Abstract: A system to facilitate distributed storage with balanced load and multi-mirroring options. The system includes a plurality of server processing central processing units, each server having one or more mount points for storage and retrieval of file data. At least one managerial system is in communication with each server, each managerial system having configure information for each server, mover module software, and checker module software. One or more pairs of remote data storage device servers are in communication with the servers so that each pair stores the same data as its counterpart so that they mirror one another, each server having software to dynamically spread workload across the available servers based on factors including the number of files already opened, the existence of files, and available space.

Abstract: A secure virtual tape management system with early read support options. The system includes at least two mainframe hosts having a catalog storing tape related information. A primary virtual tape emulation system includes an adaptor and includes software for facilitating remote configuration and utilization of the virtual tape management. A virtual tape system catalog storing tape related information is attached to the virtual tape management. Remote data storage devices may be in communication with the virtual tape management central processing unit. Software resident on the catalog monitors tape related information on the primary virtual tape emulation system for criteria matching a virtual tape to be made available to a secondary host and initiates immediate transfer of that data allowing it to be read in a paced manner by the secondary host before the primary host has completed its series of tape writes.

Abstract: Described herein are methods for predicting the recurrence, progression, and metastatic potential of a prostate cancer in a subject. For example, the method comprises detecting in a sample from a subject one or more biomarkers selected from the group consisting of FOXO1A, SOX9, CLNS1A, PTGDS, XPO1, LETMD1, RAD23B, ABCC3, APC, CHES1, EDNRA, FRZB, HSPG2, and TMPRSS2_ETV1 FUSION. The method can further comprise detecting in a sample from a subject one or more biomarkers selected from the group consisting of miR-103, miR-339, miR-183, miR-182, miR-136, and miR-221. An increase or decrease in one or more biomarkers as compared to a standard indicates a recurrent, progressive, or metastatic prostate cancer.

Abstract: Disclosed herein is a compound according to one of the formulas wherein R is Additionally, pharmaceutically acceptable salt thereof, and methods of treating disease, medicaments, and compositions related thereto, are further elaborated herein.

Abstract: Disclosed herein is a compound according to one of the formulas or a pharmaceutically acceptable salt thereof, medicaments for the treatment of glaucoma or ocular hypertension and compositions related thereto, as further elaborated herein.

Abstract: Novel compounds and their uses are disclosed herein.

Abstract: The present invention relates to a waffle chip to complement and aid in the consumption of frozen desserts and the method of making the same. The waffle chip according to the present invention includes: a top side; a curved bottom side; two angled sides, where the two angled sides connect the top side to the bottom side; and a concaved underside, where said concaved underside provides a mechanism to scoop and contain the frozen dessert. The waffle chip includes a waffle type pattern across the surface and the concaved underside creates a spoon-like shape. In one particular embodiment, the waffle chip may be 3 inches in length.

Abstract: Remote configuration and utilization of a virtual tape management system via communication of encrypted data. At least one security administrator CPU is communicably attached to a virtual tape management CPU. At least one remote data storage CPU is communicably attached to the virtual tape management CPU and to the security administrator. First software within the virtual tape management CPU validates authorized remote access to at least one remote data storage CPU and encrypts the data. Second software facilitates remote configuration and utilization of the virtual tape management CPU. At least one hardware adaptor card connects the virtual tape management CPU to a host.

Abstract: Remote configuration and utilization of a virtual tape management system with creation and management options. At least one security administrator CPU is communicably attached to a virtual tape management CPU. A pair of disk drives is communicably attached to the virtual tape management CPU and to the security administrator. First software within the virtual tape management CPU validates authorized remote access to said disk drives and encrypts the data. Second software facilitates remote configuration and utilization of the virtual tape management CPU. Third software provides tape image file processing including inspecting each remote data storage to determine if a file is present, opening the file, reading tape related information thereon, and reading from or writing to the disk arrays. Fourth software provides checker support for tape image files for enumerating tape image files on the disk drives, opening the tape image files, and reading the tape related information.

Abstract: A system for planning and verifying off-site disaster recovery plans as well as implementing alternate fall back operations in the event of a disaster. The system includes at least one primary mainframe computer having an inboard catalog component, a primary emulated device controller connected to the primary computer, and a primary virtual tape system connected to the primary computer. A primary virtual tape system catalog is connected to the primary virtual tape system. A disaster recovery administrator using remote management tools maintains user and resource profiles and controls configuration of the primary emulated device controller and the primary virtual tape system.

