Abstract: The present invention provides polynucleotide sequences of the genome of Streptococcus pneumoniae, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.

Abstract: The present invention provides essential fungal polynucleotides and their encoded polypeptides, homologues thereof and their uses. Additionally, the invention provides methods for the identification of essential polynucleotides and fungal strains which may be used for drug screening.

Abstract: The present invention provides polynucleotide sequences of the genome of Streptococcus pneumoniae, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.

Abstract: The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneumoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.

Abstract: A tissue cutting device that is especially suited for neurosurgical applications is disclosed and described. The device includes a handpiece and an outer cannula in which a reciprocating inner cannula is disposed. The inner cannula includes a hinge between a body section and a cutting section that allows the cutting section to pivot when the inner cannula reciprocates within the outer cannula. A tissue collector is also provided and is in fluid communication with the lumen of the inner cannula. A fluid supply sleeve is disposed about the outer cannula and is selectively positionable along the length of the outer cannula.

Abstract: A tissue cutting device that is especially suited for neurosurgical applications is disclosed and described. The device includes a handpiece and an outer cannula in which a reciprocating inner cannula is disposed. The inner cannula includes a hinge between a body section and a cutting section that allows the cutting section to pivot when the inner cannula reciprocates within the outer cannula. The inner cannula also includes a bending portion between the proximal end of the inner cannula and the hinge which is bendable with the outer cannula. The device is particularly suited for accessing neurosurgical sites that are not accessible along a linear path.

Abstract: An biopsy apparatus includes a pressure and vacuum generator including a first cylinder and a first piston movably disposed within the cylinder. The cylinder has a pressure generating region and a vacuum generating region. The biopsy apparatus also includes an outer cannula and an inner cannula having a lumen. The inner cannula is movably disposed within the outer cannula, and the vacuum generating region is in one-way fluid communication with the inner cannula lumen.

Abstract: A power cell (100A) has an electrolyte that includes a reodox pair comprising cerium. The electrolyte in preferred cells is an acid electrolyte that comprises a element ion complexed by an organic acid or a chelating agent, and contemplated electrolytes may further include a compound that reduces the hydrogen overpotential. Where the power cell comprises a plurality of cells (100B), preferred configurations may include glassy carbon as bipolar electrolytes.

Abstract: A battery (100B) comprises an electrolyte in which a first element forms a redox pair with a second element, wherein the battery (100B) is charged at a voltage sufficient to plate the first element at the anode (122B) and wherein the voltage is insufficient to plate the second element on the anode (122B). Preferred batteries include secondary batteries comprising a mixed electrolyte that includes a redox pair formed by a first element and a second element.

Abstract: The presnt invention provides essential fungal polynucleotides and their encoded polypeptides, homologues thereof and their uses. Additionally, the invention provides methods for the identification of essential polynucleotides and fungal strains which may be used for drug screening.

Abstract: The present invention provides essential fungal polynucleotides and their encoded polypeptides, homologues thereof and their uses. Additionally, the invention provides methods for the identification of essential polynucleotides and fungal strains which may be used for drug screening.

Abstract: An electric device comprises a gelled acid electrolyte in complex with a lanthanide that forms a redox pair with a second element. Preferred electric devices include batteries, and especially primary batteries, while preferred acid electrolytes have a sulfonic acid group. Contemplated lanthanides especially include cerium, and preferred second elements particularly include zinc. Alternatively, contemplated electric devices may comprise a gelled electrolyte in which with a lanthanide forms a redox pair with zinc.

Abstract: An electric device comprises a gelled acid electrolyte (142A) in complex with a lanthanide that forms a redox pair with a second element. Preferred electric devices include batteries and especially primary batteries, while preferred acid electrolytes (124A) have a sulfonic acid group. Contemplated lanthanides especially include cerium, and preferred second elements particularly include zinc. Alternatively, contemplated electric devices may comprise a gelled electrolyte (142A) in which with a lanthanide forms a redox pair with zinc.

Abstract: Isolated nucleic acid and amino acid sequences for phenylalanine aminomutase enzyme and methods for purifying this enzyme are provided. Methods for altering biosynthesis of compounds in plant cell cultures are also provided. In particular, methods for altering production of taxanes and taxane-related compounds are provided.

Abstract: A load leveling battery (122) comprising an electrolyte that includes a cerium zinc redox pair wherein preferred electrolytes are acid electrolytes, and most preferably comprise methane sulfonic acid. Contemplated load leveling batteries (122) have an open circuit voltage of at least 2.4 Volt per cell. Such batteries are useful at power grid substations (120) and commercial and industrial applications were large amounts of power are used. Preferred capacity is at least 100,000 kWh, more preferably 250,000 kWh.

Abstract: The present invention provides essential fungal polynucleotides and their encoded polypeptides, homologues thereof and their uses. Additionally, the invention provides methods for the identification of essential polynucleotides and fungal strains which may be used for drug screening.

Abstract: A battery (100) comprises an electrolyte in which a lanthanide and zinc form a redox pair. Preferred electrolytes are acid electrolytes, and most preferably comprise methane sulfonic acid, and it is further contemplated that suitable electrolytes may include at least two lanthanides. Contemplated lanthanides include cerium, praseodymium, neodymium, terbium, and dysprosium, and further contemplate lanthanides are samarium, europium, thulium and ytterbium.

Abstract: The present invention provides essential fungal polynucleotides and their encoded polypeptides, homologues thereof and their uses. Additionally, the invention provides methods for the identification of essential polynucleotides and fungal strains which may be used for drug screening.

Abstract: The present invention provides polynucleotide sequences of the genome of Streptococcus pneumoniae, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.

Abstract: A battery (100) comprises a cell having a cathode compartment (120) that includes an element that is oxidized during charging of the battery (100), wherein the oxidized element forms a salt with an acid and thereby increases the H+ concentration in the cathode compartment (120) sufficient to promote an H+ flux into the anode compartment (110) across the separator (130), wherein the H+ flux across the separator (130) is sufficient to disintegrate a zinc dendrite proximal to the separator (130).