Patents by Inventor Bo-Ragnar Tolf

Bo-Ragnar Tolf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYNTHESIS OF N-(4-FLUOROBENZYL)-N-(1-METHYLPIPERIDIN-4-YL)-N'-(4-(2-METHYLPROPYLOXY)PHENYLMETHYL)CARBAMIDE AND ITS TARTRATE SALT AND CRYSTALLINE FORMS
    Publication number: 20070260064
    Abstract: Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
    Type: Application
    Filed: May 15, 2007
    Publication date: November 8, 2007
    Inventors: Bo-Ragnar Tolf, Nathalie Schlienger, Mikkel Thygesen
  • Benzimidazolidinone derivatives as muscarinic agents
    Patent number: 7291611
    Abstract: Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the same, as well as methods of treating psychosis using these compounds are disclosed.
    Type: Grant
    Filed: July 21, 2005
    Date of Patent: November 6, 2007
    Assignee: ACADIA Pharmaceuticals Inc.
    Inventors: Nicholas Michael Kelly, Kristian Norup Koch, Bo-Ragnar Tolf
  • Benzimidazolidinone derivatives as muscarinic agents
    Patent number: 7273857
    Abstract: Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the same, as well as methods of treating psychosis using these compounds are disclosed.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: September 25, 2007
    Assignee: ACADIA Pharmaceuticals Inc.
    Inventors: Nicholas Michael Kelly, Kristian Norup Koch, Bo-Ragnar Tolf
  • Benzimidazolidinone derivatives as muscarinic agents
    Publication number: 20060258707
    Abstract: Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the same, as well as methods of treating psychosis using these compounds are disclosed.
    Type: Application
    Filed: July 19, 2006
    Publication date: November 16, 2006
    Inventors: Nicholas Kelly, Kristian Koch, Bo-Ragnar Tolf
  • Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
    Publication number: 20060205780
    Abstract: Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
    Type: Application
    Filed: May 3, 2006
    Publication date: September 14, 2006
    Inventors: Mikkel Thygesen, Nathalie Schlienger, Bo-Ragnar Tolf, Carl-Magnus Andersson, Fritz Blatter, Jorg Berghausen
  • Method of synthesis and isolation of solid N-desmethylclozapine and crystalline forms thereof
    Publication number: 20060205714
    Abstract: Disclosed herein are crystalline Forms A, B, C, D, and E of N-desmethylclozapine, methods of preparing the same, pharmaceutical compositions comprising the same, and methods of therapeutic treatment involving N-desmethylclozapine polymorphic forms.
    Type: Application
    Filed: May 3, 2006
    Publication date: September 14, 2006
    Inventors: Bo-Ragnar Tolf, Mikkel Thygesen, Fritz Blatter, Jorg Berghausen
  • Benzimidazolidinone derivatives as muscarinic agents
    Publication number: 20060205785
    Abstract: Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the same, as well as methods of treating psychosis using these compounds are disclosed.
    Type: Application
    Filed: May 3, 2006
    Publication date: September 14, 2006
    Inventors: Nicholas Kelly, Kristian Koch, Bo-Ragnar Tolf
  • Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
    Publication number: 20060205781
    Abstract: Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
    Type: Application
    Filed: May 3, 2006
    Publication date: September 14, 2006
    Inventors: Mikkel Thygesen, Nathalie Schlienger, Bo-Ragnar Tolf, Carl-Magnus Andersson, Fritz Blatter, Jorg Berghausen
  • Method of synthesis and isolation of solid N-desmethylclozapine and crystalline forms thereof
    Publication number: 20060199808
    Abstract: Disclosed herein are crystalline Forms A, B, C, D, and E of N-desmethylclozapine, methods of preparing the same, pharmaceutical compositions comprising the same, and methods of therapeutic treatment involving N-desmethylclozapine polymorphic forms.
    Type: Application
    Filed: May 3, 2006
    Publication date: September 7, 2006
    Inventors: Bo-Ragnar Tolf, Mikkel Thygesen, Fritz Blatter, Jorg Berghausen
  • Tetrahydroquinoline analogues as muscarinic agonists
    Publication number: 20060199813
    Abstract: The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with a muscarinic receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.
