Patents by Inventor Bonnie L. Bassler

Bonnie L. Bassler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for regulating bacterial pathogenesis
    Patent number: 6720415
    Abstract: This invention provides a purified extracellular bacterial autoinducer-2 signaling molecule, the production of which is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. The signaling molecule stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. This invention also provides is a new class of bacterial genes involved in the biosynthesis of the signaling molecule.
    Type: Grant
    Filed: December 2, 1999
    Date of Patent: April 13, 2004
    Assignees: Princeton University, University Technologies International
    Inventors: Bonnie L. Bassler, Michael G. Surette
  • Compositions and methods for regulating bacterial pathogenesis
    Publication number: 20040033548
    Abstract: The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. A new class of bacterial genes is involved in the biosynthesis of autoinducer-2.
    Type: Application
    Filed: March 10, 2003
    Publication date: February 19, 2004
    Inventors: Bonnie L. Bassler, Michael G. Surette
  • Crystals of LuxP and complexes thereof
    Publication number: 20030175930
    Abstract: A crystal comprising LuxP is obtained, and a binding site for autoinducer-2 (AI-2) identified. The X-ray crystallographic data for LuxP and a LuxP-AI-2 complex is determined and used in a drug discovery method. Pharmaceutical compositions comprising ligands identified by such drug discovery methods are used to treat bacterial infections.
    Type: Application
    Filed: August 22, 2002
    Publication date: September 18, 2003
    Inventors: Bonnie L. Bassler, Stephan Schauder, Xin Chen, Frederick M. Hughson, Stephen R. Cooper
  • Compositions and methods for regulating bacterial pathogenesis
    Publication number: 20030166289
    Abstract: The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. A new class of bacterial genes is involved in the biosynthesis of autoinducer-2.
    Type: Application
    Filed: April 7, 2003
    Publication date: September 4, 2003
    Applicant: University Technologies International
    Inventors: Bonnie L. Bassler, Michael G. Surette
  • Inhibitors of autoinducer transporters
    Publication number: 20030165932
    Abstract: The present invention relates to the discovery of the lsr operon, the genes therein, and the polypeptides encoded by these genes. The present invention also includes strains with altered expression levels of the polypeptides encoded by the genes and the lsr operon relative to wild type cells. In some embodiments, the strains express a transporter that transports an autoinducer into the cell at a level higher than that of wild type cells. The present invention also includes methods for identifying compounds that modulate the transport of the autoinducer into cells.
    Type: Application
    Filed: October 28, 2002
    Publication date: September 4, 2003
    Inventors: Michiko E. Taga, Bonnie L. Bassler, Douglas T. McKenzie
  • COMPOSITIONS AND METHODS FOR REGULATING BACTERIAL PATHOGENESIS
    Publication number: 20030148414
    Abstract: This invention provides a purified extracellular bacterial autoinducer-2 signaling molecule, the production of which is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. The signaling molecule stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. This invention also provides is a new class of bacterial genes involved in the biosynthesis of the signaling molecule.
    Type: Application
    Filed: December 2, 1999
    Publication date: August 7, 2003
    Inventors: BONNIE L. BASSLER, MICHAEL G. SURETTE
  • Compositions and methods for regulating bacterial pathogenesis
    Publication number: 20030104606
    Abstract: The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. A new class of bacterial genes is involved in the biosynthesis of autoinducer-2.
    Type: Application
    Filed: September 21, 2001
    Publication date: June 5, 2003
    Inventors: Bonnie L. Bassler, Michael G. Surette
  • Compositions and methods for regulating bacterial pathogenesis
    Publication number: 20030096376
    Abstract: The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. A new class of bacterial genes is involved in the biosynthesis of autoinducer-2.
    Type: Application
    Filed: September 21, 2001
    Publication date: May 22, 2003
    Inventors: Bonnie L. Bassler, Michael G. Surette
  • Compositions and methods for regulating bacterial pathogenesis
    Publication number: 20030096330
    Abstract: The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. A new class of bacterial genes is involved in the biosynthesis of autoinducer-2.
    Type: Application
    Filed: September 21, 2001
    Publication date: May 22, 2003
    Inventors: Bonnie L. Bassler, Michael G. Surette
  • Compounds and methods for regulating bacterial growth and pathogenesis
    Patent number: 6559176
    Abstract: The invention provides autoinducer-2 analogs that regulate the activity of autoinducer-2 and methods of using such analogs for regulating bacterial growth and pathogenesis.
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: May 6, 2003
    Assignees: Princeton University, Quorex Pharmaceuticals, Inc., University Technologies International, Inc.
    Inventors: Bonnie L. Bassler, Carol Dammel, Stephan Schauder, Kevan Shokat, Jeffrey Stein, Michael G. Surette
  • LuxO-sigma54 interactions and methods of use
    Publication number: 20030023032
    Abstract: The invention relates to the identification and isolation of a novel sigma 54 (&sgr;54) transcription factor from Vibrio harveyi. The invention further relates to the identification of &sgr;54 interactions with LuxO. More particularly, the invention provides methods for identifying compounds that regulate bacterial cell growth and virulence by regulating LuxO-&sgr;54 activities.
    Type: Application
    Filed: May 10, 2001
    Publication date: January 30, 2003
    Inventors: Bonnie L. Bassler, Brendan N. Lilley
  • Compositions and methods for regulating bacterial pathogenesis
    Publication number: 20020107364
    Abstract: The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. A new class of bacterial genes is involved in the biosynthesis of autoinducer-2.
    Type: Application
    Filed: September 21, 2001
    Publication date: August 8, 2002
    Inventors: Bonnie L. Bassler, Michael G. Surette
  • Compositions and methods for regulating bacterial pathogenesis
    Publication number: 20020072052
    Abstract: The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. A new class of bacterial genes is involved in the biosynthesis of autoinducer-2.
    Type: Application
    Filed: September 21, 2001
    Publication date: June 13, 2002
    Inventors: Bonnie L. Bassler, Michael G. Surette