Abstract: Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.

Abstract: The invention disclosed herein is direct to compounds of Formula I and pharmaceutically acceptable salts thereof, which are useful in treating neurodegenerative diseases and promoting the generation or survival of neurons in the mammalian brain. The invention also comprises pharmaceutical compositions comprising a therapeutically effective amount of compound of Formula I or a pharmaceutically acceptable salt thereof. The invention disclosed herein is also directed to a method of promoting the generation or survival of neurons in a patient in need thereof in neurodegenerative and related diseases.

Abstract: A user interface of an entity-centric knowledge discovery system presents an entity profile including a mix of structured and unstructured data relating to an entity. As a user refines the entity profile based on information gathered from various sources, the changing entity profile can be used as a substantially continuously updating query to search, retrieve, and rank new and pertinent information specifically relevant to the profiled entity. The platform described herein provide an active loop for refining an entity description and searching for additional information in which human input and machine-based algorithms can cooperate to more quickly build a comprehensive description of an entity of interest.

Abstract: A floor cleaning system and method for use thereof is disclosed for facilitating removal of waste materials. The system includes and the method relies upon use of a floor base, a floor covering, a substrate spacing the floor base and the artificial grass surfacing apart from one another, and at least one fluid-carrying structure. The floor base receives the waste materials. The floor covering is spaced above the floor base, and is at least in part permeable to the waste materials and in liquid communication with the floor base. The fluid-carrying structure is adapted to provide cleaning fluid to the floor base to rinse the waste materials received thereon. The cleaning fluid and waste materials flow along the floor base under the floor covering to facilitate evacuation thereof.

Abstract: A database management system that manages data in a database includes a query optimizer that performs query optimization based on statistics related to data in the database. The query optimizer incrementally updates the statistics. The query optimizer organizes the statistics related to the data in the database into a statistics tree structure having a root node corresponding to global statistics, internal nodes corresponding to summary statistics of descendant nodes, and leaf nodes corresponding to disjoint data ranges in the database. The query optimizer performs statistics tree transformation operations on the statistics tree structure. The transformation operations transform the statistics tree structure into a form that at least partially minimizes the system resources needed to update the statistics. The query optimizer updates the statistics corresponding to those nodes of the statistics tree structure where a change has occurred in the disjoint data ranges.

Abstract: An insulated switchgear module is disclosed. In one example, the module comprises a vacuum interrupter, current exchange assembly, and end conductors disposed within an insulated housing. The insulated housing further comprises a tank containing an actuator mechanism for actuating the current exchange assembly. An insulating tray within the housing separates the vacuum interrupter from the components in the tank. The insulated tray has a shape that corresponds with the shape of the vacuum interrupter and the shape of the housing.

Abstract: A power system housed in one or more modules or containers may be located as a unitary structure where desired, for example secured to a locomotive platform, allowing easy retrofits. A control subsystem may maintain an RPM of a prime mover at minimum that still provides an expected level of power from an electric machine for any one of a finite number of throttle settings. The control subsystem may dynamically adjust loads between various combinations of series and/or parallel couplings. A set of processor executable instructions may be configured for specific platforms by selecting appropriate set of values based on number of loads (e.g., driven axles), rating (e.g., horse power), other criteria (e.g., manufacturer, model, year). Characteristics may be determined and verified, and operation based on the outcome of such. A telematics system method logs and provides remote access to operational data, engine data, power system data, anti-idling overrides, unauthorized changes, and/or location.

Abstract: A lock cylinder generally including a shell, a plug positioned within the shell, a locking member, and a leaf spring. The plug includes an opening which is aligned with a recess formed in the shell. The locking member is configured to selectively prevent rotation of the plug with respect to the shell. The leaf spring is positioned in the opening and includes a first portion extending radially inward toward the keyway, and a second portion extending radially outward toward the recess. When a key is inserted, a tip of the second portion extends into the recess. When the plug is subsequently rotated, a tapered surface of the recess urges the tip radially inward and into contact with an inner surface of the shell.

Abstract: Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.

Abstract: The methods and systems disclosed herein include a gaming platform that may support massively-multiplayer online computer games, with elements of social networking, in which players may use mobile devices in order to verify their location and claim a measure of control over the location. Players may function like game pieces in association with other members on a team and participate in competitions to capture and defend real-world territory as part of the gaming experience. The gaming platform and associated entities may share revenue and other incentives with entities associated with the locations controlled by the players on the game platform.

