Abstract: A speculum operable to be disposed within an ear of a subject may include a housing. The housing may include a light conducting element. A transmitted optical illumination may be conducted by total internal reflection via the light conducting element. The housing may include a lumen. The housing may be configured to allow a reflected optical illumination to propagate through the lumen. The speculum may include one or more coupling portions which couple the transmitted optical illumination from a light source to the light conducting element. The one or more coupling portions may be shaped as a conic section.

Abstract: The present disclosure describes a synthetic process and novel intermediates related to spirocyclic azetidenyl-isobenzofuran derivatives having an isothiazoline moiety, which are useful as antiparasitics.

Abstract: The present disclosure describes novel compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the disclosure have activity as prostaglandin EP4 receptor antagonists, and are useful in the treatment or alleviation of pain and inflammation and other inflammation-associated disorders, such as arthritis, treating or preventing disorders or medical conditions selected from pain, inflammatory diseases and the like. Also described herein are methods of treating pain by administering the compounds of the disclosure, which are EP4 receptor antagonists.

Abstract: The present disclosure describes a synthetic process and novel intermediates related to spirocyclic azetidenyl-isobenzofuran derivatives having an isothiazoline moiety, which are useful as antiparasitics.

Abstract: The present disclosure describes novel compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the disclosure have activity as prostaglandin EP4 receptor antagonists, and are useful in the treatment or alleviation of pain and inflammation and other inflammation-associated disorders, such as arthritis, treating or preventing disorders or medical conditions selected from pain, inflammatory diseases and the like. Also described herein are methods of treating pain by administering the compounds of the disclosure, which are EP4 receptor antagonists.

Abstract: The present invention relates to a process for the preparation of rucaparib; the invention also refers to novel intermediates of synthesis as well as their use in the preparation of i.a. rucaparib.

Abstract: Packaging comprising of a display structure for displaying the hand tool. A retaining structure is combined to the display structure for engaging the working end of the ratchet tool with friction to prevent rotation of the working end. A securement structure is combined to the display structure and is configured to secure a portion of the ratchet tool in a manner that permits rotation of the handle of the ratchet tool relative to the working end while preventing the ratchet tool from being separated from the securement structure.

Abstract: The present invention relates to a process for the preparation of rucaparib; the invention also refers to novel intermediates of synthesis as well as their use in the preparation of i.a. rucaparib.

Abstract: The present disclosure describes novel compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the disclosure have activity as prostaglandin EP4 receptor antagonists, and are useful in the treatment or alleviation of pain and inflammation and other inflammation-associated disorders, such as arthritis, treating or preventing disorders or medical conditions selected from pain, inflammatory diseases and the like. Also described herein are methods of treating pain by administering the compounds of the disclosure, which are EP4 receptor antagonists.

Abstract: The present disclosure describes a synthetic process and novel intermediates related to spirocyclic azetidenyl-isobenzofuran derivatives having an isothiazoline moiety, which are useful as antiparasitics.

Abstract: An apparatus includes a flywheel, a first pivotable caliper, a first magnet supported by the first caliper opposite the flywheel, a second pivotable caliper and a second magnet supported by the second caliper opposite the flywheel. In one implementation, the apparatus further includes a first cam follower coupled to the first caliper, a second cam follower coupled to the second caliper and at least one cam member including a first cam surface against which the first cam follower moves and a second cam surface against which the second cam follower moves, wherein movement of the at least one cam member pivots the first caliper and the second caliper to move the first magnet and the second magnet relative to the flywheel. In another implementation, the apparatus further includes a strain gauge carried by the first caliper to output signals indicating braking torque.

Abstract: The present invention describes novel compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the invention have activity as prostaglandin EP4 receptor antagonists, and are useful in the treatment or alleviation of pain and inflammation and other inflammation-associated disorders, such as arthritis, treating or preventing disorders or medical conditions selected from pain, inflammatory diseases and the like. Also described herein are methods of treating pain by administering the compounds of the invention, which are EP4 receptor antagonists.

Abstract: A control apparatus for a broadcast spreader includes a gate adjustment dial mounted on, and generally coaxial with, a handle portion of a handle assembly of the spreader. Rotation of the gate adjustment dial in a first direction causes an increase in a current maximum discharge rate of the spreader and rotation of the gate adjustment dial in a second direction causes a decrease in the current maximum discharge rate of the spreader.

Abstract: A control apparatus for a broadcast spreader includes a gate adjustment dial mounted on, and generally coaxial with, a handle portion of a handle assembly of the spreader. Rotation of the gate adjustment dial in a first direction causes an increase in a current maximum discharge rate of the spreader and rotation of the gate adjustment dial in a second direction causes a decrease in the current maximum discharge rate of the spreader.

Abstract: Packaging comprising of a display structure for displaying the hand tool. A retaining structure is combined to the display structure for engaging the working end of the ratchet tool with friction to prevent rotation of the working end. A securement structure is combined to the display structure and is configured to secure a portion of the ratchet tool in a manner that permits rotation of the handle of the ratchet tool relative to the working end while preventing the ratchet tool from being separated from the securement structure.

Abstract: Packaging comprising of a display structure for displaying the hand tool. A retaining structure is combined to the display structure for engaging the working end of the ratchet tool with friction to prevent rotation of the working end. A securement structure is combined to the display structure and is configured to secure a portion of the ratchet tool in a manner that permits rotation of the handle of the ratchet tool relative to the working end while preventing the ratchet tool from being separated from the securement structure.