Patents by Inventor Boguslaw M. Mudryk

Boguslaw M. Mudryk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR PREPARING TETRAHYDROCARBAZOLE CARBOXAMIDE COMPOUND
    Publication number: 20200109133
    Abstract: Disclosed is a process for preparing Compound 8: (8) comprising the step of reacting Compound of 7: (7) wherein R is C1-8 alkyl or benzyl in the presence of a base. Also disclosed are intermediates and processes for preparing the intermediates.
    Type: Application
    Filed: December 19, 2017
    Publication date: April 9, 2020
    Inventors: Ronald Carrasquillo, Peng Geng, Eric C. Huang, Kishta Katipally, Andrew Lee, Boguslaw M. Mudryk, Xinhua Qian, Thomas M. Razler, Jianji Wang, Carolyn S. Wei, Steven R. Wisniewski, Ye Zhu
  • Methods for the preparation of HIV attachment inhibitor piperazine prodrug compound
    Patent number: 9403821
    Abstract: A method for making the compound is set forth utilizing the starting material
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: August 2, 2016
    Assignee: Bristol-Myers Squibb Company
    Inventors: Martin D. Eastgate, Michael S. Bultman, Ke Chen, Dayne Dustan Fanfair, Richard J. Fox, Thomas E. La Cruz, Boguslaw M. Mudryk, Christina Ann Risatti, James H. Simpson, Maxime C. Soumeillant, Jonathan Clive Tripp, Yi Xiao
  • Methods for the preparation of HIV attachment inhibitor piperazine prodrug compound
    Patent number: 9394322
    Abstract: A method for making the compound is set forth utilizing the starting material
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: July 19, 2016
    Assignee: Bristol-Myers Squibb Company
    Inventors: Martin D. Eastgate, Michael S. Bultman, Ke Chen, Dayne Dustan Fanfair, Richard J. Fox, Thomas E. La Cruz, Boguslaw M. Mudryk, Christina Ann Risatti, James H Simpson, Maxime C. Soumeillant, Jonathan Clive Tripp, Yi Xiao
  • Methods for the preparation of HIV attachment inhibitor piperazine prodrug compound
    Patent number: 9376458
    Abstract: A method for making the compound is set forth utilizing the starting material
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: June 28, 2016
    Assignee: Bristol-Myers Squibb Company
    Inventors: Martin D. Eastgate, Michael S. Bultman, Ke Chen, Dayne Dustan Fanfair, Richard J. Fox, Thomas E. La Cruz, Boguslaw M. Mudryk, Christina Ann Risatti, James H. Simpson, Maxime C. Soumeillant, Jonathan Clive Tripp, Yi Xiao
  • METHODS FOR THE PREPARATION OF HIV ATTACHMENT INHIBITOR PIPERAZINE PRODRUG COMPOUND
    Publication number: 20160152644
    Abstract: A method for making the compound is set forth utilizing the starting material
    Type: Application
    Filed: January 4, 2016
    Publication date: June 2, 2016
    Inventors: Martin D. Eastgate, Michael S. Bultman, Ke Chen, Dayne Dustan Fanfair, Richard J. Fox, Thomas E. La Cruz, Boguslaw M. Mudryk, Christina Ann Risatti, James H. Simpson, Maxime C. Soumeillant, Jonathan Clive Tripp, Yi Xiao
  • METHODS FOR THE PREPARATION OF HIV ATTACHMENT INHIBITOR PIPERAZINE PRODRUG COMPOUND
    Publication number: 20160108029
    Abstract: A method for making the compound is set forth utilizing the starting material
    Type: Application
    Filed: October 17, 2014
    Publication date: April 21, 2016
    Inventors: Martin D. Eastgate, Michael S. Bultman, Ke Chen, Dayne Dustan Fanfair, Richard J. Fox, Thomas E. La Cruz, Boguslaw M. Mudryk, Christina Ann Risatti, James H. Simpson, Maxime C. Soumeillant, Jonathan Clive Tripp, Yi Xiao
  • Methods for the Preparation of HIV attachment inhibitor piperazine prodrug compound
    Patent number: 9255113
    Abstract: A method for making the compound is set forth utilizing the starting material wherein R7?—H, alkyl, aryl, —SO2R, —C(O)OR, and —C(O)NR2; where R?—H, C1-C6 alkyl, -aryl, and —CH2Aryl.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: February 9, 2016
    Assignee: Bristol-Myers Squibb Company
    Inventors: Martin D. Eastgate, Michael S. Bultman, Ke Chen, Dayne Dustan Fanfair, Richard J. Fox, Thomas E. La Cruz, Boguslaw M. Mudryk, Christina Ann Risatti, James H. Simpson, Maxime C. Soumeillant, Jonathan Clive Tripp, Yi Xiao
  • Methods for the preparation of HIV attachment inhibitor piperazine prodrug compound
    Patent number: 9249168
    Abstract: A method for making the compound is set forth utilizing the starting material
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: February 2, 2016
    Assignee: Bristol-Myers Squibb Company
