Abstract: A desk platform structure for a fitness bike, including a desk platform, a desk platform fixing and sliding mechanism and a supporting rod is provided. The desk platform fixing and sliding mechanism includes a pair of fixing bars, a pair of sliding rails, and a fixing rack. The desk platform is installed on the fixing bars which are installed on the sliding rails. The sliding rails are fixed on guiding bars at two sides of the fixing rack which is connected to the supporting rod. A braking mechanism and a control mechanism for sliding and positioning of the fixing bar are disposed between the fixing bar and the fixing rack. Accordingly, the desk platform is more stable and reliable, and may slide and be positioned at any location. It is convenient to use the desk platform by further adjusting the inclination angle of the desk platform.

Abstract: Down-regulating autoimmune regulator (AIRE) function in B cells to produce antibodies is described. The antibodies can be class-switched, high affinity, and neutralizing, and have a high degree of somatic hypermutations, even in the framework region, as compared to antibodies produced in the absence of AIRE downregulation.