Patents by Inventor Boguslaw M. Mudryk

Boguslaw M. Mudryk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
    Patent number: 7435821
    Abstract: A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds can be useful as factor Xa inhibitors.
    Type: Grant
    Filed: August 15, 2007
    Date of Patent: October 14, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Boguslaw M. Mudryk, Nicolas Cuniere, Dau-Ming Hsieh, Lucius Rossano, Jing Liang, Bang-Chi Chen, Huiping Zhang, Rulin Zhao, Bei Wang, Adrian David
  • Process for preparing 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
    Patent number: 7396932
    Abstract: A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds can be useful as factor Xa inhibitors.
    Type: Grant
    Filed: September 26, 2005
    Date of Patent: July 8, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Rafael Shapiro, Lucius T Rossano, Boguslaw M Mudryk, Nicolas Cuniere, Matthew Oberholzer, Huiping Zhang, Bang-Chi Chen
  • MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY CRYSTALLINE FORMS AND PROCESS
    Publication number: 20080027084
    Abstract: The present invention provides a novel antagonist or partial agonists/antagonist of MCP-1 receptor activity: N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-2-oxo-3-(6-(trifluoromethyl)quinazolin-4 -ylamino)pyrrolidin-1-yl)cyclohexyl)acetamide, or a pharmaceutically acceptable salt, solvate or prodrug, thereof, having an unexpected combination of desirable pharmacological characteristics. Crystalline forms of the present invention are also provided. Pharmaceutical compositions containing the same and methods of using the same as agents for the treatment of inflammatory diseases, allergic, autoimmune, metabolic, cancer and/or cardiovascular diseases is also an objective of this invention. The present disclosure also provides a process for preparing compounds of Formula (I), including N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-2-oxo-3-(6-(trifluoromethyl)quinazolin-4-ylamino)pyrrolidin-1-yl)cyclohexyl)acetamide: wherein R1, R8, R9, R10, and are as described herein.
    Type: Application
    Filed: July 25, 2007
    Publication date: January 31, 2008
    Inventors: John V. Duncia, Boguslaw M. Mudryk, Michael E. Randazzo, Zili Xiao, Michael G. Yang, Rulin Zhao, Percy H. Carter
  • Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
    Patent number: 7304157
    Abstract: A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds can be useful as factor Xa inhibitors.
    Type: Grant
    Filed: September 26, 2005
    Date of Patent: December 4, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Boguslaw M. Mudryk, Nicolas Cuniere, Dau-Ming Hsieh, Lucius Rossano, Jing Liang, Bang-Chi Chen, Huiping Zhang, Rulin Zhao, Bei Wang, Adrian David
  • Process for the preparation of 3,7-disubstituted-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine compounds
    Patent number: 7074921
    Abstract: Methods for the synthesis of benzodiazepine compounds having farnesyl protein transferase inhibitory activity.
    Type: Grant
    Filed: November 12, 2002
    Date of Patent: July 11, 2006
    Assignee: Bristol Myers Squibb Company
    Inventors: David R. Kronenthal, Rao S. Bhandaru, Zhongping Shi, Boguslaw M. Mudryk
  • Process for the preparation of 3,7-disubstituted-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine compounds
    Publication number: 20030162965
    Abstract: Methods for the synthesis of benzodiazepine compounds having farnesyl protein transferase inhibitory activity.
    Type: Application
    Filed: November 12, 2002
    Publication date: August 28, 2003
    Inventors: David R. Kronenthal, Rao S. Bhandaru, Zhongping Shi, Boguslaw M. Mudryk