Patents by Inventor Brian A. Duclos

Brian A. Duclos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12102636
    Abstract: A system includes: a liquid formulation comprising an antipsychotic agent and an implantable infusion device. The implantable infusion device includes a reservoir, an outlet in communication with the reservoir, a drive mechanism configured to cause liquid formulation in the reservoir to be delivered to the outlet, and control electronics coupled to the drive mechanism. The control electronics are programmed with instructions that cause the liquid formulation to be delivered from the reservoir to the outlet at a flow rate of less than 500 microliters per hour for a period of time sufficient to reach a therapeutically effective steady state concentration in a subject's cerebrospinal fluid (CSF) if the liquid is delivered to a CSF-containing space of a subject.
    Type: Grant
    Filed: February 11, 2021
    Date of Patent: October 1, 2024
    Assignee: Medtronic, Inc.
    Inventor: Brian A. Duclos
  • Publication number: 20240099968
    Abstract: Broad cerebrospinal fluid (CSF) distribution of an agent is achievable by delivering the agent in a liquid formulation to the CSF at flow rates less than 500 microliters per hour, such as between about 2 microliters per hour and about 100 microliters per hour.
    Type: Application
    Filed: December 6, 2023
    Publication date: March 28, 2024
    Inventor: Brian A. Duclos
  • Publication number: 20240096472
    Abstract: A system includes a processor and a memory storing instructions thereon. The instructions, when executed by the processor, cause the processor to: infuse a substance into a target object, via an infusion device, according to a first flow rate; set a second flow rate associated with infusing the substance into the target object, based on a withdrawal rate of the infusion device from the target object; and infuse the substance into the target object based on the second flow rate.
    Type: Application
    Filed: September 20, 2022
    Publication date: March 21, 2024
    Inventors: Brian A. Duclos, Vinod Sharma
  • Patent number: 11883529
    Abstract: Broad cerebrospinal fluid (CSF) distribution of an agent is achievable by delivering the agent in a liquid formulation to the CSF at flow rates less than 500 microliters per hour, such as between about 2 microliters per hour and about 100 microliters per hour.
    Type: Grant
    Filed: August 5, 2021
    Date of Patent: January 30, 2024
    Assignee: Medtronic, Inc.
    Inventor: Brian A. Duclos
  • Publication number: 20230398285
    Abstract: A system is provided for treating ailments associated with a liver of a subject. The system may comprise an implantable infusion pump or similar device that is configured to deliver a liquid formulation to the liver of the subject. In some examples, the liquid formulation may be delivered to the liver based on a catheter that is attached to the implantable infusion pump at a proximal end and implanted in a target location of the subject at a distal end, such as a hepatic artery of the subject. Additionally, the liquid formulation may be configured to be delivered at a programmable flow rate for a period of time to reach a steady state concentration in the liver for providing a treatment for an ailment associated with the liver. In some examples, the ailment associated with the liver of the patient may comprise a non-alcoholic fatty liver disease.
    Type: Application
    Filed: May 9, 2023
    Publication date: December 14, 2023
    Inventor: Brian A. Duclos
  • Publication number: 20220249472
    Abstract: A method includes: (i) selecting a subject to which administration of an antipsychotic agent is desired; and (ii) administering a liquid formulation comprising the antipsychotic agent directly to cerebrospinal fluid (CSF)-containing space of the subject at a flow rate of less than 500 microliters per hour. The liquid formulation is administered for a period of time sufficient to reach a therapeutically effective steady state concentration in CSF of a brain of the subject.
    Type: Application
    Filed: February 11, 2021
    Publication date: August 11, 2022
    Inventor: Brian A. Duclos
  • Publication number: 20220062171
    Abstract: Broad cerebrospinal fluid (CSF) distribution of an agent is achievable by delivering the agent in a liquid formulation to the CSF at flow rates less than 500 microliters per hour, such as between about 2 microliters per hour and about 100 microliters per hour.
    Type: Application
    Filed: August 5, 2021
    Publication date: March 3, 2022
    Inventor: Brian A. Duclos
  • Publication number: 20150344412
    Abstract: The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical compositions containing these novel compounds, and methods for the preparation of these compounds.