    Type: Application
    Filed: May 3, 2006
    Publication date: September 7, 2006
    Inventors: Niels Skiaerbaek, Kristian Koch, Bo Lennart Friberg, Bo-Ragnar Tolf
  • Muscarinic agonists
    Publication number: 20060199810
    Abstract: The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with a muscarinic receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.
    Type: Application
    Filed: May 3, 2006
    Publication date: September 7, 2006
    Inventors: Niels Skjaerbaek, Kristian Koch, Bo Lennart Friberg, Bo-Ragnar Tolf
  • Benzimidazolidinone derivatives as muscarinic agents
    Publication number: 20060199799
    Abstract: Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the same, as well as methods of treating psychosis using these compounds are disclosed.
    Type: Application
    Filed: May 3, 2006
    Publication date: September 7, 2006
    Inventors: Nicholas Kelly, Kristian Koch, Bo-Ragnar Tolf
  • Benzimidazolidinone derivatives as muscarinic agents
    Patent number: 7087593
    Abstract: Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the same, as well as methods of treating psychosis using these compounds are disclosed.
    Type: Grant
    Filed: September 30, 2002
    Date of Patent: August 8, 2006
    Assignee: ACADIA Pharmaceuticals Inc.
    Inventors: Nicholas Michael Kelly, Kristian Norup Koch, Bo-Ragnar Tolf
  • Salts of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and their preparation
    Publication number: 20060111399
    Abstract: Disclosed herein are salts of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)phenylmethyl)carbamide including the citrate, fumarate, maleate, malate, phosphate, succinate, sulphate, and edisylate salts.
    Type: Application
    Filed: September 26, 2005
    Publication date: May 25, 2006
    Inventors: Mikkel Thygesen, Nathalie Schlienger, Bo-Ragnar Tolf, Fritz Blatter, Jorg Berghausen
  • Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
    Publication number: 20060106063
    Abstract: Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
    Type: Application
    Filed: September 26, 2005
    Publication date: May 18, 2006
    Inventors: Mikkel Thygesen, Nathalie Schlienger, Bo-Ragnar Tolf, Carl-Magnus Andersson, Fritz Blatter, Jorg Berghausen
  • Benzimidazolidinone derivatives as muscarinic agents
    Publication number: 20060025402
    Abstract: Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the same, as well as methods of treating psychosis using these compounds are disclosed.
    Type: Application
    Filed: July 21, 2005
    Publication date: February 2, 2006
    Inventors: Nicholas Kelly, Kristian Koch, Bo-Ragnar Tolf
  • Method of synthesis and isolation of solid N-desmethylclozapine and crystalline forms thereof
    Publication number: 20050282800
    Abstract: Disclosed herein are crystalline Forms A, B, C, D, and E of N-desmethylclozapine, methods of preparing the same, pharmaceutical compositions comprising the same, and methods of therapeutic treatment involving N-desmethylclozapine polymorphic forms.
    Type: Application
    Filed: March 31, 2005
    Publication date: December 22, 2005
    Inventors: Bo-Ragnar Tolf, Mikkel Thygesen, Fritz Blatter, Jörg Berghausen
  • Benzimidazolidinone derivatives as muscarinic agents
    Patent number: 6951849
    Abstract: Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the same, as well as methods of treating psychosis using these compounds are disclosed.
    Type: Grant
    Filed: April 3, 2003
    Date of Patent: October 4, 2005
    Assignee: ACADIA Pharmaceuticals Inc.
    Inventors: Nicholas Michael Kelly, Kristian Norup Koch, Bo-Ragnar Tolf
  • Tetrahydroquinoline analogues as muscarinic agonists
    Publication number: 20050209226
    Abstract: The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with a muscarinic receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.
    Type: Application
    Filed: December 21, 2004
    Publication date: September 22, 2005
    Inventors: Niels Skjaerbaek, Kristian Koch, Bo Mikael Friberg, Bo-Ragnar Tolf
  • Benzimidazolidinone derivatives as muscarinic agents
    Publication number: 20040067931
    Abstract: Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the same, as well as methods of treating psychosis using these compounds are disclosed.
    Type: Application
    Filed: April 3, 2003
    Publication date: April 8, 2004
    Inventors: Nicholas Michael Kelly, Kristian Norup Koch, Bo-Ragnar Tolf