Patents by Inventor Boaz Ran
Boaz Ran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11480565Abstract: An instrument for detecting signal from a biological sample includes a pipettor module configured to hold a plurality of pipettes in respective pipette positions, to hold liquid in one or more pipette tips, and to pipette liquid in and out of the one or more pipette tips. Each of the one or more pipette tips has a pipette tip point. The instrument further includes one or more magnets positioned such that each of the one or more pipette tips is adjacent one of the one or more magnets.Type: GrantFiled: June 12, 2020Date of Patent: October 25, 2022Assignee: Bio-Rad Laboratories, Inc.Inventors: Shai Nimri, Yochanan Uri, Boaz Ran
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Publication number: 20210389305Abstract: An instrument for detecting signal from a biological sample includes a pipettor module configured to hold a plurality of pipettes in respective pipette positions, to hold liquid in one or more pipette tips, and to pipette liquid in and out of the one or more pipette tips. Each of the one or more pipette tips has a pipette tip point. The instrument further includes one or more magnets positioned such that each of the one or more pipette tips is adjacent one of the one or more magnets.Type: ApplicationFiled: June 12, 2020Publication date: December 16, 2021Inventors: Shai NIMRI, Yochanan URI, Boaz RAN
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Patent number: 10326952Abstract: In one application, an imaging device includes an image sensor having an array of pixels, and a mask coupled with the image sensor. The mask is configured to darken a plurality of isolated pixels or groups of pixels interspersed within the array of pixels. The imaging device also includes a processor coupled with the image sensor and configured to receive image data from the image sensor, and determine a dark current fixed pattern noise based on the image data received from the plurality of darkened pixels or groups of pixels.Type: GrantFiled: August 11, 2017Date of Patent: June 18, 2019Assignee: Bio-Rad Laboratories, Inc.Inventors: Boaz Ran, Steve Swihart, Evan Thrush, Itay Barak
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Patent number: 10104307Abstract: Methods and digital imaging devices disclosed herein are adapted to capture images of a specimen in a chemical reaction using a series of short exposures of light emissions from the specimen over a period of time. The series of short exposures is captured using an array of pixels of an image sensor in the digital imaging device that are configured for performing continuous non-destructive read operations to read out a set of non-destructive read images of the specimen from the pixel array. In one embodiment, images are captured by delaying the read out until at or near the end of the chemical reaction to reduce read noise in the images. The signals read out from the image sensor can be continuously monitored and the capturing of images can be discontinued either automatically or based on a command from a user. The captured images can then be displayed in a graphical display.Type: GrantFiled: August 2, 2017Date of Patent: October 16, 2018Assignee: Bio-Rad Laboratories, Inc.Inventors: Steve Swihart, Evan Thrush, Boaz Ran
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Patent number: 10041906Abstract: Integrated electrophoresis and electroblotting systems and methods are provided. In one embodiment, a cassette includes a separation gel and a sheet adjacent to a surface of the separation gel, wherein the sheet is configured to be removed from the cassette without opening the cassette. Systems and methods are also described and illustrated.Type: GrantFiled: March 2, 2016Date of Patent: August 7, 2018Assignee: Bio-Rad Laboratories, Inc.Inventor: Boaz Ran
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Patent number: 9933565Abstract: Devices, systems, methods, and kits for contact imaging are provided. A contact imaging device includes an imaging sensor, a fixed fiber faceplate mechanically coupled to the imaging sensor, and an optical filtering layer mechanically coupled to the fixed fiber faceplate. The optical filtering layer can include an interference filter, an absorptive filter, and/or a removable fiber faceplate. The contact imaging device can be used to image fluorescent samples by filtering out excitation light on the basis of wavelength and/or angle of incidence.Type: GrantFiled: July 15, 2016Date of Patent: April 3, 2018Assignee: Bio-Rad Laboratories, Inc.Inventors: Steve Swihart, Evan Thrush, Yochanan Uri, Boaz Ran, Itay Barak, Kevin McDonald