    Inventors: Martin D. Eastgate, Michael S. Bultman, Ke Chen, Dayne Dustan Fanfair, Richard J. Fox, Thomas E. La Cruz, Boguslaw M. Mudryk, Christina Ann Risatti, James H. Simpson, Maxime C. Soumeillant, Jonathan Clive Tripp, Yi Xiao
  • Methods for the preparation of HIV attachment inhibitor piperazine prodrug compound
    Patent number: 9243010
    Abstract: A process for the preparation of the compound of Formula I is set forth utilizing the starting compound 1 and the acid chloride compound
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: January 26, 2016
    Assignee: Bristol-Myers Squibb Company
    Inventors: Martin D. Eastgate, Michael S. Bultman, Ke Chen, Dayne Dustan Fanfair, Richard J. Fox, Thomas E. La Cruz, Boguslaw M. Mudryk, Christina Ann Risatti, James H. Simpson, Maxime C. Soumeillant, Jonathan Clive Tripp, Yi Xiao
  • METHODS FOR THE PREPARATION OF HIV ATTACHMENT INHIBITOR PIPERAZINE PRODRUG COMPOUND
    Publication number: 20150038717
    Abstract: A method for making the compound is set forth utilizing the starting material
    Type: Application
    Filed: October 17, 2014
    Publication date: February 5, 2015
    Inventors: Martin D. Eastgate, Michael S. Bultman, Ke Chen, Dayne Dustan Fanfair, Richard J. Fox, Thomas E. La Cruz, Boguslaw M. Mudryk, Christina Ann Risatti, James H. Simpson, Maxime C. Soumeillant, Jonathan Clive Tripp, Yi Xiao
  • METHODS FOR THE PREPARATION OF HIV ATTACHMENT INHIBITOR PIPERAZINE PRODRUG COMPOUND
    Publication number: 20150038711
    Abstract: A method for making the compound is set forth utilizing the starting material
    Type: Application
    Filed: October 17, 2014
    Publication date: February 5, 2015
    Inventors: Martin D. Eastgate, Michael S. Bultman, Ke Chen, Dayne Dustan Fanfair, Richard J. Fox, Thomas E. La Cruz, Boguslaw M. Mudryk, Christina Ann Risatti, James H. Simpson, Maxime C. Soumeillant, Jonathan Clive Tripp, Yi Xiao
  • METHODS FOR THE PREPARATION OF HIV ATTACHMENT INHIBITOR PIPERAZINE PRODRUG COMPOUND
    Publication number: 20150038716
    Abstract: A method for making the compound is set forth utilizing the starting material
    Type: Application
    Filed: October 17, 2014
    Publication date: February 5, 2015
    Inventors: Martin D. Eastgate, Michael S. Bultman, Ke Chen, Dayne Dustan Fanfair, Richard J. Fox, Thomas E. La Cruz, Boguslaw M. Mudryk, Christina Ann Risatti, James H. Simpson, Maxime C. Soumeillant, Jonathan Clive Tripp, Yi Xiao
  • METHODS FOR THE PREPARATION OF HIV ATTACHMENT INHIBITOR PIPERAZINE PRODRUG COMPOUND
    Publication number: 20150038710
    Abstract: A method for making the compound is set forth utilizing the starting material
    Type: Application
    Filed: October 17, 2014
    Publication date: February 5, 2015
    Inventors: Martin D. Eastgate, Michael S. Bultman, Ke Chen, Dayne Dustan Fanfair, Richard J. Fox, Thomas E. La Cruz, Boguslaw M. Mudryk, Christina Ann Risatti, James H. Simpson, Maxime C. Soumeillant, Jonathan Clive Tripp, Yi Xiao
  • METHODS FOR THE PREPARATION OF HIV ATTACHMENT INHIBITOR PIPERAZINE PRODRUG COMPOUND
    Publication number: 20150038709
    Abstract: A method for making the compound is set forth utilizing the starting material
    Type: Application
    Filed: October 17, 2014
    Publication date: February 5, 2015
    Inventors: Martin D. Eastgate, Michael S. Bultman, Ke Chen, Dayne Dustan Fanfair, Richard J. Fox, Thomas E. La Cruz, Boguslaw M. Mudryk, Christina Ann Risatti, James H. Simpson, Maxime C. Soumeillant, Jonathan Clive Tripp, Yi Xiao
  • METHODS FOR THE PREPARATION OF HIV ATTACHMENT INHIBITOR PIPERAZINE PRODRUG COMPOUND
    Publication number: 20150038712
    Abstract: A method for making the compound is set forth utilizing the starting material
    Type: Application
    Filed: October 17, 2014
    Publication date: February 5, 2015
    Inventors: Martin D. Eastgate, Michael S. Bultman, Ke Chen, Dayne Dustan Fanfair, Richard J. Fox, Thomas E. La Cruz, Boguslaw M. Mudryk, Christina Ann Risatti, James H. Simpson, Maxime C. Soumeillant, Jonathan Clive Tripp, Yi Xiao
  • Methods for the preparation of HIV attachment inhibitor piperazine prodrug compound
    Patent number: 8889869
    Abstract: A method for making the compound is set forth utilizing the starting material
    Type: Grant
    Filed: February 6, 2013
    Date of Patent: November 18, 2014
    Assignee: Bristol-Myers Squibb Company
    Inventors: Martin D. Eastgate, Michael S. Bultman, Ke Chen, Dayne Dustan Fanfair, Richard J. Fox, Thomas E. La Cruz, Boguslaw M. Mudryk, Christina Ann Risatti, James H. Simpson, Maxime C. Soumeillant, Jonathan Clive Tripp, Yi Xiao