Abstract: Systems and associated processes for guiding users to provide more useful reviews are described. These systems and processes can provide guided reviews in certain embodiments by presenting questions to a user in the form of an interview. The questions can be relevant to the item being reviewed, and as such, may be specifically and dynamically selected based on the particular item under consideration. Many other criteria may be used to select the types of questions presented to users, examples of which will be described below. Presenting review questions to users can have the effect of reducing or eliminating the “blank page” effect of having to write a review from scratch, with no guidance. Accordingly, review questions can potentially elicit more thorough and useful feedback than existing review systems in some embodiments.

Abstract: The invention disclosed herein is directed to compounds of Formula (I) and pharmaceutically acceptable salts thereof, which are useful in the treatment of prostate, breast, colon, pancreatic, human chronic lymphocytic leukemia, melanoma and other cancers. The invention also comprises pharmaceutical compositions comprising a therapeutically effective amount of compound of Formula (I), or a pharmaceutically acceptable salt thereof. The invention disclosed herein is also directed to methods of treating prostate, breast, ovarian, liver, kidney, colon, pancreatic, human chronic lymphocytic leukemia, melanoma and other cancers. The invention disclosed herein is further directed to methods of treating prostate, breast, colon, pancreatic, chronic lymphocytic leukemia, melanoma and other cancers comprising administration of a of a therapeutically effective amount of a selective PPAR? antagonist.

Abstract: A power system housed in one or more modules or containers may be located as a unitary structure where desired, for example secured to a locomotive platform, allowing easy retrofits. A control subsystem may maintain an RPM of a prime mover at minimum that still provides an expected level of power from an electric machine for any one of a finite number of throttle settings. The control subsystem may dynamically adjust loads between various combinations of series and/or parallel couplings. A set of processor executable instructions may be configured for specific platforms by selecting appropriate set of values based on number of loads (e.g., driven axles), rating (e.g., horse power), other criteria (e.g., manufacturer, model, year). Characteristics may be determined and verified, and operation based on the outcome of such. A telematics system method logs and provides remote access to operational data, engine data, power system data, anti-idling overrides, unauthorized changes, and/or location.

Abstract: The invention is to system and methods for automatically identifying the language(s) contained in text. The system comprises two language classifiers, one that classifies the text based on the letters present, and a second classifier that classifies the text based on the words present. Each classifier produces a list of languages and a weight for each language. Each classifier also computes an overall confidence applied to the classifier as a whole. The results of the classifiers are combined together incorporating the classifier confidence and language weights. The combined results produce a list of languages and weights and an overall confidence.

Abstract: A power system housed in modules or containers may be located as a unitary structure for example secured to a locomotive platform, allowing easy retrofits. A control subsystem may maintain an RPM of a prime mover at minimum that still provides an expected level of power from an electric machine for any one of a finite number of throttle settings. The control subsystem may dynamically adjust loads between various combinations of series and/or parallel couplings. A set of processor executable instructions may be configured for specific platforms by selecting appropriate set of values based on number of loads (e.g., driven axles), rating (e.g., horse power), other criteria (e.g., manufacturer, model, year). Characteristics may be determined and verified, and operation based on the outcome of such. A telematics system method logs and provides remote access to operational data, engine data, power system data, anti-idling overrides, unauthorized changes, and/or location.

Abstract: A database management system that manages data in a database includes a query optimizer that performs query optimization based on statistics related to data in the database. The query optimizer incrementally updates the statistics. The query optimizer organizes the statistics related to the data in the database into a statistics tree structure having a root node corresponding to global statistics, internal nodes corresponding to summary statistics of descendant nodes, and leaf nodes corresponding to disjoint data ranges in the database. The query optimizer performs statistics tree transformation operations on the statistics tree structure. The transformation operations transform the statistics tree structure into a form that at least partially minimizes the system resources needed to update the statistics. The query optimizer updates the statistics corresponding to those nodes of the statistics tree structure where a change has occurred in the disjoint data ranges.

Abstract: This document describes, among other things, systems and methods for generating advertising campaigns or listings utilizing catalog information. A method comprises receiving, by an online publication system, a product catalog; accessing, by the online publication system, a merchant profile; and using the product catalog and the merchant profile to develop advertising data, wherein the advertising data includes at least one of an advertising campaign, a marketplace listing, or a store listing. The advertising campaign is published across multiple communication channels and focuses on the merchant's identity in at least one of the communication channels and specific products sold by the merchant in at least one other communication channel.

Abstract: The methods and systems disclosed herein include a gaming platform that may support massively-multiplayer online computer games, with elements of social networking, in which players may use mobile devices in order to verify their location and claim a measure of control over the location. Players may function like game pieces in association with other members on a team and participate in competitions to capture and defend real-world territory as part of the gaming experience. The gaming platform and associated entities may share revenue and other incentives with entities associated with the locations controlled by the players on the game platform.