Abstract: The invention relates to a fluidic system that includes a body structure having a chamber disposed therein. The fluidic system includes at least one fluid input at a first end of the chamber and at least one fluid output at a second end of the chamber. The fluidic system also includes a sensor device (e.g., an acoustic device) having a surface defining a portion of a surface of the chamber. The fluidic system also includes a first surface at the first end of the chamber oriented at an oblique or arcuate (e.g., curved) angle relative to the surface of the sensor device to direct fluid through the chamber.

Abstract: Methods for detecting analytes in a sample are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for the analyte, is combined with the sample to form a plurality of analyte-particle complexes. The system also includes a transport arrangement for transporting the sample to the sensor surface, and a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of analyte-particle complexes that are bound to the sensor surface.

Abstract: Methods for therapeutic drug monitoring are provided. A plurality of particles, each of which is coated with a capture agent capable of binding a therapeutic drug of choice is combined with the sample to form a plurality of therapeutic drug-particle complexes. The system also includes a transport arrangement for transporting the sample and/or particles to the sensor surface, and optionally a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of therapeutic drug-particle complexes that are bound to the sensor surface.

Abstract: The technology provided herein generally relates to reusable detection surfaces and methods for reusing a detection surface after using the detection surface in an assay for an analyte.

Abstract: The invention relates to fluid paths in etchable materials. Fluid paths are formed by forming a cavity through a substrate material with a first dry removal process to produce a first surface of the cavity. The first surface of the cavity is associated with a first roughness. The first surface of the cavity is etched with a second wet removal process to reduce the first roughness and produce a second roughness associated with the first surface of the cavity. A coating is applied to the first surface of the cavity to produce a second surface to improve wettability of the first or second surface of the cavity, reduce in size or number gas nucleation sites in the first or second surface of the cavity, reduce the amount of debris associated with the first roughness carried by the fluid flow, and/or improve hydrophilicity of the first or second surface.

Abstract: The invention relates to micro-fabricated devices having a suspended membrane or plate structure and micro-fabrication techniques for making such devices. A substrate defines a cavity passing through the substrate, and the cavity defines a first opening. An intermediate portion is disposed over the substrate and defines a second opening. The second opening is larger in size than the first opening, and the dimensions of the second opening are controlled according to a parameter associated with performance of the device. A membrane is positioned adjacent the second opening.

Abstract: A system for detecting an analyte in a sample includes a resonant sensor that has a sensor surface coated with the capture agent. A plurality of magnetic particles, each of which is coated with a capture agent having an affinity for the analyte, is combined with the sample to form a plurality of analyte-particle complexes. The system also includes a transport arrangement for transporting the sample to the sensor surface, and a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of analyte-particle complexes that are bound to the sensor surface.

Abstract: Laser beam machining is applied to form arbitrarily shaped electroactive ceramics for transducers (e.g., electromechanical sensors and actuators). One particularly preferred embodiment of the invention comprises machining parallel grooves in a ceramic plate to improve flexibility. The grooves provide strain relief in bending by relieving Poisson strains transverse to the direction of bending. This embodiment offers the further benefit that planar anisotropy or directionality is introduced in the transducer. The machining process of the invention further enables the production of more complex geometries than those currently known in the art. Because of the flexibility of the machining process, virtually any desired transducer shape may be produced.

Abstract: Laser beam machining is applied to form arbitrarily shaped electroactive ceramics for transducers (e.g., electromechanical sensors and actuators). One particularly preferred embodiment of the invention comprises machining parallel grooves in a ceramic plate to improve flexibility. The grooves provide strain relief in bending by relieving Poisson strains transverse to the direction of bending. This embodiment offers the further benefit that planar anisotropy or directionality is introduced in the transducer. The machining process of the invention further enables the production of more complex geometries than those currently known in the art. Because of the flexibility of the machining process, virtually any desired transducer shape may be produced.

