Patents by Inventor Brian A. Bernick

Brian A. Bernick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NATURAL COMBINATION HORMONE REPLACEMENT FORMULATIONS AND THERAPIES
    Publication number: 20240115584
    Abstract: Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.
    Type: Application
    Filed: September 15, 2023
    Publication date: April 11, 2024
    Applicant: TherapeuticsMD, Inc..
    Inventors: Brian A. Bernick, Janice Louise Cacace, Peter H.R. Persicaner, Neda Irani, Julia M. Amadio, Frederick D. Sancilio
  • Progesterone formulations having a desirable PK profile
    Patent number: 11865179
    Abstract: This disclosure provides progesterone formulations, methods of using these formulations, and their related pharmacokinetic parameters. In particular embodiments, the formulations disclosed herein allow for a reduction in the amount of progesterone administered to a patient in need thereof, while still providing the benefits of a larger dosage amount.
    Type: Grant
    Filed: June 15, 2021
    Date of Patent: January 9, 2024
    Assignee: TherapeuticsMD, Inc.
    Inventors: Janice Cacace, Peter H. R. Persicaner, Thorsteinn Thorsteinsson, Frederick Sancilio, Julia Amadio, Brian Bernick, Neda Irani
  • Natural combination hormone replacement formulations and therapies
    Patent number: 11793819
    Abstract: Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.
    Type: Grant
    Filed: August 16, 2018
    Date of Patent: October 24, 2023
    Assignee: TherapeuticsMD, Inc.
    Inventors: Brian A. Bernick, Janice Louise Cacace, Peter H. R. Persicaner, Neda Irani, Julia M. Amadio, Frederick D. Sancilio
  • NATURAL COMBINATION HORMONE REPLACEMENT FORMULATIONS AND THERAPIES
    Publication number: 20230302015
    Abstract: Pharmaceutical compositions for co-administering estradiol and progesterone to a human subject in need thereof are provided. In some embodiments, the pharmaceutical composition comprises solubilized estradiol, suspended progesterone, and a solubilizing agent comprising a medium chain (C6-C12) oil.
    Type: Application
    Filed: December 7, 2022
    Publication date: September 28, 2023
    Inventors: Julia M. Amadio, Brian A. Bernick, Sebastian Mirkin
  • Natural Combination Hormone Replacement Formulations and Therapies
    Publication number: 20230218636
    Abstract: Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.
    Type: Application
    Filed: November 7, 2022
    Publication date: July 13, 2023
    Inventors: Brian A. BERNICK, Janice Louise CACACE, Peter H.R. PERSICANER, Neda IRANI, Julia M. AMADIO, Frederick D. SANCILIO
  • VAGINAL INSERTED ESTRADIOL PHARMACEUTICAL COMPOSITIONS AND METHODS
    Publication number: 20230210765
    Abstract: According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
    Type: Application
    Filed: October 12, 2022
    Publication date: July 6, 2023
    Applicant: TherapeuticsMD, Inc.
    Inventors: Brian A. BERNICK, Julia AMADIO, Peter H.R. PERSICANER
  • Soluble estradiol capsule for vaginal insertion
    Patent number: 11622933
    Abstract: According to various embodiments of this disclosure, pharmaceutical formulations comprising solubilized estradiol are provided. In various embodiments, such formulations are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
    Type: Grant
    Filed: January 27, 2020
    Date of Patent: April 11, 2023
    Assignee: THERAPEUTICSMD, INC.
    Inventors: Brian A. Bernick, Julia M. Amadio, Peter H. R. Persicaner, Thorsteinn Thorsteinsson, Janice Louise Cacace, Frederick D. Sancilio, Neda Irani
  • VAGINAL INSERTED ESTRADIOL PHARMACEUTICAL COMPOSITIONS AND METHODS
    Publication number: 20230062295
    Abstract: According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
    Type: Application
    Filed: March 28, 2022
    Publication date: March 2, 2023
    Applicant: TherapeuticsMD, Inc.
    Inventors: Brian A. BERNICK, Thorsteinn THORSTEINSSON, Peter H.R. PERSICANER, Janice Louise CACACE, Frederick D. SANCILIO, Neda IRANI, Julia AMADIO
  • Natural combination hormone replacement formulations and therapies
    Patent number: 11529360
    Abstract: Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: December 20, 2022
    Assignee: TherapeuticsMD, Inc.
    Inventors: Brian A. Bernick, Janice Louise Cacace, Peter H. R. Persicaner, Neda Irani, Julia M. Amadio, Frederick D. Sancilio
  • Vaginal inserted estradiol pharmaceutical compositions and methods
    Patent number: 11497709
    Abstract: According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: November 15, 2022
    Assignee: TherapeuticsMD, Inc.
    Inventors: Brian A. Bernick, Julia Amadio, Peter H.R. Persicaner
  • Vaginal inserted estradiol pharmaceutical compositions and methods
    Patent number: 11351182
    Abstract: According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: June 7, 2022
    Assignee: TherapeuticsMD, Inc.
