Patents by Inventor Brian A. Duclos

Brian A. Duclos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Development of molecular imaging probes for carbonic anhydrase-IX using click chemistry
    Patent number: 7829063
    Abstract: The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.
    Type: Grant
    Filed: April 7, 2008
    Date of Patent: November 9, 2010
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventors: Hartmuth C. Kolb, Joseph C. Walsh, Dhanalakshmi Kasi, Vani P. Mocharla, Bing Wang, Umesh B. Gangadharmath, Brian A. Duclos, Kai Chen, Wei Zhang, Gang Chen, Henry Clifton Padgett, Farhad Karimi, Peter J. H. Scott, Zhiyong Gao, Qianwa Liang, Thomas Lee Collier, Tieming Zhao, Chunfang Xia
  • Nitro-imidazole hypoxia imaging agents
    Patent number: 7807394
    Abstract: The present invention relates to novel radioactively labeled bioreducible tracers of Formula I useful for detecting hypoxic tumors or ischemic tissue in vivo. In one embodiment, the tracers consist of a 2-nitroimidazole moiety, a triazole, metabolically stable linker with pharmacokinetics enhancing substituents, and a radioisotope. The preferred in vivo imaging modality is positron emission tomography.
    Type: Grant
    Filed: April 4, 2008
    Date of Patent: October 5, 2010
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventors: Hartmuth C. Kolb, Joseph C. Walsh, Umesh B. Gangadharmath, Farhad Karimi, Henry Clifton Padgett, Dhanalakshmi Kasi, Zhiyong Gao, Qianwa Liang, Thomas Lee Collier, Brian A. Duclos, Tieming Zhao
  • DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY
    Publication number: 20090123372
    Abstract: The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.
    Type: Application
    Filed: April 7, 2008
    Publication date: May 14, 2009
    Inventors: Hartmuth C. Kolb, Joseph C. Walsh, Dhanalakshmi Kasi, Vani P. Mocharla, Bing Wang, Umesh B. Gangadharmath, Brian A. Duclos, Kai Chen, Wei Zhang, Gang Chen, Henry Clifton Padgett, Farhad Karimi, Peter J. H. Scott, Zhiyong Gao, Qianwa Liang, Thomas Lee Collier, Tieming Zhao, Chunfang Xia
  • Nucleoside based proliferation imaging markers
    Publication number: 20090016958
    Abstract: Disclosed herein are novel radiolabeled nucleosides and methods for detecting cellular proliferation in a mammal, the method comprising administrating an effective amount of a radiolabeled nucleoside; the method comprising: a) administering to the mammal a diagnostically effective amount of the nucleoside to the mammal; b) allowing the nucleoside to distribute into the effective tissue; and c) imaging the tissue, wherein an increase in binding of the compound to tissue compared to a normal control level of binding indicates that the mammal is suffering from a disease involving cellular proliferation.
    Type: Application
    Filed: March 3, 2008
    Publication date: January 15, 2009
    Inventors: Hartmuth C. Kolb, Joseph C. Walsh, Robert M. Yeh, Kai Chen, Umesh Gangadharmath, Brian Duclos, Vani P. Mocharla, Farhad Karimi, Henry C. Padgett, Qianwa Liang, Tieming Zhao
  • Nitro-Imidazole Hypoxia Imaging Agents
    Publication number: 20090010846
    Abstract: The present invention relates to novel radioactively labeled bioreducible tracers of Formula I useful for detecting hypoxic tumors or ischemic tissue in vivo. In one embodiment, the tracers consist of a 2-nitroimidazole moiety, a triazole, metabolically stable linker with pharmacokinetics enhancing substituents, and a radioisotope. The preferred in vivo imaging modality is positron emission tomography.
    Type: Application
    Filed: April 4, 2008
    Publication date: January 8, 2009
    Inventors: Hartmuth C. Kolb, Joseph C. Walsh, Umesh B. Gangadharmath, Farhad Karimi, Henry Clifton Padgett, Dhanalakshmi Kasi, Zhiyong Gao, Qianwa Liang, Thomas Lee Collier, Brian A. Duclos, Tieming Zhao
  • Click chemistry-derived cyclic peptidomimetics as integrin markers
    Publication number: 20080213175
    Abstract: The present application is directed to radiolabeled cyclic peptidomimetics, pharmaceutical compositions comprising radiolabeled cyclic peptidomimetics, and methods of using the radiolabeled cyclic peptidomimetics. Such peptidomimetics can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).
    Type: Application
    Filed: September 17, 2007
    Publication date: September 4, 2008
    Inventors: Hartmuth C. Kolb, Kai Chen, Joseph C. Walsh, Umesh Gangadharmath, Dhanalakshmi Kasi, Bing Wang, Brian Duclos, Qianwa Liang, Henry Clifton Padgett, Farhad Karimi