Abstract: Polarization sensitive devices utilizing stacked organic and inorganic photovoltaics and related methods are disclosed. According to an aspect, a polarization sensitive photovoltaic (PV) cell may include an anode, a cathode, and a photoactive layer and a polarizing structure between the anode and the cathode. The photoactive layer may be formed from inorganic or organic materials. The polarizing structure may be integrated with the photoactive layer. Two or more PV cells may be stacked along an axis to form a polarization sensitive device such as, for example, a polarimeter.

Abstract: Disclosed are the ERK inhibitors of formula (1.0), having a pyrazolopyridine base structure, and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1.0).

Abstract: Provided are peptide analogues of PA-IL and compositions containing them. The PA-IL peptide analogues have altered carbohydrate binding specificity relative to a PA-IL of SEQ ID NO:1, and thus the analogues contain amino acid substitutions in SEQ ID NO:1. The substitutions can be at positions 50, 52 and 53 of SEQ ID NO:1 and can include combinations of amino acid substitutions at those positions. Also included are methods for detecting changes in the glycosylation of carbohydrates and for separating biomolecules which contain glycoproteins or glycoconjugates.

Abstract: Provided are triazole derivatives of Formula I which are potent inhibitors of spleen tyrosine kinase and pharmaceutical composition. The triazole derivatives are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.

Abstract: A handheld, cordless scanning device for the three-dimensional image capture of patient anatomy without the use of potentially hazardous lasers, optical reference targets for frame alignment, magnetic reference receivers, or the requirement that the scanning device be plugged in while scanning. The device generally includes a housing having a front end and a rear end. The rear end includes a handle and trigger. The front end includes a pattern projector for projecting a unique pattern onto a target object and a camera for capturing live video of the projected pattern as it is deformed around the object. The front end of the housing also includes a pair of focus beam generators and an indexing beam generator. By utilizing data collected with the present invention, patient anatomy such as anatomical features and residual limbs may be digitized to create accurate three-dimensional representations which may be utilized in combination with computer-aided-drafting programs.

Abstract: Provided herein are compositions, kits, methods and devices for cyanide detection, particularly for cyanide detection in biological samples such as whole blood. The method comprises (1) contacting a sample with a cobinamide conjugate comprising a cobinamide moiety and a carrier; and (2) measuring the absorbance of light by the cobinamide conjugate. The present disclosure provides field-deployable cyanide detection methods, compositions, kits and devices, which provide rapid, accurate readout at the point of contact. Further provided herein is a method for determining exposure of a subject to cyanide.

Abstract: The current invention relates to the use of a bacterial species in the preparation of a composition adapted for oral administration for the delivery of an agent to a site in the body. The site in the body may be an organ or a tumour site. The bacterial species is a food grade, non-pathogenic, gram-positive bacteria capable of anaerobic growth.

Abstract: The present invention relates to a process for preparing silylated polyurethane polymers which have increased stability under ambient condition or storage toward atmospheric moisture, in the presence of at least one of titanium-containing catalyst or zirconium-containing catalyst and to silylated polyurethane polymer compositions comprising these catalysts.

Abstract: Provided are peptide analogs of PA-IL and compositions containing them. The PA-IL peptide analogs have altered carbohydrate binding specificity relative to a PA-IL of SEQ ID NO:1, and thus the analogs contain amino acid substitutions in SEQ ID NO:1. The substitutions can be at positions 50, 52 and 53 of SEQ ID NO:1 and can include combinations of amino acid substitutions at those positions. Also included are methods for detecting changes in the glycosylation of carbohydrates and for separating biomolecules which contain glycoproteins or glycoconjugates.

Abstract: Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1).

Abstract: Disclosed is a method and a system for determining a velocity of a relative movement between a system for determining the velocity and a fluidal medium. The method includes directing at least two light beams through at least a portion of the fluidal medium using the system such that a portion of light of each light beam is absorbed by the fluidal medium. Further, the method includes detecting first and second spectral intensity profiles of at least two light beams to detect the light absorption. The method also includes determining a difference profile associated with spectral intensity differences between a first and a second spectral intensity profile; and integrating an absolute value function of the difference profile to determine the velocity. The at least two light beams are directed such that the first and second spectral intensity profiles each have a different spectral position. The system has components that are arranged to allow operation of the above-described method.

Abstract: Methods for forming cell arrays of multiple cell samples arranged substantially in a monolayer on a single substrate particularly suited for diagnostic analysis are disclosed. The cell arrays are formed with a high-speed dispensing apparatus capable of dispensing small volumes in precise, complex patterns. Also disclosed are substrates upon which cell arrays may be formed, and methods for conducting diagnostic analyses on the formed cell arrays.

Abstract: The present invention relates to novel lateral flow devices using two dimensional features, preferably, uniform two dimensional test and control signal readout patterns, and the methods for detecting an analyte using the lateral flow devices.

Abstract: Methods for forming cell arrays of multiple cell samples arranged substantially in a monolayer on a single substrate particularly suited for diagnostic analysis are disclosed. The cell arrays are formed with a high-speed dispensing apparatus capable of dispensing small volumes in precise, complex patterns. Also disclosed are substrates upon which cell arrays may be formed, and methods for conducting diagnostic analyzes on the formed cell arrays.

Abstract: Systems and methods are disclosed for providing storage at indoor golf driving ranges. In various embodiments, the disclosed systems and methods permit golfers to store their baggage in close proximity to the golfers while the golfers practice their swing.

Abstract: The disclosure concerns notification message generation. A first message template is generated based on a series of first notification messages intended for push delivery to recipient user devices. The first message template includes non-personalised information identified as substantially common to the series of first notification messages, and one or more parameters representing personalised information identified in the stream of first notification messages. An alternative second message template that includes at least one variation from the non-personalised information in the first message template is then generated. Using the first message template and second message template, a series of second notification messages is generated for push delivery to the recipient user devices. Generating the second notification messages includes replacing the one or more parameters with personalised information associated with the recipient user devices.

Abstract: Methods and systems for secure client-side communication between multiple domains is provided. Such methods and systems can provide for decreased communication latency particularly effective for dynamic multi-domain and/or multi-tenant environments while allowing for granular security or specific security of messages and operations with regard to users, user sessions, groups, organizations, permissions sets, applications, or any other logical delineation. Such methods and systems may involve a variety of security components, for example, at least one set of instructions including a plurality of defined instruction to be utilized by users of the set of instructions to communicate, and cryptographic construct data in order to verify the data integrity and the authenticity of messages sent and received using the secure client-side communication between multiple domains.

Abstract: Systems and methods are disclosed for providing storage at indoor golf driving ranges. In various embodiments, the disclosed systems and methods permit golfers to store their baggage in close proximity to the golfers while the golfers practice their swing.

Abstract: Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1).

Abstract: A method of forming an insulating structure, comprising forming an insulating region comprising at least one electrical or electronic component or part thereof embedded within the insulating region, and forming a surface structure in a surface of the insulating region.