Abstract: A mechanical locking assembly for an endovascular device, comprising a shaft comprising a main body a shaft comprising a main body and enlarged end, an inner channel component comprising a full collar formed on proximal end of the inner channel component, and an outer cage component comprising a partial collar formed on the outer cage component wherein the full collar of the inner channel component fully surrounds the outer cage component and the partial collar of the outer cage component at least partially surrounds the shaft.

Abstract: A method and/or use of restoring blood flow in neurovasculature by removing thrombus in a plurality of human patients experiencing ischemic stroke. A first stent retriever device is passed by, through, or about a cerebral occlusion in a blood vessel of one of the plurality of human patients. Then a revascularization device is passed by, through, or about the cerebral occlusion in the blood vessel of the one of the plurality of human patients to restore perfusion to the blood vessel and achieve at least approximately 88% final revascularization rate for the plurality of human patients under the modified treatment in cerebral infarction score of equal to or greater than a grade of 2b (mTICI?2b).

Abstract: A method and system applying glue to a fabric to create a bonded seam by applying a carrier liquid to a predetermined area of a first piece of fabric and in a pre-determined pattern; applying uniformly, to the first piece of fabric, particles of a powdered elastomer such that the particles of the powdered elastomer adhere to the applied carrier liquid; removing excess particles of the powdered elastomer, the excess particles of the powdered elastomer being particles of the powdered elastomer not adhering to the applied carrier liquid; applying a second piece of fabric to the predetermined area of a first piece of fabric; and curing the particles of a powdered elastomer to create a bonded seam between the first piece of fabric and the second piece of fabric.

Abstract: An aspiration control device can have an aspiration control valve and a switch, button, slider, trigger, grip, lever, rotating wheel, rotating valve, handle or other interface for resizing the aspiration control valve. The aspiration control interface can be conveniently positioned and configured to be manipulated while simultaneously stabilizing a catheter and/or retracting an elongated member. The aspiration control device can be integrated with a hemostasis valve, integrated with a wire gripping device, and/or attached to an inlet, outlet, hose, pump, or syringe in series with an aspiration flow path.

Abstract: A mechanical locking assembly for an endovascular device, comprising a shaft comprising a main body a shaft comprising a main body and enlarged end, an inner channel component comprising a full collar formed on proximal end of the inner channel component, and an outer cage component comprising a partial collar formed on the outer cage component wherein the full collar of the inner channel component fully surrounds the outer cage component and the partial collar of the outer cage component at least partially surrounds the shaft.

Abstract: A clot retrieval device for removing an occlusive clot from a blood vessel. The device includes a clot engagement section having a constrained delivery configuration and an expanded deployed configuration, wherein in the expanded deployed configuration. The clot engagement section can include a plurality of peak sections configured to vary contact pressure between the clot and the device along a length of the device; and a plurality of troughs between respective peak sections comprising a clot reception space. Each peak is configured to exert a relatively high compressive force on the clot whereas each trough is configured to exert little or no compressive force on the clot.

Abstract: A system for assisting in the retrieval of a clot from a vessel. The system can include an outer catheter and an inner catheter disposed in a lumen of the outer catheter. The inner catheter can include a distal end, a proximal end, a distal segment, a proximal segment, and a lumen extending proximal of the distal end and terminating at a transfer port at the proximal end of the distal segment. A seal is located on the outer surface of the inner catheter distal of the transfer port, the seal capable of sealing against the lumen of the outer catheter so that aspiration applied through the outer catheter is configured to be transferred to the inner catheter.

Abstract: A balloon guide catheter system including a balloon guide catheter having a catheter shaft that includes: (i) a main lumen; (ii) an inflation lumen; and (iii) an exhaust lumen. The terminating distal end of the inflation lumen and the terminating distal end of the exhaust lumen being in localized fluid communication with one another underneath the balloon while in a non-inflated state. A balloon is disposed about a distal region of an outer surface of the catheter shaft. The exhaust lumen is configured to purge the residual air in a proximal direction and out from a proximal region of the balloon guide catheter.

Abstract: The designs and methods disclosed herein are for a clot retrieval catheter with a large bore shaft and a distal braid-supported tip that is expandable to a diameter larger than the outer sheath through which it is delivered. The shaft can have a plurality of supporting braids fixed distally to a radiopaque marker band. The tip can have another plurality of supporting braids fixed proximally to the marker band and a decreasing braid angle distally so that the tip can be heat set to an expanded funnel shape. The wires of the tip braids can follow one spiral direction distally and then invert proximally back on themselves to form the other spiral direction of the braid. This inversion of the wires results in atraumatic distal hoops at the distal termination of the braid. Designs can further have spines capable of resisting elongation of the catheter shaft during a procedure.

Abstract: The designs and methods disclosed herein are for a clot retrieval catheter with a large bore shaft and a distal braid-supported tip that is expandable. A distal expansile section of the braid-supported tip can have a delivery inner diameter approximately equal to the inner diameter of the shaft. The braid of the tip can have a decreasing braid angle distally so that the tip can expand to a larger expanded inner diameter when impinged radially by an ingested clot to manage the clot and prevent shearing of clot fragments. The wires of the tip braids can follow one spiral direction distally and then invert proximally back on themselves to form the other spiral direction of the braid. This inversion of the wires results in atraumatic distal hoops at the distal termination of the braid. Designs can further have spines capable of resisting elongation of the catheter shaft during a procedure.