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Publication number: 20170366768Abstract: In one application, an imaging device includes an image sensor having an array of pixels, and a mask coupled with the image sensor. The mask is configured to darken a plurality of isolated pixels or groups of pixels interspersed within the array of pixels. The imaging device also includes a processor coupled with the image sensor and configured to receive image data from the image sensor, and determine a dark current fixed pattern noise based on the image data received from the plurality of darkened pixels or groups of pixels.Type: ApplicationFiled: August 11, 2017Publication date: December 21, 2017Inventors: Boaz RAN, Steve SWIHART, Evan THRUSH, Itay BARAK
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Patent number: 9829434Abstract: A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.Type: GrantFiled: March 15, 2016Date of Patent: November 28, 2017Assignee: Bio-Rad Laboratories Inc.Inventors: Yochanan Uri, Boaz Ran, Ariel G. Notcovich, Shay Nimri
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Publication number: 20170332001Abstract: Methods and digital imaging devices disclosed herein are adapted to capture images of a specimen in a chemical reaction using a series of short exposures of light emissions from the specimen over a period of time. The series of short exposures is captured using an array of pixels of an image sensor in the digital imaging device that are configured for performing continuous non-destructive read operations to read out a set of non-destructive read images of the specimen from the pixel array. In one embodiment, images are captured by delaying the read out until at or near the end of the chemical reaction to reduce read noise in the images. The signals read out from the image sensor can be continuously monitored and the capturing of images can be discontinued either automatically or based on a command from a user. The captured images can then be displayed in a graphical display.Type: ApplicationFiled: August 2, 2017Publication date: November 16, 2017Inventors: Steve SWIHART, Evan THRUSH, Boaz RAN
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Patent number: 9794454Abstract: Provided herein are imaging cassettes for detecting a luminescent and/or radioactive signals. Such cassettes are useful in common biological assays, e.g., immunoassays, nucleotide detection assays, and other affinity assays.Type: GrantFiled: July 1, 2015Date of Patent: October 17, 2017Assignee: Bio-Rad Laboratories, Inc.Inventors: Yochanan Uri, Boaz Ran, Itay Barak, Steven Swihart, Evan Thrush
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Patent number: 9774804Abstract: In one application, an imaging device includes an image sensor having an array of pixels, and a mask coupled with the image sensor. The mask is configured to darken a plurality of isolated pixels or groups of pixels interspersed within the array of pixels. The imaging device also includes a processor coupled with the image sensor and configured to receive image data from the image sensor, and determine a dark current fixed pattern noise based on the image data received from the plurality of darkened pixels or groups of pixels.Type: GrantFiled: December 8, 2014Date of Patent: September 26, 2017Assignee: Bio-Rad Laboratories, Inc.Inventors: Boaz Ran, Steve Swihart, Evan Thrush, Itay Barak
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Patent number: 9736388Abstract: Methods and digital imaging devices disclosed herein are adapted to capture images of a specimen in a chemical reaction using a series of short exposures of light emissions from the specimen over a period of time. The series of short exposures is captured using an array of pixels of an image sensor in the digital imaging device that are configured for performing continuous non-destructive read operations to read out a set of non-destructive read images of the specimen from the pixel array. In one embodiment, images are captured by delaying the read out until at or near the end of the chemical reaction to reduce read noise in the images. The signals read out from the image sensor can be continuously monitored and the capturing of images can be discontinued either automatically or based on a command from a user. The captured images can then be displayed in a graphical display.Type: GrantFiled: December 8, 2014Date of Patent: August 15, 2017Assignee: Bio-Rad Laboratories, Inc.Inventors: Steve Swihart, Evan Thrush, Boaz Ran