    Inventors: Brian A. Bernick, Thorsteinn Thorsteinsson, Peter H. R. Persicaner, Janice Louise Cacace, Frederick D. Sancilio, Neda Irani, Julia Amadio
  • Vaginal inserted estradiol pharmaceutical compositions and methods
    Patent number: 11304959
    Abstract: According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: April 19, 2022
    Assignee: TherapeuticsMD, Inc.
    Inventors: Brian A. Bernick, Thorsteinn Thorsteinsson, Peter H. R. Persicaner, Janice Louise Cacace, Frederick D. Sancilio, Neda Irani, Julia Amadio
  • Vaginal inserted estradiol pharmaceutical compositions and methods
    Patent number: 11266661
    Abstract: Disclosed herein is, among other things, a soft gel vaginal pharmaceutical composition and dosage form containing solubilized estradiol for the treatment of vulvovaginal atrophy (VVA) and female sexual dysfunction (FSD).
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: March 8, 2022
    Assignee: TherapeuticsMD, Inc.
    Inventors: Sebastian Mirkin, Julia M. Amadio, Brian Bernick
  • VAGINAL INSERTED ESTRADIOL PHARMACEUTICAL COMPOSITIONS AND METHODS
    Publication number: 20220047609
    Abstract: The invention described herein relates to pharmaceutical compositions that are capable of delivering active pharmaceutical ingredients, such as estrogens, to the vagina and vagina-associated tissues and related methods of making and using such compositions (e.g., in the treatment of disease). Compositions of the invention are capable of being absorbed by the vagina or vagina-associated tissues such that subjects receiving treatment with the compositions may resume ambulatory activity immediately after receiving the treatment, the frequency or amount of discharge associated with the composition is low or negligible, there is little or no systemic absorption associated with the administration of the active pharmaceutical composition, or results in a combination of any or all thereof.
    Type: Application
    Filed: October 29, 2021
    Publication date: February 17, 2022
    Inventors: Sebastian Mirkin, Julia M. Amadio, Brian A. Bernick
  • Vaginal inserted estradiol pharmaceutical compositions and methods
    Patent number: 11246875
    Abstract: Disclosed herein is, among other things, a soft gel vaginal pharmaceutical composition and dosage form containing solubilized estradiol for the treatment of vulvovaginal atrophy (VVA) and female sexual dysfunction (FSD).
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: February 15, 2022
    Assignee: TherapeuticsMD, Inc.
    Inventors: Brian A. Bernick, Julia M. Amadio, Sebastian Mirkin
  • PROGESTERONE FORMULATIONS HAVING A DESIRABLE PK PROFILE
    Publication number: 20220040307
    Abstract: This disclosure provides progesterone formulations, methods of using these formulations, and their related pharmacokinetic parameters. In particular embodiments, the formulations disclosed herein allow for a reduction in the amount of progesterone administered to a patient in need thereof, while still providing the benefits of a larger dosage amount.
    Type: Application
    Filed: June 15, 2021
    Publication date: February 10, 2022
    Applicant: TherapeuticsMD, Inc.
    Inventors: Janice Cacace, Peter H.R. Persicaner, Thorsteinn Thorsteinsson, Frederick Sancilio, Julia Amadio, Brian Bernick, Neda IRANI
  • Vaginal inserted estradiol pharmaceutical compositions and methods
    Patent number: 11241445
    Abstract: According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: February 8, 2022
    Assignee: TherapeuticsMD, Inc.
    Inventors: Brian A. Bernick, Thorsteinn Thorsteinsson, Peter H. R. Persicaner, Janice Louise Cacace, Frederick D. Sancilio, Neda Irani, Julia Amadio
  • VAGINAL INSERTED ESTRADIOL PHARMACEUTICAL COMPOSITIONS AND METHODS
    Publication number: 20220016133
    Abstract: Disclosed herein is, among other things, a soft gel vaginal pharmaceutical composition and dosage form containing solubilized estradiol for the treatment of vulvovaginal atrophy (VVA) and female sexual dysfunction (FSD).
    Type: Application
    Filed: December 7, 2016
    Publication date: January 20, 2022
    Inventors: Sebastian Mirkin, Julia M. Amadio, Brian Bernick
  • Natural combination hormone replacement formulations and therapies
    Patent number: 11166963
    Abstract: Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.
    Type: Grant
    Filed: August 16, 2018
    Date of Patent: November 9, 2021
    Assignee: THERAPEUTICSMD, INC.
    Inventors: Brian A. Bernick, Janice Louise Cacace, Peter H. R. Persicaner, Neda Irani, Julia M. Amadio, Frederick D. Sancilio
  • Soluble estradiol capsule for vaginal insertion
    Patent number: 11123283
    Abstract: According to various embodiments of this disclosure, pharmaceutical formulations comprising solubilized estradiol are provided. In various embodiments, such formulations are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
    Type: Grant
    Filed: April 1, 2020
    Date of Patent: September 21, 2021
    Assignee: TherapeuticsMD, Inc.
    Inventors: Brian A. Bernick, Julia M. Amadio, Peter H. R. Persicaner, Thorsteinn Thorsteinsson, Janice Louise Cacace, Frederick D. Sancilio, Neda Irani