Abstract: A system has a balloon guide catheter for use in mechanical thrombectomy procedures which requires very little preparation to inflate the balloon compared to most contemporary designs. The balloon guide catheter can have an elongated tubular member and a proximal luer. The elongated tubular member of the catheter can have two internal lumens. A first inner hollow lumen can have a large opening for aspiration and the advancement of auxiliary devices, and a second inflation lumen can provide a fluidic passageway to inflate the balloon. The proximal luer can have a luer lumen, an inflation port, and a mandrel hub. A removable mandrel can extend distally from the mandrel hub to occupy the full length and volume of the inflation lumen of the tubular member. A tab of the mandrel can extend external to the luer to facilitate removal of the mandrel from the catheter prior to inflating the balloon.

Abstract: The designs and methods disclosed herein are for a clot retrieval catheter that can have a proximal elongate body with a large bore lumen and a distal tip expandable to a diameter larger than the outer sheath through which it is delivered. The distal tip can have a flexible metallic support frame to provide radial scaffolding and the ability for further flexible expansion when ingesting a clot. The support frame can be designed so that the expanding movement is focused in a portion of the circumference though a plurality of deformable cells that can collapse to be almost flat and parallel to the longitudinal axis for deliverability, but expand to a very steep angle for good resistance to collapse under aspiration. The designs can be sufficiently flexible to navigate tortuous anatomy but recover to maintain the inner diameter of the lumen when displaced in a vessel.

Abstract: A balloon guide catheter system including a balloon guide catheter having a catheter shaft that includes: (i) a main lumen; (ii) an inflation lumen; and (iii) an exhaust lumen. The terminating distal end of the inflation lumen and the terminating distal end of the exhaust lumen being in localized fluid communication with one another underneath the balloon while in a non-inflated state. A balloon is disposed about a distal region of an outer surface of the catheter shaft. The exhaust lumen is configured to purge the residual air in a proximal direction and out from a proximal region of the balloon guide catheter.

Abstract: A clot retrieval device comprising an elongate shaft having a proximal end and a distal end and a clot retrieval element at the distal end of the elongate shaft. A proximal end of the elongate shaft configured to retract a first catheter over the elongate shaft. The shaft extension member comprising one or more raised profiles configured to interfere with one or more indentations along the elongate shaft such that the shaft extension member is configured to extend between a first length and an intermediate length. A second catheter is advanced to or adjacent to the distal end of the clot retrieval device shaft to enable enhanced aspiration adjacent to the clot retrieval element.

Abstract: A staged printing system includes: a printing station for printing an image upon an object; a curing station, operatively connected to the printing station, for curing the image printed upon the object; and a pretreatment station, operatively connected to the printing station, for pretreating the object before printing an image upon the object. The printing station includes a plurality of vertically mounted print heads for ejecting ink and a rotating platform for rotating the object as the plurality of vertically mounted print heads eject ink upon the object.

Abstract: Method for using a clot retrieval device for treating a clot in a blood vessel for use in the treatment of ischemic stroke to reperfuse an obstructed vessel. Use of the clot retrieval device reducing in-hospital mortality.

Abstract: Devices described herein include a stentriever for removing an occlusive clot. The stentriever can include a membrane cover on the proximal end which can be sized to form a seal with the tip of an intermediate catheter. Clot engagement sections and/or a distal engagement section of the stentriever can also include a full or partial membrane covering to control the direction of aspiration and/or areas where the aspiration applies suction to the thrombus or clot. The membranes can be used to direct the aspiration so as to pull the clot deeper into the clot engagement sections of the stentriever, thereby improving grip on the clot. The design can also increase the effectiveness of clot fragment protection for friable clots by providing pores and/or clot cells in a distal engagement section.

Abstract: Method for using a clot retrieval device for treating a clot in a blood vessel for use in the treatment of ischemic stroke to reperfuse an obstructed vessel. Use of the clot retrieval device reducing in-hospital mortality.

Abstract: A clot removal device that includes an expandable structure comprising interconnected struts configured to engage with clot. The interconnected struts are configured in the expanded clot engaging deployed configuration so at least a portion of the plurality of interconnected struts interpenetrates clot. The expandable structure includes a distal section, a proximal pinch section proximal of the distal section, and a clot capture mechanism.

Abstract: A clot capture catheter having an outer inflatable expansile member and an inner inflatable expansile member positioned within the outer inflatable expansile member at a distal end of a shaft of the catheter is presented herein. The inner and outer inflatable expansile members can have differing compliance than each other. Inflation of a higher compliance inner inflatable expansile member can cause a lower compliance outer inflatable expansile member to shorten and provide tension to the distal end of the shaft to case the distal end to open to a funnel shape. Inflation of a lower compliance inner inflatable expansile member can center the distal end of the shaft within a vessel, and inflation of a higher compliance outer inflatable member can provide atraumatic flow arrest to the vessel.