Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A replacement heart valve prosthesis is loaded onto a balloon mounted onto a balloon shaft of a catheter system. The balloon shaft is rotatably engaged with an actuator on the handle of the catheter system. Rotation of the actuator by a first amount in a first direction permits rotation of the heart valve prosthesis by a known amount during the procedure so that alignment of the commissures of the replacement valve with the commissures of the existing valve can be predictably achieved.

Abstract: An approach to arrange sensors needed for automated driving, especially where semitrailer trucks are operating in an autonomous convoy with one automated or semi-automated truck following another. The sensors are fitted to a location adjacent to or within the exterior rearview mirrors, on each of the left- and right-hand side of the tractor. The sensors provide overlapping fields of view looking forward of the vehicle and to both the left and right hand sides at the same time.

Abstract: In some scenarios, the approach may be used with two or more vehicles travelling in formation where selected vehicles may be fully or partially autonomously controlled. Information is collected at each vehicle and from the drivers and it is shared with other vehicles and drivers to make a collective decision to enter or leave autonomy.

Abstract: An approach to arrange sensors needed for automated driving, especially where semitrailer trucks are operating in an autonomous convoy with one automated or semi-automated truck following another. The sensors are fitted to a location adjacent to or within the exterior rearview mirrors, on each of the left- and right-hand side of the tractor. The sensors provide overlapping fields of view looking forward of the vehicle and to both the left and right hand sides at the same time.

Abstract: An approach to arrange sensors needed for automated driving, especially where semitrailer trucks are operating in an autonomous convoy with one automated or semi-automated truck following another. The sensors are fitted to a location adjacent to or within the exterior rearview mirrors, on each of the left- and right-hand side of the tractor. The sensors provide overlapping fields of view looking forward of the vehicle and to both the left and right hand sides at the same time.

Abstract: A retrofit pneumatic circuit complements an existing factory braking system to preserve the original function of the driver's foot pedal while also adding the ability for a computer to actuate the brakes separately and independently. In the event where both the primary and secondary drivers are actuating the brakes at any time, the braking force applied is the maximum of the two. In the preferred approach, a shuttle valve is connected between a primary proportional valve and a copy of that proportional valve. Directional control valves are also included to isolate both the input and the output portions of the secondary circuit in order to enforce positive shutdown of computer control. One directional valve blocks a supply pressure to prevent bleeding of the system in any situation where pressure is requested when computer control is supposed to be disabled.

Abstract: An approach to arrange sensors needed for automated driving, especially where semitrailer trucks are operating in an autonomous convoy with one automated or semi-automated truck following another. The sensors are fitted to a location adjacent to or within the exterior rearview mirrors, on each of the left- and right-hand side of the tractor. The sensors provide overlapping fields of view looking forward of the vehicle and to both the left and right hand sides at the same time.

Abstract: An approach to arrange sensors needed for automated driving, especially where semitrailer trucks are operating in an autonomous convoy with one automated or semi-automated truck following another. The sensors are fitted to a location adjacent to or within the exterior rearview mirrors, on each of the left- and right-hand side of the tractor. The sensors provide overlapping fields of view looking forward of the vehicle and to both the left and right hand sides at the same time.

Abstract: An approach to arrange sensors needed for automated driving, especially where semitrailer trucks are operating in an autonomous convoy with one automated or semi-automated truck following another. The sensors are fitted to a location adjacent to or within the exterior rearview mirrors, on each of the left- and right-hand side of the tractor. The sensors provide overlapping fields of view looking forward of the vehicle and to both the left and right hand sides at the same time.

Abstract: An approach to arrange sensors needed for automated driving, especially where semitrailer trucks are operating in an autonomous convoy with one automated or semi-automated truck following another. The sensors are fitted to a location adjacent to or within the exterior rearview mirrors, on each of the left- and right-hand side of the tractor. The sensors provide overlapping fields of view looking forward of the vehicle and to both the left and right hand sides at the same time.

Abstract: A virtual reality (VR) olfactory apparatus includes an odorant saturation chamber having an inlet and an outlet. At least a portion of the odorant saturation chamber includes a plurality of beads and a liquid. The liquid includes an odorant concentrate. The inlet extends into this portion of the odorant saturation chamber. The VR apparatus also includes a mass flow controller to generate an air flow to the inlet of the odorant saturation chamber such that the air flow passes through the portion of the odorant saturation chamber to form an odorant. The air flow passes the odorant through the outlet of the odorant saturation chamber. The VR apparatus further includes a nose chamber connected to the outlet and configured to receive the odorant.