    Type: Application
    Filed: August 7, 2015
    Publication date: December 3, 2015
    Inventors: Brian A. Duclos, Richard Andrew Ewin, Paul D. Johnson, Timothy Allan Johnson, Graham M. Kyne, Derek James Sheehan, Susan Mary Kult Sheehan, Donald James Skalitzky, Rajendran Vairagoundar
  • Patent number: 9145355
    Abstract: The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical compositions containing these novel compounds, and methods for the preparation of these compounds.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: September 29, 2015
    Assignee: Zoetis Services LLC
    Inventors: Brian A. Duclos, Richard Andrew Ewin, Paul D. Johnson, Timothy Allan Johnson, Graham M. Kyne, Derek James Sheehan, Susan Mary Kult Sheehan, Donald James Skalitzky, Rajendran Vairagoundar
  • Publication number: 20150266910
    Abstract: The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical composition containing these novel compounds, and methods for the preparation of these compounds.
    Type: Application
    Filed: June 5, 2015
    Publication date: September 24, 2015
    Inventors: Michael Curtis, Brian A. Duclos, Richard A. Ewin, Paul D. Johnson, Timothy Allan Johnson, Rajendran Vairagoundar, Denis Billen, Richard M. Goodwin, Andrea K. Haber-Stuk, Graham M. Kyne, Susan M. K. Sheehan
  • Publication number: 20140303384
    Abstract: The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical compositions containing these novel compounds, and methods for the preparation of these compounds.
    Type: Application
    Filed: October 5, 2012
    Publication date: October 9, 2014
    Inventors: Brian A. Duclos, Richard Andrew Ewin, Paul D. Johnson, Timothy Allan Johnson, Graham M. Kyne, Derek James Sheehan, Susan Mary Kult Sheehan, Donald James Skalitzky, Rajendran Vairagoundar
  • Patent number: 8722656
    Abstract: The present invention provides novel cephalosporin derivatives of formula I, their analogues, their use for the treatment of infections in mammals, pharmaceutical composition containing these novel compounds, and methods for the preparation of these compounds.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: May 13, 2014
    Assignee: Zoetis LLC
    Inventors: Brian A. Duclos, Edmund L. Ellsworth, Richard A. Ewin, Paul D. Johnson, Timothy A. Johnson, Graham M. Kyne, Susan M. K. Sheehan, Rajendran Vairagoundar
  • Publication number: 20130237502
    Abstract: The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical composition containing these novel compounds, and methods for the preparation of these compounds.
    Type: Application
    Filed: March 5, 2013
    Publication date: September 12, 2013
    Inventors: Michael Curtis, Brian A. Duclos, Richard A. Ewin, Paul D. Johnson, Timothy Allen Johnson, Rajendran Vairagoundar, Denis Billen, Richard M. Goodwin, Andrea K. Haber-Stuk, Graham M. Kyne, Susan M. K. Sheehan
  • Patent number: 8354092
    Abstract: The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.
    Type: Grant
    Filed: August 25, 2010
    Date of Patent: January 15, 2013
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventors: Hartmuth C. Kolb, Joseph C. Walsh, Dhanalakshmi Kasi, Vani P. Mocharla, Bing Wang, Umesh B. Gangadharmath, Brian A. Duclos, Kai Chen, Wei Zhang, Gang Chen, Henry Clifton Padgett, Farhad Karimi, Peter J. H. Scott, Zhiyong Gao, Qianwa Liang, Thomas Lee Collier, Tieming Zhao, Chunfang Xia
  • Publication number: 20120283237
    Abstract: The present invention provides novel cephalosporin derivatives of formula I, their analogues, their use for the treatment of infections in mammals, pharmaceutical composition containing these novel compounds, and methods for the preparation of these compounds.
    Type: Application
    Filed: April 30, 2012
    Publication date: November 8, 2012
    Applicant: PFIZER INC.
