Abstract: The present invention is directed to cyclopropylamine derivatives which are LSD1 inhibitors useful in the treatment of diseases such as cancer.

Abstract: A pipeline-based processor and method. The method includes partitioning a particular pipeline into one or more base pipeline stages and a plurality of enhanced pipeline stages, each enhanced pipeline stage configured to be either a shutdown enhanced pipeline stage or an activated enhanced pipeline stage. Each enhanced pipeline stage has an enhanced stage priority level. The method also includes configuring each enhanced pipeline stage to be activated or shut down based at least on the enhanced stage priority level. The method additionally includes partitioning a particular pipeline stage into at least one base module and a plurality of enhanced modules, each enhanced pipeline stage configured to be either a shutdown enhanced pipeline stage or an activated enhanced pipeline stage. Each enhanced module has a particular priority level. The method further includes configuring each enhanced module to be activated or shut down based at least on the particular priority level.

Abstract: The present invention is directed to cyclopropylamine derivatives which are LSD1 inhibitors useful in the treatment of diseases such as cancer.

Abstract: The present disclosure relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR4 enzyme and are useful in the treatment of FGFR4-associated diseases such as cancer.

Abstract: The present invention is directed to cyclopropylamine derivatives which are LSD1 inhibitors useful in the treatment of diseases such as cancer.

Abstract: Genetic male sterile plants are provided in which complementing constructs result in suppression of a parental phenotype in the progeny. Methods to generate and maintain such plants and methods of use of said plants, are provided, including use of parental plants to produce sterile plants for hybrid seed production.

Abstract: Disclosed are compounds of Formula (I?), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

Abstract: A method and system for servicing streaming media is disclosed. The method includes receiving the streaming media and determining an allocation of available processing and memory resources. In addition, the method includes performing a multi-stage service on the streaming media and caching an intermediate result from one of the stages of the multi-stage process. The intermediate result is selected according to the available processing and memory resources.

Abstract: A centralized authorization system authorizes content access requests for electronic content distributed over one or more networks in association with multiple third-party entities. Access to content is controlled by subscriptions. Subscriptions are requested by clients and granted if eligibility criteria are met. User accounts are assigned to different subscription states reflecting the states of their subscriptions. Subscription states may include, for example, an activated state, a deactivated state, a suspended state, a grace state, and/or a parking state. Different access rules are assigned to different states. A content authorization component authorizes content access requests based on applying these rules to the appropriate assigned states for the user accounts. The system includes a configuration interface by which third parties may configure specific access rules and other options that apply for their user accounts or subscriptions. Subscription retry and fallback logic may be provided.

Abstract: The present disclosure relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR4 enzyme and are useful in the treatment of FGFR4-associated diseases such as cancer.

Abstract: The present invention discloses a pipeline-based central processing unit, wherein the pipeline is partitioned into base pipeline stages and enhanced pipeline stages according to functions, the base pipeline stages being activated all the while, and the enhanced pipeline stages being activated or shutdown according to requirements for performance of a workload. The present invention further discloses a pipeline-based central processing unit, wherein the pipeline is partitioned into base pipeline stages and enhanced pipeline stages according to functions, each pipeline stage being partitioned into a base module and at least one enhanced module, the base module being activated all the while, and the enhanced module being activated or shutdown according to requirements for performance of a workload.

Abstract: A bit for removing damaged screws includes: a shaft portion and a head portion connected to the shaft portion. The head portion includes a tip section, a threaded conical section, and scraping portions extending continuously from the tip section to the threaded conical section. The scraping portions are able to perform continuous and non-stopping scraping operation toward the damaged screw. The scraping portions on the threaded conical section can scrape out a space big enough to allow passage of the threaded conical section, thus reducing resistance when the threaded conical section performs scraping and cutting operation. The threaded conical section can be guided to bite into and unscrew out the damaged screw, right after the scraping operation is performed by the tip section, so that the scraping and unscrewing operation can be performed more smoothly.

Abstract: The present invention is directed to cyclopropylamine derivatives which are LSD1 inhibitors useful in the treatment of diseases such as cancer.

Abstract: Transgenic oilseeds having increased total fatty acid content of at least 10% and altered fatty acid profiles when compared to the total fatty acid content of null segregant oilseeds are described. Novel DGAT genes are used to achieve the increase in seed storage lipids.

Abstract: A media content distribution service identifies a type of media device sending a request to the service over a network and to dynamically adapt content requested by the media device based on the identification. A request sent by a media device may, for example, identify a media content item a user desires to view at the media device, specify a search query for media content items, or otherwise request interaction with the service. According an embodiment, a media content distribution service may use information known about an identified media device type to dynamically adapt media content or other requested resources for display by the media device. By dynamically adapting media content and other resources based on an identified media device type, the media content distribution service may provide access to the services that is compatible with a wide range of media devices having varying device specifications and capabilities.

Abstract: A method for controlling a pipeline-based processor. The method includes determining a change in a workload. The method also includes activating or shutting down, by at least one controller circuit, one or more of the plurality of enhanced pipeline stages based on at least one corresponding enhanced stage priority level of the one or more of the plurality of enhanced pipeline stages and requirements for performance of the workload. The method additionally includes activating or shutting down, by the at least one controller circuit, one or more of the plurality of enhanced modules of the particular pipeline stage based on at least one corresponding priority level of the one or more of the plurality of enhanced modules of the particular pipeline stage and the requirements for the performance of the workload.

Abstract: The present invention is directed to cyclopropylamine derivatives which are LSD1 inhibitors useful in the treatment of diseases such as cancer.

Abstract: Methods and compositions for modulating plant development are provided. Nucleotide sequences and amino acid sequences encoding Ovule Development Protein 2 (ODP2) proteins are provided. The sequences can be used in a variety of methods including modulating development, developmental pathways, altering oil content in a plant, increasing transformation efficiencies, modulating stress tolerance, and modulating the regenerative capacity of a plant. Transformed plants, plant cells, tissues, and seed are also provided.