Abstract: A virtual reality (VR) olfactory apparatus includes an odorant saturation chamber having an inlet and an outlet. At least a portion of the odorant saturation chamber includes a plurality of beads and a liquid. The liquid includes an odorant concentrate. The inlet extends into this portion of the odorant saturation chamber. The VR apparatus also includes a mass flow controller to generate an air flow to the inlet of the odorant saturation chamber such that the air flow passes through the portion of the odorant saturation chamber to form an odorant. The air flow passes the odorant through the outlet of the odorant saturation chamber. The VR apparatus further includes a nose chamber connected to the outlet and configured to receive the odorant.

Abstract: A pneumatic liquid dispenser includes a container and a lid. When the lid is mounted on the container, the container supports passaging defining a gas supply inlet for receiving pressurized gas, a gas outlet for delivering pressurized gas to the container, and a gas flow path between the inlet and the outlet. A pressure valve is located between the gas supply inlet and the gas outlet. The pressure valve is configured to automatically permit gas flow along the gas flow path when pressure in the interior of the container is less than a threshold pressure and to automatically block gas flow along the gas flow path when pressure in the interior of the container is greater than the threshold pressure. When gas flows freely through the gas flow path, the gas pressurizes the container to dispense liquid in the container through a liquid passage.

Abstract: A liquid flow device includes a container and a lid. When the lid is mounted on the container, the container supports a gas supply passage, a pressurization passage, an evacuation passage, and a liquid passage. A control valve is located between the gas supply passage and both the pressurization passage and the evacuation passage. In one configuration, the control valve provides communication between the gas supply passage and pressurization passage to pressurize the container and dispense liquid from the container through the liquid passage. In another configuration, the control valve provides communication between the gas supply passage and evacuation passage to create a vacuum pressure inside the container for evacuating liquid into the container through the liquid passage.

Abstract: A liquid dispenser includes a container and a lid. When the lid is mounted on the container, the container supports passaging including a gas supply inlet and a venturi. A control valve in fluid communication with the passaging is adjustable to a dispensing configuration and an evacuation configuration and a separate mode selector valve is adjustable to a dispensing configuration and an evacuation configuration. The dispenser dispenses liquid when both valves are in the dispensing configuration and evacuates liquid when both valves are in the evacuation configuration. The mode selector valve can block flow through a pressurization passage of the passaging in the evacuation configuration and through the venturi or other evacuation passage in the dispensing configuration.

Abstract: A liquid dispenser includes a container and a lid. When the lid is mounted on the container, the container supports passaging including a gas supply inlet and a venturi. A control valve in fluid communication with the passaging is adjustable to a dispensing configuration and an evacuation configuration and a separate mode selector valve is adjustable to a dispensing configuration and an evacuation configuration. The dispenser dispenses liquid when both valves are in the dispensing configuration and evacuates liquid when both valves are in the evacuation configuration. The mode selector valve can block flow through a pressurization passage of the passaging in the evacuation configuration and through the venturi or other evacuation passage in the dispensing configuration.

Abstract: A liquid flow device includes a container and a lid. When the lid is mounted on the container, the container supports a gas supply passage, a pressurization passage, an evacuation passage, and a liquid passage. A control valve is located between the gas supply passage and both the pressurization passage and the evacuation passage. In one configuration, the control valve provides communication between the gas supply passage and pressurization passage to pressurize the container and dispense liquid from the container through the liquid passage. In another configuration, the control valve provides communication between the gas supply passage and evacuation passage to create a vacuum pressure inside the container for evacuating liquid into the container through the liquid passage.

Abstract: A pneumatic liquid dispenser includes a container and a lid. When the lid is mounted on the container, the container supports passaging defining a gas supply inlet for receiving pressurized gas, a gas outlet for delivering pressurized gas to the container, and a gas flow path between the inlet and the outlet. A pressure valve is located between the gas supply inlet and the gas outlet. The pressure valve is configured to automatically permit gas flow along the gas flow path when pressure in the interior of the container is less than a threshold pressure and to automatically block gas flow along the gas flow path when pressure in the interior of the container is greater than the threshold pressure. When gas flows freely through the gas flow path, the gas pressurizes the container to dispense liquid in the container through a liquid passage.

Abstract: A flow measuring device for measuring flow of a fluid. A housing has a passage which extends between an inlet and an outlet. A shaft is disposed within the housing and is rotatable about a central axis. A flow detector is mounted on the shaft and disposed at least partially within the passage. The flow detector includes a rotatable, generally cylindrical body that rotates about a central axis as the fluid flows. A magnet is disposed within the housing such that the central axis extends through it, and is configured to rotate simultaneously with the body about the central axis. A magnetic encoder is disposed within the housing and configured to sense rotation of the magnet as the flow detector angularly displaces about the central axis so as to detect angular displacement of the flow detector.