Patents by Inventor Boaz Ran
Boaz Ran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150172526Abstract: Methods and digital imaging devices disclosed herein are adapted to capture images of a specimen in a chemical reaction using a series of short exposures of light emissions from the specimen over a period of time. The series of short exposures is captured using an array of pixels of an image sensor in the digital imaging device that are configured for performing continuous non-destructive read operations to read out a set of non-destructive read images of the specimen from the pixel array. In one embodiment, images are captured by delaying the read out until at or near the end of the chemical reaction to reduce read noise in the images. The signals read out from the image sensor can be continuously monitored and the capturing of images can be discontinued either automatically or based on a command from a user. The captured images can then be displayed in a graphical display.Type: ApplicationFiled: December 8, 2014Publication date: June 18, 2015Inventors: Steve Swihart, Evan Thrush, Boaz Ran
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Patent number: 8927294Abstract: A method of determining a normalized quantity of an analyte adhering to beads in a detection area of a bead-based assaying system, the method comprising: a) causing a complex of the analyte to fluorescently or chemically emit a first light, or to release a dye; b) measuring an integrated intensity of the first light emitted from the beads in the detection area, or a concentration of the dye released from the beads in the detection area, or both; c) causing light to interact with the beads in the detection area, the interaction not depending on whether or how much analyte is adhering to the beads; d) measuring a second light resulting from the interaction with the beads which does not depend on the analyte; and e) determining the normalized quantity of analyte from the integrated intensity of the first light or concentration of the dye or both, and from the measured second light.Type: GrantFiled: November 29, 2010Date of Patent: January 6, 2015Assignee: Bio-Rad Laboratories Inc.Inventors: Boaz Ran, Chanan Sluszny, Shay Nimri
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Patent number: 8743367Abstract: An SPR or other optical resonance based analysis system in which, light is provided at multiple angles to a specimen and then the light modified by the specimen is processed to select only some of the light. Optionally, the processing selects light at a particular incidence angle. Optionally, the detection is by imaging of the light on a 2D imager array.Type: GrantFiled: May 21, 2008Date of Patent: June 3, 2014Assignee: Bio-Rad Laboratories Inc.Inventors: Boaz Ran, Tal Rosenzweig, Ariel G. Notcovich, Ariel Shemesh, Yochanan Uri, Michael Kanevsky, James W. Hillendahl, Barak Abraham Liraz
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Patent number: 8743369Abstract: An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.Type: GrantFiled: August 14, 2013Date of Patent: June 3, 2014Assignee: Bio-Rad Laboratories Inc.Inventors: Boaz Ran, Ariel G. Notcovich, Ariel Lipson, Shay Nimri, Stephen G. Lipson, Doron Lipson
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Publication number: 20130344623Abstract: A system for measuring an evanescent wave phenomenon at total internal reflection, the system comprising: a) a sensing surface comprising a plurality of areas of interest; b) an illumination sub-system comprising a light source, which illuminates each area of interest on the sensing surface over a range of angles of incidence; c) a detector which responds differently to an intensity of light received by it at different locations; and d) projection optics comprising primary optics and a plurality of secondary elements, the primary optics projecting an image of the illuminated sensing surface onto the secondary elements, which project their received light onto the detector in such a way that it is possible to determine, from the response of the detector, how much light is reflected from each area of interest, as a function of angle of incidence over the range of angles for that area.Type: ApplicationFiled: August 29, 2013Publication date: December 26, 2013Applicant: Bio-Rad Laboratories Inc.Inventors: Boaz RAN, Itay Barak
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Publication number: 20130330230Abstract: A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.Type: ApplicationFiled: June 6, 2013Publication date: December 12, 2013Inventors: Yochanan URI, Boaz Ran, Ariel G. Notcovich, Shay Nimri
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Publication number: 20130330838Abstract: An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.Type: ApplicationFiled: August 14, 2013Publication date: December 12, 2013Applicant: Bio-Rad Laboratories Inc.Inventors: Boaz RAN, Ariel G. Notcovich, Ariel Lipson, Shay Nimri, Stephen G. Lipson, Doron Lipson