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Publication number: 20170016829Abstract: Devices, systems, methods, and kits for contact imaging are provided. A contact imaging device includes an imaging sensor, a fixed fiber faceplate mechanically coupled to the imaging sensor, and an optical filtering layer mechanically coupled to the fixed fiber faceplate. The optical filtering layer can include an interference filter, an absorptive filter, and/or a removable fiber faceplate. The contact imaging device can be used to image fluorescent samples by filtering out excitation light on the basis of wavelength and/or angle of incidence.Type: ApplicationFiled: July 15, 2016Publication date: January 19, 2017Inventors: Steve SWIHART, Evan THRUSH, Yochanan URI, Boaz RAN, Itay BARAK, Kevin MCDONAL
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Publication number: 20160356712Abstract: A system for measuring an evanescent wave phenomenon at total internal reflection, the system comprising: a) a sensing surface comprising a plurality of areas of interest; b) an illumination sub-system comprising a light source, which illuminates each area of interest on the sensing surface over a range of angles of incidence; c) a detector which responds differently to an intensity of light received by it at different locations; and d) projection optics comprising primary optics and a plurality of secondary elements, the primary optics projecting an image of the illuminated sensing surface onto the secondary elements, which project their received light onto the detector in such a way that it is possible to determine, from the response of the detector, how much light is reflected from each area of interest, as a function of angle of incidence over the range of angles for that area.Type: ApplicationFiled: June 8, 2016Publication date: December 8, 2016Applicant: Bio-Rad Laboratories Inc.Inventors: Boaz RAN, Itay BARAK
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Publication number: 20160299070Abstract: A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.Type: ApplicationFiled: March 15, 2016Publication date: October 13, 2016Applicant: Bio-Rad Laboratories Inc.Inventors: Yochanan URI, Boaz RAN, Ariel G. NOTCOVICH, Shay NIMRI
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Publication number: 20160258903Abstract: Integrated electrophoresis and electroblotting systems and methods are provided. In one embodiment, a cassette includes a separation gel and a sheet adjacent to a surface of the separation gel, wherein the sheet is configured to be removed from the cassette without opening the cassette. Systems and methods are also described and illustrated.Type: ApplicationFiled: March 2, 2016Publication date: September 8, 2016Inventor: Boaz Ran
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Patent number: 9383311Abstract: A system for measuring an evanescent wave phenomenon at total internal reflection, the system comprising: a) a sensing surface comprising a plurality of areas of interest; b) an illumination sub-system comprising a light source, which illuminates each area of interest on the sensing surface over a range of angles of incidence; c) a detector which responds differently to an intensity of light received by it at different locations; and d) projection optics comprising primary optics and a plurality of secondary elements, the primary optics projecting an image of the illuminated sensing surface onto the secondary elements, which project their received light onto the detector in such a way that it is possible to determine, from the response of the detector, how much light is reflected from each area of interest, as a function of angle of incidence over the range of angles for that area.Type: GrantFiled: August 29, 2013Date of Patent: July 5, 2016Assignee: Bio-Rad Laboratories Inc.Inventors: Boaz Ran, Itay Barak
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Patent number: 9354179Abstract: A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.Type: GrantFiled: June 6, 2013Date of Patent: May 31, 2016Assignee: Bio-Rad Laboratories Inc.Inventors: Yochanan Uri, Boaz Ran, Ariel G. Notcovich, Shay Nimri
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Publication number: 20160028976Abstract: One embodiment of the invention is directed to an imaging device comprising an image sensor comprising an array of pixels, and a mask coupled with the image sensor, the mask configured to darken at least one pixel in the array of pixels.Type: ApplicationFiled: December 8, 2014Publication date: January 28, 2016Inventors: Boaz Ran, Steve Swihart, Evan Thrush, Itay Barak
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Publication number: 20160006910Abstract: Provided herein are imaging cassettes for detecting a luminescent and/or radioactive signals. Such cassettes are useful in common biological assays, e.g., immunoassays, nucleotide detection assays, and other affinity assays.Type: ApplicationFiled: July 1, 2015Publication date: January 7, 2016Inventors: Yochanan Uri, Boaz Ran, Itay Barak, Steven Swihart, Evan Thrush