Abstract: A temperature regulation and flow control device is described. A web of material, e.g., for a wet suit, has a layer of gel particles embedded in a flow control layer, preferably a foam matrix. A water permeable neoprene layer covers the flow control layer and allows water to enter the suit. The flow of water in the suit is regulated by the expansion and contraction of the gel as it undergoes a volume phase transition in response to a change in temperature. When the diver is in cold water, the cold water enters the foam substrate and the gel expands, causing permeability (i.e., flow) to decrease. Flow is restricted in response to cooling, and the foam substrate expands and tightens the fit of the wet suit. In warmer water, an opposite effect occurs, whereby the gel contracts and flow increases. The gel contracts relaxing the fit of the suit. A gel having a particular volume phase transition critical temperature is selected in order to maintain body temperature in a particular environment.

Abstract: A temperature regulation and flow control device is described. A web of material, e.g., for a wet suit, has a layer of gel particles embedded in a flow control layer, preferably a foam matrix. A water permeable neoprene layer covers the flow control layer and allows water to enter the suit. The flow of water in the suit is regulated by the expansion and contraction of the gel as it undergoes a volume phase transition in response to a change in temperature. When the diver is in cold water, the cold water enters the foam substrate and the gel expands, causing permeability (i.e., flow) to decrease. Flow is restricted in response to cooling, and the foam substrate expands and tightens the fit of the wet suit. In warmer water, an opposite effect occurs, whereby the gel contracts and flow increases. The gel contracts relaxing the fit of the suit. A gel having a particular volume phase transition critical temperature is selected in order to maintain body temperature in a particular environment.

Abstract: Impact resistant components and methods of protecting structures from impacts. The components are interposed between a potential point of impact and a structure to be protected. They comprise a shape memory alloy (SMA) exhibiting pseudoelastic behavior, and having a high strain to failure.

Abstract: A shaft for a golf club or other sporting equipment is disclosed, wherein the shaft is hollow and contains a wire or cable placed under tension therein, the wire being made of a superelastic material. The wire is connected at one end to a variation device such as a cam which varies the tension on the wire and thus the bending stiffness of the golf club. Because the wire is made of a superelastic material, for example Nitinol, it can reversibly elongate in response to pre-tensioning and dynamic stresses encountered during swinging the golf club, in order to counterbalance and accommodate, the stress encountered during normal use of the golf club, thus ensuring a long life and preventing damage to the golf club shaft.

Abstract: A temperature regulation and flow control device is described. A web of material, e.g., for a wet suit, has a layer of gel particles embedded in a flow control layer, preferably a foam matrix. A water permeable neoprene layer covers the flow control layer and allows water to enter the suit. The flow of water in the suit is regulated by the expansion and contraction of the gel as it undergoes a volume phase transition in response to a change in temperature. When the diver is in cold water, the cold water enters the foam substrate and the gel expands, causing permeability (i.e., flow) to decrease. Flow is restricted in response to cooling, and the foam substrate expands and tightens the fit of the wet suit. In warmer water, an opposite effect occurs, whereby the gel contracts and flow increases. The gel contracts relaxing the fit of the suit. A gel having a particular volume phase transition critical temperature is selected in order to maintain body temperature in a particular environment.

Abstract: Laser beam machining is applied to form arbitrarily shaped electroactive ceramics for transducers (e.g. electromechanical sensors and actuators). One particularly preferred embodiment of the invention comprises machining parallel grooves in a ceramic plate to improve flexibility. The grooves provide strain relief in bending by relieving Poisson strains transverse to the direction of bending. This embodiment offers the further benefit that planar anisotropy or directionality is introduced in the transducer. The machining process of the invention further enables the production of more complex geometries than those currently known in the art. Because of the flexibility of the machining process, virtually any desired transducer shape may be produced.

Abstract: An variable shaft, for example for a golf club. A hollow shaft has a cable or wire in the center, and means for varying the tension of the cable or wire. Increasing tension on the cable or wire places the shaft in compression and thereby reduces its bending stiffness. Preferably, the variation means are designed so that the wire tension may be quickly and easily varied by the user.

Abstract: Laser beam machining is applied to form arbitrarily shaped electroactive ceramics for transducers (e.g., electromechanical sensors and actuators). One particularly preferred embodiment of the invention comprises machining parallel grooves in a ceramic plate to improve flexibility. The grooves provide strain relief in bending by relieving Poisson strains transverse to the direction of bending. This embodiment offers the further benefit that planar anisotropy or directionality is introduced in the transducer. The machining process of the invention further enables the production of more complex geometries than those currently known in the art. Because of the flexibility of the machining process, virtually any desired transducer shape may be produced.