Patents by Inventor Bo-Ragnar Tolf

Bo-Ragnar Tolf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetrahydroquinoline analogues as muscarinic agonists
    Patent number: 9522906
    Abstract: The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with a muscarinic receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: December 20, 2016
    Assignee: ACADIA PHARMACEUTICALS, INC.
    Inventors: Niels Skjaerbaek, Kristian Norup Koch, Bo Lennart Mikael Friberg, Bo-Ragnar Tolf
  • TETRAHYDROQUINOLINE ANALOGUES AS MUSCARINIC AGONISTS
    Publication number: 20140221364
    Abstract: The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with a muscarinic receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.
    Type: Application
    Filed: February 5, 2014
    Publication date: August 7, 2014
    Applicant: ACADIA PHARMACEUTICALS, INC.
    Inventors: NIELS SKJAERBAEK, KRISTIAN NORUP KOCH, BO LENNART MIKAEL FRIBERG, BO-RAGNAR TOLF
  • Tetrahydroquinoline analogues as muscarinic agonists
    Patent number: 8680115
    Abstract: The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with a muscarinic receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: March 25, 2014
    Assignee: Acadia Pharmaceuticals, Inc.
    Inventors: Niels Skjaerback, Kristian Norup Koch, Bo Lennart Mikael Friberg, Bo-Ragnar Tolf
  • Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy) phenylmethyl)carbamide and its tartrate salt and crystalline forms
    Patent number: 8236960
    Abstract: Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl) -N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2 -methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
    Type: Grant
    Filed: April 6, 2011
    Date of Patent: August 7, 2012
    Assignee: ACADIA Pharmaceuticals Inc.
    Inventors: Mikkel Boas Thygesen, Nathalie Schlienger, Bo-Ragnar Tolf, Carl-Magnus A. Andersson, Fritz Blatter, Jörg Berghausen
  • Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy) phenylmethyl)carbamide and its Tartrate Salt and Crystalline Forms
    Publication number: 20110184179
    Abstract: Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
    Type: Application
    Filed: April 6, 2011
    Publication date: July 28, 2011
    Inventors: Mikkel Boas THYGESEN, Nathalie Schlienger, Bo-Ragnar Tolf, Carl-Magnus A. Andersson, Fritz Blatter, Jörg Berghausen
  • Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy) phenylmethyl)carbamide and its tartrate salt and crystalline forms
    Patent number: 7923564
    Abstract: Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
    Type: Grant
    Filed: June 7, 2010
    Date of Patent: April 12, 2011
    Assignee: ACADIA Pharmaceuticals, Inc.
    Inventors: Mikkel Boas Thygesen, Nathalie Schlienger, Bo-Ragnar Tolf, Carl-Magnus A. Andersson, Fritz Blatter, Jörg Berghausen
  • Salts of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-y1)-N?-(4-(2-methylpropyloxy)phenylmethyl)carbamide and their preparation
    Patent number: 7868176
    Abstract: Disclosed herein are salts of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy) phenylmethyl)carbamide including the citrate, fumarate, maleate, malate, phosphate, succinate, sulphate, and edisylate salts.
    Type: Grant
    Filed: September 26, 2005
    Date of Patent: January 11, 2011
    Assignee: ACADIA Pharmaceuticals, Inc.
    Inventors: Mikkel Boas Thygesen, Nathalie Schlienger, Bo-Ragnar Tolf, Fritz Blatter, Jörg Berghausen
  • Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy) phenylmethyl)carbamide and its Tartrate Salt and Crystalline Forms
    Publication number: 20100305329
    Abstract: Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
    Type: Application
    Filed: June 7, 2010
    Publication date: December 2, 2010
    Inventors: Mikkel Boas THYGESEN, Nathalie Schlienger, Bo-Ragnar Tolf, Carl-Magnus A. Andersson, Fritz Blatter, Jorg Berghausen
  • Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
    Patent number: 7790899
    Abstract: Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
    Type: Grant
    Filed: May 15, 2007
    Date of Patent: September 7, 2010
    Assignee: ACADIA Pharmaceuticals, Inc.
    Inventors: Bo-Ragnar Tolf, Nathalie Schlienger, Mikkel Boas Thygesen
  • BENZIMIDAZOLIDINONE DERIVATIVES AS MUSCARINIC AGENTS
    Publication number: 20100216840
    Abstract: Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the same, as well as methods of treating psychosis using these compounds are disclosed.
