 20150060276
    Abstract: There is provided a nanopore system including a nanopore in a solid state membrane. A first reservoir is in fluidic connection with the nanopore, the first reservoir being configured to provide, to the nanopore, nucleic acid molecules in an electrolytic solution. A second reservoir is in fluidic connection with the nanopore, with the nanopore membrane separating the first and second reservoirs. A pressure source is connected to the first reservoir to apply an external pressure to the first reservoir to cause nanopore translocation of nucleic acid molecules in the solution in the first reservoir. A voltage source is connected between the second and first reservoirs, across the nanopore, with a voltage bias polarity that applies an electric field counter to the externally applied pressure. Force of the externally applied pressure is greater than force of the electric field during nanopore translocation by the nucleic acid molecules.
    Type: Application
    Filed: September 12, 2014
    Publication date: March 5, 2015
    Applicants: PEKING UNIVERSITY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Jene A. Golovchenko, Bo Lu, David P. Hoogerheide, Dapeng Yu, Qing Zhao
  • Publication number: 20150060277
    Abstract: There is provided a nanopore system including a nanopore in a support structure. A first reservoir is in fluidic connection with the nanopore and a second reservoir is in fluidic connection with the nanopore. The support structure separates the first and second reservoirs. A pressure source is connected to one of the first and second reservoirs to apply an external pressure to one of the first and second reservoirs. A voltage source is connected between the first and second reservoirs to apply a voltage bias between the first and second reservoirs, across the nanopore. This system enables a method for analysis of species in solution, wherein there is provided to the nanopore a fluidic solution that includes a species for translocation through the nanopore, with an external pressure applied to the species in fluidic solution and a voltage bias applied across the nanopore.
    Type: Application
    Filed: September 12, 2014
    Publication date: March 5, 2015
    Applicants: PEKING UNIVERSITY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Jene A. Golovchenko, Bo Lu, David P. Hoogerheide, Dapeng Yu, Qing Zhao
  • Publication number: 20150058986
    Abstract: Disclosed are a method, device, and system for implementing network access, and a network system. The method comprises: in the case that a terminal requests to access a webpage, a server determining content of the webpage that the terminal requests to access; and the server searching for a webpage, used as a reference webpage, with relevant content matching the content of the webpage, and providing information of the found reference webpage for the terminal. The present invention can enable a user terminal to obtain multiple associated access results by performing webpage access once.
    Type: Application
    Filed: March 19, 2013
    Publication date: February 26, 2015
    Inventors: Gang Zhao, Bo Lu, Yuanjiang Zhou
  • Patent number: 8899531
    Abstract: A clamping device includes a first clamping member, a second clamping member, and a connecting arrangement providing on the first clamping member and the second clamping member. The connecting arrangement is configured to exert a clamping force between the first clamping member and the second clamping member, in such a manner that when the electrical cable slightly deforms due to thermal expansion and contraction, the first clamping member and the second clamping member are arranged to move with respect to each other so as to allow a slight relative movement between the first clamping member and the second clamping member for preventing unwanted damage to the electrical cable.
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: December 2, 2014
    Inventor: Bo Lu
  • Patent number: 8877489
    Abstract: Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 ?m to 5 ?m thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be rough compared with the smooth front sides. The membranes can be used in vitro to grow monolayers of cells in a laboratory or in vivo as surgically implantable growth layers, such as to replace the Bruch's membrane in the eye. The thin regions of parylene are semipermeable to allow for proteins in serum to pass through, and the thick regions give mechanical support for handling by a surgeon. The smooth front side allows for monolayer cell growth, and the rough back side helps prevents cells from attaching there.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: November 4, 2014
    Assignees: California Institute of Technology, University of Southern California
    Inventors: Yu-Chong Tai, Bo Lu, Mark Humayun
  • Patent number: 8815092
    Abstract: A microfiltration apparatus and method for separating cells, such as circulating tumor cells, from a sample using a microfiltration device having a top porous membrane and a bottom porous membrane. The porous membranes are formed from parylene and assembled using microfabrication techniques. The porous membranes are arranged so that the pores in the top membrane are offset from the pores in the bottom membrane.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: August 26, 2014
    Assignees: California Institute of Technology, University of Southern California
    Inventors: Siyang Zheng, Richard Cote, Henry Lin, Bo Lu, Yu-Chong Tai
  • Publication number: 20140158838
    Abstract: A clamping device includes a first clamping member, a second clamping member, and a connecting arrangement providing on the first clamping member and the second clamping member. The connecting arrangement is configured to exert a clamping force between the first clamping member and the second clamping member, in such a manner that when the electrical cable slightly deforms due to thermal expansion and contraction, the first clamping member and the second clamping member are arranged to move with respect to each other so as to allow a slight relative movement between the first clamping member and the second clamping member for preventing unwanted damage to the electrical cable.
    Type: Application
    Filed: August 15, 2013
    Publication date: June 12, 2014
    Inventor: Bo LU
  • Publication number: 20140038271
    Abstract: The present invention provides a method for diagnosing cancer, predicting a disease outcome or response to therapy in a patient sample. The method involves isolating a circulating tumor cell (CTC), for example, a viable CTC, from a sample using a parylene microfilter device comprising a membrane filter having or consisting of a parylene substrate, which has an array of holes with a predetermined shape and size; and detecting and quantifying telomerase activity in blood circulating tumor cells. The invention further provides methods of using cells live-captured in various applications.
    Type: Application
    Filed: September 6, 2013
    Publication date: February 6, 2014
    Applicants: University of Southern California, California Institute of Technology
    Inventors: Amir Goldkorn, Yu-Chong Tai, Tong Xu, Bo Lu