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Patent number: 8530243Abstract: A system for measuring an evanescent wave phenomenon at total internal reflection, the system comprising: a) a sensing surface comprising a plurality of areas of interest; b) an illumination sub-system comprising a light source, which illuminates each area of interest on the sensing surface over a range of angles of incidence; c) a detector which responds differently to an intensity of light received by it at different locations; and d) projection optics comprising primary optics and a plurality of secondary elements, the primary optics projecting an image of the illuminated sensing surface onto the secondary elements, which project their received light onto the detector in such a way that it is possible to determine, from the response of the detector, how much light is reflected from each area of interest, as a function of angle of incidence over the range of angles for that area.Type: GrantFiled: April 18, 2010Date of Patent: September 10, 2013Assignee: Bio-Rad Laboratories Inc.Inventors: Boaz Ran, Itay Barak
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Patent number: 8363223Abstract: An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.Type: GrantFiled: January 12, 2012Date of Patent: January 29, 2013Assignee: Bio-Rad Laboratories Inc.Inventors: Boaz Ran, Ariel G. Notcovich, Ariel Lipson, Shay Nimri, Stephen G. Lipson, Doron Lipson
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Publication number: 20120113428Abstract: An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.Type: ApplicationFiled: January 12, 2012Publication date: May 10, 2012Applicant: Bio-Rad Laboratories Inc.Inventors: Boaz RAN, Ariel G. Notcovich, Ariel Lipson, Shay Nimri, Stephen G. Lipson, Doron Lipson
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Patent number: 8111400Abstract: An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.Type: GrantFiled: July 13, 2011Date of Patent: February 7, 2012Assignee: Bio-Rad Laboratories Inc.Inventors: Boaz Ran, Ariel G. Notcovich, Ariel Lipson, Shay Nimri, Stephen G. Lipson, Doron Lipson
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Publication number: 20110267622Abstract: An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.Type: ApplicationFiled: July 13, 2011Publication date: November 3, 2011Applicant: Bio-Rad Laboratories Inc.Inventors: Boaz RAN, Ariel G. Notcovich, Ariel Lipson, Shay Nimri, Stephen G. Lipson, Doron Lipson
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Patent number: 7999942Abstract: An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.Type: GrantFiled: August 5, 2009Date of Patent: August 16, 2011Assignee: Bio-Rad Laboratories Inc.Inventors: Boaz Ran, Ariel G. Notcovich, Ariel Lipson, Shay Nimri, Stephen G. Lipson, Doron Lipson
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Publication number: 20110136250Abstract: A method of determining a normalized quantity of an analyte adhering to beads in a detection area of a bead-based assaying system, the method comprising: a) causing a complex of the analyte to fluorescently or chemically emit a first light, or to release a dye; b) measuring an integrated intensity of the first light emitted from the beads in the detection area, or a concentration of the dye released from the beads in the detection area, or both; c) causing light to interact with the beads in the detection area, the interaction not depending on whether or how much analyte is adhering to the beads; d) measuring a second light resulting from the interaction with the beads which does not depend on the analyte; and e) determining the normalized quantity of analyte from the integrated intensity of the first light or concentration of the dye or both, and from the measured second light.Type: ApplicationFiled: November 29, 2010Publication date: June 9, 2011Applicant: Bio-Rad Laboratories Inc.Inventors: Boaz RAN, Chanan Sluszny, Shay Nimri
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Publication number: 20100267163Abstract: A system for measuring an evanescent wave phenomenon at total internal reflection, the system comprising: a) a sensing surface comprising a plurality of areas of interest; b) an illumination sub-system comprising a light source, which illuminates each area of interest on the sensing surface over a range of angles of incidence; c) a detector which responds differently to an intensity of light received by it at different locations; and d) projection optics comprising primary optics and a plurality of secondary elements, the primary optics projecting an image of the illuminated sensing surface onto the secondary elements, which project their received light onto the detector in such a way that it is possible to determine, from the response of the detector, how much light is reflected from each area of interest, as a function of angle of incidence over the range of angles for that area.Type: ApplicationFiled: April 18, 2010Publication date: October 21, 2010Applicant: Bio-Rad Laboratories Inc.Inventors: Boaz RAN, Itay Barak
