Abstract: A modified immune effector cell may be one in which the functions of a T cell antigen receptor (TCR) and major histocompatibility complexes (MHCI, MHCII) in the modified immune effector cell are inhibited in a T cell. Such a modified immune effector cell may include a chimeric antigen receptor (CAR) targeting GD2. Such a modified immune effector cell may knock out TCR and HLA-A genes expressed by the cell while recognizing surface antigens of tumor cells, so that multiple effects of improving the anti-tumor effect of CAR-T cells, prolonging the survival time of the cells, and reducing the immune rejection response caused by allogeneic cell therapy may be reduced.

Abstract: The present disclosure discloses a preparation method of an aluminum nitride (AlN) composite structure based on a two-dimensional (2D) crystal transition layer. The preparation method of the present disclosure includes: transferring the 2D crystal transition layer on a first periodic groove of an epitaxial substrate; forming a second periodic groove staggered with the first periodic groove on the 2D crystal transition layer; depositing a supporting protective layer; depositing a functional layer of a required AlN-based material; and removing the 2D crystal transition layer through thermal oxidation to obtain a semi-suspended AlN composite structure. The preparation method of the present disclosure has low difficulty and is suitable for large-scale industrial production.

Abstract: This application relates to solid forms and salt forms of the PD-1/PD-L1 inhibitor 4,4?-(((((2,2?-dichloro-[1,1?-biphenyl]-3,3?-diyl)bis(azanediyl))bis(carbonyl))bis(1-methyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-2,5-diyl))bis(ethane-2,1-diyl))bis(bicyclo[2.2.1]heptane-1-carboxylic acid), including processes of preparation thereof, where the solid forms and salt forms are useful in the treatment of various diseases including infectious diseases and cancer.

Abstract: Soybean plants producing soybean seeds comprising leghemoglobin are produced by modifying the genome of the soybean plant. Soybean plants, soybean seeds and soy protein compositions comprising leghemoglobin are provided. Soybean plants, soybean seeds and soy protein compositions comprising leghemoglobin and additionally one or more of high oleic acid, low linolenic acid, high protein, low stachyose, low raffinose and low protease inhibitors are provided. Protein compositions comprising leghemoglobin, such as soy isolates and concentrates can be made from the soybean seeds. Additionally, methods for generating and using plants, seeds and protein compositions comprising leghemoglobin are disclosed.

Abstract: The present disclosure relates to a magnetic circuit of a loudspeaker and a loudspeaker, which can improve the non-linearity of magnetic permeability, thereby reducing the distortion of the loudspeaker. A magnetic circuit comprises a T-yoke with a base and a columnar portion protruding upward from the base, a magnetic steel arranged on the base, and a front sheet arranged on the magnetic steel, wherein the magnetic steel and the front sheet are arranged around a periphery of the columnar portion, and a short-circuit ring is arranged on an inner side of the magnetic steel and/or the front sheet. A first short-circuit ring is provided between the inner wall of the magnetic steel and the outer wall of the columnar portion, and a second short-circuit ring is provided on the inner wall of the front sheet.

Abstract: A live detection system, a thermal infrared (IR) imager and a method for power grid equipment are provided. The system includes an environmental parameter module for acquiring environmental temperature, humidity and wind speed data; a ranging module for measuring a linear distance to the power grid equipment; an equipment type recognition module for acquiring an image of the power grid equipment, and recognizing a type of the power grid equipment; an equipment material determination module for determining a material type of the power grid equipment; an emissivity setting module for setting an emissivity; an temperature measurement module for obtaining a temperature of the power grid equipment by focusing on positions of the power grid equipment which need temperature measurement; and a report generation module for selecting a corresponding diagnostic model, displaying a temperature measurement position and a temperature value, drawing a conclusion, and generating a report.

Abstract: A mid-range loudspeaker, including a frame, a diaphragm arranged on the frame, a magnetic circuit system arranged on the frame, and a voice coil connected to the diaphragm. The diaphragm includes a honeycomb plate having a front surface and a back surface. Covering films respectively cover the front surface and the back surface of the honeycomb plate. The honeycomb plate is provided with a plurality of holes.

Abstract: Disclosed is a method for preparing a three-dimensional porous nano composite cooling film in large scale. The cooling film is prepared from 0.1-0.5 parts of cellulose acetate, 1-5 parts of water, 20-100 parts of acetone, an additive, and 10-20 parts of nano microspheres through a cooperative formulation of cellulose acetate, nano microsphere materials and the additive. The composite cooling film is obtained by self-deposition of cellulose acetate and nano microspheres, and liquid volatilization during film forming process leads to formation of the three-dimensional porous structure. The film has an effect of enhancing radiation of infrared heat into space, which could significantly reduce a temperature of a substrate surface and achieve rapid and strong cooling. The film could achieve effective cooling without external power and other active cooling equipment, with or without sunlight.

Abstract: Disclosed are a GaN power device and a manufacturing method thereof. The GaN power device includes a substrate, and a buffer layer, a GaN channel layer and a barrier layer sequentially stacked on the substrate from bottom to top. The barrier layer is provided with a p-GaN cap layer and a p-GaN thin layer, and the p-GaN thin layer is configured to cover the surface of the barrier layer and is connected to the p-GaN cap layer; the upper surface of the barrier layer is also provided with an input electrode and an output electrode, and a control electrode is provided on the upper surface of the p-GaN cap layer. The control electrode and the p-GaN thin layer are located between the input electrode and the output electrode.

Abstract: A modified nucleoside or nucleotide, the 3?-OH of the modified nucleoside or nucleotide being reversibly blocked; meanwhile, the present invention also relates to a kit comprising the nucleoside or nucleotide, and a sequencing method based on the nucleoside or nucleotide.