Abstract: Disclosed herein are therapeutic methods related to brimonidine.

Abstract: Disclosed herein is a compound according to one of the formulas or a pharmaceutically acceptable salt thereof, medicaments for the treatment of glaucoma or ocular hypertension and compositions related thereto, as further elaborated herein.

Abstract: A secure virtual tape management system with early read support options. The system includes at least two mainframe hosts having a catalog storing tape related information. A primary virtual tape emulation system includes an adaptor and includes software for facilitating remote configuration and utilization of the virtual tape management. A virtual tape system catalog storing tape related information is attached to the virtual tape management. Remote data storage devices may be in communication with the virtual tape management central processing unit. Software resident on the catalog monitors tape related information on the primary virtual tape emulation system for criteria matching a virtual tape to be made available to a secondary host and initiates immediate transfer of that data allowing it to be read in a paced manner by the secondary host before the primary host has completed its series of tape writes.

Abstract: A system to facilitate distributed storage with balanced load and multi-mirroring options. The system includes a plurality of server processing central processing units, each server having one or more mount points for storage and retrieval of file data. At least one managerial system is in communication with each server, each managerial system having configure information for each server, mover module software, and checker module software. One or more pairs of remote data storage device servers are in communication with the servers so that each pair stores the same data as its counterpart so that they mirror one another, each server having software to dynamically spread workload across the available servers based on factors including the number of files already opened, the existence of files, and available space.

Abstract: A secure virtual tape management system with console and catalog monitoring and updating. The system includes at least one mainframe host processor having a catalog storing tape related information and having an operator console communicably attached thereto. A virtual tape management central processing unit includes software for facilitating remote configuration and utilization of the virtual tape management CPU. A virtual tape catalog storing tape related information is attached to the virtual tape management CPU. An inboard software component resident in the mainframe host obtains and collects any and all console messages issued to the operator console of the mainframe host for conveyance to the virtual tape management CPU to allow automation steps and routines to be performed in response to the console messages.

Abstract: Remote configuration and utilization of a virtual tape management system via communication of encrypted data. At least one security administrator CPU is communicably attached to a virtual tape management CPU. At least one remote data storage CPU is communicably attached to the virtual tape management CPU and to the security administrator. First software within the virtual tape management CPU validates authorized remote access to at least one remote data storage CPU and encrypts the data. Second software facilitates remote configuration and utilization of the virtual tape management CPU. At least one hardware adaptor card connects the virtual tape management CPU to a host.

Abstract: A system for planning and verifying off-site disaster recovery plans as well as implementing alternate fall back operations in the event of a disaster. The system includes at least one primary mainframe computer having an inboard catalog component, a primary emulated device controller connected to the primary computer, and a primary virtual tape system connected to the primary computer. A primary virtual tape system catalog is connected to the primary virtual tape system. A disaster recovery administrator using remote management tools maintains user and resource profiles and controls configuration of the primary emulated device controller and the primary virtual tape system.

Abstract: The disclosed systems and methods include a mold assembly having a malleable mold (4), a moldable blank (2) and a bladder (1) positioned about the moldable blank (2) to transmit an external force applied to the mold assembly uniformly to the moldable blank (2) and hence to the malleable mold (4). The invention further includes a method of replicating a surface by use of the mold assembly. The method may include manipulating the malleable mold (4) to record the image to be replicated. This manipulation may include a physical engagement of the mold with a physical surface to be replicated. Alternatively, an image, e.g., photograph or laser scan of the surface may be transmitted to a computer numerically controlled (“CNC”) system. The CNC system then manipulates the malleable mold (4) to reflect the surface to be replicated. An activated moldable blank, e.g., a blank (2) fabricated from a thermo-forming material, is then positioned over the malleable mold.

Abstract: Novel compounds and their uses are disclosed herein.

Abstract: Disclosed herein is a compound according to one of the formulas wherein R Additionally, pharmaceutically acceptable salt thereof, and methods of treating disease, medicaments, and compositions related thereto, are further elaborated herein.