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Publication number: 20100220330Abstract: An SPR or other optical resonance based analysis system in which, light is provided at multiple angles to a specimen and then the light modified by the specimen is processed to select only some of the light. Optionally, the processing selects light at a particular incidence angle. Optionally, the detection is by imaging of the light on a 2D imager array.Type: ApplicationFiled: May 21, 2008Publication date: September 2, 2010Applicant: Bio-Rad Laboratories Inc.Inventors: Boaz Ran, Tal Rosenzweig, Ariel G. Notcovich, Ariel Shemesh, Yochanan Uri, Michael Kanevsky, James W. Hillendahl, Barak Abraham Liraz
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Publication number: 20090296095Abstract: An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.Type: ApplicationFiled: August 5, 2009Publication date: December 3, 2009Applicant: Bio-Rad Laboratories Inc.Inventors: Boaz RAN, Ariel G. Notcovich, Ariel Lipson, Shay Nimri, Stephen G. Lipson, Doron Lipson
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Patent number: 7586616Abstract: An SPR sensor comprising: a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate; an illumination system controllable to illuminate an interface between the conducting layer and the substrate; a photosensitive surface that generates signals responsive to light from the light source that is reflected from a region of the interface; a flow cell formed with at least one flow channel having a lumen defined by a wall at least a portion of which is formed from an elastic material and a portion of which is formed by a region of the conducting layer; and at least one hollow needle having an exit orifice communicating with the needle's lumen and wherein fluid flow is enabled between the flow channel and the needle's lumen by puncturing the elastic material with the at least one needle so that the exit orifice communicates with the flow channel lumen.Type: GrantFiled: April 28, 2008Date of Patent: September 8, 2009Assignee: Bio-Rad Laboratories Inc.Inventors: Boaz Ran, Ariel G. Notcovich, Ariel Lipson, Shay Nimri, Stephen G. Lipson, Doron Lipson
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Patent number: 7443507Abstract: An SPR sensor comprising: a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate; an illumination system controllable to illuminate an interface between the conducting layer and the substrate; a photosensitive surface that generates signals responsive to light from the light source that is reflected from a region of the interface; a flow cell formed with at least one flow channel having a lumen defined by a wall at least a portion of which is formed from an elastic material and a portion of which is formed by a region of the conducting layer; and at least one hollow needle having an exit orifice communicating with the needle's lumen and wherein fluid flow is enabled between the flow channel and the needle's lumen by puncturing the elastic material with the at least one needle so that the exit orifice communicates with the flow channel lumen.Type: GrantFiled: December 25, 2002Date of Patent: October 28, 2008Assignee: Bio-Rad Laboratories Inc.Inventors: Boaz Ran, Ariel G. Notcovich, Ariel Lipson, Shay Nimri, Stephen G. Lipson, Doron Lipson
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Publication number: 20080198384Abstract: An SPR sensor comprising: a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate; an illumination system controllable to illuminate an interface between the conducting layer and the substrate; a photosensitive surface that generates signals responsive to light from the light source that is reflected from a region of the interface; a flow cell formed with at least one flow channel having a lumen defined by a wall at least a portion of which is formed from an elastic material and a portion of which is formed by a region of the conducting layer; and at least one hollow needle having an exit orifice communicating with the needle's lumen and wherein fluid flow is enabled between the flow channel and the needle's lumen by puncturing the elastic material with the at least one needle so that the exit orifice communicates with the flow channel lumen.Type: ApplicationFiled: April 28, 2008Publication date: August 21, 2008Applicant: Bio-Rad Haifa Ltd.Inventors: Boaz Ran, Ariel G. Notcovich, Ariel Lipson, Shay Nimri, Stephen G. Lipson, Doron Lipson