Abstract: A method for aging and storage of Jiang-flavor raw liquor involves “growing, nourishing and storing.” The Jiang-flavor new liquors of different rounds are subjected to outdoor storage in jars for not more than 1 year, then the Jiang-flavor raw liquors of different rounds having experienced the outdoor storage in jars for not more than 1 year are blended and put into stainless steel tank for blending and aging for a period of 1 to 2 years, and finally the Jiang-flavor raw liquor having experiencing the blending and ageing in the stainless steel tank for 1 to 2 years undergoes indoor storage in jars for 2 to 10 years. The method combines different storage containers with different storage years, improving the aging and storage effect and the quality of the Jiang-flavor raw liquor in a targeted manner.

Abstract: Disclosed herein are methods, systems, and apparatus for automated license plate recognition and methods for training a machine learning model to undertake automated license plate recognition. For example, a method can comprise dividing an image or video frame comprising a license plate into a plurality of image patches, determining a positional vector for each of the image patches, adding the positional vector to each of the image patches and inputting the image patches and their associated positional vectors to a text-adapted vision transformer. The text-adapted vision transformer can be configured to output a prediction concerning the license plate number of the license plate.

Abstract: Provided are compositions comprising polynucleotides encoding modified diacylglycerol acyltransferase-1 (DGAT1) polypeptides having improved properties, such as increased enzymatic activity and/or increased stability. Plants, plant cells, seed, grain and comprising the polynucleotides are provided which have one or more of increased fatty acid or protein content. Methods of generating the polynucleotides in plant cells include transformation and genetic modification. Methods of employing the polynucleotides in plants, methods for increasing DGAT1 activity in a plant, and methods for increasing fatty acid content or protein content in a plant are provided.

Abstract: For in mold spraying, a double-inclined mixing nozzle is connected obliquely and fixedly with a side surface of a third half-mold through a lateral sealing structure and connected with a side surface of a first half-mold in an inclined and sealing manner, side faces of a first half-mold and the third half-mold are respectively provided with installation inclined surfaces. A lateral sealing structure includes a mounting plate and a sealing member. The sealing member is sleeved on the double-inclined mixing nozzle and is in transition fit with the double-inclined mixing nozzle and the mounting plate respectively. A butt sealing groove provided on the installation inclined surface of the first half-mold and is in sealing fit with the mounting plate.

Abstract: The disclosure provides plants, plant parts, plant cells, seeds and grain containing a targeted genetic modification that inserts an endogenous microRNA recognition sequence into a gene. The disclosure provides plants, plant parts, plant cells, seeds and grain containing a targeted genetic modification that modifies an endogenous microRNA sequence so that the modified microRNA hybridizes to an endogenous gene.

Abstract: Disclosed herein are methods and systems for managing traffic violation or enforcement data using a distributed ledger. The distributed ledger provides a transparent chain of custody/evidence related to all digital interactions with traffic violation or enforcement data. The distributed ledger can be audited for data accuracy and integrity by nodes making up the system each time one of the nodes interacts with the traffic violation or enforcement data. For example, a digital evidence package related to a traffic violation event can be generated by a node within the system and a package digest can be logged in the distributed ledger beginning with the creation of the digital evidence package and each time that the digital evidence package is processed, modified, or reviewed by nodes within the system.

Abstract: An improved heat pump including an integrated system for the management of refrigerant charge is provided. The integrated system actively adjusts charge allocation and thereby optimizes operational efficiencies in all modes of operation. In one embodiment, the integrated system includes three four-way valves, two expansion valves, two one-way check valves, and a suction line accumulator to optimize charge allocation. The four-way valves dictate the mode switch and refrigerant flow directions, and the expansion valves automatically allocate refrigerant mass in active components and store excess charge in an idle heat exchanger and suction line accumulator by controlling the compressor discharge pressure (equivalent to controlling condenser subcooling degree) as a function of the entering air and water temperatures. The integrated system provides seven working modes and is uniquely suited for spacing cooling, spacing heating, and water heating in both residential and commercial applications.

Abstract: This application relates to solid forms and salt forms of the PD-1/PD-L1 inhibitor 4,4?-(((((2,2?-dichloro-[1,1?-biphenyl]-3,3?-diyl)bis(azanediyl))bis(carbonyl))bis(1-methyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-2,5-diyl))bis(ethane-2,1-diyl))bis(bicyclo[2.2.1]heptane-1-carboxylic acid), including processes of preparation thereof, where the solid forms and salt forms are useful in the treatment of various diseases including infectious diseases and cancer.

Abstract: This application relates to processes and intermediates for the preparation of the PD-1/PD-L1 inhibitor (R)-1-((7-cyano-2-(3?-((2-(difluoromethyl)-7-((3-hydroxypyrrolidin-1-yl)methyl)pyrido[3,2-d]pyrimidin-4-yl)amino)-2,2?-dimethyl-[1,1?-biphenyl]-3-yl)benzo[d]oxazol-5-yl)methyl)piperidine-4-carboxylic acid, and salts and crystalline forms thereof, where the PD-1/PD-L1 inhibitor and solid forms and salt forms thereof are useful in the treatment of various diseases including infectious diseases and cancer.

Abstract: The present invention relates to processes of preparing PD-1/PD-L1 inhibitor (R)-1-((7-cyano-2-(3?-(3-(((R)-3-hydroxypyrrolidin-1-yl)methyl)-1,7-naphthyridin-8-ylamino)-2,2?-dimethylbiphenyl-3-yl)benzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic acid, or salts thereof, related synthetic intermediates, and salts of the intermediates, where the PD-1/PD-L1 inhibitor is useful in the treatment of various diseases including infectious diseases and cancer.