Abstract: A joint assembly for an endovascular device, comprising a shaft comprising a main body and an enlarged end, a proximal strut comprising a slot, wherein the slot engages the enlarged end of the shaft and a locking collar comprising a proximal face and a distal face, and at least partially covering the enlarged end of the shaft and the slot of the proximal strut, such that the locking collar constrains the proximal strut such that the proximal strut cannot disengage from the enlarged end of the shaft when the joint assembly and the clot retrieval device is under load.

Abstract: A balloon guide catheter including a catheter shaft having a main lumen defined therein extending axially therethrough to receive a guidewire therein and an inflation lumen defined axially therein arranged semi-encircling the main lumen. The inflation lumen having an inlet port radially outward from the catheter shaft and an exhaust vent(s) disposed proximate the distal end of the catheter shaft. The exhaust vent(s) being disposed longitudinally through a distal terminating end of the inflation lumen or radially inward in fluid communication with the main lumen. A porous membrane is disposed at the exhaust vent(s) to permit only gas to pass therethrough. Secured about the outer surface proximate the distal end of the catheter shaft and coinciding with the inlet port is a balloon.

Abstract: A self-expanding intravascular medical device including a multi-component assembly with a self-expanding outer cage component comprising a plurality of struts; and a single cell wave-shape component disposed within the self-expanding outer cage component forming a channel therein. The proximal end of the single cell wave-shape component is connected to the self-expanding outer cage component at a proximal joint.

Abstract: A method for creating three-dimensional object and a three-dimensional printing system (a) provide a substrate; (b) provide construction material to coat the substrate; (c) curie a portion of the construction material on the substrate to create an object on the substrate; (d) remove excess construction material from the substrate; (e) cut an outline around the object created on the substrate; (f) repeating (a)-(e) until a desired number of substrates with an object created thereon have been processed; (g) stack the processed substrates; and (h) finish the stacked processed substrates to bond the stacked processed substrates together.

Abstract: A system has an outer catheter and an inner aspirating clot retrieval catheter having an expansile distal tip for flow restriction, improved aspiration efficiency, and a large mouth into which a clot or other obstructions can be retrieved. The clot retrieval catheter can have a support tube proximal of the tip. The expansile tip can be a strut framework, and a flexible, low-modulus cover is disposed around at least a portion of the tip strut framework and the proximal support tube. The distal end of the tip can be encapsulated by a low-friction elastomeric lip for atraumatic contact with the walls of a blood vessel. The tip has a collapsed delivery configuration and expands radially into a deployed configuration. The tip strut framework, support tube, and cover can all have characteristics which enhance the deliverability of the clot retrieval catheter to the target.

Abstract: A clot retrieval device for removing clot from a blood vessel, including a shaft; a plurality of expandable bodies distal of the shaft, each expandable body comprising a plurality of scaffolding segments forming closed cells, wherein at least one of the clot scaffolding segments terminates in a distal apex free from connection to an adjacent closed cell; and a plurality of clot inlet mouths between expandable bodies through which clot may pass and enter the device.

Abstract: A balloon guide catheter having a sleeved inflation lumen secured with a wire wrap for improved inflation lumen kink protection and a welded balloon construction provides a robust and flexible catheter with an exceptionally large inner lumen relative to its outer profile and enables rapid and reliable balloon inflation and deflation in a highly deliverable and kink resistant catheter. Balloon guide catheters having multiple sleeved inflation lumens and proximal luers for utilizing the multiple inflation lumens are also provided.

Abstract: A method and/or use of restoring blood flow in neurovasculature by removing thrombus in a plurality of human patients experiencing ischemic stroke using a revascularization device as either a first-line device or a second-line device.

Abstract: A self-expanding intravascular medical device including a multi-component assembly with a self-expanding outer cage component comprising a plurality of struts; and a single cell wave-shape component disposed within the self-expanding outer cage component forming a channel therein. The proximal end of the single cell wave-shape component is connected to the self-expanding outer cage component at a proximal joint.

Abstract: A reperfusion device for an occluded vessel. The device includes a framework of struts that form a porous body comprising a collapsed delivery configuration capable of being stored in a microcatheter and an expanded deployed configuration when delivered to an occlusion and distal of the microcatheter. The framework of struts is constructed from a material visible under fluoroscopy and capable of recovering its shape in the expanded deployed configuration once released from the collapsed delivery configuration in the microcatheter.

Abstract: A clot removal device for removing clot from a body vessel includes an expandable structure having a constrained delivery configuration, an expanded clot engaging deployed configuration, and an at least partially constrained clot pinching configuration, the expandable structure including a proximal section comprising a plurality of struts with opening angles; a mid-section distal of the proximal section and comprising a plurality of struts with opening angles and cells larger than cells of the proximal section, the mid-section being configured to expand a larger radial extent in the deployed configuration than the proximal section to provide clot grip and retention during retraction of the clot; wherein the proximal section is configured to pinch the clot from the body vessel when partially resheathed by a microcatheter.

