Patents by Inventor Brett T. STAAHL

Brett T. STAAHL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR ENHANCING GENOME EDITING
    Publication number: 20200115688
    Abstract: The present disclosure provides a composition comprising an RNA-guided endonuclease and an agent that decreases the acidity of an endosome. The present disclosure provides a composition comprising: a) a ribonucleoprotein (RNP) complex comprising: i) an RNA-guided endonuclease; and ii) a guide RNA comprising a segment that binds to the RNA-guided endonuclease and a segment that binds to a target nucleic acid; and b) an agent that decreases the acidity of an endosome. The present disclosure provides methods of binding a target nucleic acid in a eukaryotic cell; and methods of genetically modifying a target eukaryotic cell.
    Type: Application
    Filed: July 31, 2018
    Publication date: April 16, 2020
    Inventors: Jennifer A. Doudna, Brett T. Staahl, Jennifer Sabo
  • Methods and compositions for RNA-directed target DNA modification
    Patent number: 10570418
    Abstract: The present disclosure provides compositions and methods of site-specific modification of a target DNA, or a protein associated with a target DNA, in a eukaryotic cell. The present disclosure provides methods of binding a target DNA in a eukaryotic cell.
    Type: Grant
    Filed: September 1, 2015
    Date of Patent: February 25, 2020
    Assignee: The Regents of the University of California
    Inventors: Jennifer A. Doudna, Steven Lin, Brett T. Staahl
  • MODIFIED SITE-DIRECTED MODIFYING POLYPEPTIDES AND METHODS OF USE THEREOF
    Publication number: 20180363009
    Abstract: The present disclosure provides modified site-directed modifying polypeptides, and ribonucleoproteins comprising the modified polypeptides. The modified site-directed modifying polypeptides are modified for passive entry into target cells. The modified site-directed modifying polypeptides are useful in a variety of methods for target nucleic acid modification, which methods are also provided.
    Type: Application
    Filed: December 15, 2016
    Publication date: December 20, 2018
    Inventors: Jennifer A. Doudna, Brett T. Staahl, Anirvan Ghosh
  • METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION
    Publication number: 20180044700
    Abstract: The present disclosure provides compositions and methods of site-specific modification of a target DNA, or a protein associated with a target DNA, in a eukaryotic cell. The present disclosure provides methods of binding a target DNA in a eukaryotic cell.
    Type: Application
    Filed: September 1, 2015
    Publication date: February 15, 2018
    Inventors: Jennifer A. DOUDNA, Steven LIN, Brett T. STAAHL