    Inventors: Brian A. Duclos, Edmund L. Ellsworth, Richard A. Ewin, Paul D. Johnson, Timothy A. Johnson, Graham M. Kyne, Susan M. K. Sheehan, Rajendran Vairagoundar
  • Patent number: 7977361
    Abstract: The present invention relates to novel radioactively labeled bioreducible tracers of Formula I useful for detecting hypoxic tumors or ischemic tissue in vivo. In one embodiment, the tracers consist of a 2-nitroimidazole moiety, a triazole, metabolically stable linker with pharmacokinetics enhancing substituents, and a radioisotope. The preferred in vivo imaging modality is positron emission tomography.
    Type: Grant
    Filed: July 15, 2010
    Date of Patent: July 12, 2011
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventors: Thomas Lee Collier, Brian A. Duclos, Umesh B. Gangadharmath, Zhiyong Gao, Farhad Karimi, Dhanalakshmi Kasi, Hartmuth C. Kolb, Qianwa Liang, Henry Clifton Padgett, Joseph C. Walsh, Tieming Zhao
  • Publication number: 20110091382
    Abstract: Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled flavones, coumarins, carbazoles, quinolinones, chromenones, imidazoles and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease.
    Type: Application
    Filed: February 17, 2009
    Publication date: April 21, 2011
    Inventors: Hartmuth C. Kolb, Joseph C. Walsh, Qianwa Liang, Brian A. Duclos, Wei Zhang, Peter J.H. Scott, Kai Chen, Zhiyong Gao, Tieming Zhao, Vani P. Mocharla, Dhanalakshmi Kasi, Gang Chen, Eric Wang, Anjana Sinha, Chunfang Xia, Henry Clifton Padgett, Farhad Karimi
  • Patent number: 7928210
    Abstract: Disclosed herein are novel radiolabeled nucleosides and methods for detecting cellular proliferation in a mammal, the method comprising administrating an effective amount of a radiolabeled nucleoside; the method comprising: a) administering to the mammal a diagnostically effective amount of the nucleoside to the mammal; b) allowing the nucleoside to distribute into the effective tissue; and c) imaging the tissue, wherein an increase in binding of the compound to tissue compared to a normal control level of binding indicates that the mammal is suffering from a disease involving cellular proliferation.
    Type: Grant
    Filed: March 3, 2008
    Date of Patent: April 19, 2011
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventors: Hartmuth C. Kolb, Joseph C. Walsh, Robert M Yeh, Kai Chen, Umesh Gangadharmath, Brian Duclos, Vani P. Mocharla, Farhad Karimi, Henry C. Padgett, Qianwa Liang, Tieming Zhao
  • Publication number: 20110046378
    Abstract: Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled flavones, coumarins, carbazoles, quinolinones, chromenones, imidazoles and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease
    Type: Application
    Filed: February 17, 2009
    Publication date: February 24, 2011
    Applicant: SIEMENS MEDICAL SOLUTIONS USA, INC.
    Inventors: Hartmuth C. Kolb, Joseph C. Walsh, Qianwa Liang, Brian A. Duclos, Wei Zhang, Peter J.H. Scott, Kai Chen, Zhiyong Gao, Tieming Zhao, Vani P. Mocharla, Dhanalakshmi Kasi, Gang Chen, Eric Wang, Anjana Sinha, Chunfang Xia, Henry Clifton Padgett, Farhad Karimi
  • Publication number: 20110002850
    Abstract: The present invention relates to novel radioactively labeled bioreducible tracers of Formula I useful for detecting hypoxic tumors or ischemic tissue in vivo. In one embodiment, the tracers consist of a 2-nitroimidazole moiety, a triazole, metabolically stable linker with pharmacokinetics enhancing substituents, and a radioisotope. The preferred in vivo imaging modality is positron emission tomography.
    Type: Application
    Filed: July 15, 2010
    Publication date: January 6, 2011
    Applicant: SIEMENS MEDICAL SOLUTIONS USA, INC.
    Inventors: Thomas Lee Collier, Brian A. Duclos, Umesh B. Gangadharmath, Zhiyong Gao, Farhad Karimi, Dhanalakshmi Kasi, Hartmuth C. Kolb, Qianwa Liang, Henry Clifton Padgett, Joseph C. Walsh, Tieming Zhao