  • Substituted pyrrolidine-2-one compounds
    Patent number: 8049019
    Abstract: The present invention provides a novel antagonist or partial agonists/antagonist of MCP-1 receptor activity: N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-2-oxo-3-(6-(trifluoromethyl)quinazolin-4-ylamino) pyrrolidin-1-yl)cyclohexyl)acetamide, or a pharmaceutically acceptable salt, solvate or prodrug, thereof, having an unexpected combination of desirable pharmacological characteristics. Crystalline forms of the present invention are also provided. Pharmaceutical compositions containing the same and methods of using the same as agents for the treatment of inflammatory diseases, allergic, autoimmune, metabolic, cancer and/or cardiovascular diseases is also an objective of this invention. The present disclosure also provides a process for preparing compounds of Formula (I), including N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-2-oxo-3-(6-(trifluoromethyl)quinazolin-4-ylamino)pyrrolidin-1-yl)cyclohexyl)acetamide: wherein R1, R8, R9, R10, and are as described herein.
    Type: Grant
    Filed: October 27, 2009
    Date of Patent: November 1, 2011
    Assignee: Bristol-Myers Squibb Company
    Inventors: Boguslaw M. Mudryk, Michael E. Randazzo, Rulin Zhao
  • MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY, CRYSTALLINE FORMS AND PROCESS
    Publication number: 20100113489
    Abstract: The present invention provides a novel antagonist or partial agonists/antagonist of MCP-1 receptor activity: N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-2-oxo-3-(6-(trifluoromethyl)quinazolin- 4-ylamino)pyrrolidin-1-yl)cyclohexyl)acetamide, or a pharmaceutically acceptable salt, solvate or prodrug, thereof, having an unexpected combination of desirable pharmacological characteristics. Crystalline forms of the present invention are also provided. Pharmaceutical compositions containing the same and methods of using the same as agents for the treatment of inflammatory diseases, allergic, autoimmune, metabolic, cancer and/or cardiovascular diseases is also an objective of this invention. The present disclosure also provides a process for preparing compounds of Formula (I), including N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-2-oxo-3-(6-(trifluoromethyl)quinazolin-4-ylamino)pyrrolidin-1-yl)cyclohexyl)acetamide: wherein R1, R8, R9, R10, and are as described herein.
    Type: Application
    Filed: October 27, 2009
    Publication date: May 6, 2010
    Inventors: John V. Duncia, Boguslaw M. Mudryk, Michael E. Randazzo, Zili Xiao, Michael G. Yang, Rulin Zhao, Percy H. Carter
  • N-((1R,2S,5R)-5-(-butylamino)-2-((S)-2-oxo-3-(6-(trifluoromethyl)quinazolin-4-ylamino) pyrrolidin-1-yl)cyclohexyl)acetamide and other modulators of chemokine receptor activity, crystalline forms and process
    Patent number: 7629351
    Abstract: The present invention provides a novel antagonist or partial agonists/antagonist of MCP-1 receptor activity: N-((1R,2S,5R)-5-tert-butylamino)-2-((S)-2-oxo-3-(6-(trifluoromethyl)quinazolin-4-ylamino)pyrrolidin-1-yl)cyclohexyl)acetamide, or a pharmaceutically acceptable salt, solvate or prodrug, thereof, having an unexpected combination of desirable pharmacological characteristics. Crystalline forms of the present invention are also provided. Pharmaceutical compositions containing the same and methods of using the same as agents for the treatment of inflammatory diseases, allergic, autoimmune, metabolic, cancer and/or cardiovascular diseases is also an objective of this invention. The present disclosure also provides a process for preparing compounds of Formula (I), including N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-2-oxo-3-(6-trifluoromethyl)quinazolin-4-ylamino)pyrrolidin-1-yl)cyclohexyl)acetamide: wherein R1, R8,R9, R10, and are as described herein.
    Type: Grant
    Filed: July 25, 2007
    Date of Patent: December 8, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Percy H. Carter, John V. Duncia, Boguslaw M. Mudryk, Michael E. Randazzo, Zili Xiao, Michael G. Yang, Rulin Zhao
  • Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
    Patent number: 7579472
    Abstract: A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds can be useful as factor Xa inhibitors.
    Type: Grant
    Filed: August 15, 2007
    Date of Patent: August 25, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Boguslaw M. Mudryk, Nicolas Cuniere, Dau-Ming Hsieh, Lucius Rossano, Jing Liang, Bang-Chi Chen, Huiping Zhang, Rulin Zhao, Bei Wang, Adrian David