    Type: Application
    Filed: May 7, 2010
    Publication date: August 26, 2010
    Applicant: ACADIA PHARMACEUTICALS INC.
    Inventors: NICHOLAS MICHAEL KELLY, KRISTIAN NORUP KOCH, BO-RAGNAR TOLF
  • N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
    Patent number: 7732615
    Abstract: Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2 -methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
    Type: Grant
    Filed: September 26, 2005
    Date of Patent: June 8, 2010
    Assignee: ACADIA Pharmaceuticals Inc.
    Inventors: Mikkel Boas Thygesen, Nathalie Schlienger, Bo-Ragnar Tolf, Carl-Magnus A. Andersson, Fritz Blatter, Jörg Berghausen
  • TETRAHYDROQUINOLINE ANALOGUES AS MUSCARINIC AGONISTS
    Publication number: 20090239903
    Abstract: The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with a muscarinic receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.
    Type: Application
    Filed: May 27, 2009
    Publication date: September 24, 2009
    Applicant: ACADIA PHARMACEUTICALS, INC.
    Inventors: Niels Skjaerback, Kristian Norup Koch, Bo Lennart Mikael Friberg, Bo-Ragnar Tolf
  • Tetrahydroquinoline analogues as muscarinic agonists
    Patent number: 7576078
    Abstract: The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with a muscarinic receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: August 18, 2009
    Assignee: Acadia Pharmaceuticals, Inc.
    Inventors: Niels Skjaerbaek, Kristian Norup Koch, Bo Lennart Mikael Friberg, Bo-Ragnar Tolf
  • Muscarinic agonists
    Patent number: 7576100
    Abstract: The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with a muscarinic receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: August 18, 2009
    Assignee: Acadia Pharmaceuticals, Inc.
    Inventors: Niels Skjaerbaek, Kristian Norup Koch, Bo Lennart Mikael Friberg, Bo-Ragnar Tolf
  • Tetrahydroquinoline analogues as muscarinic agonists
    Patent number: 7550459
    Abstract: The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with a muscarinic receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.
    Type: Grant
    Filed: December 21, 2004
    Date of Patent: June 23, 2009
    Assignee: Acadia Pharmaceuticals, Inc.
    Inventors: Niels Skjaerbaek, Kristian Norup Koch, Bo Lennart Mikael Friberg, Bo-Ragnar Tolf
  • BENZIMIDAZOLIDINONE DERIVATIVES AS MUSCARINIC AGENTS
    Publication number: 20080070948
    Abstract: Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the same, as well as methods of treating psychosis using these compounds are disclosed.
    Type: Application
    Filed: November 27, 2007
    Publication date: March 20, 2008
    Applicant: ACADIA Pharmaceuticals Inc.
    Inventors: Nicholas Kelly, Kristian Koch, Bo-Ragnar Tolf
  • BENZIMIDAZOLIDINONE DERIVATIVES AS MUSCARINIC AGENTS
    Publication number: 20080009520
    Abstract: Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the same, as well as methods of treating psychosis using these compounds are disclosed.
    Type: Application
    Filed: September 20, 2007
    Publication date: January 10, 2008
    Applicant: ACADIA Pharmaceuticals Inc.
    Inventors: Nicholas Kelly, Kristian Koch, Bo-Ragnar Tolf
  • Tetrahydroquinoline analogues as muscarinic agonists
    Patent number: 7307075
    Abstract: The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with a muscarinic receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.
    Type: Grant
    Filed: December 23, 2002
    Date of Patent: December 11, 2007
    Assignee: ACADIA Pharmaceuticals Inc.
    Inventors: Niels Skjaerbaek, Kristian Norup Koch, Bo Lennart Mikael Friberg, Bo-Ragnar Tolf
  • Benzimidazolidinone derivatives as muscarinic agents
    Patent number: 7300928
    Abstract: Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the same, as well as methods of treating psychosis using these compounds are disclosed.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: November 27, 2007
    Assignee: Acadia Pharmaceuticals, Inc.
    Inventors: Nicholas Michael Kelly, Kristian Norup Koch, Bo-Ragnar Tolf
  • PHARMACEUTICAL FORMULATIONS OF PIMAVANSERIN
    Publication number: 20070264330
    Abstract: Disclosed herein are stable pharmaceutical formulations of pimavanserin, which is useful for treating conditions associated with serotonin receptors.
    Type: Application
    Filed: May 15, 2007
    Publication date: November 15, 2007
    Inventors: Bo Ragnar-Tolf, Nathalie Schlienger, Mikkel Thygesen