Abstract: A clot retrieval catheter can have an expansile distal tip for flow restriction/arrest and improved aspiration efficiency and a large, distal facing mouth into which clots or other obstructions can be retrieved. The tip can be formed from a distal ring of leaflets or hoops. One or more pull cables can be retracted to actuate and radially expand the expansile distal tip. The clot retrieval catheter can have a catheter shaft with flexibility-adding features proximal of the tip. The catheter shaft can be a multi-lumen configuration with a large catheter lumen for passing auxiliary devices and directing aspiration and one or more guide lumens which can route the pull cables to the leaflets or hoops of the expansile tip. A flexible, low-modulus membrane can be disposed around at least a portion of the expansile tip and catheter shaft.

Abstract: A device for retrieving an obstruction in a blood vessel can have an outer sheath with a distal end, a proximal end, a proximal luer encompassing the proximal end, and an internal lumen extending proximal of the distal end and terminating within the proximal luer; and an inner funnel catheter within the outer sheath comprising an expanding distal tip, a proximal end, a distal end located at the distal tip, a proximal luer encompassing the proximal end, and an internal lumen extending proximal of the distal end and terminating at the luer. The outer sheath and inner funnel catheter can be capable of moving telescopically with respect to each other. In some examples, a slider mechanism or rotating knob located on one of the proximal luers can be used to actuate the relative motion.

Abstract: A clot retrieval device for removing clot from a blood vessel, including a shaft extending between a proximal end and a distal end; a first expandable body coupled to the distal end of the shaft, the first expandable body comprising a plurality of scaffolding segments forming closed cells, wherein at least one of the clot scaffolding segments terminates in a distal apex free from connection to an adjacent closed cell; a second expandable body distal of the first expandable body and comprising a plurality of scaffolding segments forming closed cells; and at least one clot inlet mouth between the first and second expandable bodies and the distal apex through which clot may pass and enter the device.

Abstract: A method and system applying glue to a fabric to create a bonded seam by applying a carrier liquid to a predetermined area of a first piece of fabric and in a pre-determined pattern; applying uniformly, to the first piece of fabric, particles of a powdered elastomer such that the particles of the powdered elastomer adhere to the applied carrier liquid; removing excess particles of the powdered elastomer, the excess particles of the powdered elastomer being particles of the powdered elastomer not adhering to the applied carrier liquid; applying a second piece of fabric to the predetermined area of a first piece of fabric; and curing the particles of a powdered elastomer to create a bonded seam between the first piece of fabric and the second piece of fabric.

Abstract: Methods and systems for using a clot retrieval device for treating a clot in a blood vessel for use in the treatment of ischemic stroke to achieve a clinically effective revascularization or perfusion rate for clots comprising a higher ratio of red blood cells to fibrin.

Abstract: An aspiration catheter for assisting in the retrieval of a clot from a vessel of a patient including at least one electrode pair and a first pressure sensor positioned within an inner lumen of the aspiration catheter and a second and third pressure sensor positioned on an exterior surface of the aspiration catheter. The electrode pair and pressure sensors are in electrical communication with a control console. The control console is configured to modulate an aspiration vacuum pressure waveform pattern applied through the aspiration catheter based on electrical and pressure inputs from the one or more sensors, and optionally based on a blood pressure waveform pattern of the patient.

Abstract: A clot retrieval device for removing an occlusive clot from a blood vessel. The device includes a clot engagement section having a constrained delivery configuration and an expanded deployed configuration, wherein in the expanded deployed configuration. The clot engagement section can include a plurality of peak sections configured to vary contact pressure between the clot and the device along a length of the device; and a plurality of troughs between respective peak sections comprising a clot reception space. Each peak is configured to exert a relatively high compressive force on the clot whereas each trough is configured to exert little or no compressive force on the clot.

Abstract: A clot retrieval catheter can have an expansile distal tip for flow restriction/arrest and improved aspiration efficiency and a large, distal facing mouth into which clots or other obstructions can be retrieved. The tip can be formed from a distal ring of leaflets or hoops. One or more pull cables can be retracted to actuate and radially expand the expansile distal tip. The clot retrieval catheter can have a catheter shaft with flexibility-adding features proximal of the tip. The catheter shaft can be a multi-lumen configuration with a large catheter lumen for passing auxiliary devices and directing aspiration and one or more guide lumens which can route the pull cables to the leaflets or hoops of the expansile tip. A flexible, low-modulus membrane can be disposed around at least a portion of the expansile tip and catheter shaft.

Abstract: Method for using a clot retrieval device for treating a clot in a blood vessel for use in the treatment of ischemic stroke to reperfuse an obstructed vessel. The method comprising delivering a revascularization device to a blood vessel of a respective human patient of a first plurality of human patients for retrieving a clot and removing the revascularization device and restoring perfusion to the blood vessel for the first plurality of human patients with one or more clots by passing the revascularization device by, through, or about the clot to achieve a reperfusion outcome greater than approximately 53.5% under a modified Rankin Scale (mRS) score of 0-2 within a predetermined time period.